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Pseudomembranous colitis in Clostridium difficile-monoassociated rats
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| Zeitschriftentitel: | Infection and Immunity |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Infection and Immunity, 39, 1983, 3, S. 1368-1376 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
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| Schlagwörter: |
| author_facet |
Czuprynski, C J Johnson, W J Balish, E Wilkins, T Czuprynski, C J Johnson, W J Balish, E Wilkins, T |
|---|---|
| author |
Czuprynski, C J Johnson, W J Balish, E Wilkins, T |
| spellingShingle |
Czuprynski, C J Johnson, W J Balish, E Wilkins, T Infection and Immunity Pseudomembranous colitis in Clostridium difficile-monoassociated rats Infectious Diseases Immunology Microbiology Parasitology |
| author_sort |
czuprynski, c j |
| spelling |
Czuprynski, C J Johnson, W J Balish, E Wilkins, T 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.39.3.1368-1376.1983 <jats:p>Germfree rats were monoassociated with either a toxin-producing strain of Clostridium difficile (Tox+) or a variant of this strain (ToxR) which produced much less toxin (1/10,000) in vivo and in vitro. Monoassociation of germfree rats with C. difficile Tox+ resulted in mortality (17%) and in pathology to the small and large intestines, livers, and lungs. Cecal filtrates from the Tox+-monoassociated rats were cytotoxic for tissue culture cells. The cytotoxicity of cecal filtrates could be blocked by sera from Tox+-monoassociated rats. Monoassociation of rats with C. difficile ToxR resulted in no deaths or pathology, and much less toxin was detected in the cecal filtrates of these animals than in those of rats colonized with the Tox+ strain. This gnotobiotic model may be useful for investigating the etiology, prophylaxis, therapy, and exacerbation of C. difficile-induced pseudomembranous colitis.</jats:p> Pseudomembranous colitis in Clostridium difficile-monoassociated rats Infection and Immunity |
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American Society for Microbiology, 1983 |
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| title |
Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
| title_unstemmed |
Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
| title_full |
Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
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Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
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Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
| title_short |
Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
| title_sort |
pseudomembranous colitis in clostridium difficile-monoassociated rats |
| topic |
Infectious Diseases Immunology Microbiology Parasitology |
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http://dx.doi.org/10.1128/iai.39.3.1368-1376.1983 |
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1983 |
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1368-1376 |
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<jats:p>Germfree rats were monoassociated with either a toxin-producing strain of Clostridium difficile (Tox+) or a variant of this strain (ToxR) which produced much less toxin (1/10,000) in vivo and in vitro. Monoassociation of germfree rats with C. difficile Tox+ resulted in mortality (17%) and in pathology to the small and large intestines, livers, and lungs. Cecal filtrates from the Tox+-monoassociated rats were cytotoxic for tissue culture cells. The cytotoxicity of cecal filtrates could be blocked by sera from Tox+-monoassociated rats. Monoassociation of rats with C. difficile ToxR resulted in no deaths or pathology, and much less toxin was detected in the cecal filtrates of these animals than in those of rats colonized with the Tox+ strain. This gnotobiotic model may be useful for investigating the etiology, prophylaxis, therapy, and exacerbation of C. difficile-induced pseudomembranous colitis.</jats:p> |
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| author | Czuprynski, C J, Johnson, W J, Balish, E, Wilkins, T |
| author_facet | Czuprynski, C J, Johnson, W J, Balish, E, Wilkins, T, Czuprynski, C J, Johnson, W J, Balish, E, Wilkins, T |
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| description | <jats:p>Germfree rats were monoassociated with either a toxin-producing strain of Clostridium difficile (Tox+) or a variant of this strain (ToxR) which produced much less toxin (1/10,000) in vivo and in vitro. Monoassociation of germfree rats with C. difficile Tox+ resulted in mortality (17%) and in pathology to the small and large intestines, livers, and lungs. Cecal filtrates from the Tox+-monoassociated rats were cytotoxic for tissue culture cells. The cytotoxicity of cecal filtrates could be blocked by sera from Tox+-monoassociated rats. Monoassociation of rats with C. difficile ToxR resulted in no deaths or pathology, and much less toxin was detected in the cecal filtrates of these animals than in those of rats colonized with the Tox+ strain. This gnotobiotic model may be useful for investigating the etiology, prophylaxis, therapy, and exacerbation of C. difficile-induced pseudomembranous colitis.</jats:p> |
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| imprint_str_mv | American Society for Microbiology, 1983 |
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| spelling | Czuprynski, C J Johnson, W J Balish, E Wilkins, T 0019-9567 1098-5522 American Society for Microbiology Infectious Diseases Immunology Microbiology Parasitology http://dx.doi.org/10.1128/iai.39.3.1368-1376.1983 <jats:p>Germfree rats were monoassociated with either a toxin-producing strain of Clostridium difficile (Tox+) or a variant of this strain (ToxR) which produced much less toxin (1/10,000) in vivo and in vitro. Monoassociation of germfree rats with C. difficile Tox+ resulted in mortality (17%) and in pathology to the small and large intestines, livers, and lungs. Cecal filtrates from the Tox+-monoassociated rats were cytotoxic for tissue culture cells. The cytotoxicity of cecal filtrates could be blocked by sera from Tox+-monoassociated rats. Monoassociation of rats with C. difficile ToxR resulted in no deaths or pathology, and much less toxin was detected in the cecal filtrates of these animals than in those of rats colonized with the Tox+ strain. This gnotobiotic model may be useful for investigating the etiology, prophylaxis, therapy, and exacerbation of C. difficile-induced pseudomembranous colitis.</jats:p> Pseudomembranous colitis in Clostridium difficile-monoassociated rats Infection and Immunity |
| spellingShingle | Czuprynski, C J, Johnson, W J, Balish, E, Wilkins, T, Infection and Immunity, Pseudomembranous colitis in Clostridium difficile-monoassociated rats, Infectious Diseases, Immunology, Microbiology, Parasitology |
| title | Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
| title_full | Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
| title_fullStr | Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
| title_full_unstemmed | Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
| title_short | Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
| title_sort | pseudomembranous colitis in clostridium difficile-monoassociated rats |
| title_unstemmed | Pseudomembranous colitis in Clostridium difficile-monoassociated rats |
| topic | Infectious Diseases, Immunology, Microbiology, Parasitology |
| url | http://dx.doi.org/10.1128/iai.39.3.1368-1376.1983 |