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The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses
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| Zeitschriftentitel: | Journal of Virology |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Journal of Virology, 85, 2011, 10, S. 5208-5212 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Loewendorf, Andrea I. Steinbrueck, Lars Peter, Christoph Busche, Andreas Benedict, Chris A. Kay-Jackson, Penelope C. Loewendorf, Andrea I. Steinbrueck, Lars Peter, Christoph Busche, Andreas Benedict, Chris A. Kay-Jackson, Penelope C. |
|---|---|
| author |
Loewendorf, Andrea I. Steinbrueck, Lars Peter, Christoph Busche, Andreas Benedict, Chris A. Kay-Jackson, Penelope C. |
| spellingShingle |
Loewendorf, Andrea I. Steinbrueck, Lars Peter, Christoph Busche, Andreas Benedict, Chris A. Kay-Jackson, Penelope C. Journal of Virology The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses Virology Insect Science Immunology Microbiology |
| author_sort |
loewendorf, andrea i. |
| spelling |
Loewendorf, Andrea I. Steinbrueck, Lars Peter, Christoph Busche, Andreas Benedict, Chris A. Kay-Jackson, Penelope C. 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.02178-10 <jats:title>ABSTRACT</jats:title> <jats:p>Cytomegaloviruses (CMV) utilize a variety of immunomodulatory strategies to facilitate the establishment of lifelong persistence in their infected hosts. We show that the mouse CMV (MCMV) m155 open reading frame (ORF) is required for the posttranscriptional inhibition of CD40 expression in infected antigen-presenting cells. Consistent with the known importance of CD40-mediated costimulation of T cells, a m155-deficient virus induces enhanced MCMV epitope-specific CD4 T cell responses.</jats:p> The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses Journal of Virology |
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| title |
The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| title_unstemmed |
The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| title_full |
The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| title_fullStr |
The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| title_full_unstemmed |
The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| title_short |
The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| title_sort |
the mouse cytomegalovirus glycoprotein m155 inhibits cd40 expression and restricts cd4 t cell responses |
| topic |
Virology Insect Science Immunology Microbiology |
| url |
http://dx.doi.org/10.1128/jvi.02178-10 |
| publishDate |
2011 |
| physical |
5208-5212 |
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<jats:title>ABSTRACT</jats:title>
<jats:p>Cytomegaloviruses (CMV) utilize a variety of immunomodulatory strategies to facilitate the establishment of lifelong persistence in their infected hosts. We show that the mouse CMV (MCMV) m155 open reading frame (ORF) is required for the posttranscriptional inhibition of CD40 expression in infected antigen-presenting cells. Consistent with the known importance of CD40-mediated costimulation of T cells, a m155-deficient virus induces enhanced MCMV epitope-specific CD4 T cell responses.</jats:p> |
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| author | Loewendorf, Andrea I., Steinbrueck, Lars, Peter, Christoph, Busche, Andreas, Benedict, Chris A., Kay-Jackson, Penelope C. |
| author_facet | Loewendorf, Andrea I., Steinbrueck, Lars, Peter, Christoph, Busche, Andreas, Benedict, Chris A., Kay-Jackson, Penelope C., Loewendorf, Andrea I., Steinbrueck, Lars, Peter, Christoph, Busche, Andreas, Benedict, Chris A., Kay-Jackson, Penelope C. |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p>Cytomegaloviruses (CMV) utilize a variety of immunomodulatory strategies to facilitate the establishment of lifelong persistence in their infected hosts. We show that the mouse CMV (MCMV) m155 open reading frame (ORF) is required for the posttranscriptional inhibition of CD40 expression in infected antigen-presenting cells. Consistent with the known importance of CD40-mediated costimulation of T cells, a m155-deficient virus induces enhanced MCMV epitope-specific CD4 T cell responses.</jats:p> |
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| physical | 5208-5212 |
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| spelling | Loewendorf, Andrea I. Steinbrueck, Lars Peter, Christoph Busche, Andreas Benedict, Chris A. Kay-Jackson, Penelope C. 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.02178-10 <jats:title>ABSTRACT</jats:title> <jats:p>Cytomegaloviruses (CMV) utilize a variety of immunomodulatory strategies to facilitate the establishment of lifelong persistence in their infected hosts. We show that the mouse CMV (MCMV) m155 open reading frame (ORF) is required for the posttranscriptional inhibition of CD40 expression in infected antigen-presenting cells. Consistent with the known importance of CD40-mediated costimulation of T cells, a m155-deficient virus induces enhanced MCMV epitope-specific CD4 T cell responses.</jats:p> The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses Journal of Virology |
| spellingShingle | Loewendorf, Andrea I., Steinbrueck, Lars, Peter, Christoph, Busche, Andreas, Benedict, Chris A., Kay-Jackson, Penelope C., Journal of Virology, The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses, Virology, Insect Science, Immunology, Microbiology |
| title | The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| title_full | The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| title_fullStr | The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| title_full_unstemmed | The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| title_short | The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| title_sort | the mouse cytomegalovirus glycoprotein m155 inhibits cd40 expression and restricts cd4 t cell responses |
| title_unstemmed | The Mouse Cytomegalovirus Glycoprotein m155 Inhibits CD40 Expression and Restricts CD4 T Cell Responses |
| topic | Virology, Insect Science, Immunology, Microbiology |
| url | http://dx.doi.org/10.1128/jvi.02178-10 |