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Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Ca...
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| Zeitschriftentitel: | Journal of Clinical Microbiology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , |
| In: | Journal of Clinical Microbiology, 50, 2012, 12, S. 3921-3926 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Cantón, Emilia Pemán, Javier Hervás, David Iñiguez, Carmen Navarro, David Echeverría, Julia Martínez-Alarcón, José Fontanals, Dionisia Gomila-Sard, Bárbara Buendía, Buenaventura Torroba, Luis Ayats, Josefina Bratos, Angel Sánchez-Reus, Ferran Fernández-Natal, Isabel Cantón, Emilia Pemán, Javier Hervás, David Iñiguez, Carmen Navarro, David Echeverría, Julia Martínez-Alarcón, José Fontanals, Dionisia Gomila-Sard, Bárbara Buendía, Buenaventura Torroba, Luis Ayats, Josefina Bratos, Angel Sánchez-Reus, Ferran Fernández-Natal, Isabel |
|---|---|
| author |
Cantón, Emilia Pemán, Javier Hervás, David Iñiguez, Carmen Navarro, David Echeverría, Julia Martínez-Alarcón, José Fontanals, Dionisia Gomila-Sard, Bárbara Buendía, Buenaventura Torroba, Luis Ayats, Josefina Bratos, Angel Sánchez-Reus, Ferran Fernández-Natal, Isabel |
| spellingShingle |
Cantón, Emilia Pemán, Javier Hervás, David Iñiguez, Carmen Navarro, David Echeverría, Julia Martínez-Alarcón, José Fontanals, Dionisia Gomila-Sard, Bárbara Buendía, Buenaventura Torroba, Luis Ayats, Josefina Bratos, Angel Sánchez-Reus, Ferran Fernández-Natal, Isabel Journal of Clinical Microbiology Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method Microbiology (medical) |
| author_sort |
cantón, emilia |
| spelling |
Cantón, Emilia Pemán, Javier Hervás, David Iñiguez, Carmen Navarro, David Echeverría, Julia Martínez-Alarcón, José Fontanals, Dionisia Gomila-Sard, Bárbara Buendía, Buenaventura Torroba, Luis Ayats, Josefina Bratos, Angel Sánchez-Reus, Ferran Fernández-Natal, Isabel 0095-1137 1098-660X American Society for Microbiology Microbiology (medical) http://dx.doi.org/10.1128/jcm.01730-12 <jats:title>ABSTRACT</jats:title> <jats:p> The Sensititre YeastOne (SYO) method is a widely used method to determine the susceptibility of <jats:named-content content-type="genus-species">Candida</jats:named-content> spp. to antifungal agents. CLSI clinical breakpoints (CBP) have been reported for antifungals, but not using this method. In the absence of CBP, epidemiological cutoff values (ECVs) are useful to separate wild-type (WT) isolates (those without mechanisms of resistance) from non-WT isolates (those that can harbor some resistance mechanisms), which is the goal of any susceptibility test. The ECVs for five agents, obtained using the MIC distributions determined by the SYO test, were calculated and contrasted with those for three statistical methods and the MIC <jats:sub>50</jats:sub> and modal MIC, both plus 2-fold dilutions. The median ECVs (in mg/liter) (% of isolates inhibited by MICs equal to or less than the ECV; number of isolates tested) of the five methods for anidulafungin, micafungin, caspofungin, amphotericin B, and flucytosine, respectively, were as follows: 0.25 (98.5%; 656), 0.06 (95.1%; 659), 0.25 (98.7%; 747), 2 (100%; 923), and 1 (98.5%; 915) for <jats:named-content content-type="genus-species">Candida albicans</jats:named-content> ; 8 (100%; 352), 4 (99.2%; 392), 2 (99.2%; 480), 1 (99.8%; 603), and 0.5 (97.9%; 635) for <jats:named-content content-type="genus-species">C. parapsilosis</jats:named-content> ; 1 (99.2%; 123), 0.12 (99.2%; 121), 0.25 (99.2%; 138), 2 (100%; 171), and 0.5 (97.2%; 175) for <jats:named-content content-type="genus-species">C. tropicalis</jats:named-content> ; 0.12 (96.6%; 174), 0.06 (96%; 176), 0.25 (98.4%; 188), 2 (100%; 209), and 0.25 (97.6%; 208) for <jats:named-content content-type="genus-species">C. glabrata</jats:named-content> ; 0.25 (97%; 33), 0.5 (93.9%; 33), 1 (91.9%; 37), 4 (100%; 51), and 32 (100%; 53) for <jats:named-content content-type="genus-species">C. krusei</jats:named-content> ; and 4 (100%; 33), 2 (100%; 33), 2 (100%; 54), 1 (100%; 90), and 0.25 (93.4%; 91) for <jats:named-content content-type="genus-species">C. orthopsilosis</jats:named-content> . The three statistical methods gave similar ECVs (within one dilution) and included ≥95% of isolates. These tentative ECVs would be useful for monitoring the emergence of isolates with reduced susceptibility by use of the SYO method. </jats:p> Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method Journal of Clinical Microbiology |
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American Society for Microbiology, 2012 |
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American Society for Microbiology, 2012 |
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American Society for Microbiology |
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Journal of Clinical Microbiology |
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49 |
| title |
Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| title_unstemmed |
Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| title_full |
Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| title_fullStr |
Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| title_full_unstemmed |
Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| title_short |
Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| title_sort |
comparison of three statistical methods for establishing tentative wild-type population and epidemiological cutoff values for echinocandins, amphotericin b, flucytosine, and six candida species as determined by the colorimetric sensititre yeastone method |
| topic |
Microbiology (medical) |
| url |
http://dx.doi.org/10.1128/jcm.01730-12 |
| publishDate |
2012 |
| physical |
3921-3926 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>
The Sensititre YeastOne (SYO) method is a widely used method to determine the susceptibility of
<jats:named-content content-type="genus-species">Candida</jats:named-content>
spp. to antifungal agents. CLSI clinical breakpoints (CBP) have been reported for antifungals, but not using this method. In the absence of CBP, epidemiological cutoff values (ECVs) are useful to separate wild-type (WT) isolates (those without mechanisms of resistance) from non-WT isolates (those that can harbor some resistance mechanisms), which is the goal of any susceptibility test. The ECVs for five agents, obtained using the MIC distributions determined by the SYO test, were calculated and contrasted with those for three statistical methods and the MIC
<jats:sub>50</jats:sub>
and modal MIC, both plus 2-fold dilutions. The median ECVs (in mg/liter) (% of isolates inhibited by MICs equal to or less than the ECV; number of isolates tested) of the five methods for anidulafungin, micafungin, caspofungin, amphotericin B, and flucytosine, respectively, were as follows: 0.25 (98.5%; 656), 0.06 (95.1%; 659), 0.25 (98.7%; 747), 2 (100%; 923), and 1 (98.5%; 915) for
<jats:named-content content-type="genus-species">Candida albicans</jats:named-content>
; 8 (100%; 352), 4 (99.2%; 392), 2 (99.2%; 480), 1 (99.8%; 603), and 0.5 (97.9%; 635) for
<jats:named-content content-type="genus-species">C. parapsilosis</jats:named-content>
; 1 (99.2%; 123), 0.12 (99.2%; 121), 0.25 (99.2%; 138), 2 (100%; 171), and 0.5 (97.2%; 175) for
<jats:named-content content-type="genus-species">C. tropicalis</jats:named-content>
; 0.12 (96.6%; 174), 0.06 (96%; 176), 0.25 (98.4%; 188), 2 (100%; 209), and 0.25 (97.6%; 208) for
<jats:named-content content-type="genus-species">C. glabrata</jats:named-content>
; 0.25 (97%; 33), 0.5 (93.9%; 33), 1 (91.9%; 37), 4 (100%; 51), and 32 (100%; 53) for
<jats:named-content content-type="genus-species">C. krusei</jats:named-content>
; and 4 (100%; 33), 2 (100%; 33), 2 (100%; 54), 1 (100%; 90), and 0.25 (93.4%; 91) for
<jats:named-content content-type="genus-species">C. orthopsilosis</jats:named-content>
. The three statistical methods gave similar ECVs (within one dilution) and included ≥95% of isolates. These tentative ECVs would be useful for monitoring the emergence of isolates with reduced susceptibility by use of the SYO method.
</jats:p> |
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| author | Cantón, Emilia, Pemán, Javier, Hervás, David, Iñiguez, Carmen, Navarro, David, Echeverría, Julia, Martínez-Alarcón, José, Fontanals, Dionisia, Gomila-Sard, Bárbara, Buendía, Buenaventura, Torroba, Luis, Ayats, Josefina, Bratos, Angel, Sánchez-Reus, Ferran, Fernández-Natal, Isabel |
| author_facet | Cantón, Emilia, Pemán, Javier, Hervás, David, Iñiguez, Carmen, Navarro, David, Echeverría, Julia, Martínez-Alarcón, José, Fontanals, Dionisia, Gomila-Sard, Bárbara, Buendía, Buenaventura, Torroba, Luis, Ayats, Josefina, Bratos, Angel, Sánchez-Reus, Ferran, Fernández-Natal, Isabel, Cantón, Emilia, Pemán, Javier, Hervás, David, Iñiguez, Carmen, Navarro, David, Echeverría, Julia, Martínez-Alarcón, José, Fontanals, Dionisia, Gomila-Sard, Bárbara, Buendía, Buenaventura, Torroba, Luis, Ayats, Josefina, Bratos, Angel, Sánchez-Reus, Ferran, Fernández-Natal, Isabel |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p> The Sensititre YeastOne (SYO) method is a widely used method to determine the susceptibility of <jats:named-content content-type="genus-species">Candida</jats:named-content> spp. to antifungal agents. CLSI clinical breakpoints (CBP) have been reported for antifungals, but not using this method. In the absence of CBP, epidemiological cutoff values (ECVs) are useful to separate wild-type (WT) isolates (those without mechanisms of resistance) from non-WT isolates (those that can harbor some resistance mechanisms), which is the goal of any susceptibility test. The ECVs for five agents, obtained using the MIC distributions determined by the SYO test, were calculated and contrasted with those for three statistical methods and the MIC <jats:sub>50</jats:sub> and modal MIC, both plus 2-fold dilutions. The median ECVs (in mg/liter) (% of isolates inhibited by MICs equal to or less than the ECV; number of isolates tested) of the five methods for anidulafungin, micafungin, caspofungin, amphotericin B, and flucytosine, respectively, were as follows: 0.25 (98.5%; 656), 0.06 (95.1%; 659), 0.25 (98.7%; 747), 2 (100%; 923), and 1 (98.5%; 915) for <jats:named-content content-type="genus-species">Candida albicans</jats:named-content> ; 8 (100%; 352), 4 (99.2%; 392), 2 (99.2%; 480), 1 (99.8%; 603), and 0.5 (97.9%; 635) for <jats:named-content content-type="genus-species">C. parapsilosis</jats:named-content> ; 1 (99.2%; 123), 0.12 (99.2%; 121), 0.25 (99.2%; 138), 2 (100%; 171), and 0.5 (97.2%; 175) for <jats:named-content content-type="genus-species">C. tropicalis</jats:named-content> ; 0.12 (96.6%; 174), 0.06 (96%; 176), 0.25 (98.4%; 188), 2 (100%; 209), and 0.25 (97.6%; 208) for <jats:named-content content-type="genus-species">C. glabrata</jats:named-content> ; 0.25 (97%; 33), 0.5 (93.9%; 33), 1 (91.9%; 37), 4 (100%; 51), and 32 (100%; 53) for <jats:named-content content-type="genus-species">C. krusei</jats:named-content> ; and 4 (100%; 33), 2 (100%; 33), 2 (100%; 54), 1 (100%; 90), and 0.25 (93.4%; 91) for <jats:named-content content-type="genus-species">C. orthopsilosis</jats:named-content> . The three statistical methods gave similar ECVs (within one dilution) and included ≥95% of isolates. These tentative ECVs would be useful for monitoring the emergence of isolates with reduced susceptibility by use of the SYO method. </jats:p> |
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| match_str | canton2012comparisonofthreestatisticalmethodsforestablishingtentativewildtypepopulationandepidemiologicalcutoffvaluesforechinocandinsamphotericinbflucytosineandsixcandidaspeciesasdeterminedbythecolorimetricsensititreyeastonemethod |
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| physical | 3921-3926 |
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| spelling | Cantón, Emilia Pemán, Javier Hervás, David Iñiguez, Carmen Navarro, David Echeverría, Julia Martínez-Alarcón, José Fontanals, Dionisia Gomila-Sard, Bárbara Buendía, Buenaventura Torroba, Luis Ayats, Josefina Bratos, Angel Sánchez-Reus, Ferran Fernández-Natal, Isabel 0095-1137 1098-660X American Society for Microbiology Microbiology (medical) http://dx.doi.org/10.1128/jcm.01730-12 <jats:title>ABSTRACT</jats:title> <jats:p> The Sensititre YeastOne (SYO) method is a widely used method to determine the susceptibility of <jats:named-content content-type="genus-species">Candida</jats:named-content> spp. to antifungal agents. CLSI clinical breakpoints (CBP) have been reported for antifungals, but not using this method. In the absence of CBP, epidemiological cutoff values (ECVs) are useful to separate wild-type (WT) isolates (those without mechanisms of resistance) from non-WT isolates (those that can harbor some resistance mechanisms), which is the goal of any susceptibility test. The ECVs for five agents, obtained using the MIC distributions determined by the SYO test, were calculated and contrasted with those for three statistical methods and the MIC <jats:sub>50</jats:sub> and modal MIC, both plus 2-fold dilutions. The median ECVs (in mg/liter) (% of isolates inhibited by MICs equal to or less than the ECV; number of isolates tested) of the five methods for anidulafungin, micafungin, caspofungin, amphotericin B, and flucytosine, respectively, were as follows: 0.25 (98.5%; 656), 0.06 (95.1%; 659), 0.25 (98.7%; 747), 2 (100%; 923), and 1 (98.5%; 915) for <jats:named-content content-type="genus-species">Candida albicans</jats:named-content> ; 8 (100%; 352), 4 (99.2%; 392), 2 (99.2%; 480), 1 (99.8%; 603), and 0.5 (97.9%; 635) for <jats:named-content content-type="genus-species">C. parapsilosis</jats:named-content> ; 1 (99.2%; 123), 0.12 (99.2%; 121), 0.25 (99.2%; 138), 2 (100%; 171), and 0.5 (97.2%; 175) for <jats:named-content content-type="genus-species">C. tropicalis</jats:named-content> ; 0.12 (96.6%; 174), 0.06 (96%; 176), 0.25 (98.4%; 188), 2 (100%; 209), and 0.25 (97.6%; 208) for <jats:named-content content-type="genus-species">C. glabrata</jats:named-content> ; 0.25 (97%; 33), 0.5 (93.9%; 33), 1 (91.9%; 37), 4 (100%; 51), and 32 (100%; 53) for <jats:named-content content-type="genus-species">C. krusei</jats:named-content> ; and 4 (100%; 33), 2 (100%; 33), 2 (100%; 54), 1 (100%; 90), and 0.25 (93.4%; 91) for <jats:named-content content-type="genus-species">C. orthopsilosis</jats:named-content> . The three statistical methods gave similar ECVs (within one dilution) and included ≥95% of isolates. These tentative ECVs would be useful for monitoring the emergence of isolates with reduced susceptibility by use of the SYO method. </jats:p> Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method Journal of Clinical Microbiology |
| spellingShingle | Cantón, Emilia, Pemán, Javier, Hervás, David, Iñiguez, Carmen, Navarro, David, Echeverría, Julia, Martínez-Alarcón, José, Fontanals, Dionisia, Gomila-Sard, Bárbara, Buendía, Buenaventura, Torroba, Luis, Ayats, Josefina, Bratos, Angel, Sánchez-Reus, Ferran, Fernández-Natal, Isabel, Journal of Clinical Microbiology, Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method, Microbiology (medical) |
| title | Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| title_full | Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| title_fullStr | Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| title_full_unstemmed | Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| title_short | Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| title_sort | comparison of three statistical methods for establishing tentative wild-type population and epidemiological cutoff values for echinocandins, amphotericin b, flucytosine, and six candida species as determined by the colorimetric sensititre yeastone method |
| title_unstemmed | Comparison of Three Statistical Methods for Establishing Tentative Wild-Type Population and Epidemiological Cutoff Values for Echinocandins, Amphotericin B, Flucytosine, and Six Candida Species as Determined by the Colorimetric Sensititre YeastOne Method |
| topic | Microbiology (medical) |
| url | http://dx.doi.org/10.1128/jcm.01730-12 |