Eintrag weiter verarbeiten
A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast
Gespeichert in:
| Zeitschriftentitel: | Journal of Cell Science |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Cell Science, 2012 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
|
| Schlagwörter: |
| author_facet |
Yan, Hongyan Balasubramanian, Mohan K. Yan, Hongyan Balasubramanian, Mohan K. |
|---|---|
| author |
Yan, Hongyan Balasubramanian, Mohan K. |
| spellingShingle |
Yan, Hongyan Balasubramanian, Mohan K. Journal of Cell Science A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast Cell Biology |
| author_sort |
yan, hongyan |
| spelling |
Yan, Hongyan Balasubramanian, Mohan K. 1477-9137 0021-9533 The Company of Biologists Cell Biology http://dx.doi.org/10.1242/jcs.jcs091561 <jats:p>Sporulation is a unique form of cytokinesis that occurs following meiosis II in many yeasts, during which four daughter cells (spores) are generated within a single mother cell. Here we characterize the role of F-actin in the process of sporulation in the fission yeast Schizosaccharomyces pombe. As shown previously, we find that F-actin assembles into 4 ring structures per ascus, referred to as the MeiAR (meiotic actin ring). The actin nucleators Arp2/3 and formin-For3 assemble into ring structures that overlap with Meu14, a protein known to assemble into the so-called leading edge, a ring structure that is known to guide forespore membrane assembly. Interestingly, F-actin makes rings that occupy a larger region behind the leading edge ring. Time-lapse microscopy showed that the MeiAR assembles near the spindle pole bodies and undergoes an expansion in diameter during the early stages of meiosis II, followed by closure in later stages of meiosis II. MeiAR closure completes the process of forespore membrane assembly. Loss of MeiAR leads to excessive assembly of forespore membranes with a deformed appearance. The rate of closure of the MeiAR is dictated by the function of the Septation Initiation Network (SIN). We conclude that the MeiAR ensures proper targeting of the membrane biogenesis machinery to the leading edge, thereby ensuring the formation of spherically shaped spores.</jats:p> A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast Journal of Cell Science |
| doi_str_mv |
10.1242/jcs.jcs091561 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTI0Mi9qY3MuamNzMDkxNTYx |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTI0Mi9qY3MuamNzMDkxNTYx |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
The Company of Biologists, 2012 |
| imprint_str_mv |
The Company of Biologists, 2012 |
| issn |
0021-9533 1477-9137 |
| issn_str_mv |
0021-9533 1477-9137 |
| language |
English |
| mega_collection |
The Company of Biologists (CrossRef) |
| match_str |
yan2012ameioticactinringmeiaressentialforpropersporulationinfissionyeast |
| publishDateSort |
2012 |
| publisher |
The Company of Biologists |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Cell Science |
| source_id |
49 |
| title |
A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| title_unstemmed |
A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| title_full |
A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| title_fullStr |
A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| title_full_unstemmed |
A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| title_short |
A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| title_sort |
a meiotic actin ring (meiar) essential for proper sporulation in fission yeast |
| topic |
Cell Biology |
| url |
http://dx.doi.org/10.1242/jcs.jcs091561 |
| publishDate |
2012 |
| physical |
|
| description |
<jats:p>Sporulation is a unique form of cytokinesis that occurs following meiosis II in many yeasts, during which four daughter cells (spores) are generated within a single mother cell. Here we characterize the role of F-actin in the process of sporulation in the fission yeast Schizosaccharomyces pombe. As shown previously, we find that F-actin assembles into 4 ring structures per ascus, referred to as the MeiAR (meiotic actin ring). The actin nucleators Arp2/3 and formin-For3 assemble into ring structures that overlap with Meu14, a protein known to assemble into the so-called leading edge, a ring structure that is known to guide forespore membrane assembly. Interestingly, F-actin makes rings that occupy a larger region behind the leading edge ring. Time-lapse microscopy showed that the MeiAR assembles near the spindle pole bodies and undergoes an expansion in diameter during the early stages of meiosis II, followed by closure in later stages of meiosis II. MeiAR closure completes the process of forespore membrane assembly. Loss of MeiAR leads to excessive assembly of forespore membranes with a deformed appearance. The rate of closure of the MeiAR is dictated by the function of the Septation Initiation Network (SIN). We conclude that the MeiAR ensures proper targeting of the membrane biogenesis machinery to the leading edge, thereby ensuring the formation of spherically shaped spores.</jats:p> |
| container_start_page |
0 |
| container_title |
Journal of Cell Science |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792347619451731972 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:58:10.018Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=A+Meiotic+Actin+Ring+%28MeiAR%29+Essential+for+Proper+Sporulation+in+Fission+Yeast&rft.date=2012-01-01&genre=article&issn=0021-9533&jtitle=Journal+of+Cell+Science&atitle=A+Meiotic+Actin+Ring+%28MeiAR%29+Essential+for+Proper+Sporulation+in+Fission+Yeast&aulast=Balasubramanian&aufirst=Mohan+K.&rft_id=info%3Adoi%2F10.1242%2Fjcs.jcs091561&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792347619451731972 |
| author | Yan, Hongyan, Balasubramanian, Mohan K. |
| author_facet | Yan, Hongyan, Balasubramanian, Mohan K., Yan, Hongyan, Balasubramanian, Mohan K. |
| author_sort | yan, hongyan |
| container_start_page | 0 |
| container_title | Journal of Cell Science |
| description | <jats:p>Sporulation is a unique form of cytokinesis that occurs following meiosis II in many yeasts, during which four daughter cells (spores) are generated within a single mother cell. Here we characterize the role of F-actin in the process of sporulation in the fission yeast Schizosaccharomyces pombe. As shown previously, we find that F-actin assembles into 4 ring structures per ascus, referred to as the MeiAR (meiotic actin ring). The actin nucleators Arp2/3 and formin-For3 assemble into ring structures that overlap with Meu14, a protein known to assemble into the so-called leading edge, a ring structure that is known to guide forespore membrane assembly. Interestingly, F-actin makes rings that occupy a larger region behind the leading edge ring. Time-lapse microscopy showed that the MeiAR assembles near the spindle pole bodies and undergoes an expansion in diameter during the early stages of meiosis II, followed by closure in later stages of meiosis II. MeiAR closure completes the process of forespore membrane assembly. Loss of MeiAR leads to excessive assembly of forespore membranes with a deformed appearance. The rate of closure of the MeiAR is dictated by the function of the Septation Initiation Network (SIN). We conclude that the MeiAR ensures proper targeting of the membrane biogenesis machinery to the leading edge, thereby ensuring the formation of spherically shaped spores.</jats:p> |
| doi_str_mv | 10.1242/jcs.jcs091561 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTI0Mi9qY3MuamNzMDkxNTYx |
| imprint | The Company of Biologists, 2012 |
| imprint_str_mv | The Company of Biologists, 2012 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0021-9533, 1477-9137 |
| issn_str_mv | 0021-9533, 1477-9137 |
| language | English |
| last_indexed | 2024-03-01T17:58:10.018Z |
| match_str | yan2012ameioticactinringmeiaressentialforpropersporulationinfissionyeast |
| mega_collection | The Company of Biologists (CrossRef) |
| physical | |
| publishDate | 2012 |
| publishDateSort | 2012 |
| publisher | The Company of Biologists |
| record_format | ai |
| recordtype | ai |
| series | Journal of Cell Science |
| source_id | 49 |
| spelling | Yan, Hongyan Balasubramanian, Mohan K. 1477-9137 0021-9533 The Company of Biologists Cell Biology http://dx.doi.org/10.1242/jcs.jcs091561 <jats:p>Sporulation is a unique form of cytokinesis that occurs following meiosis II in many yeasts, during which four daughter cells (spores) are generated within a single mother cell. Here we characterize the role of F-actin in the process of sporulation in the fission yeast Schizosaccharomyces pombe. As shown previously, we find that F-actin assembles into 4 ring structures per ascus, referred to as the MeiAR (meiotic actin ring). The actin nucleators Arp2/3 and formin-For3 assemble into ring structures that overlap with Meu14, a protein known to assemble into the so-called leading edge, a ring structure that is known to guide forespore membrane assembly. Interestingly, F-actin makes rings that occupy a larger region behind the leading edge ring. Time-lapse microscopy showed that the MeiAR assembles near the spindle pole bodies and undergoes an expansion in diameter during the early stages of meiosis II, followed by closure in later stages of meiosis II. MeiAR closure completes the process of forespore membrane assembly. Loss of MeiAR leads to excessive assembly of forespore membranes with a deformed appearance. The rate of closure of the MeiAR is dictated by the function of the Septation Initiation Network (SIN). We conclude that the MeiAR ensures proper targeting of the membrane biogenesis machinery to the leading edge, thereby ensuring the formation of spherically shaped spores.</jats:p> A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast Journal of Cell Science |
| spellingShingle | Yan, Hongyan, Balasubramanian, Mohan K., Journal of Cell Science, A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast, Cell Biology |
| title | A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| title_full | A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| title_fullStr | A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| title_full_unstemmed | A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| title_short | A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| title_sort | a meiotic actin ring (meiar) essential for proper sporulation in fission yeast |
| title_unstemmed | A Meiotic Actin Ring (MeiAR) Essential for Proper Sporulation in Fission Yeast |
| topic | Cell Biology |
| url | http://dx.doi.org/10.1242/jcs.jcs091561 |