Preferential usage of the T-cell receptor by influenza virus hemagglutinin-specific human CD4+ T lymphocytes: in vitro life span of clonotypic T cells

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Bibliographische Detailangaben
Zeitschriftentitel:	Journal of Virology
Personen und Körperschaften:	Prévost-Blondel, A, Chassin, D, Zeliszewski, D, Dorval, I, Sterkers, G, Pannetier, C, Guillet, J G
In:	Journal of Virology, 69, 1995, 12, S. 8046-8050
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Society for Microbiology
Schlagwörter:	Virology Insect Science Immunology Microbiology

Details
Zusammenfassung:	<jats:p>Human helper T-cell (Th) responses to influenza A virus were studied by analyzing T-cell receptor V beta gene diversity in hemagglutinin-specific Th lymphocytes. The T-lymphocyte population from peripheral blood became quickly oligoclonal when stimulated in vitro with the HA306-329 peptide, and T-cell receptor V beta 3 genes were mainly expanded. Moreover, specific junctional region oligonucleotide probes corresponding to hemagglutinin-specific clones were used to estimate temporal diversity during antigenic stimulations.</jats:p>
Umfang:	8046-8050
ISSN:	0022-538X 1098-5514
DOI:	10.1128/jvi.69.12.8046-8050.1995