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An illustrated anatomical ontology of the developing mouse lower urogenital tract
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| Zeitschriftentitel: | Development |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , |
| In: | Development, 142, 2015, 10, S. 1893-1908 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
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| Schlagwörter: |
| author_facet |
Georgas, Kylie M. Armstrong, Jane Keast, Janet R. Larkins, Christine E. McHugh, Kirk M. Southard-Smith, E. Michelle Cohn, Martin J. Batourina, Ekatherina Dan, Hanbin Schneider, Kerry Buehler, Dennis P. Wiese, Carrie B. Brennan, Jane Davies, Jamie A. Harding, Simon D. Baldock, Richard A. Little, Melissa H. Vezina, Chad M. Mendelsohn, Cathy Georgas, Kylie M. Armstrong, Jane Keast, Janet R. Larkins, Christine E. McHugh, Kirk M. Southard-Smith, E. Michelle Cohn, Martin J. Batourina, Ekatherina Dan, Hanbin Schneider, Kerry Buehler, Dennis P. Wiese, Carrie B. Brennan, Jane Davies, Jamie A. Harding, Simon D. Baldock, Richard A. Little, Melissa H. Vezina, Chad M. Mendelsohn, Cathy |
|---|---|
| author |
Georgas, Kylie M. Armstrong, Jane Keast, Janet R. Larkins, Christine E. McHugh, Kirk M. Southard-Smith, E. Michelle Cohn, Martin J. Batourina, Ekatherina Dan, Hanbin Schneider, Kerry Buehler, Dennis P. Wiese, Carrie B. Brennan, Jane Davies, Jamie A. Harding, Simon D. Baldock, Richard A. Little, Melissa H. Vezina, Chad M. Mendelsohn, Cathy |
| spellingShingle |
Georgas, Kylie M. Armstrong, Jane Keast, Janet R. Larkins, Christine E. McHugh, Kirk M. Southard-Smith, E. Michelle Cohn, Martin J. Batourina, Ekatherina Dan, Hanbin Schneider, Kerry Buehler, Dennis P. Wiese, Carrie B. Brennan, Jane Davies, Jamie A. Harding, Simon D. Baldock, Richard A. Little, Melissa H. Vezina, Chad M. Mendelsohn, Cathy Development An illustrated anatomical ontology of the developing mouse lower urogenital tract Developmental Biology Molecular Biology |
| author_sort |
georgas, kylie m. |
| spelling |
Georgas, Kylie M. Armstrong, Jane Keast, Janet R. Larkins, Christine E. McHugh, Kirk M. Southard-Smith, E. Michelle Cohn, Martin J. Batourina, Ekatherina Dan, Hanbin Schneider, Kerry Buehler, Dennis P. Wiese, Carrie B. Brennan, Jane Davies, Jamie A. Harding, Simon D. Baldock, Richard A. Little, Melissa H. Vezina, Chad M. Mendelsohn, Cathy 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.117903 <jats:p>Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine models. However, human anatomical terms do not always superimpose on the mouse, and the lack of accurate and standardised nomenclature is hampering the utility of such animal models. We previously developed an anatomical ontology for the murine urogenital system. Here, we present a comprehensive update of this ontology pertaining to mouse LUT, genital tubercle and associated reproductive structures (E10.5 to adult). Ontology changes were based on recently published insights into the cellular and gross anatomy of these structures, and on new analyses of epithelial cell types present in the pelvic urethra and regions of the bladder. Ontology changes include new structures, tissue layers and cell types within the LUT, external genitalia and lower reproductive structures. Representative illustrations, detailed text descriptions and molecular markers that selectively label muscle, nerves/ganglia and epithelia of the lower urogenital system are also presented. The revised ontology will be an important tool for researchers studying urogenital development/malformation in mouse models and will improve our capacity to appropriately interpret these with respect to the human situation.</jats:p> An illustrated anatomical ontology of the developing mouse lower urogenital tract Development |
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| title |
An illustrated anatomical ontology of the developing mouse lower urogenital tract |
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An illustrated anatomical ontology of the developing mouse lower urogenital tract |
| title_full |
An illustrated anatomical ontology of the developing mouse lower urogenital tract |
| title_fullStr |
An illustrated anatomical ontology of the developing mouse lower urogenital tract |
| title_full_unstemmed |
An illustrated anatomical ontology of the developing mouse lower urogenital tract |
| title_short |
An illustrated anatomical ontology of the developing mouse lower urogenital tract |
| title_sort |
an illustrated anatomical ontology of the developing mouse lower urogenital tract |
| topic |
Developmental Biology Molecular Biology |
| url |
http://dx.doi.org/10.1242/dev.117903 |
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2015 |
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1893-1908 |
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<jats:p>Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine models. However, human anatomical terms do not always superimpose on the mouse, and the lack of accurate and standardised nomenclature is hampering the utility of such animal models. We previously developed an anatomical ontology for the murine urogenital system. Here, we present a comprehensive update of this ontology pertaining to mouse LUT, genital tubercle and associated reproductive structures (E10.5 to adult). Ontology changes were based on recently published insights into the cellular and gross anatomy of these structures, and on new analyses of epithelial cell types present in the pelvic urethra and regions of the bladder. Ontology changes include new structures, tissue layers and cell types within the LUT, external genitalia and lower reproductive structures. Representative illustrations, detailed text descriptions and molecular markers that selectively label muscle, nerves/ganglia and epithelia of the lower urogenital system are also presented. The revised ontology will be an important tool for researchers studying urogenital development/malformation in mouse models and will improve our capacity to appropriately interpret these with respect to the human situation.</jats:p> |
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| description | <jats:p>Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine models. However, human anatomical terms do not always superimpose on the mouse, and the lack of accurate and standardised nomenclature is hampering the utility of such animal models. We previously developed an anatomical ontology for the murine urogenital system. Here, we present a comprehensive update of this ontology pertaining to mouse LUT, genital tubercle and associated reproductive structures (E10.5 to adult). Ontology changes were based on recently published insights into the cellular and gross anatomy of these structures, and on new analyses of epithelial cell types present in the pelvic urethra and regions of the bladder. Ontology changes include new structures, tissue layers and cell types within the LUT, external genitalia and lower reproductive structures. Representative illustrations, detailed text descriptions and molecular markers that selectively label muscle, nerves/ganglia and epithelia of the lower urogenital system are also presented. The revised ontology will be an important tool for researchers studying urogenital development/malformation in mouse models and will improve our capacity to appropriately interpret these with respect to the human situation.</jats:p> |
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| spelling | Georgas, Kylie M. Armstrong, Jane Keast, Janet R. Larkins, Christine E. McHugh, Kirk M. Southard-Smith, E. Michelle Cohn, Martin J. Batourina, Ekatherina Dan, Hanbin Schneider, Kerry Buehler, Dennis P. Wiese, Carrie B. Brennan, Jane Davies, Jamie A. Harding, Simon D. Baldock, Richard A. Little, Melissa H. Vezina, Chad M. Mendelsohn, Cathy 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.117903 <jats:p>Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine models. However, human anatomical terms do not always superimpose on the mouse, and the lack of accurate and standardised nomenclature is hampering the utility of such animal models. We previously developed an anatomical ontology for the murine urogenital system. Here, we present a comprehensive update of this ontology pertaining to mouse LUT, genital tubercle and associated reproductive structures (E10.5 to adult). Ontology changes were based on recently published insights into the cellular and gross anatomy of these structures, and on new analyses of epithelial cell types present in the pelvic urethra and regions of the bladder. Ontology changes include new structures, tissue layers and cell types within the LUT, external genitalia and lower reproductive structures. Representative illustrations, detailed text descriptions and molecular markers that selectively label muscle, nerves/ganglia and epithelia of the lower urogenital system are also presented. The revised ontology will be an important tool for researchers studying urogenital development/malformation in mouse models and will improve our capacity to appropriately interpret these with respect to the human situation.</jats:p> An illustrated anatomical ontology of the developing mouse lower urogenital tract Development |
| spellingShingle | Georgas, Kylie M., Armstrong, Jane, Keast, Janet R., Larkins, Christine E., McHugh, Kirk M., Southard-Smith, E. Michelle, Cohn, Martin J., Batourina, Ekatherina, Dan, Hanbin, Schneider, Kerry, Buehler, Dennis P., Wiese, Carrie B., Brennan, Jane, Davies, Jamie A., Harding, Simon D., Baldock, Richard A., Little, Melissa H., Vezina, Chad M., Mendelsohn, Cathy, Development, An illustrated anatomical ontology of the developing mouse lower urogenital tract, Developmental Biology, Molecular Biology |
| title | An illustrated anatomical ontology of the developing mouse lower urogenital tract |
| title_full | An illustrated anatomical ontology of the developing mouse lower urogenital tract |
| title_fullStr | An illustrated anatomical ontology of the developing mouse lower urogenital tract |
| title_full_unstemmed | An illustrated anatomical ontology of the developing mouse lower urogenital tract |
| title_short | An illustrated anatomical ontology of the developing mouse lower urogenital tract |
| title_sort | an illustrated anatomical ontology of the developing mouse lower urogenital tract |
| title_unstemmed | An illustrated anatomical ontology of the developing mouse lower urogenital tract |
| topic | Developmental Biology, Molecular Biology |
| url | http://dx.doi.org/10.1242/dev.117903 |