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High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Can...
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| Zeitschriftentitel: | Journal of Clinical Oncology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , |
| In: | Journal of Clinical Oncology, 25, 2007, 22, S. 3337-3343 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Clinical Oncology (ASCO)
|
| Schlagwörter: |
| author_facet |
Marcucci, Guido Maharry, Kati Whitman, Susan P. Vukosavljevic, Tamara Paschka, Peter Langer, Christian Mrózek, Krzysztof Baldus, Claudia D. Carroll, Andrew J. Powell, Bayard L. Kolitz, Jonathan E. Larson, Richard A. Bloomfield, Clara D. Marcucci, Guido Maharry, Kati Whitman, Susan P. Vukosavljevic, Tamara Paschka, Peter Langer, Christian Mrózek, Krzysztof Baldus, Claudia D. Carroll, Andrew J. Powell, Bayard L. Kolitz, Jonathan E. Larson, Richard A. Bloomfield, Clara D. |
|---|---|
| author |
Marcucci, Guido Maharry, Kati Whitman, Susan P. Vukosavljevic, Tamara Paschka, Peter Langer, Christian Mrózek, Krzysztof Baldus, Claudia D. Carroll, Andrew J. Powell, Bayard L. Kolitz, Jonathan E. Larson, Richard A. Bloomfield, Clara D. |
| spellingShingle |
Marcucci, Guido Maharry, Kati Whitman, Susan P. Vukosavljevic, Tamara Paschka, Peter Langer, Christian Mrózek, Krzysztof Baldus, Claudia D. Carroll, Andrew J. Powell, Bayard L. Kolitz, Jonathan E. Larson, Richard A. Bloomfield, Clara D. Journal of Clinical Oncology High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study Cancer Research Oncology |
| author_sort |
marcucci, guido |
| spelling |
Marcucci, Guido Maharry, Kati Whitman, Susan P. Vukosavljevic, Tamara Paschka, Peter Langer, Christian Mrózek, Krzysztof Baldus, Claudia D. Carroll, Andrew J. Powell, Bayard L. Kolitz, Jonathan E. Larson, Richard A. Bloomfield, Clara D. 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2007.10.8720 <jats:sec><jats:title>Purpose</jats:title><jats:p> To validate ERG overexpression as an adverse predictor and assess its prognostic value in the context of other molecular markers in cytogenetically normal (CN) -acute myeloid leukemia (AML). </jats:p></jats:sec><jats:sec><jats:title>Patients and Methods</jats:title><jats:p> Seventy-six adult patients with primary CN-AML, younger than 60 years and treated on Cancer and Leukemia Group B (CALGB) trial 19808, were evaluated for ERG expression by quantitative reverse transcriptase polymerase chain reaction. They were then combined with 72 patients enrolled onto CALGB 9621 for analyses that included other molecular markers. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Similar to patients enrolled onto CALGB 9621, high ERG expressers on CALGB 19808 had fewer complete remissions (CRs; P = .03) and worse event-free survival (EFS; P = .016) than low ERG expressers. In the combined set, high expressers (n = 55) had fewer CRs (P = .004) and shorter EFS (P < .001) than low expressers (n = 93). High ERG predicted failure to achieve CR (P = .004) after adjusting for BAALC expression (P = .04) and age (P = .008), and EFS (P = .004) after adjusting for FLT3 internal tandem duplication (ITD; P < .001). Among patients without FLT3-ITD (FLT3-ITD negative), only high ERG predicted shorter EFS (P = .001). Among NPM1-mutated (NPM1 positive) patients, high ERG predicted shorter EFS (P = .003), after adjusting for FLT3-ITD (P < .001). When all three markers were considered together, in the favorable FLT3-ITD–negative/NPM1-positive subset, high ERG was the only factor predicting shorter EFS (P = .002). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> We validated ERG overexpression as an adverse predictor in CN-AML. Moreover, by using ERG expression levels, we improved the previously proposed molecular-risk classification of CN-AML based on the presence or absence of FLT3-ITD and NPM1 mutations, given that we identified subsets with different outcome among FLT3-ITD–negative, NPM1-positive, and FLT3-ITD–negative/NPM1-positive patients. </jats:p></jats:sec> High Expression Levels of the <i>ETS</i>-Related Gene, <i>ERG</i>, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study Journal of Clinical Oncology |
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American Society of Clinical Oncology (ASCO), 2007 |
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American Society of Clinical Oncology (ASCO), 2007 |
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0732-183X 1527-7755 |
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American Society of Clinical Oncology (ASCO) |
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Journal of Clinical Oncology |
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| title |
High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| title_unstemmed |
High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| title_full |
High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| title_fullStr |
High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| title_full_unstemmed |
High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| title_short |
High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| title_sort |
high expression levels of the <i>ets</i>-related gene, <i>erg</i>, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: a cancer and leukemia group b study |
| topic |
Cancer Research Oncology |
| url |
http://dx.doi.org/10.1200/jco.2007.10.8720 |
| publishDate |
2007 |
| physical |
3337-3343 |
| description |
<jats:sec><jats:title>Purpose</jats:title><jats:p> To validate ERG overexpression as an adverse predictor and assess its prognostic value in the context of other molecular markers in cytogenetically normal (CN) -acute myeloid leukemia (AML). </jats:p></jats:sec><jats:sec><jats:title>Patients and Methods</jats:title><jats:p> Seventy-six adult patients with primary CN-AML, younger than 60 years and treated on Cancer and Leukemia Group B (CALGB) trial 19808, were evaluated for ERG expression by quantitative reverse transcriptase polymerase chain reaction. They were then combined with 72 patients enrolled onto CALGB 9621 for analyses that included other molecular markers. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Similar to patients enrolled onto CALGB 9621, high ERG expressers on CALGB 19808 had fewer complete remissions (CRs; P = .03) and worse event-free survival (EFS; P = .016) than low ERG expressers. In the combined set, high expressers (n = 55) had fewer CRs (P = .004) and shorter EFS (P < .001) than low expressers (n = 93). High ERG predicted failure to achieve CR (P = .004) after adjusting for BAALC expression (P = .04) and age (P = .008), and EFS (P = .004) after adjusting for FLT3 internal tandem duplication (ITD; P < .001). Among patients without FLT3-ITD (FLT3-ITD negative), only high ERG predicted shorter EFS (P = .001). Among NPM1-mutated (NPM1 positive) patients, high ERG predicted shorter EFS (P = .003), after adjusting for FLT3-ITD (P < .001). When all three markers were considered together, in the favorable FLT3-ITD–negative/NPM1-positive subset, high ERG was the only factor predicting shorter EFS (P = .002). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> We validated ERG overexpression as an adverse predictor in CN-AML. Moreover, by using ERG expression levels, we improved the previously proposed molecular-risk classification of CN-AML based on the presence or absence of FLT3-ITD and NPM1 mutations, given that we identified subsets with different outcome among FLT3-ITD–negative, NPM1-positive, and FLT3-ITD–negative/NPM1-positive patients. </jats:p></jats:sec> |
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| author | Marcucci, Guido, Maharry, Kati, Whitman, Susan P., Vukosavljevic, Tamara, Paschka, Peter, Langer, Christian, Mrózek, Krzysztof, Baldus, Claudia D., Carroll, Andrew J., Powell, Bayard L., Kolitz, Jonathan E., Larson, Richard A., Bloomfield, Clara D. |
| author_facet | Marcucci, Guido, Maharry, Kati, Whitman, Susan P., Vukosavljevic, Tamara, Paschka, Peter, Langer, Christian, Mrózek, Krzysztof, Baldus, Claudia D., Carroll, Andrew J., Powell, Bayard L., Kolitz, Jonathan E., Larson, Richard A., Bloomfield, Clara D., Marcucci, Guido, Maharry, Kati, Whitman, Susan P., Vukosavljevic, Tamara, Paschka, Peter, Langer, Christian, Mrózek, Krzysztof, Baldus, Claudia D., Carroll, Andrew J., Powell, Bayard L., Kolitz, Jonathan E., Larson, Richard A., Bloomfield, Clara D. |
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| description | <jats:sec><jats:title>Purpose</jats:title><jats:p> To validate ERG overexpression as an adverse predictor and assess its prognostic value in the context of other molecular markers in cytogenetically normal (CN) -acute myeloid leukemia (AML). </jats:p></jats:sec><jats:sec><jats:title>Patients and Methods</jats:title><jats:p> Seventy-six adult patients with primary CN-AML, younger than 60 years and treated on Cancer and Leukemia Group B (CALGB) trial 19808, were evaluated for ERG expression by quantitative reverse transcriptase polymerase chain reaction. They were then combined with 72 patients enrolled onto CALGB 9621 for analyses that included other molecular markers. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Similar to patients enrolled onto CALGB 9621, high ERG expressers on CALGB 19808 had fewer complete remissions (CRs; P = .03) and worse event-free survival (EFS; P = .016) than low ERG expressers. In the combined set, high expressers (n = 55) had fewer CRs (P = .004) and shorter EFS (P < .001) than low expressers (n = 93). High ERG predicted failure to achieve CR (P = .004) after adjusting for BAALC expression (P = .04) and age (P = .008), and EFS (P = .004) after adjusting for FLT3 internal tandem duplication (ITD; P < .001). Among patients without FLT3-ITD (FLT3-ITD negative), only high ERG predicted shorter EFS (P = .001). Among NPM1-mutated (NPM1 positive) patients, high ERG predicted shorter EFS (P = .003), after adjusting for FLT3-ITD (P < .001). When all three markers were considered together, in the favorable FLT3-ITD–negative/NPM1-positive subset, high ERG was the only factor predicting shorter EFS (P = .002). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> We validated ERG overexpression as an adverse predictor in CN-AML. Moreover, by using ERG expression levels, we improved the previously proposed molecular-risk classification of CN-AML based on the presence or absence of FLT3-ITD and NPM1 mutations, given that we identified subsets with different outcome among FLT3-ITD–negative, NPM1-positive, and FLT3-ITD–negative/NPM1-positive patients. </jats:p></jats:sec> |
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| spelling | Marcucci, Guido Maharry, Kati Whitman, Susan P. Vukosavljevic, Tamara Paschka, Peter Langer, Christian Mrózek, Krzysztof Baldus, Claudia D. Carroll, Andrew J. Powell, Bayard L. Kolitz, Jonathan E. Larson, Richard A. Bloomfield, Clara D. 0732-183X 1527-7755 American Society of Clinical Oncology (ASCO) Cancer Research Oncology http://dx.doi.org/10.1200/jco.2007.10.8720 <jats:sec><jats:title>Purpose</jats:title><jats:p> To validate ERG overexpression as an adverse predictor and assess its prognostic value in the context of other molecular markers in cytogenetically normal (CN) -acute myeloid leukemia (AML). </jats:p></jats:sec><jats:sec><jats:title>Patients and Methods</jats:title><jats:p> Seventy-six adult patients with primary CN-AML, younger than 60 years and treated on Cancer and Leukemia Group B (CALGB) trial 19808, were evaluated for ERG expression by quantitative reverse transcriptase polymerase chain reaction. They were then combined with 72 patients enrolled onto CALGB 9621 for analyses that included other molecular markers. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Similar to patients enrolled onto CALGB 9621, high ERG expressers on CALGB 19808 had fewer complete remissions (CRs; P = .03) and worse event-free survival (EFS; P = .016) than low ERG expressers. In the combined set, high expressers (n = 55) had fewer CRs (P = .004) and shorter EFS (P < .001) than low expressers (n = 93). High ERG predicted failure to achieve CR (P = .004) after adjusting for BAALC expression (P = .04) and age (P = .008), and EFS (P = .004) after adjusting for FLT3 internal tandem duplication (ITD; P < .001). Among patients without FLT3-ITD (FLT3-ITD negative), only high ERG predicted shorter EFS (P = .001). Among NPM1-mutated (NPM1 positive) patients, high ERG predicted shorter EFS (P = .003), after adjusting for FLT3-ITD (P < .001). When all three markers were considered together, in the favorable FLT3-ITD–negative/NPM1-positive subset, high ERG was the only factor predicting shorter EFS (P = .002). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> We validated ERG overexpression as an adverse predictor in CN-AML. Moreover, by using ERG expression levels, we improved the previously proposed molecular-risk classification of CN-AML based on the presence or absence of FLT3-ITD and NPM1 mutations, given that we identified subsets with different outcome among FLT3-ITD–negative, NPM1-positive, and FLT3-ITD–negative/NPM1-positive patients. </jats:p></jats:sec> High Expression Levels of the <i>ETS</i>-Related Gene, <i>ERG</i>, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study Journal of Clinical Oncology |
| spellingShingle | Marcucci, Guido, Maharry, Kati, Whitman, Susan P., Vukosavljevic, Tamara, Paschka, Peter, Langer, Christian, Mrózek, Krzysztof, Baldus, Claudia D., Carroll, Andrew J., Powell, Bayard L., Kolitz, Jonathan E., Larson, Richard A., Bloomfield, Clara D., Journal of Clinical Oncology, High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study, Cancer Research, Oncology |
| title | High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| title_full | High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| title_fullStr | High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| title_full_unstemmed | High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| title_short | High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| title_sort | high expression levels of the <i>ets</i>-related gene, <i>erg</i>, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: a cancer and leukemia group b study |
| title_unstemmed | High Expression Levels of the ETS-Related Gene, ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study |
| topic | Cancer Research, Oncology |
| url | http://dx.doi.org/10.1200/jco.2007.10.8720 |