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Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis
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| Zeitschriftentitel: | Development |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Development, 130, 2003, 24, S. 6111-6119 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
The Company of Biologists
|
| Schlagwörter: |
| author_facet |
Huang, Chengqun Sheikh, Farah Hollander, Melinda Cai, Chengleng Becker, David Chu, Po-Hsien Evans, Sylvia Chen, Ju Huang, Chengqun Sheikh, Farah Hollander, Melinda Cai, Chengleng Becker, David Chu, Po-Hsien Evans, Sylvia Chen, Ju |
|---|---|
| author |
Huang, Chengqun Sheikh, Farah Hollander, Melinda Cai, Chengleng Becker, David Chu, Po-Hsien Evans, Sylvia Chen, Ju |
| spellingShingle |
Huang, Chengqun Sheikh, Farah Hollander, Melinda Cai, Chengleng Becker, David Chu, Po-Hsien Evans, Sylvia Chen, Ju Development Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis Developmental Biology Molecular Biology |
| author_sort |
huang, chengqun |
| spelling |
Huang, Chengqun Sheikh, Farah Hollander, Melinda Cai, Chengleng Becker, David Chu, Po-Hsien Evans, Sylvia Chen, Ju 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.00831 <jats:p>The requirement for atrial function in developing heart is unknown. To address this question, we have generated mice deficient in atrial myosin light chain 2 (MLC2a), a major structural component of the atrial myofibrillar apparatus. Inactivation of the Mlc2a gene resulted in severely diminished atrial contraction and consequent embryonic lethality at ED10.5-11.5, demonstrating that atrial function is essential for embryogenesis. Our data also address two longstanding questions in cardiovascular development: the connection between function and form during cardiac morphogenesis, and the requirement for cardiac function during vascular development. Diminished atrial function in MLC2a-null embryos resulted in a number of consistent secondary abnormalities in both cardiac morphogenesis and angiogenesis. Our results unequivocally demonstrate that normal cardiac function is directly linked to normal morphogenic development of heart and vasculature. These data have important implications for the etiology of congenital heart disease.</jats:p> Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis Development |
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The Company of Biologists, 2003 |
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Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_unstemmed |
Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_full |
Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_fullStr |
Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_full_unstemmed |
Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_short |
Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_sort |
embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| topic |
Developmental Biology Molecular Biology |
| url |
http://dx.doi.org/10.1242/dev.00831 |
| publishDate |
2003 |
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6111-6119 |
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<jats:p>The requirement for atrial function in developing heart is unknown. To address this question, we have generated mice deficient in atrial myosin light chain 2 (MLC2a), a major structural component of the atrial myofibrillar apparatus. Inactivation of the Mlc2a gene resulted in severely diminished atrial contraction and consequent embryonic lethality at ED10.5-11.5, demonstrating that atrial function is essential for embryogenesis. Our data also address two longstanding questions in cardiovascular development: the connection between function and form during cardiac morphogenesis, and the requirement for cardiac function during vascular development. Diminished atrial function in MLC2a-null embryos resulted in a number of consistent secondary abnormalities in both cardiac morphogenesis and angiogenesis. Our results unequivocally demonstrate that normal cardiac function is directly linked to normal morphogenic development of heart and vasculature. These data have important implications for the etiology of congenital heart disease.</jats:p> |
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| author | Huang, Chengqun, Sheikh, Farah, Hollander, Melinda, Cai, Chengleng, Becker, David, Chu, Po-Hsien, Evans, Sylvia, Chen, Ju |
| author_facet | Huang, Chengqun, Sheikh, Farah, Hollander, Melinda, Cai, Chengleng, Becker, David, Chu, Po-Hsien, Evans, Sylvia, Chen, Ju, Huang, Chengqun, Sheikh, Farah, Hollander, Melinda, Cai, Chengleng, Becker, David, Chu, Po-Hsien, Evans, Sylvia, Chen, Ju |
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| description | <jats:p>The requirement for atrial function in developing heart is unknown. To address this question, we have generated mice deficient in atrial myosin light chain 2 (MLC2a), a major structural component of the atrial myofibrillar apparatus. Inactivation of the Mlc2a gene resulted in severely diminished atrial contraction and consequent embryonic lethality at ED10.5-11.5, demonstrating that atrial function is essential for embryogenesis. Our data also address two longstanding questions in cardiovascular development: the connection between function and form during cardiac morphogenesis, and the requirement for cardiac function during vascular development. Diminished atrial function in MLC2a-null embryos resulted in a number of consistent secondary abnormalities in both cardiac morphogenesis and angiogenesis. Our results unequivocally demonstrate that normal cardiac function is directly linked to normal morphogenic development of heart and vasculature. These data have important implications for the etiology of congenital heart disease.</jats:p> |
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| imprint | The Company of Biologists, 2003 |
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| institution | DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
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| spelling | Huang, Chengqun Sheikh, Farah Hollander, Melinda Cai, Chengleng Becker, David Chu, Po-Hsien Evans, Sylvia Chen, Ju 1477-9129 0950-1991 The Company of Biologists Developmental Biology Molecular Biology http://dx.doi.org/10.1242/dev.00831 <jats:p>The requirement for atrial function in developing heart is unknown. To address this question, we have generated mice deficient in atrial myosin light chain 2 (MLC2a), a major structural component of the atrial myofibrillar apparatus. Inactivation of the Mlc2a gene resulted in severely diminished atrial contraction and consequent embryonic lethality at ED10.5-11.5, demonstrating that atrial function is essential for embryogenesis. Our data also address two longstanding questions in cardiovascular development: the connection between function and form during cardiac morphogenesis, and the requirement for cardiac function during vascular development. Diminished atrial function in MLC2a-null embryos resulted in a number of consistent secondary abnormalities in both cardiac morphogenesis and angiogenesis. Our results unequivocally demonstrate that normal cardiac function is directly linked to normal morphogenic development of heart and vasculature. These data have important implications for the etiology of congenital heart disease.</jats:p> Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis Development |
| spellingShingle | Huang, Chengqun, Sheikh, Farah, Hollander, Melinda, Cai, Chengleng, Becker, David, Chu, Po-Hsien, Evans, Sylvia, Chen, Ju, Development, Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis, Developmental Biology, Molecular Biology |
| title | Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_full | Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_fullStr | Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_full_unstemmed | Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_short | Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_sort | embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| title_unstemmed | Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis |
| topic | Developmental Biology, Molecular Biology |
| url | http://dx.doi.org/10.1242/dev.00831 |