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Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors
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| Zeitschriftentitel: | Journal of Experimental Biology |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Journal of Experimental Biology, 208, 2005, 4, S. 697-705 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
|
| Schlagwörter: |
| author_facet |
Zhao, Yanmei Sun, Hui Lu, Jun Li, Xiaoxue Chen, Xia Tao, Dan Huang, Weifeng Huang, Baiqu Zhao, Yanmei Sun, Hui Lu, Jun Li, Xiaoxue Chen, Xia Tao, Dan Huang, Weifeng Huang, Baiqu |
|---|---|
| author |
Zhao, Yanmei Sun, Hui Lu, Jun Li, Xiaoxue Chen, Xia Tao, Dan Huang, Weifeng Huang, Baiqu |
| spellingShingle |
Zhao, Yanmei Sun, Hui Lu, Jun Li, Xiaoxue Chen, Xia Tao, Dan Huang, Weifeng Huang, Baiqu Journal of Experimental Biology Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors Insect Science Molecular Biology Animal Science and Zoology Aquatic Science Physiology Ecology, Evolution, Behavior and Systematics |
| author_sort |
zhao, yanmei |
| spelling |
Zhao, Yanmei Sun, Hui Lu, Jun Li, Xiaoxue Chen, Xia Tao, Dan Huang, Weifeng Huang, Baiqu 1477-9145 0022-0949 The Company of Biologists Insect Science Molecular Biology Animal Science and Zoology Aquatic Science Physiology Ecology, Evolution, Behavior and Systematics http://dx.doi.org/10.1242/jeb.01439 <jats:title>SUMMARY</jats:title><jats:p>The heat shock proteins (Hsps) play a positive role in lifespan determination, and histone acetylation has been shown to be involved in transcription of hsp genes in Drosophila. To further determine if hsp22 and hsp70 expression is correlated with lifespan, and if histone acetylation participates in this process, RNA levels for hsp22 and hsp70 were analyzed throughout the lifespan in the long-lived and short-lived iso-female lines. The results showed that hsp22 and hsp70 RNA levels were higher in long-lived line than in short-lived line and that the long-lived flies responded more rapidly to heat but were more tolerant to high temperature. Moreover, we investigated the influences of histone acetylation modification on longevity and on hsp gene expression by using histone deacetylase (HDAC) inhibitors TSA and BuA. The results demonstrated that both inhibitors were able to extend the lifespan and promote hsp22 and hsp70 expression. However, the optimal concentrations of these inhibitors, and probably the mechanisms of their actions, vary with the genetic background. In addition, we showed that HDAC inhibitors caused the hyperacetylation of core histone H3,implicating the involvement of chromatin modulation in hsp gene transcription. These data suggested a close correlation among histone acetylation, hsp gene expression and longevity in D. melanogaster.</jats:p> Lifespan extension and elevated<i>hsp</i>gene expression in<i>Drosophila</i>caused by histone deacetylase inhibitors Journal of Experimental Biology |
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The Company of Biologists, 2005 |
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2005 |
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Journal of Experimental Biology |
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| title |
Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| title_unstemmed |
Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| title_full |
Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| title_fullStr |
Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| title_full_unstemmed |
Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| title_short |
Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| title_sort |
lifespan extension and elevated<i>hsp</i>gene expression in<i>drosophila</i>caused by histone deacetylase inhibitors |
| topic |
Insect Science Molecular Biology Animal Science and Zoology Aquatic Science Physiology Ecology, Evolution, Behavior and Systematics |
| url |
http://dx.doi.org/10.1242/jeb.01439 |
| publishDate |
2005 |
| physical |
697-705 |
| description |
<jats:title>SUMMARY</jats:title><jats:p>The heat shock proteins (Hsps) play a positive role in lifespan determination, and histone acetylation has been shown to be involved in transcription of hsp genes in Drosophila. To further determine if hsp22 and hsp70 expression is correlated with lifespan, and if histone acetylation participates in this process, RNA levels for hsp22 and hsp70 were analyzed throughout the lifespan in the long-lived and short-lived iso-female lines. The results showed that hsp22 and hsp70 RNA levels were higher in long-lived line than in short-lived line and that the long-lived flies responded more rapidly to heat but were more tolerant to high temperature. Moreover, we investigated the influences of histone acetylation modification on longevity and on hsp gene expression by using histone deacetylase (HDAC) inhibitors TSA and BuA. The results demonstrated that both inhibitors were able to extend the lifespan and promote hsp22 and hsp70 expression. However, the optimal concentrations of these inhibitors, and probably the mechanisms of their actions, vary with the genetic background. In addition, we showed that HDAC inhibitors caused the hyperacetylation of core histone H3,implicating the involvement of chromatin modulation in hsp gene transcription. These data suggested a close correlation among histone acetylation, hsp gene expression and longevity in D. melanogaster.</jats:p> |
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| author | Zhao, Yanmei, Sun, Hui, Lu, Jun, Li, Xiaoxue, Chen, Xia, Tao, Dan, Huang, Weifeng, Huang, Baiqu |
| author_facet | Zhao, Yanmei, Sun, Hui, Lu, Jun, Li, Xiaoxue, Chen, Xia, Tao, Dan, Huang, Weifeng, Huang, Baiqu, Zhao, Yanmei, Sun, Hui, Lu, Jun, Li, Xiaoxue, Chen, Xia, Tao, Dan, Huang, Weifeng, Huang, Baiqu |
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| description | <jats:title>SUMMARY</jats:title><jats:p>The heat shock proteins (Hsps) play a positive role in lifespan determination, and histone acetylation has been shown to be involved in transcription of hsp genes in Drosophila. To further determine if hsp22 and hsp70 expression is correlated with lifespan, and if histone acetylation participates in this process, RNA levels for hsp22 and hsp70 were analyzed throughout the lifespan in the long-lived and short-lived iso-female lines. The results showed that hsp22 and hsp70 RNA levels were higher in long-lived line than in short-lived line and that the long-lived flies responded more rapidly to heat but were more tolerant to high temperature. Moreover, we investigated the influences of histone acetylation modification on longevity and on hsp gene expression by using histone deacetylase (HDAC) inhibitors TSA and BuA. The results demonstrated that both inhibitors were able to extend the lifespan and promote hsp22 and hsp70 expression. However, the optimal concentrations of these inhibitors, and probably the mechanisms of their actions, vary with the genetic background. In addition, we showed that HDAC inhibitors caused the hyperacetylation of core histone H3,implicating the involvement of chromatin modulation in hsp gene transcription. These data suggested a close correlation among histone acetylation, hsp gene expression and longevity in D. melanogaster.</jats:p> |
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| imprint_str_mv | The Company of Biologists, 2005 |
| institution | DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15 |
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| physical | 697-705 |
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| series | Journal of Experimental Biology |
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| spelling | Zhao, Yanmei Sun, Hui Lu, Jun Li, Xiaoxue Chen, Xia Tao, Dan Huang, Weifeng Huang, Baiqu 1477-9145 0022-0949 The Company of Biologists Insect Science Molecular Biology Animal Science and Zoology Aquatic Science Physiology Ecology, Evolution, Behavior and Systematics http://dx.doi.org/10.1242/jeb.01439 <jats:title>SUMMARY</jats:title><jats:p>The heat shock proteins (Hsps) play a positive role in lifespan determination, and histone acetylation has been shown to be involved in transcription of hsp genes in Drosophila. To further determine if hsp22 and hsp70 expression is correlated with lifespan, and if histone acetylation participates in this process, RNA levels for hsp22 and hsp70 were analyzed throughout the lifespan in the long-lived and short-lived iso-female lines. The results showed that hsp22 and hsp70 RNA levels were higher in long-lived line than in short-lived line and that the long-lived flies responded more rapidly to heat but were more tolerant to high temperature. Moreover, we investigated the influences of histone acetylation modification on longevity and on hsp gene expression by using histone deacetylase (HDAC) inhibitors TSA and BuA. The results demonstrated that both inhibitors were able to extend the lifespan and promote hsp22 and hsp70 expression. However, the optimal concentrations of these inhibitors, and probably the mechanisms of their actions, vary with the genetic background. In addition, we showed that HDAC inhibitors caused the hyperacetylation of core histone H3,implicating the involvement of chromatin modulation in hsp gene transcription. These data suggested a close correlation among histone acetylation, hsp gene expression and longevity in D. melanogaster.</jats:p> Lifespan extension and elevated<i>hsp</i>gene expression in<i>Drosophila</i>caused by histone deacetylase inhibitors Journal of Experimental Biology |
| spellingShingle | Zhao, Yanmei, Sun, Hui, Lu, Jun, Li, Xiaoxue, Chen, Xia, Tao, Dan, Huang, Weifeng, Huang, Baiqu, Journal of Experimental Biology, Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors, Insect Science, Molecular Biology, Animal Science and Zoology, Aquatic Science, Physiology, Ecology, Evolution, Behavior and Systematics |
| title | Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| title_full | Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| title_fullStr | Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| title_full_unstemmed | Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| title_short | Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| title_sort | lifespan extension and elevated<i>hsp</i>gene expression in<i>drosophila</i>caused by histone deacetylase inhibitors |
| title_unstemmed | Lifespan extension and elevatedhspgene expression inDrosophilacaused by histone deacetylase inhibitors |
| topic | Insect Science, Molecular Biology, Animal Science and Zoology, Aquatic Science, Physiology, Ecology, Evolution, Behavior and Systematics |
| url | http://dx.doi.org/10.1242/jeb.01439 |