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The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae
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| Zeitschriftentitel: | Infection and Immunity |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Infection and Immunity, 71, 2003, 11, S. 6676-6679 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Kadioglu, Aras Echenique, Josè Manco, Sonia Trombe, Marie-Claude Andrew, Peter W. Kadioglu, Aras Echenique, Josè Manco, Sonia Trombe, Marie-Claude Andrew, Peter W. |
|---|---|
| author |
Kadioglu, Aras Echenique, Josè Manco, Sonia Trombe, Marie-Claude Andrew, Peter W. |
| spellingShingle |
Kadioglu, Aras Echenique, Josè Manco, Sonia Trombe, Marie-Claude Andrew, Peter W. Infection and Immunity The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae Infectious Diseases Immunology Microbiology Parasitology |
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kadioglu, aras |
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Kadioglu, Aras Echenique, Josè Manco, Sonia Trombe, Marie-Claude Andrew, Peter W. 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.71.11.6676-6679.2003 <jats:title>ABSTRACT</jats:title> <jats:p> In <jats:italic>Streptococcus pneumoniae</jats:italic> , the two-component signaling system MicAB was previously shown to contribute to repression of competence when oxygen is limited. In virulent strains expressing the serotype 2 and 6 capsule, mutation of the MicB kinase reduced the lag period of growth when cultures were switched from an aerobic to anaerobic atmosphere. After intranasal challenge of mice, the <jats:italic>micB</jats:italic> :: <jats:italic>km</jats:italic> mutation decreased virulence, as shown by the absence of symptoms and by a lower level of recovery of CFU from lungs and blood. It is proposed that MicAB is involved in the adaptive response of the bacteria to changes in oxygen level during the course of infection. </jats:p> The MicAB Two-Component Signaling System Is Involved in Virulence of <i>Streptococcus pneumoniae</i> Infection and Immunity |
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| title |
The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| title_unstemmed |
The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| title_full |
The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| title_fullStr |
The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| title_full_unstemmed |
The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| title_short |
The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| title_sort |
the micab two-component signaling system is involved in virulence of
<i>streptococcus pneumoniae</i> |
| topic |
Infectious Diseases Immunology Microbiology Parasitology |
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http://dx.doi.org/10.1128/iai.71.11.6676-6679.2003 |
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2003 |
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6676-6679 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>
In
<jats:italic>Streptococcus pneumoniae</jats:italic>
, the two-component signaling system MicAB was previously shown to contribute to repression of competence when oxygen is limited. In virulent strains expressing the serotype 2 and 6 capsule, mutation of the MicB kinase reduced the lag period of growth when cultures were switched from an aerobic to anaerobic atmosphere. After intranasal challenge of mice, the
<jats:italic>micB</jats:italic>
::
<jats:italic>km</jats:italic>
mutation decreased virulence, as shown by the absence of symptoms and by a lower level of recovery of CFU from lungs and blood. It is proposed that MicAB is involved in the adaptive response of the bacteria to changes in oxygen level during the course of infection.
</jats:p> |
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| author | Kadioglu, Aras, Echenique, Josè, Manco, Sonia, Trombe, Marie-Claude, Andrew, Peter W. |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p> In <jats:italic>Streptococcus pneumoniae</jats:italic> , the two-component signaling system MicAB was previously shown to contribute to repression of competence when oxygen is limited. In virulent strains expressing the serotype 2 and 6 capsule, mutation of the MicB kinase reduced the lag period of growth when cultures were switched from an aerobic to anaerobic atmosphere. After intranasal challenge of mice, the <jats:italic>micB</jats:italic> :: <jats:italic>km</jats:italic> mutation decreased virulence, as shown by the absence of symptoms and by a lower level of recovery of CFU from lungs and blood. It is proposed that MicAB is involved in the adaptive response of the bacteria to changes in oxygen level during the course of infection. </jats:p> |
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| spelling | Kadioglu, Aras Echenique, Josè Manco, Sonia Trombe, Marie-Claude Andrew, Peter W. 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.71.11.6676-6679.2003 <jats:title>ABSTRACT</jats:title> <jats:p> In <jats:italic>Streptococcus pneumoniae</jats:italic> , the two-component signaling system MicAB was previously shown to contribute to repression of competence when oxygen is limited. In virulent strains expressing the serotype 2 and 6 capsule, mutation of the MicB kinase reduced the lag period of growth when cultures were switched from an aerobic to anaerobic atmosphere. After intranasal challenge of mice, the <jats:italic>micB</jats:italic> :: <jats:italic>km</jats:italic> mutation decreased virulence, as shown by the absence of symptoms and by a lower level of recovery of CFU from lungs and blood. It is proposed that MicAB is involved in the adaptive response of the bacteria to changes in oxygen level during the course of infection. </jats:p> The MicAB Two-Component Signaling System Is Involved in Virulence of <i>Streptococcus pneumoniae</i> Infection and Immunity |
| spellingShingle | Kadioglu, Aras, Echenique, Josè, Manco, Sonia, Trombe, Marie-Claude, Andrew, Peter W., Infection and Immunity, The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae, Infectious Diseases, Immunology, Microbiology, Parasitology |
| title | The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| title_full | The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| title_fullStr | The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| title_full_unstemmed | The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| title_short | The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| title_sort | the micab two-component signaling system is involved in virulence of <i>streptococcus pneumoniae</i> |
| title_unstemmed | The MicAB Two-Component Signaling System Is Involved in Virulence of Streptococcus pneumoniae |
| topic | Infectious Diseases, Immunology, Microbiology, Parasitology |
| url | http://dx.doi.org/10.1128/iai.71.11.6676-6679.2003 |