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Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate
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| Zeitschriftentitel: | Development |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Development, 132, 2005, 19, S. 4397-4406 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
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| Schlagwörter: |
| author_facet |
Yu, Ling Gu, Shuping Alappat, Sylvia Song, Yiqiang Yan, Mingquan Zhang, Xiaoyun Zhang, Guozhong Jiang, Yiping Zhang, Zunyi Zhang, Yanding Chen, YiPing Yu, Ling Gu, Shuping Alappat, Sylvia Song, Yiqiang Yan, Mingquan Zhang, Xiaoyun Zhang, Guozhong Jiang, Yiping Zhang, Zunyi Zhang, Yanding Chen, YiPing |
|---|---|
| author |
Yu, Ling Gu, Shuping Alappat, Sylvia Song, Yiqiang Yan, Mingquan Zhang, Xiaoyun Zhang, Guozhong Jiang, Yiping Zhang, Zunyi Zhang, Yanding Chen, YiPing |
| spellingShingle |
Yu, Ling Gu, Shuping Alappat, Sylvia Song, Yiqiang Yan, Mingquan Zhang, Xiaoyun Zhang, Guozhong Jiang, Yiping Zhang, Zunyi Zhang, Yanding Chen, YiPing Development Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate Developmental Biology Molecular Biology |
| author_sort |
yu, ling |
| spelling |
Yu, Ling Gu, Shuping Alappat, Sylvia Song, Yiqiang Yan, Mingquan Zhang, Xiaoyun Zhang, Guozhong Jiang, Yiping Zhang, Zunyi Zhang, Yanding Chen, YiPing 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.02013 <jats:p>The short stature homeobox gene SHOX is associated with idiopathic short stature in humans, as seen in Turner syndrome and Leri-Weill dyschondrosteosis, while little is known about its close relative SHOX2. We report the restricted expression of Shox2 in the anterior domain of the secondary palate in mice and humans. Shox2-/- mice develop an incomplete cleft that is confined to the anterior region of the palate, an extremely rare type of clefting in humans. The Shox2-/- palatal shelves initiate, grow and elevate normally, but the anterior region fails to contact and fuse at the midline, owing to altered cell proliferation and apoptosis, leading to incomplete clefting within the presumptive hard palate. Accompanied with these cellular alterations is an ectopic expression of Fgf10 and Fgfr2c in the anterior palatal mesenchyme of the mutants. Tissue recombination and bead implantation experiments revealed that signals from the anterior palatal epithelium are responsible for the restricted mesenchymal Shox2 expression. BMP activity is necessary but not sufficient for the induction of palatal Shox2 expression. Our results demonstrate an intrinsic requirement for Shox2 in palatogenesis, and support the idea that palatogenesis is differentially regulated along the anteroposterior axis. Furthermore, our results demonstrate that fusion of the posterior palate can occur independently of fusion in the anterior palate.</jats:p> <i>Shox2</i>-deficient mice exhibit a rare type of incomplete clefting of the secondary palate Development |
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| title |
Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_unstemmed |
Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_full |
Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_fullStr |
Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_full_unstemmed |
Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_short |
Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_sort |
<i>shox2</i>-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| topic |
Developmental Biology Molecular Biology |
| url |
http://dx.doi.org/10.1242/dev.02013 |
| publishDate |
2005 |
| physical |
4397-4406 |
| description |
<jats:p>The short stature homeobox gene SHOX is associated with idiopathic short stature in humans, as seen in Turner syndrome and Leri-Weill dyschondrosteosis, while little is known about its close relative SHOX2. We report the restricted expression of Shox2 in the anterior domain of the secondary palate in mice and humans. Shox2-/- mice develop an incomplete cleft that is confined to the anterior region of the palate, an extremely rare type of clefting in humans. The Shox2-/- palatal shelves initiate, grow and elevate normally, but the anterior region fails to contact and fuse at the midline, owing to altered cell proliferation and apoptosis, leading to incomplete clefting within the presumptive hard palate. Accompanied with these cellular alterations is an ectopic expression of Fgf10 and Fgfr2c in the anterior palatal mesenchyme of the mutants. Tissue recombination and bead implantation experiments revealed that signals from the anterior palatal epithelium are responsible for the restricted mesenchymal Shox2 expression. BMP activity is necessary but not sufficient for the induction of palatal Shox2 expression. Our results demonstrate an intrinsic requirement for Shox2 in palatogenesis, and support the idea that palatogenesis is differentially regulated along the anteroposterior axis. Furthermore, our results demonstrate that fusion of the posterior palate can occur independently of fusion in the anterior palate.</jats:p> |
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| author | Yu, Ling, Gu, Shuping, Alappat, Sylvia, Song, Yiqiang, Yan, Mingquan, Zhang, Xiaoyun, Zhang, Guozhong, Jiang, Yiping, Zhang, Zunyi, Zhang, Yanding, Chen, YiPing |
| author_facet | Yu, Ling, Gu, Shuping, Alappat, Sylvia, Song, Yiqiang, Yan, Mingquan, Zhang, Xiaoyun, Zhang, Guozhong, Jiang, Yiping, Zhang, Zunyi, Zhang, Yanding, Chen, YiPing, Yu, Ling, Gu, Shuping, Alappat, Sylvia, Song, Yiqiang, Yan, Mingquan, Zhang, Xiaoyun, Zhang, Guozhong, Jiang, Yiping, Zhang, Zunyi, Zhang, Yanding, Chen, YiPing |
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| description | <jats:p>The short stature homeobox gene SHOX is associated with idiopathic short stature in humans, as seen in Turner syndrome and Leri-Weill dyschondrosteosis, while little is known about its close relative SHOX2. We report the restricted expression of Shox2 in the anterior domain of the secondary palate in mice and humans. Shox2-/- mice develop an incomplete cleft that is confined to the anterior region of the palate, an extremely rare type of clefting in humans. The Shox2-/- palatal shelves initiate, grow and elevate normally, but the anterior region fails to contact and fuse at the midline, owing to altered cell proliferation and apoptosis, leading to incomplete clefting within the presumptive hard palate. Accompanied with these cellular alterations is an ectopic expression of Fgf10 and Fgfr2c in the anterior palatal mesenchyme of the mutants. Tissue recombination and bead implantation experiments revealed that signals from the anterior palatal epithelium are responsible for the restricted mesenchymal Shox2 expression. BMP activity is necessary but not sufficient for the induction of palatal Shox2 expression. Our results demonstrate an intrinsic requirement for Shox2 in palatogenesis, and support the idea that palatogenesis is differentially regulated along the anteroposterior axis. Furthermore, our results demonstrate that fusion of the posterior palate can occur independently of fusion in the anterior palate.</jats:p> |
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| spelling | Yu, Ling Gu, Shuping Alappat, Sylvia Song, Yiqiang Yan, Mingquan Zhang, Xiaoyun Zhang, Guozhong Jiang, Yiping Zhang, Zunyi Zhang, Yanding Chen, YiPing 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.02013 <jats:p>The short stature homeobox gene SHOX is associated with idiopathic short stature in humans, as seen in Turner syndrome and Leri-Weill dyschondrosteosis, while little is known about its close relative SHOX2. We report the restricted expression of Shox2 in the anterior domain of the secondary palate in mice and humans. Shox2-/- mice develop an incomplete cleft that is confined to the anterior region of the palate, an extremely rare type of clefting in humans. The Shox2-/- palatal shelves initiate, grow and elevate normally, but the anterior region fails to contact and fuse at the midline, owing to altered cell proliferation and apoptosis, leading to incomplete clefting within the presumptive hard palate. Accompanied with these cellular alterations is an ectopic expression of Fgf10 and Fgfr2c in the anterior palatal mesenchyme of the mutants. Tissue recombination and bead implantation experiments revealed that signals from the anterior palatal epithelium are responsible for the restricted mesenchymal Shox2 expression. BMP activity is necessary but not sufficient for the induction of palatal Shox2 expression. Our results demonstrate an intrinsic requirement for Shox2 in palatogenesis, and support the idea that palatogenesis is differentially regulated along the anteroposterior axis. Furthermore, our results demonstrate that fusion of the posterior palate can occur independently of fusion in the anterior palate.</jats:p> <i>Shox2</i>-deficient mice exhibit a rare type of incomplete clefting of the secondary palate Development |
| spellingShingle | Yu, Ling, Gu, Shuping, Alappat, Sylvia, Song, Yiqiang, Yan, Mingquan, Zhang, Xiaoyun, Zhang, Guozhong, Jiang, Yiping, Zhang, Zunyi, Zhang, Yanding, Chen, YiPing, Development, Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate, Developmental Biology, Molecular Biology |
| title | Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_full | Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_fullStr | Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_full_unstemmed | Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_short | Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_sort | <i>shox2</i>-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| title_unstemmed | Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate |
| topic | Developmental Biology, Molecular Biology |
| url | http://dx.doi.org/10.1242/dev.02013 |