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Dynamics of cortical domains in earlyDrosophiladevelopment
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| Zeitschriftentitel: | Journal of Cell Science |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Cell Science, 131, 2018, 7 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
|
| Schlagwörter: |
| author_facet |
Schmidt, Anja Grosshans, Jörg Schmidt, Anja Grosshans, Jörg |
|---|---|
| author |
Schmidt, Anja Grosshans, Jörg |
| spellingShingle |
Schmidt, Anja Grosshans, Jörg Journal of Cell Science Dynamics of cortical domains in earlyDrosophiladevelopment Cell Biology |
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schmidt, anja |
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Schmidt, Anja Grosshans, Jörg 1477-9137 0021-9533 The Company of Biologists Cell Biology http://dx.doi.org/10.1242/jcs.212795 <jats:title>ABSTRACT</jats:title><jats:p>Underlying the plasma membrane of eukaryotic cells is an actin cortex that includes actin filaments and associated proteins. A special feature of all polarized and epithelial cells are cortical domains, each of which is characterized by specific sets of proteins. Typically, an epithelial cell contains apical, subapical, lateral and basal domains. The domain-specific protein sets contain evolutionarily conserved proteins, as well as cell-type-specific factors. Among the conserved proteins are, the Par proteins, Crumbs complex and the lateral proteins Scribbled and Discs large 1. Organization of the plasma membrane into cortical domains is dynamic and depends on cell type, differentiation and developmental stage. The dynamics of cortical organization is strikingly visible in early Drosophila embryos, which increase the number of distinct cortical domains from one, during the pre-blastoderm stage, to two in syncytial blastoderm embryos, before finally acquiring the four domains that are typical for epithelial cells during cellularization. In this Review, we will describe the dynamics of cortical organization in early Drosophila embryos and discuss the processes and mechanisms underlying cortical remodeling.</jats:p> Dynamics of cortical domains in early<i>Drosophila</i>development Journal of Cell Science |
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| title |
Dynamics of cortical domains in earlyDrosophiladevelopment |
| title_unstemmed |
Dynamics of cortical domains in earlyDrosophiladevelopment |
| title_full |
Dynamics of cortical domains in earlyDrosophiladevelopment |
| title_fullStr |
Dynamics of cortical domains in earlyDrosophiladevelopment |
| title_full_unstemmed |
Dynamics of cortical domains in earlyDrosophiladevelopment |
| title_short |
Dynamics of cortical domains in earlyDrosophiladevelopment |
| title_sort |
dynamics of cortical domains in early<i>drosophila</i>development |
| topic |
Cell Biology |
| url |
http://dx.doi.org/10.1242/jcs.212795 |
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2018 |
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<jats:title>ABSTRACT</jats:title><jats:p>Underlying the plasma membrane of eukaryotic cells is an actin cortex that includes actin filaments and associated proteins. A special feature of all polarized and epithelial cells are cortical domains, each of which is characterized by specific sets of proteins. Typically, an epithelial cell contains apical, subapical, lateral and basal domains. The domain-specific protein sets contain evolutionarily conserved proteins, as well as cell-type-specific factors. Among the conserved proteins are, the Par proteins, Crumbs complex and the lateral proteins Scribbled and Discs large 1. Organization of the plasma membrane into cortical domains is dynamic and depends on cell type, differentiation and developmental stage. The dynamics of cortical organization is strikingly visible in early Drosophila embryos, which increase the number of distinct cortical domains from one, during the pre-blastoderm stage, to two in syncytial blastoderm embryos, before finally acquiring the four domains that are typical for epithelial cells during cellularization. In this Review, we will describe the dynamics of cortical organization in early Drosophila embryos and discuss the processes and mechanisms underlying cortical remodeling.</jats:p> |
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| description | <jats:title>ABSTRACT</jats:title><jats:p>Underlying the plasma membrane of eukaryotic cells is an actin cortex that includes actin filaments and associated proteins. A special feature of all polarized and epithelial cells are cortical domains, each of which is characterized by specific sets of proteins. Typically, an epithelial cell contains apical, subapical, lateral and basal domains. The domain-specific protein sets contain evolutionarily conserved proteins, as well as cell-type-specific factors. Among the conserved proteins are, the Par proteins, Crumbs complex and the lateral proteins Scribbled and Discs large 1. Organization of the plasma membrane into cortical domains is dynamic and depends on cell type, differentiation and developmental stage. The dynamics of cortical organization is strikingly visible in early Drosophila embryos, which increase the number of distinct cortical domains from one, during the pre-blastoderm stage, to two in syncytial blastoderm embryos, before finally acquiring the four domains that are typical for epithelial cells during cellularization. In this Review, we will describe the dynamics of cortical organization in early Drosophila embryos and discuss the processes and mechanisms underlying cortical remodeling.</jats:p> |
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| spelling | Schmidt, Anja Grosshans, Jörg 1477-9137 0021-9533 The Company of Biologists Cell Biology http://dx.doi.org/10.1242/jcs.212795 <jats:title>ABSTRACT</jats:title><jats:p>Underlying the plasma membrane of eukaryotic cells is an actin cortex that includes actin filaments and associated proteins. A special feature of all polarized and epithelial cells are cortical domains, each of which is characterized by specific sets of proteins. Typically, an epithelial cell contains apical, subapical, lateral and basal domains. The domain-specific protein sets contain evolutionarily conserved proteins, as well as cell-type-specific factors. Among the conserved proteins are, the Par proteins, Crumbs complex and the lateral proteins Scribbled and Discs large 1. Organization of the plasma membrane into cortical domains is dynamic and depends on cell type, differentiation and developmental stage. The dynamics of cortical organization is strikingly visible in early Drosophila embryos, which increase the number of distinct cortical domains from one, during the pre-blastoderm stage, to two in syncytial blastoderm embryos, before finally acquiring the four domains that are typical for epithelial cells during cellularization. In this Review, we will describe the dynamics of cortical organization in early Drosophila embryos and discuss the processes and mechanisms underlying cortical remodeling.</jats:p> Dynamics of cortical domains in early<i>Drosophila</i>development Journal of Cell Science |
| spellingShingle | Schmidt, Anja, Grosshans, Jörg, Journal of Cell Science, Dynamics of cortical domains in earlyDrosophiladevelopment, Cell Biology |
| title | Dynamics of cortical domains in earlyDrosophiladevelopment |
| title_full | Dynamics of cortical domains in earlyDrosophiladevelopment |
| title_fullStr | Dynamics of cortical domains in earlyDrosophiladevelopment |
| title_full_unstemmed | Dynamics of cortical domains in earlyDrosophiladevelopment |
| title_short | Dynamics of cortical domains in earlyDrosophiladevelopment |
| title_sort | dynamics of cortical domains in early<i>drosophila</i>development |
| title_unstemmed | Dynamics of cortical domains in earlyDrosophiladevelopment |
| topic | Cell Biology |
| url | http://dx.doi.org/10.1242/jcs.212795 |