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Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications
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| Zeitschriftentitel: | Journal of Clinical Oncology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Journal of Clinical Oncology, 29, 2011, 5, S. 475-486 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Clinical Oncology (ASCO)
|
| Schlagwörter: |
| author_facet |
Marcucci, Guido Haferlach, Torsten Döhner, Hartmut Marcucci, Guido Haferlach, Torsten Döhner, Hartmut |
|---|---|
| author |
Marcucci, Guido Haferlach, Torsten Döhner, Hartmut |
| spellingShingle |
Marcucci, Guido Haferlach, Torsten Döhner, Hartmut Journal of Clinical Oncology Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications Cancer Research Oncology |
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marcucci, guido |
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Marcucci, Guido Haferlach, Torsten Döhner, Hartmut 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2010.30.2554 <jats:p> Molecular analyses of leukemic blasts from patients with acute myeloid leukemia (AML) have revealed a striking heterogeneity with regard to the presence of acquired gene mutations and changes in gene and microRNA expression. Multiple submicroscopic genetic alterations with prognostic significance have been discovered. Application of gene- and microRNA profiling has identified genome-wide expression signatures that separate cytogenetic and molecular subsets of patients with AML into previously unrecognized biologic and/or prognostic subgroups. These and similar future findings are likely to have a major impact on the clinical management of AML because many of the identified genetic alterations not only represent independent prognosticators, but also may constitute targets for specific therapeutic intervention. In this report, we review genetic findings in AML and discuss their clinical implications. </jats:p> Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications Journal of Clinical Oncology |
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| title |
Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| title_unstemmed |
Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| title_full |
Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| title_fullStr |
Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| title_full_unstemmed |
Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| title_short |
Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| title_sort |
molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1200/jco.2010.30.2554 |
| publishDate |
2011 |
| physical |
475-486 |
| description |
<jats:p> Molecular analyses of leukemic blasts from patients with acute myeloid leukemia (AML) have revealed a striking heterogeneity with regard to the presence of acquired gene mutations and changes in gene and microRNA expression. Multiple submicroscopic genetic alterations with prognostic significance have been discovered. Application of gene- and microRNA profiling has identified genome-wide expression signatures that separate cytogenetic and molecular subsets of patients with AML into previously unrecognized biologic and/or prognostic subgroups. These and similar future findings are likely to have a major impact on the clinical management of AML because many of the identified genetic alterations not only represent independent prognosticators, but also may constitute targets for specific therapeutic intervention. In this report, we review genetic findings in AML and discuss their clinical implications. </jats:p> |
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| author | Marcucci, Guido, Haferlach, Torsten, Döhner, Hartmut |
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| description | <jats:p> Molecular analyses of leukemic blasts from patients with acute myeloid leukemia (AML) have revealed a striking heterogeneity with regard to the presence of acquired gene mutations and changes in gene and microRNA expression. Multiple submicroscopic genetic alterations with prognostic significance have been discovered. Application of gene- and microRNA profiling has identified genome-wide expression signatures that separate cytogenetic and molecular subsets of patients with AML into previously unrecognized biologic and/or prognostic subgroups. These and similar future findings are likely to have a major impact on the clinical management of AML because many of the identified genetic alterations not only represent independent prognosticators, but also may constitute targets for specific therapeutic intervention. In this report, we review genetic findings in AML and discuss their clinical implications. </jats:p> |
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| physical | 475-486 |
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| spelling | Marcucci, Guido Haferlach, Torsten Döhner, Hartmut 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2010.30.2554 <jats:p> Molecular analyses of leukemic blasts from patients with acute myeloid leukemia (AML) have revealed a striking heterogeneity with regard to the presence of acquired gene mutations and changes in gene and microRNA expression. Multiple submicroscopic genetic alterations with prognostic significance have been discovered. Application of gene- and microRNA profiling has identified genome-wide expression signatures that separate cytogenetic and molecular subsets of patients with AML into previously unrecognized biologic and/or prognostic subgroups. These and similar future findings are likely to have a major impact on the clinical management of AML because many of the identified genetic alterations not only represent independent prognosticators, but also may constitute targets for specific therapeutic intervention. In this report, we review genetic findings in AML and discuss their clinical implications. </jats:p> Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications Journal of Clinical Oncology |
| spellingShingle | Marcucci, Guido, Haferlach, Torsten, Döhner, Hartmut, Journal of Clinical Oncology, Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications, Cancer Research, Oncology |
| title | Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| title_full | Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| title_fullStr | Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| title_full_unstemmed | Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| title_short | Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| title_sort | molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications |
| title_unstemmed | Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1200/jco.2010.30.2554 |