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The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo
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| Zeitschriftentitel: | Infection and Immunity |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Infection and Immunity, 73, 2005, 11, S. 7190-7197 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Cheng, Shaoji Clancy, Cornelius J. Checkley, Mary Ann Zhang, Zongde Wozniak, Karen L. Seshan, Kalpathi R. Jia, Hong Yan Fidel, Paul Cole, Garry Nguyen, M. Hong Cheng, Shaoji Clancy, Cornelius J. Checkley, Mary Ann Zhang, Zongde Wozniak, Karen L. Seshan, Kalpathi R. Jia, Hong Yan Fidel, Paul Cole, Garry Nguyen, M. Hong |
|---|---|
| author |
Cheng, Shaoji Clancy, Cornelius J. Checkley, Mary Ann Zhang, Zongde Wozniak, Karen L. Seshan, Kalpathi R. Jia, Hong Yan Fidel, Paul Cole, Garry Nguyen, M. Hong |
| spellingShingle |
Cheng, Shaoji Clancy, Cornelius J. Checkley, Mary Ann Zhang, Zongde Wozniak, Karen L. Seshan, Kalpathi R. Jia, Hong Yan Fidel, Paul Cole, Garry Nguyen, M. Hong Infection and Immunity The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo Infectious Diseases Immunology Microbiology Parasitology |
| author_sort |
cheng, shaoji |
| spelling |
Cheng, Shaoji Clancy, Cornelius J. Checkley, Mary Ann Zhang, Zongde Wozniak, Karen L. Seshan, Kalpathi R. Jia, Hong Yan Fidel, Paul Cole, Garry Nguyen, M. Hong 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.73.11.7190-7197.2005 <jats:title>ABSTRACT</jats:title> <jats:p> We previously identified <jats:italic>Candida albicans</jats:italic> Not5p as an immunogenic protein expressed during oropharyngeal candidiasis (OPC). In this study, we demonstrate that <jats:italic>C. albicans NOT5</jats:italic> reverses the growth defects of a <jats:italic>Saccharomyces cerevisiae not5</jats:italic> mutant strain at 37°C, suggesting that the genes share at least some functional equivalence. We implicate <jats:italic>C. albicans NOT5</jats:italic> in the pathogenesis of disseminated candidiasis (DC) induced by intravenous infection among neutropenic and nonimmunosuppressed mice, as well as in that of OPC in mice immunosuppressed with corticosteroids. We find no role in virulence, however, among neutropenic and corticosteroid-suppressed mice with DC resulting from gastrointestinal translocation, nor do we implicate the gene in vulvovaginal candidiasis among mice in pseudoestrus. These findings suggest that the role of <jats:italic>NOT5</jats:italic> in virulence depends on the specific in vivo environment and is influenced by diverse factors such as tissue site, portal of entry, and the status of host defenses. <jats:italic>NOT5</jats:italic> is necessary for normal adherence to colonic and cervical epithelial cells in vitro, demonstrating that such assays cannot fully replicate disease processes in vivo. Lastly, antibody responses against Not5p do not differ in the sera of patients with OPC, patients with DC, and healthy controls, suggesting that the protein is associated with both commensalism and the pathogenesis of disease. </jats:p> The Role of <i>Candida albicans NOT5</i> in Virulence Depends upon Diverse Host Factors In Vivo Infection and Immunity |
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10.1128/iai.73.11.7190-7197.2005 |
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| title |
The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| title_unstemmed |
The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| title_full |
The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| title_fullStr |
The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| title_full_unstemmed |
The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| title_short |
The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| title_sort |
the role of
<i>candida albicans not5</i>
in virulence depends upon diverse host factors in vivo |
| topic |
Infectious Diseases Immunology Microbiology Parasitology |
| url |
http://dx.doi.org/10.1128/iai.73.11.7190-7197.2005 |
| publishDate |
2005 |
| physical |
7190-7197 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>
We previously identified
<jats:italic>Candida albicans</jats:italic>
Not5p as an immunogenic protein expressed during oropharyngeal candidiasis (OPC). In this study, we demonstrate that
<jats:italic>C. albicans NOT5</jats:italic>
reverses the growth defects of a
<jats:italic>Saccharomyces cerevisiae not5</jats:italic>
mutant strain at 37°C, suggesting that the genes share at least some functional equivalence. We implicate
<jats:italic>C. albicans NOT5</jats:italic>
in the pathogenesis of disseminated candidiasis (DC) induced by intravenous infection among neutropenic and nonimmunosuppressed mice, as well as in that of OPC in mice immunosuppressed with corticosteroids. We find no role in virulence, however, among neutropenic and corticosteroid-suppressed mice with DC resulting from gastrointestinal translocation, nor do we implicate the gene in vulvovaginal candidiasis among mice in pseudoestrus. These findings suggest that the role of
<jats:italic>NOT5</jats:italic>
in virulence depends on the specific in vivo environment and is influenced by diverse factors such as tissue site, portal of entry, and the status of host defenses.
<jats:italic>NOT5</jats:italic>
is necessary for normal adherence to colonic and cervical epithelial cells in vitro, demonstrating that such assays cannot fully replicate disease processes in vivo. Lastly, antibody responses against Not5p do not differ in the sera of patients with OPC, patients with DC, and healthy controls, suggesting that the protein is associated with both commensalism and the pathogenesis of disease.
</jats:p> |
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| author | Cheng, Shaoji, Clancy, Cornelius J., Checkley, Mary Ann, Zhang, Zongde, Wozniak, Karen L., Seshan, Kalpathi R., Jia, Hong Yan, Fidel, Paul, Cole, Garry, Nguyen, M. Hong |
| author_facet | Cheng, Shaoji, Clancy, Cornelius J., Checkley, Mary Ann, Zhang, Zongde, Wozniak, Karen L., Seshan, Kalpathi R., Jia, Hong Yan, Fidel, Paul, Cole, Garry, Nguyen, M. Hong, Cheng, Shaoji, Clancy, Cornelius J., Checkley, Mary Ann, Zhang, Zongde, Wozniak, Karen L., Seshan, Kalpathi R., Jia, Hong Yan, Fidel, Paul, Cole, Garry, Nguyen, M. Hong |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p> We previously identified <jats:italic>Candida albicans</jats:italic> Not5p as an immunogenic protein expressed during oropharyngeal candidiasis (OPC). In this study, we demonstrate that <jats:italic>C. albicans NOT5</jats:italic> reverses the growth defects of a <jats:italic>Saccharomyces cerevisiae not5</jats:italic> mutant strain at 37°C, suggesting that the genes share at least some functional equivalence. We implicate <jats:italic>C. albicans NOT5</jats:italic> in the pathogenesis of disseminated candidiasis (DC) induced by intravenous infection among neutropenic and nonimmunosuppressed mice, as well as in that of OPC in mice immunosuppressed with corticosteroids. We find no role in virulence, however, among neutropenic and corticosteroid-suppressed mice with DC resulting from gastrointestinal translocation, nor do we implicate the gene in vulvovaginal candidiasis among mice in pseudoestrus. These findings suggest that the role of <jats:italic>NOT5</jats:italic> in virulence depends on the specific in vivo environment and is influenced by diverse factors such as tissue site, portal of entry, and the status of host defenses. <jats:italic>NOT5</jats:italic> is necessary for normal adherence to colonic and cervical epithelial cells in vitro, demonstrating that such assays cannot fully replicate disease processes in vivo. Lastly, antibody responses against Not5p do not differ in the sera of patients with OPC, patients with DC, and healthy controls, suggesting that the protein is associated with both commensalism and the pathogenesis of disease. </jats:p> |
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| imprint_str_mv | American Society for Microbiology, 2005 |
| institution | DE-15, DE-Pl11, DE-Rs1, FID-BBI-DE-23, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4 |
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| spelling | Cheng, Shaoji Clancy, Cornelius J. Checkley, Mary Ann Zhang, Zongde Wozniak, Karen L. Seshan, Kalpathi R. Jia, Hong Yan Fidel, Paul Cole, Garry Nguyen, M. Hong 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.73.11.7190-7197.2005 <jats:title>ABSTRACT</jats:title> <jats:p> We previously identified <jats:italic>Candida albicans</jats:italic> Not5p as an immunogenic protein expressed during oropharyngeal candidiasis (OPC). In this study, we demonstrate that <jats:italic>C. albicans NOT5</jats:italic> reverses the growth defects of a <jats:italic>Saccharomyces cerevisiae not5</jats:italic> mutant strain at 37°C, suggesting that the genes share at least some functional equivalence. We implicate <jats:italic>C. albicans NOT5</jats:italic> in the pathogenesis of disseminated candidiasis (DC) induced by intravenous infection among neutropenic and nonimmunosuppressed mice, as well as in that of OPC in mice immunosuppressed with corticosteroids. We find no role in virulence, however, among neutropenic and corticosteroid-suppressed mice with DC resulting from gastrointestinal translocation, nor do we implicate the gene in vulvovaginal candidiasis among mice in pseudoestrus. These findings suggest that the role of <jats:italic>NOT5</jats:italic> in virulence depends on the specific in vivo environment and is influenced by diverse factors such as tissue site, portal of entry, and the status of host defenses. <jats:italic>NOT5</jats:italic> is necessary for normal adherence to colonic and cervical epithelial cells in vitro, demonstrating that such assays cannot fully replicate disease processes in vivo. Lastly, antibody responses against Not5p do not differ in the sera of patients with OPC, patients with DC, and healthy controls, suggesting that the protein is associated with both commensalism and the pathogenesis of disease. </jats:p> The Role of <i>Candida albicans NOT5</i> in Virulence Depends upon Diverse Host Factors In Vivo Infection and Immunity |
| spellingShingle | Cheng, Shaoji, Clancy, Cornelius J., Checkley, Mary Ann, Zhang, Zongde, Wozniak, Karen L., Seshan, Kalpathi R., Jia, Hong Yan, Fidel, Paul, Cole, Garry, Nguyen, M. Hong, Infection and Immunity, The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo, Infectious Diseases, Immunology, Microbiology, Parasitology |
| title | The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| title_full | The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| title_fullStr | The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| title_full_unstemmed | The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| title_short | The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| title_sort | the role of <i>candida albicans not5</i> in virulence depends upon diverse host factors in vivo |
| title_unstemmed | The Role of Candida albicans NOT5 in Virulence Depends upon Diverse Host Factors In Vivo |
| topic | Infectious Diseases, Immunology, Microbiology, Parasitology |
| url | http://dx.doi.org/10.1128/iai.73.11.7190-7197.2005 |