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Immature hematopoietic stem cells undergo maturation in the fetal liver
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| Zeitschriftentitel: | Development |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Development, 139, 2012, 19, S. 3521-3530 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
|
| Schlagwörter: |
| author_facet |
Kieusseian, Aurelie de la Grange, Philippe Brunet Burlen-Defranoux, Odile Godin, Isabelle Cumano, Ana Kieusseian, Aurelie de la Grange, Philippe Brunet Burlen-Defranoux, Odile Godin, Isabelle Cumano, Ana |
|---|---|
| author |
Kieusseian, Aurelie de la Grange, Philippe Brunet Burlen-Defranoux, Odile Godin, Isabelle Cumano, Ana |
| spellingShingle |
Kieusseian, Aurelie de la Grange, Philippe Brunet Burlen-Defranoux, Odile Godin, Isabelle Cumano, Ana Development Immature hematopoietic stem cells undergo maturation in the fetal liver Developmental Biology Molecular Biology |
| author_sort |
kieusseian, aurelie |
| spelling |
Kieusseian, Aurelie de la Grange, Philippe Brunet Burlen-Defranoux, Odile Godin, Isabelle Cumano, Ana 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.079210 <jats:p>Hematopoietic stem cells (HSCs), which are defined by their capacity to reconstitute adult conventional mice, are first found in the dorsal aorta after 10.5 days post coitus (dpc) and in the fetal liver at 11 dpc. However, lympho-myeloid hematopoietic progenitors are detected in the dorsal aorta from 9 dpc, raising the issue of their role in establishing adult hematopoiesis. Here, we show that these progenitors are endowed with long-term reconstitution capacity, but only engraft natural killer (NK)-deficient Rag2γc–/– mice. This novel population, called here immature HSCs, evolves in culture with thrombopoietin and stromal cells, into HSCs, defined by acquisition of CD45 and MHC-1 expression and by the capacity to reconstitute NK-competent mice. This evolution occurs during ontogeny, as early colonization of fetal liver by immature HSCs precedes that of HSCs. Moreover, organ culture experiments show that immature HSCs acquire, in this environment, the features of HSCs.</jats:p> Immature hematopoietic stem cells undergo maturation in the fetal liver Development |
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| title |
Immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_unstemmed |
Immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_full |
Immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_fullStr |
Immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_full_unstemmed |
Immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_short |
Immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_sort |
immature hematopoietic stem cells undergo maturation in the fetal liver |
| topic |
Developmental Biology Molecular Biology |
| url |
http://dx.doi.org/10.1242/dev.079210 |
| publishDate |
2012 |
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3521-3530 |
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<jats:p>Hematopoietic stem cells (HSCs), which are defined by their capacity to reconstitute adult conventional mice, are first found in the dorsal aorta after 10.5 days post coitus (dpc) and in the fetal liver at 11 dpc. However, lympho-myeloid hematopoietic progenitors are detected in the dorsal aorta from 9 dpc, raising the issue of their role in establishing adult hematopoiesis. Here, we show that these progenitors are endowed with long-term reconstitution capacity, but only engraft natural killer (NK)-deficient Rag2γc–/– mice. This novel population, called here immature HSCs, evolves in culture with thrombopoietin and stromal cells, into HSCs, defined by acquisition of CD45 and MHC-1 expression and by the capacity to reconstitute NK-competent mice. This evolution occurs during ontogeny, as early colonization of fetal liver by immature HSCs precedes that of HSCs. Moreover, organ culture experiments show that immature HSCs acquire, in this environment, the features of HSCs.</jats:p> |
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| author | Kieusseian, Aurelie, de la Grange, Philippe Brunet, Burlen-Defranoux, Odile, Godin, Isabelle, Cumano, Ana |
| author_facet | Kieusseian, Aurelie, de la Grange, Philippe Brunet, Burlen-Defranoux, Odile, Godin, Isabelle, Cumano, Ana, Kieusseian, Aurelie, de la Grange, Philippe Brunet, Burlen-Defranoux, Odile, Godin, Isabelle, Cumano, Ana |
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| description | <jats:p>Hematopoietic stem cells (HSCs), which are defined by their capacity to reconstitute adult conventional mice, are first found in the dorsal aorta after 10.5 days post coitus (dpc) and in the fetal liver at 11 dpc. However, lympho-myeloid hematopoietic progenitors are detected in the dorsal aorta from 9 dpc, raising the issue of their role in establishing adult hematopoiesis. Here, we show that these progenitors are endowed with long-term reconstitution capacity, but only engraft natural killer (NK)-deficient Rag2γc–/– mice. This novel population, called here immature HSCs, evolves in culture with thrombopoietin and stromal cells, into HSCs, defined by acquisition of CD45 and MHC-1 expression and by the capacity to reconstitute NK-competent mice. This evolution occurs during ontogeny, as early colonization of fetal liver by immature HSCs precedes that of HSCs. Moreover, organ culture experiments show that immature HSCs acquire, in this environment, the features of HSCs.</jats:p> |
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| spelling | Kieusseian, Aurelie de la Grange, Philippe Brunet Burlen-Defranoux, Odile Godin, Isabelle Cumano, Ana 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.079210 <jats:p>Hematopoietic stem cells (HSCs), which are defined by their capacity to reconstitute adult conventional mice, are first found in the dorsal aorta after 10.5 days post coitus (dpc) and in the fetal liver at 11 dpc. However, lympho-myeloid hematopoietic progenitors are detected in the dorsal aorta from 9 dpc, raising the issue of their role in establishing adult hematopoiesis. Here, we show that these progenitors are endowed with long-term reconstitution capacity, but only engraft natural killer (NK)-deficient Rag2γc–/– mice. This novel population, called here immature HSCs, evolves in culture with thrombopoietin and stromal cells, into HSCs, defined by acquisition of CD45 and MHC-1 expression and by the capacity to reconstitute NK-competent mice. This evolution occurs during ontogeny, as early colonization of fetal liver by immature HSCs precedes that of HSCs. Moreover, organ culture experiments show that immature HSCs acquire, in this environment, the features of HSCs.</jats:p> Immature hematopoietic stem cells undergo maturation in the fetal liver Development |
| spellingShingle | Kieusseian, Aurelie, de la Grange, Philippe Brunet, Burlen-Defranoux, Odile, Godin, Isabelle, Cumano, Ana, Development, Immature hematopoietic stem cells undergo maturation in the fetal liver, Developmental Biology, Molecular Biology |
| title | Immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_full | Immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_fullStr | Immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_full_unstemmed | Immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_short | Immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_sort | immature hematopoietic stem cells undergo maturation in the fetal liver |
| title_unstemmed | Immature hematopoietic stem cells undergo maturation in the fetal liver |
| topic | Developmental Biology, Molecular Biology |
| url | http://dx.doi.org/10.1242/dev.079210 |