Eintrag weiter verarbeiten
Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fl...
Gespeichert in:
| Zeitschriftentitel: | Antimicrobial Agents and Chemotherapy |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Antimicrobial Agents and Chemotherapy, 49, 2005, 10, S. 4315-4326 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Stanhope, Michael J. Walsh, Stacey L. Becker, Julie A. Italia, Michael J. Ingraham, Karen A. Gwynn, Michael N. Mathie, Tom Poupard, James A. Miller, Linda A. Brown, James R. Amrine-Madsen, Heather Stanhope, Michael J. Walsh, Stacey L. Becker, Julie A. Italia, Michael J. Ingraham, Karen A. Gwynn, Michael N. Mathie, Tom Poupard, James A. Miller, Linda A. Brown, James R. Amrine-Madsen, Heather |
|---|---|
| author |
Stanhope, Michael J. Walsh, Stacey L. Becker, Julie A. Italia, Michael J. Ingraham, Karen A. Gwynn, Michael N. Mathie, Tom Poupard, James A. Miller, Linda A. Brown, James R. Amrine-Madsen, Heather |
| spellingShingle |
Stanhope, Michael J. Walsh, Stacey L. Becker, Julie A. Italia, Michael J. Ingraham, Karen A. Gwynn, Michael N. Mathie, Tom Poupard, James A. Miller, Linda A. Brown, James R. Amrine-Madsen, Heather Antimicrobial Agents and Chemotherapy Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread Infectious Diseases Pharmacology (medical) Pharmacology |
| author_sort |
stanhope, michael j. |
| spelling |
Stanhope, Michael J. Walsh, Stacey L. Becker, Julie A. Italia, Michael J. Ingraham, Karen A. Gwynn, Michael N. Mathie, Tom Poupard, James A. Miller, Linda A. Brown, James R. Amrine-Madsen, Heather 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.49.10.4315-4326.2005 <jats:title>ABSTRACT</jats:title> <jats:p> Fluoroquinolones are an important class of antibiotics for the treatment of infections arising from the gram-positive respiratory pathogen <jats:italic>Streptococcus pneumoniae</jats:italic> . Although there is evidence supporting interspecific lateral DNA transfer of fluoroquinolone target loci, no studies have specifically been designed to assess the role of intraspecific lateral transfer of these genes in the spread of fluoroquinolone resistance. This study involves a comparative evolutionary perspective, in which the evolutionary history of a diverse set of <jats:italic>S. pneumoniae</jats:italic> clinical isolates is reconstructed from an expanded multilocus sequence typing data set, with putative recombinants excluded. This control history is then assessed against networks of each of the four fluoroquinolone target loci from the same isolates. The results indicate that although the majority of fluoroquinolone target loci from this set of 60 isolates are consistent with a clonal dissemination hypothesis, 3 to 10% of the sequences are consistent with an intraspecific lateral transfer hypothesis. Also evident were examples of interspecific transfer, with two isolates possessing a <jats:italic>parE</jats:italic> - <jats:italic>parC</jats:italic> gene region arising from viridans group streptococci. The Spain 23F-1 clone is the most dominant fluoroquinolone-nonsusceptible clone in this set of isolates, and the analysis suggests that its members act as frequent donors of fluoroquinolone-nonsusceptible loci. Although the majority of fluoroquinolone target gene sequences in this set of isolates can be explained on the basis of clonal dissemination, a significant number are more parsimoniously explained by intraspecific lateral DNA transfer, and in situations of high <jats:italic>S. pneumoniae</jats:italic> population density, such events could be an important means of resistance spread. </jats:p> Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in <i>Streptococcus pneumoniae</i> , with Implications for Fluoroquinolone Resistance Development and Spread Antimicrobial Agents and Chemotherapy |
| doi_str_mv |
10.1128/aac.49.10.4315-4326.2005 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9hYWMuNDkuMTAuNDMxNS00MzI2LjIwMDU |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9hYWMuNDkuMTAuNDMxNS00MzI2LjIwMDU |
| institution |
DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 |
| imprint |
American Society for Microbiology, 2005 |
| imprint_str_mv |
American Society for Microbiology, 2005 |
| issn |
0066-4804 1098-6596 |
| issn_str_mv |
0066-4804 1098-6596 |
| language |
English |
| mega_collection |
American Society for Microbiology (CrossRef) |
| match_str |
stanhope2005molecularevolutionperspectivesonintraspecificlateraldnatransferoftopoisomeraseandgyraselociinstreptococcuspneumoniaewithimplicationsforfluoroquinoloneresistancedevelopmentandspread |
| publishDateSort |
2005 |
| publisher |
American Society for Microbiology |
| recordtype |
ai |
| record_format |
ai |
| series |
Antimicrobial Agents and Chemotherapy |
| source_id |
49 |
| title |
Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| title_unstemmed |
Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| title_full |
Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| title_fullStr |
Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| title_full_unstemmed |
Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| title_short |
Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| title_sort |
molecular evolution perspectives on intraspecific lateral dna transfer of topoisomerase and gyrase loci in
<i>streptococcus pneumoniae</i>
, with implications for fluoroquinolone resistance development and spread |
| topic |
Infectious Diseases Pharmacology (medical) Pharmacology |
| url |
http://dx.doi.org/10.1128/aac.49.10.4315-4326.2005 |
| publishDate |
2005 |
| physical |
4315-4326 |
| description |
<jats:title>ABSTRACT</jats:title>
<jats:p>
Fluoroquinolones are an important class of antibiotics for the treatment of infections arising from the gram-positive respiratory pathogen
<jats:italic>Streptococcus pneumoniae</jats:italic>
. Although there is evidence supporting interspecific lateral DNA transfer of fluoroquinolone target loci, no studies have specifically been designed to assess the role of intraspecific lateral transfer of these genes in the spread of fluoroquinolone resistance. This study involves a comparative evolutionary perspective, in which the evolutionary history of a diverse set of
<jats:italic>S. pneumoniae</jats:italic>
clinical isolates is reconstructed from an expanded multilocus sequence typing data set, with putative recombinants excluded. This control history is then assessed against networks of each of the four fluoroquinolone target loci from the same isolates. The results indicate that although the majority of fluoroquinolone target loci from this set of 60 isolates are consistent with a clonal dissemination hypothesis, 3 to 10% of the sequences are consistent with an intraspecific lateral transfer hypothesis. Also evident were examples of interspecific transfer, with two isolates possessing a
<jats:italic>parE</jats:italic>
-
<jats:italic>parC</jats:italic>
gene region arising from viridans group streptococci. The Spain 23F-1 clone is the most dominant fluoroquinolone-nonsusceptible clone in this set of isolates, and the analysis suggests that its members act as frequent donors of fluoroquinolone-nonsusceptible loci. Although the majority of fluoroquinolone target gene sequences in this set of isolates can be explained on the basis of clonal dissemination, a significant number are more parsimoniously explained by intraspecific lateral DNA transfer, and in situations of high
<jats:italic>S. pneumoniae</jats:italic>
population density, such events could be an important means of resistance spread.
</jats:p> |
| container_issue |
10 |
| container_start_page |
4315 |
| container_title |
Antimicrobial Agents and Chemotherapy |
| container_volume |
49 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792336189449043983 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:56:29.8Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Molecular+Evolution+Perspectives+on+Intraspecific+Lateral+DNA+Transfer+of+Topoisomerase+and+Gyrase+Loci+in++++++++++++Streptococcus+pneumoniae++++++++++++%2C+with+Implications+for+Fluoroquinolone+Resistance+Development+and+Spread&rft.date=2005-10-01&genre=article&issn=1098-6596&volume=49&issue=10&spage=4315&epage=4326&pages=4315-4326&jtitle=Antimicrobial+Agents+and+Chemotherapy&atitle=Molecular+Evolution+Perspectives+on+Intraspecific+Lateral+DNA+Transfer+of+Topoisomerase+and+Gyrase+Loci+in%0A++++++++++++%3Ci%3EStreptococcus+pneumoniae%3C%2Fi%3E%0A++++++++++++%2C+with+Implications+for+Fluoroquinolone+Resistance+Development+and+Spread&aulast=Amrine-Madsen&aufirst=Heather&rft_id=info%3Adoi%2F10.1128%2Faac.49.10.4315-4326.2005&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792336189449043983 |
| author | Stanhope, Michael J., Walsh, Stacey L., Becker, Julie A., Italia, Michael J., Ingraham, Karen A., Gwynn, Michael N., Mathie, Tom, Poupard, James A., Miller, Linda A., Brown, James R., Amrine-Madsen, Heather |
| author_facet | Stanhope, Michael J., Walsh, Stacey L., Becker, Julie A., Italia, Michael J., Ingraham, Karen A., Gwynn, Michael N., Mathie, Tom, Poupard, James A., Miller, Linda A., Brown, James R., Amrine-Madsen, Heather, Stanhope, Michael J., Walsh, Stacey L., Becker, Julie A., Italia, Michael J., Ingraham, Karen A., Gwynn, Michael N., Mathie, Tom, Poupard, James A., Miller, Linda A., Brown, James R., Amrine-Madsen, Heather |
| author_sort | stanhope, michael j. |
| container_issue | 10 |
| container_start_page | 4315 |
| container_title | Antimicrobial Agents and Chemotherapy |
| container_volume | 49 |
| description | <jats:title>ABSTRACT</jats:title> <jats:p> Fluoroquinolones are an important class of antibiotics for the treatment of infections arising from the gram-positive respiratory pathogen <jats:italic>Streptococcus pneumoniae</jats:italic> . Although there is evidence supporting interspecific lateral DNA transfer of fluoroquinolone target loci, no studies have specifically been designed to assess the role of intraspecific lateral transfer of these genes in the spread of fluoroquinolone resistance. This study involves a comparative evolutionary perspective, in which the evolutionary history of a diverse set of <jats:italic>S. pneumoniae</jats:italic> clinical isolates is reconstructed from an expanded multilocus sequence typing data set, with putative recombinants excluded. This control history is then assessed against networks of each of the four fluoroquinolone target loci from the same isolates. The results indicate that although the majority of fluoroquinolone target loci from this set of 60 isolates are consistent with a clonal dissemination hypothesis, 3 to 10% of the sequences are consistent with an intraspecific lateral transfer hypothesis. Also evident were examples of interspecific transfer, with two isolates possessing a <jats:italic>parE</jats:italic> - <jats:italic>parC</jats:italic> gene region arising from viridans group streptococci. The Spain 23F-1 clone is the most dominant fluoroquinolone-nonsusceptible clone in this set of isolates, and the analysis suggests that its members act as frequent donors of fluoroquinolone-nonsusceptible loci. Although the majority of fluoroquinolone target gene sequences in this set of isolates can be explained on the basis of clonal dissemination, a significant number are more parsimoniously explained by intraspecific lateral DNA transfer, and in situations of high <jats:italic>S. pneumoniae</jats:italic> population density, such events could be an important means of resistance spread. </jats:p> |
| doi_str_mv | 10.1128/aac.49.10.4315-4326.2005 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin, Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9hYWMuNDkuMTAuNDMxNS00MzI2LjIwMDU |
| imprint | American Society for Microbiology, 2005 |
| imprint_str_mv | American Society for Microbiology, 2005 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14 |
| issn | 0066-4804, 1098-6596 |
| issn_str_mv | 0066-4804, 1098-6596 |
| language | English |
| last_indexed | 2024-03-01T14:56:29.8Z |
| match_str | stanhope2005molecularevolutionperspectivesonintraspecificlateraldnatransferoftopoisomeraseandgyraselociinstreptococcuspneumoniaewithimplicationsforfluoroquinoloneresistancedevelopmentandspread |
| mega_collection | American Society for Microbiology (CrossRef) |
| physical | 4315-4326 |
| publishDate | 2005 |
| publishDateSort | 2005 |
| publisher | American Society for Microbiology |
| record_format | ai |
| recordtype | ai |
| series | Antimicrobial Agents and Chemotherapy |
| source_id | 49 |
| spelling | Stanhope, Michael J. Walsh, Stacey L. Becker, Julie A. Italia, Michael J. Ingraham, Karen A. Gwynn, Michael N. Mathie, Tom Poupard, James A. Miller, Linda A. Brown, James R. Amrine-Madsen, Heather 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.49.10.4315-4326.2005 <jats:title>ABSTRACT</jats:title> <jats:p> Fluoroquinolones are an important class of antibiotics for the treatment of infections arising from the gram-positive respiratory pathogen <jats:italic>Streptococcus pneumoniae</jats:italic> . Although there is evidence supporting interspecific lateral DNA transfer of fluoroquinolone target loci, no studies have specifically been designed to assess the role of intraspecific lateral transfer of these genes in the spread of fluoroquinolone resistance. This study involves a comparative evolutionary perspective, in which the evolutionary history of a diverse set of <jats:italic>S. pneumoniae</jats:italic> clinical isolates is reconstructed from an expanded multilocus sequence typing data set, with putative recombinants excluded. This control history is then assessed against networks of each of the four fluoroquinolone target loci from the same isolates. The results indicate that although the majority of fluoroquinolone target loci from this set of 60 isolates are consistent with a clonal dissemination hypothesis, 3 to 10% of the sequences are consistent with an intraspecific lateral transfer hypothesis. Also evident were examples of interspecific transfer, with two isolates possessing a <jats:italic>parE</jats:italic> - <jats:italic>parC</jats:italic> gene region arising from viridans group streptococci. The Spain 23F-1 clone is the most dominant fluoroquinolone-nonsusceptible clone in this set of isolates, and the analysis suggests that its members act as frequent donors of fluoroquinolone-nonsusceptible loci. Although the majority of fluoroquinolone target gene sequences in this set of isolates can be explained on the basis of clonal dissemination, a significant number are more parsimoniously explained by intraspecific lateral DNA transfer, and in situations of high <jats:italic>S. pneumoniae</jats:italic> population density, such events could be an important means of resistance spread. </jats:p> Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in <i>Streptococcus pneumoniae</i> , with Implications for Fluoroquinolone Resistance Development and Spread Antimicrobial Agents and Chemotherapy |
| spellingShingle | Stanhope, Michael J., Walsh, Stacey L., Becker, Julie A., Italia, Michael J., Ingraham, Karen A., Gwynn, Michael N., Mathie, Tom, Poupard, James A., Miller, Linda A., Brown, James R., Amrine-Madsen, Heather, Antimicrobial Agents and Chemotherapy, Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread, Infectious Diseases, Pharmacology (medical), Pharmacology |
| title | Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| title_full | Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| title_fullStr | Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| title_full_unstemmed | Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| title_short | Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| title_sort | molecular evolution perspectives on intraspecific lateral dna transfer of topoisomerase and gyrase loci in <i>streptococcus pneumoniae</i> , with implications for fluoroquinolone resistance development and spread |
| title_unstemmed | Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae , with Implications for Fluoroquinolone Resistance Development and Spread |
| topic | Infectious Diseases, Pharmacology (medical), Pharmacology |
| url | http://dx.doi.org/10.1128/aac.49.10.4315-4326.2005 |