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Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide
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| Zeitschriftentitel: | Journal of Virology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Virology, 84, 2010, 15, S. 7726-7729 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Ren, Xiaoxia Rasgon, Jason L. Ren, Xiaoxia Rasgon, Jason L. |
|---|---|
| author |
Ren, Xiaoxia Rasgon, Jason L. |
| spellingShingle |
Ren, Xiaoxia Rasgon, Jason L. Journal of Virology Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide Virology Insect Science Immunology Microbiology |
| author_sort |
ren, xiaoxia |
| spelling |
Ren, Xiaoxia Rasgon, Jason L. 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.00631-10 <jats:title>ABSTRACT</jats:title> <jats:p> “Evolution-proof” or “late-life-acting” insecticides (LLAIs) preferentially kill older adult mosquitoes and are of extreme interest to control vector-borne diseases such as malaria. We used quantitative PCR to assess whether the <jats:italic>Anopheles gambiae</jats:italic> densonucleosis virus (AgDNV) had potential as an LLAI. After infection, AgDNV titers increased modestly during larval development but replicated slower than the host cells, resulting in a significant decrease in the normalized virus titer during larval and pupal development. Normalized virus titers dramatically increased after adult emergence, peaking in 7- to 10-day-old adults. Unlike other DNVs, AgDNV does not significantly replicate in preadult mosquitoes but rather preferentially replicates in older adults. The natural dynamics of AgDNV make it ideal for expression of insect-specific toxin genes as a biological LLAI. </jats:p> Potential for the <i>Anopheles gambiae</i> Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide Journal of Virology |
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American Society for Microbiology, 2010 |
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| title |
Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
| title_unstemmed |
Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
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Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
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Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
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Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
| title_short |
Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
| title_sort |
potential for the
<i>anopheles gambiae</i>
densonucleosis virus to act as an “evolution-proof” biopesticide |
| topic |
Virology Insect Science Immunology Microbiology |
| url |
http://dx.doi.org/10.1128/jvi.00631-10 |
| publishDate |
2010 |
| physical |
7726-7729 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>
“Evolution-proof” or “late-life-acting” insecticides (LLAIs) preferentially kill older adult mosquitoes and are of extreme interest to control vector-borne diseases such as malaria. We used quantitative PCR to assess whether the
<jats:italic>Anopheles gambiae</jats:italic>
densonucleosis virus (AgDNV) had potential as an LLAI. After infection, AgDNV titers increased modestly during larval development but replicated slower than the host cells, resulting in a significant decrease in the normalized virus titer during larval and pupal development. Normalized virus titers dramatically increased after adult emergence, peaking in 7- to 10-day-old adults. Unlike other DNVs, AgDNV does not significantly replicate in preadult mosquitoes but rather preferentially replicates in older adults. The natural dynamics of AgDNV make it ideal for expression of insect-specific toxin genes as a biological LLAI.
</jats:p> |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p> “Evolution-proof” or “late-life-acting” insecticides (LLAIs) preferentially kill older adult mosquitoes and are of extreme interest to control vector-borne diseases such as malaria. We used quantitative PCR to assess whether the <jats:italic>Anopheles gambiae</jats:italic> densonucleosis virus (AgDNV) had potential as an LLAI. After infection, AgDNV titers increased modestly during larval development but replicated slower than the host cells, resulting in a significant decrease in the normalized virus titer during larval and pupal development. Normalized virus titers dramatically increased after adult emergence, peaking in 7- to 10-day-old adults. Unlike other DNVs, AgDNV does not significantly replicate in preadult mosquitoes but rather preferentially replicates in older adults. The natural dynamics of AgDNV make it ideal for expression of insect-specific toxin genes as a biological LLAI. </jats:p> |
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| spelling | Ren, Xiaoxia Rasgon, Jason L. 0022-538X 1098-5514 American Society for Microbiology Virology Insect Science Immunology Microbiology http://dx.doi.org/10.1128/jvi.00631-10 <jats:title>ABSTRACT</jats:title> <jats:p> “Evolution-proof” or “late-life-acting” insecticides (LLAIs) preferentially kill older adult mosquitoes and are of extreme interest to control vector-borne diseases such as malaria. We used quantitative PCR to assess whether the <jats:italic>Anopheles gambiae</jats:italic> densonucleosis virus (AgDNV) had potential as an LLAI. After infection, AgDNV titers increased modestly during larval development but replicated slower than the host cells, resulting in a significant decrease in the normalized virus titer during larval and pupal development. Normalized virus titers dramatically increased after adult emergence, peaking in 7- to 10-day-old adults. Unlike other DNVs, AgDNV does not significantly replicate in preadult mosquitoes but rather preferentially replicates in older adults. The natural dynamics of AgDNV make it ideal for expression of insect-specific toxin genes as a biological LLAI. </jats:p> Potential for the <i>Anopheles gambiae</i> Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide Journal of Virology |
| spellingShingle | Ren, Xiaoxia, Rasgon, Jason L., Journal of Virology, Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide, Virology, Insect Science, Immunology, Microbiology |
| title | Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
| title_full | Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
| title_fullStr | Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
| title_full_unstemmed | Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
| title_short | Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
| title_sort | potential for the <i>anopheles gambiae</i> densonucleosis virus to act as an “evolution-proof” biopesticide |
| title_unstemmed | Potential for the Anopheles gambiae Densonucleosis Virus To Act as an “Evolution-Proof” Biopesticide |
| topic | Virology, Insect Science, Immunology, Microbiology |
| url | http://dx.doi.org/10.1128/jvi.00631-10 |