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Focal adhesion kinase: the first ten years

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Bibliographische Detailangaben
Zeitschriftentitel: Journal of Cell Science
Personen und Körperschaften: Parsons, J. Thomas
In: Journal of Cell Science, 116, 2003, 8, S. 1409-1416
Format: E-Article
Sprache: Englisch
veröffentlicht:
The Company of Biologists
Schlagwörter:
Cell Biology
author_facet Parsons, J. Thomas
Parsons, J. Thomas
author Parsons, J. Thomas
spellingShingle Parsons, J. Thomas
Journal of Cell Science
Focal adhesion kinase: the first ten years
Cell Biology
author_sort parsons, j. thomas
spelling Parsons, J. Thomas 1477-9137 0021-9533 The Company of Biologists Cell Biology http://dx.doi.org/10.1242/jcs.00373 <jats:p>The protein tyrosine kinase focal adhesion kinase (FAK) plays a prominent role in integrin signaling. FAK activation, demonstrated by an increase in phosphorylation of Tyr397 as well as other sites in the protein, is best understood in the context of the engagement of integrins at the cell surface. Activation of FAK results in recruitment of a number of SH2-domain- and SH3-domain-containing proteins, which mediate signaling to several downstream pathways. FAK-dependent activation of these pathways has been implicated in a diverse array of cellular processes, including cell migration, growth factor signaling, cell cycle progression and cell survival.</jats:p> Focal adhesion kinase: the first ten years Journal of Cell Science
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title Focal adhesion kinase: the first ten years
title_unstemmed Focal adhesion kinase: the first ten years
title_full Focal adhesion kinase: the first ten years
title_fullStr Focal adhesion kinase: the first ten years
title_full_unstemmed Focal adhesion kinase: the first ten years
title_short Focal adhesion kinase: the first ten years
title_sort focal adhesion kinase: the first ten years
topic Cell Biology
url http://dx.doi.org/10.1242/jcs.00373
publishDate 2003
physical 1409-1416
description <jats:p>The protein tyrosine kinase focal adhesion kinase (FAK) plays a prominent role in integrin signaling. FAK activation, demonstrated by an increase in phosphorylation of Tyr397 as well as other sites in the protein, is best understood in the context of the engagement of integrins at the cell surface. Activation of FAK results in recruitment of a number of SH2-domain- and SH3-domain-containing proteins, which mediate signaling to several downstream pathways. FAK-dependent activation of these pathways has been implicated in a diverse array of cellular processes, including cell migration, growth factor signaling, cell cycle progression and cell survival.</jats:p>
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description <jats:p>The protein tyrosine kinase focal adhesion kinase (FAK) plays a prominent role in integrin signaling. FAK activation, demonstrated by an increase in phosphorylation of Tyr397 as well as other sites in the protein, is best understood in the context of the engagement of integrins at the cell surface. Activation of FAK results in recruitment of a number of SH2-domain- and SH3-domain-containing proteins, which mediate signaling to several downstream pathways. FAK-dependent activation of these pathways has been implicated in a diverse array of cellular processes, including cell migration, growth factor signaling, cell cycle progression and cell survival.</jats:p>
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spelling Parsons, J. Thomas 1477-9137 0021-9533 The Company of Biologists Cell Biology http://dx.doi.org/10.1242/jcs.00373 <jats:p>The protein tyrosine kinase focal adhesion kinase (FAK) plays a prominent role in integrin signaling. FAK activation, demonstrated by an increase in phosphorylation of Tyr397 as well as other sites in the protein, is best understood in the context of the engagement of integrins at the cell surface. Activation of FAK results in recruitment of a number of SH2-domain- and SH3-domain-containing proteins, which mediate signaling to several downstream pathways. FAK-dependent activation of these pathways has been implicated in a diverse array of cellular processes, including cell migration, growth factor signaling, cell cycle progression and cell survival.</jats:p> Focal adhesion kinase: the first ten years Journal of Cell Science
spellingShingle Parsons, J. Thomas, Journal of Cell Science, Focal adhesion kinase: the first ten years, Cell Biology
title Focal adhesion kinase: the first ten years
title_full Focal adhesion kinase: the first ten years
title_fullStr Focal adhesion kinase: the first ten years
title_full_unstemmed Focal adhesion kinase: the first ten years
title_short Focal adhesion kinase: the first ten years
title_sort focal adhesion kinase: the first ten years
title_unstemmed Focal adhesion kinase: the first ten years
topic Cell Biology
url http://dx.doi.org/10.1242/jcs.00373