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Prevalence and Significance of a Negative Extended-Spectrum β-Lactamase (ESBL) Confirmation Test Result after a Positive ESBL Screening Test Result for Isolates of Esche...
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| Zeitschriftentitel: | Journal of Clinical Microbiology |
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| Personen und Körperschaften: | , , , , , |
| In: | Journal of Clinical Microbiology, 45, 2007, 5, S. 1478-1482 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>ABSTRACT</jats:title> <jats:p> A negative extended-spectrum β-lactamase (ESBL) confirmation test result obtained after a positive ESBL screening test result using Clinical and Laboratory Standards Institute methods has been a common occurrence among isolates of <jats:italic>Escherichia coli</jats:italic> and <jats:italic>Klebsiella pneumoniae</jats:italic> in the SENTRY Antimicrobial Surveillance Program in the Asia-Pacific region. Among isolates collected between 1998 and 2004 this screen-positive, nonconfirmed profile (failed to show clavulanate synergy) was observed in 8.9% of 4,515 <jats:italic>E. coli</jats:italic> isolates and 20.3% of 2,303 <jats:italic>K. pneumoniae</jats:italic> isolates. We then selected 52 <jats:italic>E. coli</jats:italic> isolates and 68 <jats:italic>K. pneumoniae</jats:italic> isolates with a negative ESBL confirmation test, as well as comparable number of isolates with confirmed ESBL-positive tests, and examined them for the presence of TEM, SHV, plasmid-borne <jats:italic>ampC</jats:italic> , and CTX-M genes. We found that 62% of nonconfirming <jats:italic>E. coli</jats:italic> isolates and 75% of nonconfirming <jats:italic>K. pneumoniae</jats:italic> harbored a plasmid-borne AmpC enzyme of the CIT or DHA type. The majority of nonconfirming <jats:italic>E. coli</jats:italic> and <jats:italic>K. pneumoniae</jats:italic> from the Asia-Pacific region harbor important β-lactamases, and a positive screening test alone should be sufficient grounds to report resistance to extended-spectrum cephalosporins in this region. </jats:p> |
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| Umfang: | 1478-1482 |
| ISSN: |
0095-1137
1098-660X |
| DOI: | 10.1128/jcm.02470-06 |