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No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104
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| Zeitschriftentitel: | Applied and Environmental Microbiology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Applied and Environmental Microbiology, 79, 2013, 9, S. 2914-2921 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Janczyk, Pawel Kreuzer, Susanne Assmus, Jens Nöckler, Karsten Brockmann, Gudrun A. Janczyk, Pawel Kreuzer, Susanne Assmus, Jens Nöckler, Karsten Brockmann, Gudrun A. |
|---|---|
| author |
Janczyk, Pawel Kreuzer, Susanne Assmus, Jens Nöckler, Karsten Brockmann, Gudrun A. |
| spellingShingle |
Janczyk, Pawel Kreuzer, Susanne Assmus, Jens Nöckler, Karsten Brockmann, Gudrun A. Applied and Environmental Microbiology No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 Ecology Applied Microbiology and Biotechnology Food Science Biotechnology |
| author_sort |
janczyk, pawel |
| spelling |
Janczyk, Pawel Kreuzer, Susanne Assmus, Jens Nöckler, Karsten Brockmann, Gudrun A. 0099-2240 1098-5336 American Society for Microbiology Ecology Applied Microbiology and Biotechnology Food Science Biotechnology http://dx.doi.org/10.1128/aem.03577-12 <jats:title>ABSTRACT</jats:title> <jats:p> Twenty-eight-day-old weaned pigs were fed diets with a low (LZn), medium (MZn), or high (MZn) Zn concentration (50 to 80, 150, or 2,500 mg Zn/kg of diet, respectively) provided as zinc oxide (ZnO)(24 pigs per group). They were infected orally with <jats:named-content content-type="genus-species">Salmonella enterica</jats:named-content> serovar Typhimurium DT104 on day 32. Salmonellae were cultivated from feces (up to 42 days postinfection [dpi]) and organs (2 and 42 dpi). Activation of the adaptive systemic and mucosal immune systems was investigated by recording anti- <jats:named-content content-type="genus-species">Salmonella</jats:named-content> IgG levels and levels of B and T lymphocyte subpopulations in blood and gut-associated lymphatic tissue. Growth performance was recorded as well. Salmonellae were shed at higher levels and for longer periods in the HZn group ( <jats:italic>P</jats:italic> < 0.05), with no differences in the tissues. At 2 dpi, the relative percentages of CD4 <jats:sup>+</jats:sup> T helper cells ( <jats:italic>P</jats:italic> < 0.01) and of CD2 <jats:sup>+</jats:sup> T and NK cells ( <jats:italic>P</jats:italic> < 0.01) in blood were reduced from the relative cell counts obtained at 0 dpi, irrespective of the Zn group. The lowest percentage of cytotoxic T cells was found 14 dpi in the HZn group relative to the MZn ( <jats:italic>P</jats:italic> < 0.05) and LZn ( <jats:italic>P</jats:italic> < 0.01) groups. Supplementation of the feed with 2,500 mg Zn/kg of diet immediately after weaning could positively affect the immune responses of piglets infected with <jats:named-content content-type="genus-species">Salmonella</jats:named-content> Typhimurium, but for a short period only. After 2 weeks, all positive effects disappeared, and rather negative effects, such as higher shedding of salmonellae, lower T cell frequencies, and worse performance, occurred. Thus, supplementation with ZnO at high levels in the pig industry should be limited to 2 to 3 weeks. </jats:p> No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 Applied and Environmental Microbiology |
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10.1128/aem.03577-12 |
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Technik Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft Geographie Biologie |
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American Society for Microbiology, 2013 |
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American Society for Microbiology, 2013 |
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1098-5336 0099-2240 |
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Applied and Environmental Microbiology |
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| title |
No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| title_unstemmed |
No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| title_full |
No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| title_fullStr |
No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| title_full_unstemmed |
No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| title_short |
No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| title_sort |
no protective effects of high-dosage dietary zinc oxide on weaned pigs infected with salmonella enterica serovar typhimurium dt104 |
| topic |
Ecology Applied Microbiology and Biotechnology Food Science Biotechnology |
| url |
http://dx.doi.org/10.1128/aem.03577-12 |
| publishDate |
2013 |
| physical |
2914-2921 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>
Twenty-eight-day-old weaned pigs were fed diets with a low (LZn), medium (MZn), or high (MZn) Zn concentration (50 to 80, 150, or 2,500 mg Zn/kg of diet, respectively) provided as zinc oxide (ZnO)(24 pigs per group). They were infected orally with
<jats:named-content content-type="genus-species">Salmonella enterica</jats:named-content>
serovar Typhimurium DT104 on day 32. Salmonellae were cultivated from feces (up to 42 days postinfection [dpi]) and organs (2 and 42 dpi). Activation of the adaptive systemic and mucosal immune systems was investigated by recording anti-
<jats:named-content content-type="genus-species">Salmonella</jats:named-content>
IgG levels and levels of B and T lymphocyte subpopulations in blood and gut-associated lymphatic tissue. Growth performance was recorded as well. Salmonellae were shed at higher levels and for longer periods in the HZn group (
<jats:italic>P</jats:italic>
< 0.05), with no differences in the tissues. At 2 dpi, the relative percentages of CD4
<jats:sup>+</jats:sup>
T helper cells (
<jats:italic>P</jats:italic>
< 0.01) and of CD2
<jats:sup>+</jats:sup>
T and NK cells (
<jats:italic>P</jats:italic>
< 0.01) in blood were reduced from the relative cell counts obtained at 0 dpi, irrespective of the Zn group. The lowest percentage of cytotoxic T cells was found 14 dpi in the HZn group relative to the MZn (
<jats:italic>P</jats:italic>
< 0.05) and LZn (
<jats:italic>P</jats:italic>
< 0.01) groups. Supplementation of the feed with 2,500 mg Zn/kg of diet immediately after weaning could positively affect the immune responses of piglets infected with
<jats:named-content content-type="genus-species">Salmonella</jats:named-content>
Typhimurium, but for a short period only. After 2 weeks, all positive effects disappeared, and rather negative effects, such as higher shedding of salmonellae, lower T cell frequencies, and worse performance, occurred. Thus, supplementation with ZnO at high levels in the pig industry should be limited to 2 to 3 weeks.
</jats:p> |
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| description | <jats:title>ABSTRACT</jats:title> <jats:p> Twenty-eight-day-old weaned pigs were fed diets with a low (LZn), medium (MZn), or high (MZn) Zn concentration (50 to 80, 150, or 2,500 mg Zn/kg of diet, respectively) provided as zinc oxide (ZnO)(24 pigs per group). They were infected orally with <jats:named-content content-type="genus-species">Salmonella enterica</jats:named-content> serovar Typhimurium DT104 on day 32. Salmonellae were cultivated from feces (up to 42 days postinfection [dpi]) and organs (2 and 42 dpi). Activation of the adaptive systemic and mucosal immune systems was investigated by recording anti- <jats:named-content content-type="genus-species">Salmonella</jats:named-content> IgG levels and levels of B and T lymphocyte subpopulations in blood and gut-associated lymphatic tissue. Growth performance was recorded as well. Salmonellae were shed at higher levels and for longer periods in the HZn group ( <jats:italic>P</jats:italic> < 0.05), with no differences in the tissues. At 2 dpi, the relative percentages of CD4 <jats:sup>+</jats:sup> T helper cells ( <jats:italic>P</jats:italic> < 0.01) and of CD2 <jats:sup>+</jats:sup> T and NK cells ( <jats:italic>P</jats:italic> < 0.01) in blood were reduced from the relative cell counts obtained at 0 dpi, irrespective of the Zn group. The lowest percentage of cytotoxic T cells was found 14 dpi in the HZn group relative to the MZn ( <jats:italic>P</jats:italic> < 0.05) and LZn ( <jats:italic>P</jats:italic> < 0.01) groups. Supplementation of the feed with 2,500 mg Zn/kg of diet immediately after weaning could positively affect the immune responses of piglets infected with <jats:named-content content-type="genus-species">Salmonella</jats:named-content> Typhimurium, but for a short period only. After 2 weeks, all positive effects disappeared, and rather negative effects, such as higher shedding of salmonellae, lower T cell frequencies, and worse performance, occurred. Thus, supplementation with ZnO at high levels in the pig industry should be limited to 2 to 3 weeks. </jats:p> |
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| spelling | Janczyk, Pawel Kreuzer, Susanne Assmus, Jens Nöckler, Karsten Brockmann, Gudrun A. 0099-2240 1098-5336 American Society for Microbiology Ecology Applied Microbiology and Biotechnology Food Science Biotechnology http://dx.doi.org/10.1128/aem.03577-12 <jats:title>ABSTRACT</jats:title> <jats:p> Twenty-eight-day-old weaned pigs were fed diets with a low (LZn), medium (MZn), or high (MZn) Zn concentration (50 to 80, 150, or 2,500 mg Zn/kg of diet, respectively) provided as zinc oxide (ZnO)(24 pigs per group). They were infected orally with <jats:named-content content-type="genus-species">Salmonella enterica</jats:named-content> serovar Typhimurium DT104 on day 32. Salmonellae were cultivated from feces (up to 42 days postinfection [dpi]) and organs (2 and 42 dpi). Activation of the adaptive systemic and mucosal immune systems was investigated by recording anti- <jats:named-content content-type="genus-species">Salmonella</jats:named-content> IgG levels and levels of B and T lymphocyte subpopulations in blood and gut-associated lymphatic tissue. Growth performance was recorded as well. Salmonellae were shed at higher levels and for longer periods in the HZn group ( <jats:italic>P</jats:italic> < 0.05), with no differences in the tissues. At 2 dpi, the relative percentages of CD4 <jats:sup>+</jats:sup> T helper cells ( <jats:italic>P</jats:italic> < 0.01) and of CD2 <jats:sup>+</jats:sup> T and NK cells ( <jats:italic>P</jats:italic> < 0.01) in blood were reduced from the relative cell counts obtained at 0 dpi, irrespective of the Zn group. The lowest percentage of cytotoxic T cells was found 14 dpi in the HZn group relative to the MZn ( <jats:italic>P</jats:italic> < 0.05) and LZn ( <jats:italic>P</jats:italic> < 0.01) groups. Supplementation of the feed with 2,500 mg Zn/kg of diet immediately after weaning could positively affect the immune responses of piglets infected with <jats:named-content content-type="genus-species">Salmonella</jats:named-content> Typhimurium, but for a short period only. After 2 weeks, all positive effects disappeared, and rather negative effects, such as higher shedding of salmonellae, lower T cell frequencies, and worse performance, occurred. Thus, supplementation with ZnO at high levels in the pig industry should be limited to 2 to 3 weeks. </jats:p> No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 Applied and Environmental Microbiology |
| spellingShingle | Janczyk, Pawel, Kreuzer, Susanne, Assmus, Jens, Nöckler, Karsten, Brockmann, Gudrun A., Applied and Environmental Microbiology, No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104, Ecology, Applied Microbiology and Biotechnology, Food Science, Biotechnology |
| title | No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| title_full | No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| title_fullStr | No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| title_full_unstemmed | No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| title_short | No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| title_sort | no protective effects of high-dosage dietary zinc oxide on weaned pigs infected with salmonella enterica serovar typhimurium dt104 |
| title_unstemmed | No Protective Effects of High-Dosage Dietary Zinc Oxide on Weaned Pigs Infected with Salmonella enterica Serovar Typhimurium DT104 |
| topic | Ecology, Applied Microbiology and Biotechnology, Food Science, Biotechnology |
| url | http://dx.doi.org/10.1128/aem.03577-12 |