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Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel
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| Zeitschriftentitel: | Journal of Experimental Biology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Journal of Experimental Biology, 188, 1994, 1, S. 205-216 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
|
| Schlagwörter: |
| author_facet |
Uesaka, Toshihiro Yano, Keiichi Yamasaki, Motoo Nagashima, Kei Ando, Masaaki Uesaka, Toshihiro Yano, Keiichi Yamasaki, Motoo Nagashima, Kei Ando, Masaaki |
|---|---|
| author |
Uesaka, Toshihiro Yano, Keiichi Yamasaki, Motoo Nagashima, Kei Ando, Masaaki |
| spellingShingle |
Uesaka, Toshihiro Yano, Keiichi Yamasaki, Motoo Nagashima, Kei Ando, Masaaki Journal of Experimental Biology Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel Insect Science Molecular Biology Animal Science and Zoology Aquatic Science Physiology Ecology, Evolution, Behavior and Systematics |
| author_sort |
uesaka, toshihiro |
| spelling |
Uesaka, Toshihiro Yano, Keiichi Yamasaki, Motoo Nagashima, Kei Ando, Masaaki 0022-0949 1477-9145 The Company of Biologists Insect Science Molecular Biology Animal Science and Zoology Aquatic Science Physiology Ecology, Evolution, Behavior and Systematics http://dx.doi.org/10.1242/jeb.188.1.205 <jats:title>ABSTRACT</jats:title> <jats:p>Four somatostatin-related peptides were isolated from eel guts. Two of them were the same as eel SS-25II (eSS-25II) and eel SS-25I (eSS-25I) isolated from European eel pancreas. The remaining two peptides were C-terminal tetradecapeptides (eSS-14II and eSS-14I) of eSS25II and eSS-25I, respectively. These four peptides all enhanced the serosa-negative transepithelial potential difference and short-circuit current across the seawater eel intestine after pretreatment with isobutylmethylxanthine, serotonin (5-HT) and methacholine, an agonist of acetylcholine (ACh). Among these peptides, eSS-25II was the most potent enhancer, followed by eSS-25I and eSS-14II. Since the large peptide (eSS-25II) acts at a lower concentration than the small somatostatin (eSS-14II), the 11 N-terminal amino acid residues seem to potentiate somatostatin action in the eel intestine. In contrast, eSS-14II was more potent than mammalian SS-14, indicating that the three amino acid residues (Tyr18, Gly21, Pro22) in the C-terminal portion also contribute to the potency of somatostatin. Endogenous somatostatin (eSS-25II) activated net Na+, Cl-and water fluxes across the seawater eel intestine. This stimulatory action was not inhibited by tetrodotoxin or yohimbine, an adrenergic antagonist, indicating that eSS-25II does not act through neuronal firing or through catecholamine release. Thus, eel somatostatins may act directly on the enterocytes, but on a distinct receptor from that for adrenaline, to antagonize the inhibition of NaCl and water absorption by 5-HT and ACh in the seawater eel intestine.</jats:p> Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel Journal of Experimental Biology |
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| title |
Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_unstemmed |
Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_full |
Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_fullStr |
Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_full_unstemmed |
Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_short |
Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_sort |
somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| topic |
Insect Science Molecular Biology Animal Science and Zoology Aquatic Science Physiology Ecology, Evolution, Behavior and Systematics |
| url |
http://dx.doi.org/10.1242/jeb.188.1.205 |
| publishDate |
1994 |
| physical |
205-216 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>Four somatostatin-related peptides were isolated from eel guts. Two of them were the same as eel SS-25II (eSS-25II) and eel SS-25I (eSS-25I) isolated from European eel pancreas. The remaining two peptides were C-terminal tetradecapeptides (eSS-14II and eSS-14I) of eSS25II and eSS-25I, respectively. These four peptides all enhanced the serosa-negative transepithelial potential difference and short-circuit current across the seawater eel intestine after pretreatment with isobutylmethylxanthine, serotonin (5-HT) and methacholine, an agonist of acetylcholine (ACh). Among these peptides, eSS-25II was the most potent enhancer, followed by eSS-25I and eSS-14II. Since the large peptide (eSS-25II) acts at a lower concentration than the small somatostatin (eSS-14II), the 11 N-terminal amino acid residues seem to potentiate somatostatin action in the eel intestine. In contrast, eSS-14II was more potent than mammalian SS-14, indicating that the three amino acid residues (Tyr18, Gly21, Pro22) in the C-terminal portion also contribute to the potency of somatostatin. Endogenous somatostatin (eSS-25II) activated net Na+, Cl-and water fluxes across the seawater eel intestine. This stimulatory action was not inhibited by tetrodotoxin or yohimbine, an adrenergic antagonist, indicating that eSS-25II does not act through neuronal firing or through catecholamine release. Thus, eel somatostatins may act directly on the enterocytes, but on a distinct receptor from that for adrenaline, to antagonize the inhibition of NaCl and water absorption by 5-HT and ACh in the seawater eel intestine.</jats:p> |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p>Four somatostatin-related peptides were isolated from eel guts. Two of them were the same as eel SS-25II (eSS-25II) and eel SS-25I (eSS-25I) isolated from European eel pancreas. The remaining two peptides were C-terminal tetradecapeptides (eSS-14II and eSS-14I) of eSS25II and eSS-25I, respectively. These four peptides all enhanced the serosa-negative transepithelial potential difference and short-circuit current across the seawater eel intestine after pretreatment with isobutylmethylxanthine, serotonin (5-HT) and methacholine, an agonist of acetylcholine (ACh). Among these peptides, eSS-25II was the most potent enhancer, followed by eSS-25I and eSS-14II. Since the large peptide (eSS-25II) acts at a lower concentration than the small somatostatin (eSS-14II), the 11 N-terminal amino acid residues seem to potentiate somatostatin action in the eel intestine. In contrast, eSS-14II was more potent than mammalian SS-14, indicating that the three amino acid residues (Tyr18, Gly21, Pro22) in the C-terminal portion also contribute to the potency of somatostatin. Endogenous somatostatin (eSS-25II) activated net Na+, Cl-and water fluxes across the seawater eel intestine. This stimulatory action was not inhibited by tetrodotoxin or yohimbine, an adrenergic antagonist, indicating that eSS-25II does not act through neuronal firing or through catecholamine release. Thus, eel somatostatins may act directly on the enterocytes, but on a distinct receptor from that for adrenaline, to antagonize the inhibition of NaCl and water absorption by 5-HT and ACh in the seawater eel intestine.</jats:p> |
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| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2 |
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| spelling | Uesaka, Toshihiro Yano, Keiichi Yamasaki, Motoo Nagashima, Kei Ando, Masaaki 0022-0949 1477-9145 The Company of Biologists Insect Science Molecular Biology Animal Science and Zoology Aquatic Science Physiology Ecology, Evolution, Behavior and Systematics http://dx.doi.org/10.1242/jeb.188.1.205 <jats:title>ABSTRACT</jats:title> <jats:p>Four somatostatin-related peptides were isolated from eel guts. Two of them were the same as eel SS-25II (eSS-25II) and eel SS-25I (eSS-25I) isolated from European eel pancreas. The remaining two peptides were C-terminal tetradecapeptides (eSS-14II and eSS-14I) of eSS25II and eSS-25I, respectively. These four peptides all enhanced the serosa-negative transepithelial potential difference and short-circuit current across the seawater eel intestine after pretreatment with isobutylmethylxanthine, serotonin (5-HT) and methacholine, an agonist of acetylcholine (ACh). Among these peptides, eSS-25II was the most potent enhancer, followed by eSS-25I and eSS-14II. Since the large peptide (eSS-25II) acts at a lower concentration than the small somatostatin (eSS-14II), the 11 N-terminal amino acid residues seem to potentiate somatostatin action in the eel intestine. In contrast, eSS-14II was more potent than mammalian SS-14, indicating that the three amino acid residues (Tyr18, Gly21, Pro22) in the C-terminal portion also contribute to the potency of somatostatin. Endogenous somatostatin (eSS-25II) activated net Na+, Cl-and water fluxes across the seawater eel intestine. This stimulatory action was not inhibited by tetrodotoxin or yohimbine, an adrenergic antagonist, indicating that eSS-25II does not act through neuronal firing or through catecholamine release. Thus, eel somatostatins may act directly on the enterocytes, but on a distinct receptor from that for adrenaline, to antagonize the inhibition of NaCl and water absorption by 5-HT and ACh in the seawater eel intestine.</jats:p> Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel Journal of Experimental Biology |
| spellingShingle | Uesaka, Toshihiro, Yano, Keiichi, Yamasaki, Motoo, Nagashima, Kei, Ando, Masaaki, Journal of Experimental Biology, Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel, Insect Science, Molecular Biology, Animal Science and Zoology, Aquatic Science, Physiology, Ecology, Evolution, Behavior and Systematics |
| title | Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_full | Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_fullStr | Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_full_unstemmed | Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_short | Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_sort | somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| title_unstemmed | Somatostatin-related peptides isolated from the eel gut: effects on ion and water absorption across the intestine of the seawater eel |
| topic | Insect Science, Molecular Biology, Animal Science and Zoology, Aquatic Science, Physiology, Ecology, Evolution, Behavior and Systematics |
| url | http://dx.doi.org/10.1242/jeb.188.1.205 |