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Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse
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| Zeitschriftentitel: | Development |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Development, 133, 2006, 9, S. 1625-1634 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
|
| Schlagwörter: |
| author_facet |
Watanabe, Yusuke Kokubo, Hiroki Miyagawa-Tomita, Sachiko Endo, Maho Igarashi, Katsuhide Aisaki, Ken ichi Kanno, Jun Saga, Yumiko Watanabe, Yusuke Kokubo, Hiroki Miyagawa-Tomita, Sachiko Endo, Maho Igarashi, Katsuhide Aisaki, Ken ichi Kanno, Jun Saga, Yumiko |
|---|---|
| author |
Watanabe, Yusuke Kokubo, Hiroki Miyagawa-Tomita, Sachiko Endo, Maho Igarashi, Katsuhide Aisaki, Ken ichi Kanno, Jun Saga, Yumiko |
| spellingShingle |
Watanabe, Yusuke Kokubo, Hiroki Miyagawa-Tomita, Sachiko Endo, Maho Igarashi, Katsuhide Aisaki, Ken ichi Kanno, Jun Saga, Yumiko Development Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse Developmental Biology Molecular Biology |
| author_sort |
watanabe, yusuke |
| spelling |
Watanabe, Yusuke Kokubo, Hiroki Miyagawa-Tomita, Sachiko Endo, Maho Igarashi, Katsuhide Aisaki, Ken ichi Kanno, Jun Saga, Yumiko 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.02344 <jats:p>Notch signaling is implicated in many developmental processes. In our current study, we have employed a transgenic strategy to investigate the role of Notch signaling during cardiac development in the mouse. Cre recombinase-mediated Notch1 (NICD1) activation in the mesodermal cell lineage leads to abnormal heart morphogenesis, which is characterized by deformities of the ventricles and atrioventricular (AV) canal. The major defects observed include impaired ventricular myocardial differentiation, the ectopic appearance of cell masses in the AV cushion, the right-shifted interventricular septum (IVS) and impaired myocardium of the AV canal. However, the fates of the endocardium and myocardium were not disrupted in NICD1-activated hearts. One of the Notch target genes, Hesr1, was found to be strongly induced in both the ventricle and the AV canal of NICD1-activated hearts. However, a knockout of the Hesr1 gene from NICD-activated hearts rescues only the abnormality of the AV myocardium. We searched for additional possible targets of NICD1 activation by GeneChip analysis and found that Wnt2, Bmp6, jagged 1 and Tnni2 are strongly upregulated in NICD1-activated hearts, and that the activation of these genes was also observed in the absence of Hesr1. Our present study thus indicates that the Notch1 signaling pathway plays a suppressive role both in AV myocardial differentiation and the maturation of the ventricular myocardium.</jats:p> Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse Development |
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2006 |
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| title |
Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_unstemmed |
Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_full |
Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_fullStr |
Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_full_unstemmed |
Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_short |
Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_sort |
activation of notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| topic |
Developmental Biology Molecular Biology |
| url |
http://dx.doi.org/10.1242/dev.02344 |
| publishDate |
2006 |
| physical |
1625-1634 |
| description |
<jats:p>Notch signaling is implicated in many developmental processes. In our current study, we have employed a transgenic strategy to investigate the role of Notch signaling during cardiac development in the mouse. Cre recombinase-mediated Notch1 (NICD1) activation in the mesodermal cell lineage leads to abnormal heart morphogenesis, which is characterized by deformities of the ventricles and atrioventricular (AV) canal. The major defects observed include impaired ventricular myocardial differentiation, the ectopic appearance of cell masses in the AV cushion, the right-shifted interventricular septum (IVS) and impaired myocardium of the AV canal. However, the fates of the endocardium and myocardium were not disrupted in NICD1-activated hearts. One of the Notch target genes, Hesr1, was found to be strongly induced in both the ventricle and the AV canal of NICD1-activated hearts. However, a knockout of the Hesr1 gene from NICD-activated hearts rescues only the abnormality of the AV myocardium. We searched for additional possible targets of NICD1 activation by GeneChip analysis and found that Wnt2, Bmp6, jagged 1 and Tnni2 are strongly upregulated in NICD1-activated hearts, and that the activation of these genes was also observed in the absence of Hesr1. Our present study thus indicates that the Notch1 signaling pathway plays a suppressive role both in AV myocardial differentiation and the maturation of the ventricular myocardium.</jats:p> |
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| author | Watanabe, Yusuke, Kokubo, Hiroki, Miyagawa-Tomita, Sachiko, Endo, Maho, Igarashi, Katsuhide, Aisaki, Ken ichi, Kanno, Jun, Saga, Yumiko |
| author_facet | Watanabe, Yusuke, Kokubo, Hiroki, Miyagawa-Tomita, Sachiko, Endo, Maho, Igarashi, Katsuhide, Aisaki, Ken ichi, Kanno, Jun, Saga, Yumiko, Watanabe, Yusuke, Kokubo, Hiroki, Miyagawa-Tomita, Sachiko, Endo, Maho, Igarashi, Katsuhide, Aisaki, Ken ichi, Kanno, Jun, Saga, Yumiko |
| author_sort | watanabe, yusuke |
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| description | <jats:p>Notch signaling is implicated in many developmental processes. In our current study, we have employed a transgenic strategy to investigate the role of Notch signaling during cardiac development in the mouse. Cre recombinase-mediated Notch1 (NICD1) activation in the mesodermal cell lineage leads to abnormal heart morphogenesis, which is characterized by deformities of the ventricles and atrioventricular (AV) canal. The major defects observed include impaired ventricular myocardial differentiation, the ectopic appearance of cell masses in the AV cushion, the right-shifted interventricular septum (IVS) and impaired myocardium of the AV canal. However, the fates of the endocardium and myocardium were not disrupted in NICD1-activated hearts. One of the Notch target genes, Hesr1, was found to be strongly induced in both the ventricle and the AV canal of NICD1-activated hearts. However, a knockout of the Hesr1 gene from NICD-activated hearts rescues only the abnormality of the AV myocardium. We searched for additional possible targets of NICD1 activation by GeneChip analysis and found that Wnt2, Bmp6, jagged 1 and Tnni2 are strongly upregulated in NICD1-activated hearts, and that the activation of these genes was also observed in the absence of Hesr1. Our present study thus indicates that the Notch1 signaling pathway plays a suppressive role both in AV myocardial differentiation and the maturation of the ventricular myocardium.</jats:p> |
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| imprint | The Company of Biologists, 2006 |
| imprint_str_mv | The Company of Biologists, 2006 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
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| language | English |
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| physical | 1625-1634 |
| publishDate | 2006 |
| publishDateSort | 2006 |
| publisher | The Company of Biologists |
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| series | Development |
| source_id | 49 |
| spelling | Watanabe, Yusuke Kokubo, Hiroki Miyagawa-Tomita, Sachiko Endo, Maho Igarashi, Katsuhide Aisaki, Ken ichi Kanno, Jun Saga, Yumiko 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.02344 <jats:p>Notch signaling is implicated in many developmental processes. In our current study, we have employed a transgenic strategy to investigate the role of Notch signaling during cardiac development in the mouse. Cre recombinase-mediated Notch1 (NICD1) activation in the mesodermal cell lineage leads to abnormal heart morphogenesis, which is characterized by deformities of the ventricles and atrioventricular (AV) canal. The major defects observed include impaired ventricular myocardial differentiation, the ectopic appearance of cell masses in the AV cushion, the right-shifted interventricular septum (IVS) and impaired myocardium of the AV canal. However, the fates of the endocardium and myocardium were not disrupted in NICD1-activated hearts. One of the Notch target genes, Hesr1, was found to be strongly induced in both the ventricle and the AV canal of NICD1-activated hearts. However, a knockout of the Hesr1 gene from NICD-activated hearts rescues only the abnormality of the AV myocardium. We searched for additional possible targets of NICD1 activation by GeneChip analysis and found that Wnt2, Bmp6, jagged 1 and Tnni2 are strongly upregulated in NICD1-activated hearts, and that the activation of these genes was also observed in the absence of Hesr1. Our present study thus indicates that the Notch1 signaling pathway plays a suppressive role both in AV myocardial differentiation and the maturation of the ventricular myocardium.</jats:p> Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse Development |
| spellingShingle | Watanabe, Yusuke, Kokubo, Hiroki, Miyagawa-Tomita, Sachiko, Endo, Maho, Igarashi, Katsuhide, Aisaki, Ken ichi, Kanno, Jun, Saga, Yumiko, Development, Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse, Developmental Biology, Molecular Biology |
| title | Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_full | Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_fullStr | Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_full_unstemmed | Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_short | Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_sort | activation of notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| title_unstemmed | Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse |
| topic | Developmental Biology, Molecular Biology |
| url | http://dx.doi.org/10.1242/dev.02344 |