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Environmental Signals Controlling Production of Hemagglutinin/Protease in Vibrio cholerae
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| Zeitschriftentitel: | Infection and Immunity |
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| Personen und Körperschaften: | , , |
| In: | Infection and Immunity, 69, 2001, 10, S. 6549-6553 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>ABSTRACT</jats:title> <jats:p> <jats:italic>Vibrio cholerae</jats:italic> hemagglutinin/protease (Hap) was induced upon nutrient limitation and strongly repressed by glucose. Hap was not produced in a mutant defective in the cyclic AMP (cAMP) receptor protein, suggesting that intracellular cAMP levels mediate Hap expression. No difference was found in Hap production between an <jats:italic>rpoS</jats:italic> deletion mutant and its isogenic wild-type precursor, indicating that the alternate ς <jats:sup>s</jats:sup> factor is not essential for Hap expression. Based on these and previous results, we discuss the role of Hap in the pathogenesis of cholera. </jats:p> |
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| Umfang: | 6549-6553 |
| ISSN: |
0019-9567
1098-5522 |
| DOI: | 10.1128/iai.69.10.6549-6553.2001 |