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Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster

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Zeitschriftentitel: Development
Personen und Körperschaften: Jiang, Jianqiao, White-Cooper, Helen
In: Development, 130, 2003, 3, S. 563-573
Format: E-Article
Sprache: Englisch
veröffentlicht:
The Company of Biologists
Schlagwörter:
Developmental Biology
Molecular Biology
author_facet Jiang, Jianqiao
White-Cooper, Helen
Jiang, Jianqiao
White-Cooper, Helen
author Jiang, Jianqiao
White-Cooper, Helen
spellingShingle Jiang, Jianqiao
White-Cooper, Helen
Development
Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
Developmental Biology
Molecular Biology
author_sort jiang, jianqiao
spelling Jiang, Jianqiao White-Cooper, Helen 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.00246 <jats:p>In Drosophila spermatogenesis, meiotic cell cycle progression and cellular differentiation are linked by the function of the meiotic arrest genes. The meiotic arrest genes control differentiation by regulating the transcriptional activation of many differentiation-specific genes. The meiotic arrest genes have been subdivided into aly and can classes,based on the mechanism by which they control cell cycle progression.aly has previously been shown to encode a chromatin-associated protein. We present the identification, cloning and characterisation of a novel Drosophila meiotic arrest gene, cookie monster(comr), that has a mutant phenotype indistinguishable from that ofaly. A null mutant allele of comr is viable but male sterile. Mutant primary spermatocytes fail to initiate transcription of a large number of genes, and arrest before entry into the meiotic divisions. In adult males, expression of comr is testis specific, low levels of transcripts are detected at other stages of development. comr encodes a novel acidic protein, which is nuclear and primarily localised to regions of chromatin in primary spermatocytes. The nuclear localisation of Aly and Comr proteins are mutually dependent. Finally, we show that active RNA polymerase II is found in distinct domains in the nucleus that constitute a subset of the total Comr stained chromatin.</jats:p> Transcriptional activation in<i>Drosophila</i>spermatogenesis involves the mutually dependent function of<i>aly</i>and a novel meiotic arrest gene<i>cookie monster</i> Development
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title Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
title_unstemmed Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
title_full Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
title_fullStr Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
title_full_unstemmed Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
title_short Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
title_sort transcriptional activation in<i>drosophila</i>spermatogenesis involves the mutually dependent function of<i>aly</i>and a novel meiotic arrest gene<i>cookie monster</i>
topic Developmental Biology
Molecular Biology
url http://dx.doi.org/10.1242/dev.00246
publishDate 2003
physical 563-573
description <jats:p>In Drosophila spermatogenesis, meiotic cell cycle progression and cellular differentiation are linked by the function of the meiotic arrest genes. The meiotic arrest genes control differentiation by regulating the transcriptional activation of many differentiation-specific genes. The meiotic arrest genes have been subdivided into aly and can classes,based on the mechanism by which they control cell cycle progression.aly has previously been shown to encode a chromatin-associated protein. We present the identification, cloning and characterisation of a novel Drosophila meiotic arrest gene, cookie monster(comr), that has a mutant phenotype indistinguishable from that ofaly. A null mutant allele of comr is viable but male sterile. Mutant primary spermatocytes fail to initiate transcription of a large number of genes, and arrest before entry into the meiotic divisions. In adult males, expression of comr is testis specific, low levels of transcripts are detected at other stages of development. comr encodes a novel acidic protein, which is nuclear and primarily localised to regions of chromatin in primary spermatocytes. The nuclear localisation of Aly and Comr proteins are mutually dependent. Finally, we show that active RNA polymerase II is found in distinct domains in the nucleus that constitute a subset of the total Comr stained chromatin.</jats:p>
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author Jiang, Jianqiao, White-Cooper, Helen
author_facet Jiang, Jianqiao, White-Cooper, Helen, Jiang, Jianqiao, White-Cooper, Helen
author_sort jiang, jianqiao
container_issue 3
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container_title Development
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description <jats:p>In Drosophila spermatogenesis, meiotic cell cycle progression and cellular differentiation are linked by the function of the meiotic arrest genes. The meiotic arrest genes control differentiation by regulating the transcriptional activation of many differentiation-specific genes. The meiotic arrest genes have been subdivided into aly and can classes,based on the mechanism by which they control cell cycle progression.aly has previously been shown to encode a chromatin-associated protein. We present the identification, cloning and characterisation of a novel Drosophila meiotic arrest gene, cookie monster(comr), that has a mutant phenotype indistinguishable from that ofaly. A null mutant allele of comr is viable but male sterile. Mutant primary spermatocytes fail to initiate transcription of a large number of genes, and arrest before entry into the meiotic divisions. In adult males, expression of comr is testis specific, low levels of transcripts are detected at other stages of development. comr encodes a novel acidic protein, which is nuclear and primarily localised to regions of chromatin in primary spermatocytes. The nuclear localisation of Aly and Comr proteins are mutually dependent. Finally, we show that active RNA polymerase II is found in distinct domains in the nucleus that constitute a subset of the total Comr stained chromatin.</jats:p>
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spelling Jiang, Jianqiao White-Cooper, Helen 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.00246 <jats:p>In Drosophila spermatogenesis, meiotic cell cycle progression and cellular differentiation are linked by the function of the meiotic arrest genes. The meiotic arrest genes control differentiation by regulating the transcriptional activation of many differentiation-specific genes. The meiotic arrest genes have been subdivided into aly and can classes,based on the mechanism by which they control cell cycle progression.aly has previously been shown to encode a chromatin-associated protein. We present the identification, cloning and characterisation of a novel Drosophila meiotic arrest gene, cookie monster(comr), that has a mutant phenotype indistinguishable from that ofaly. A null mutant allele of comr is viable but male sterile. Mutant primary spermatocytes fail to initiate transcription of a large number of genes, and arrest before entry into the meiotic divisions. In adult males, expression of comr is testis specific, low levels of transcripts are detected at other stages of development. comr encodes a novel acidic protein, which is nuclear and primarily localised to regions of chromatin in primary spermatocytes. The nuclear localisation of Aly and Comr proteins are mutually dependent. Finally, we show that active RNA polymerase II is found in distinct domains in the nucleus that constitute a subset of the total Comr stained chromatin.</jats:p> Transcriptional activation in<i>Drosophila</i>spermatogenesis involves the mutually dependent function of<i>aly</i>and a novel meiotic arrest gene<i>cookie monster</i> Development
spellingShingle Jiang, Jianqiao, White-Cooper, Helen, Development, Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster, Developmental Biology, Molecular Biology
title Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
title_full Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
title_fullStr Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
title_full_unstemmed Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
title_short Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
title_sort transcriptional activation in<i>drosophila</i>spermatogenesis involves the mutually dependent function of<i>aly</i>and a novel meiotic arrest gene<i>cookie monster</i>
title_unstemmed Transcriptional activation inDrosophilaspermatogenesis involves the mutually dependent function ofalyand a novel meiotic arrest genecookie monster
topic Developmental Biology, Molecular Biology
url http://dx.doi.org/10.1242/dev.00246