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Isl1Cre reveals a common Bmp pathway in heart and limb development
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| Zeitschriftentitel: | Development |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Development, 133, 2006, 8, S. 1575-1585 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
|
| Schlagwörter: |
| author_facet |
Yang, Lei Cai, Chen-Leng Lin, Lizhu Qyang, Yibing Chung, Christine Monteiro, Rui M. Mummery, Christine L. Fishman, Glenn I. Cogen, Anna Evans, Sylvia Yang, Lei Cai, Chen-Leng Lin, Lizhu Qyang, Yibing Chung, Christine Monteiro, Rui M. Mummery, Christine L. Fishman, Glenn I. Cogen, Anna Evans, Sylvia |
|---|---|
| author |
Yang, Lei Cai, Chen-Leng Lin, Lizhu Qyang, Yibing Chung, Christine Monteiro, Rui M. Mummery, Christine L. Fishman, Glenn I. Cogen, Anna Evans, Sylvia |
| spellingShingle |
Yang, Lei Cai, Chen-Leng Lin, Lizhu Qyang, Yibing Chung, Christine Monteiro, Rui M. Mummery, Christine L. Fishman, Glenn I. Cogen, Anna Evans, Sylvia Development Isl1Cre reveals a common Bmp pathway in heart and limb development Developmental Biology Molecular Biology |
| author_sort |
yang, lei |
| spelling |
Yang, Lei Cai, Chen-Leng Lin, Lizhu Qyang, Yibing Chung, Christine Monteiro, Rui M. Mummery, Christine L. Fishman, Glenn I. Cogen, Anna Evans, Sylvia 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.02322 <jats:p>A number of human congenital disorders present with both heart and limb defects, consistent with common genetic pathways. We have recently shown that the LIM homeodomain transcription factor islet 1 (Isl1) marks a subset of cardiac progenitors. Here, we perform lineage studies with an Isl1Cre mouse line to demonstrate that Isl1 also marks a subset of limb progenitors. In both cardiac and limb progenitors, Isl1 expression is downregulated as progenitors migrate in to form either heart or limb. To investigate common heart-limb pathways in Isl1-expressing progenitors, we ablated the Type I Bmp receptor,Bmpr1a utilizing Isl1Cre/+. Analysis of consequent heart and limb phenotypes has revealed novel requirements for Bmp signaling. Additionally, we find that Bmp signaling in Isl1-expressing progenitors is required for expression of T-box transcription factors Tbx2 and Tbx3 in heart and limb. Tbx3 is required for heart and limb formation, and is mutated in ulnar-mammary syndrome. We provide evidence that the Tbx3 promoter is directly regulated by Bmp Smads in vivo.</jats:p> Isl1Cre reveals a common Bmp pathway in heart and limb development Development |
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| title |
Isl1Cre reveals a common Bmp pathway in heart and limb development |
| title_unstemmed |
Isl1Cre reveals a common Bmp pathway in heart and limb development |
| title_full |
Isl1Cre reveals a common Bmp pathway in heart and limb development |
| title_fullStr |
Isl1Cre reveals a common Bmp pathway in heart and limb development |
| title_full_unstemmed |
Isl1Cre reveals a common Bmp pathway in heart and limb development |
| title_short |
Isl1Cre reveals a common Bmp pathway in heart and limb development |
| title_sort |
isl1cre reveals a common bmp pathway in heart and limb development |
| topic |
Developmental Biology Molecular Biology |
| url |
http://dx.doi.org/10.1242/dev.02322 |
| publishDate |
2006 |
| physical |
1575-1585 |
| description |
<jats:p>A number of human congenital disorders present with both heart and limb defects, consistent with common genetic pathways. We have recently shown that the LIM homeodomain transcription factor islet 1 (Isl1) marks a subset of cardiac progenitors. Here, we perform lineage studies with an Isl1Cre mouse line to demonstrate that Isl1 also marks a subset of limb progenitors. In both cardiac and limb progenitors, Isl1 expression is downregulated as progenitors migrate in to form either heart or limb. To investigate common heart-limb pathways in Isl1-expressing progenitors, we ablated the Type I Bmp receptor,Bmpr1a utilizing Isl1Cre/+. Analysis of consequent heart and limb phenotypes has revealed novel requirements for Bmp signaling. Additionally, we find that Bmp signaling in Isl1-expressing progenitors is required for expression of T-box transcription factors Tbx2 and Tbx3 in heart and limb. Tbx3 is required for heart and limb formation, and is mutated in ulnar-mammary syndrome. We provide evidence that the Tbx3 promoter is directly regulated by Bmp Smads in vivo.</jats:p> |
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| author | Yang, Lei, Cai, Chen-Leng, Lin, Lizhu, Qyang, Yibing, Chung, Christine, Monteiro, Rui M., Mummery, Christine L., Fishman, Glenn I., Cogen, Anna, Evans, Sylvia |
| author_facet | Yang, Lei, Cai, Chen-Leng, Lin, Lizhu, Qyang, Yibing, Chung, Christine, Monteiro, Rui M., Mummery, Christine L., Fishman, Glenn I., Cogen, Anna, Evans, Sylvia, Yang, Lei, Cai, Chen-Leng, Lin, Lizhu, Qyang, Yibing, Chung, Christine, Monteiro, Rui M., Mummery, Christine L., Fishman, Glenn I., Cogen, Anna, Evans, Sylvia |
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| description | <jats:p>A number of human congenital disorders present with both heart and limb defects, consistent with common genetic pathways. We have recently shown that the LIM homeodomain transcription factor islet 1 (Isl1) marks a subset of cardiac progenitors. Here, we perform lineage studies with an Isl1Cre mouse line to demonstrate that Isl1 also marks a subset of limb progenitors. In both cardiac and limb progenitors, Isl1 expression is downregulated as progenitors migrate in to form either heart or limb. To investigate common heart-limb pathways in Isl1-expressing progenitors, we ablated the Type I Bmp receptor,Bmpr1a utilizing Isl1Cre/+. Analysis of consequent heart and limb phenotypes has revealed novel requirements for Bmp signaling. Additionally, we find that Bmp signaling in Isl1-expressing progenitors is required for expression of T-box transcription factors Tbx2 and Tbx3 in heart and limb. Tbx3 is required for heart and limb formation, and is mutated in ulnar-mammary syndrome. We provide evidence that the Tbx3 promoter is directly regulated by Bmp Smads in vivo.</jats:p> |
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| spelling | Yang, Lei Cai, Chen-Leng Lin, Lizhu Qyang, Yibing Chung, Christine Monteiro, Rui M. Mummery, Christine L. Fishman, Glenn I. Cogen, Anna Evans, Sylvia 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.02322 <jats:p>A number of human congenital disorders present with both heart and limb defects, consistent with common genetic pathways. We have recently shown that the LIM homeodomain transcription factor islet 1 (Isl1) marks a subset of cardiac progenitors. Here, we perform lineage studies with an Isl1Cre mouse line to demonstrate that Isl1 also marks a subset of limb progenitors. In both cardiac and limb progenitors, Isl1 expression is downregulated as progenitors migrate in to form either heart or limb. To investigate common heart-limb pathways in Isl1-expressing progenitors, we ablated the Type I Bmp receptor,Bmpr1a utilizing Isl1Cre/+. Analysis of consequent heart and limb phenotypes has revealed novel requirements for Bmp signaling. Additionally, we find that Bmp signaling in Isl1-expressing progenitors is required for expression of T-box transcription factors Tbx2 and Tbx3 in heart and limb. Tbx3 is required for heart and limb formation, and is mutated in ulnar-mammary syndrome. We provide evidence that the Tbx3 promoter is directly regulated by Bmp Smads in vivo.</jats:p> Isl1Cre reveals a common Bmp pathway in heart and limb development Development |
| spellingShingle | Yang, Lei, Cai, Chen-Leng, Lin, Lizhu, Qyang, Yibing, Chung, Christine, Monteiro, Rui M., Mummery, Christine L., Fishman, Glenn I., Cogen, Anna, Evans, Sylvia, Development, Isl1Cre reveals a common Bmp pathway in heart and limb development, Developmental Biology, Molecular Biology |
| title | Isl1Cre reveals a common Bmp pathway in heart and limb development |
| title_full | Isl1Cre reveals a common Bmp pathway in heart and limb development |
| title_fullStr | Isl1Cre reveals a common Bmp pathway in heart and limb development |
| title_full_unstemmed | Isl1Cre reveals a common Bmp pathway in heart and limb development |
| title_short | Isl1Cre reveals a common Bmp pathway in heart and limb development |
| title_sort | isl1cre reveals a common bmp pathway in heart and limb development |
| title_unstemmed | Isl1Cre reveals a common Bmp pathway in heart and limb development |
| topic | Developmental Biology, Molecular Biology |
| url | http://dx.doi.org/10.1242/dev.02322 |