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Gliding Motility of Mycoplasma mobile Can Occur by Repeated Binding to N -Acetylneuraminyllactose (Sialyllactose) Fixed on Solid Surface...
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| Zeitschriftentitel: | Journal of Bacteriology |
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| Personen und Körperschaften: | , |
| In: | Journal of Bacteriology, 188, 2006, 18, S. 6469-6475 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>ABSTRACT</jats:title> <jats:p> <jats:italic>Mycoplasma mobile</jats:italic> relies on an unknown mechanism to glide across solid surfaces including glass, animal cells, and plastics. To identify the direct binding target, we examined the factors that affect the binding of <jats:italic>Mycoplasma pneumoniae</jats:italic> to solid surfaces and concluded that <jats:italic>N</jats:italic> -acetylneuraminyllactose (sialyllactose) attached to a protein can mediate glass binding on the basis of the following four lines of evidence: (i) glass binding was inhibited by <jats:italic>N</jats:italic> -acetylneuraminidase, (ii) glass binding was inhibited by <jats:italic>N</jats:italic> -acetylneuraminyllactose in a structure-dependent manner, (iii) binding occurred on glass pretreated with bovine serum albumin attached to <jats:italic>N</jats:italic> -acetylneuraminyllactose, and (iv) gliding speed depended on the density of <jats:italic>N</jats:italic> -acetylneuraminyllactose on glass. </jats:p> |
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| Umfang: | 6469-6475 |
| ISSN: |
0021-9193
1098-5530 |
| DOI: | 10.1128/jb.00754-06 |