Eintrag weiter verarbeiten
Mutacin II, a bactericidal antibiotic from Streptococcus mutans
Gespeichert in:
| Zeitschriftentitel: | Antimicrobial Agents and Chemotherapy |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Antimicrobial Agents and Chemotherapy, 39, 1995, 12, S. 2656-2660 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Microbiology
|
| Schlagwörter: |
| author_facet |
Chikindas, M L Novák, J Driessen, A J Konings, W N Schilling, K M Caufield, P W Chikindas, M L Novák, J Driessen, A J Konings, W N Schilling, K M Caufield, P W |
|---|---|
| author |
Chikindas, M L Novák, J Driessen, A J Konings, W N Schilling, K M Caufield, P W |
| spellingShingle |
Chikindas, M L Novák, J Driessen, A J Konings, W N Schilling, K M Caufield, P W Antimicrobial Agents and Chemotherapy Mutacin II, a bactericidal antibiotic from Streptococcus mutans Infectious Diseases Pharmacology (medical) Pharmacology |
| author_sort |
chikindas, m l |
| spelling |
Chikindas, M L Novák, J Driessen, A J Konings, W N Schilling, K M Caufield, P W 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.39.12.2656 <jats:p>Mutacin II is an antibiotic that is produced by group II Streptococcus mutans. It inhibits the growth of other streptococci as well as many other gram-positive microorganisms by a hitherto unknown mechanism. Mutacin II possess bactericidal activity against susceptible cells. It transiently depolarizes the transmembrane electrical potential (delta psi) and the transmembrane pH gradient (delta pH) and partially inhibits amino acid transport. However, it rapidly depletes the intracellular ATP pool in glucose-energized cells and prevents the generation of ATP. It is concluded that mutacin II does not belong to the group of pore-forming antibiotics (type A) or to the type B antibiotics, which inhibit phospholipases or interfere with peptidoglycan biosynthesis. Mutacin II acts by inhibiting essential enzyme functions at the level of metabolic energy generation, an activity that has not yet been classified for antibiotics.</jats:p> Mutacin II, a bactericidal antibiotic from Streptococcus mutans Antimicrobial Agents and Chemotherapy |
| doi_str_mv |
10.1128/aac.39.12.2656 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9hYWMuMzkuMTIuMjY1Ng |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9hYWMuMzkuMTIuMjY1Ng |
| institution |
DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 |
| imprint |
American Society for Microbiology, 1995 |
| imprint_str_mv |
American Society for Microbiology, 1995 |
| issn |
0066-4804 1098-6596 |
| issn_str_mv |
0066-4804 1098-6596 |
| language |
English |
| mega_collection |
American Society for Microbiology (CrossRef) |
| match_str |
chikindas1995mutaciniiabactericidalantibioticfromstreptococcusmutans |
| publishDateSort |
1995 |
| publisher |
American Society for Microbiology |
| recordtype |
ai |
| record_format |
ai |
| series |
Antimicrobial Agents and Chemotherapy |
| source_id |
49 |
| title |
Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| title_unstemmed |
Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| title_full |
Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| title_fullStr |
Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| title_full_unstemmed |
Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| title_short |
Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| title_sort |
mutacin ii, a bactericidal antibiotic from streptococcus mutans |
| topic |
Infectious Diseases Pharmacology (medical) Pharmacology |
| url |
http://dx.doi.org/10.1128/aac.39.12.2656 |
| publishDate |
1995 |
| physical |
2656-2660 |
| description |
<jats:p>Mutacin II is an antibiotic that is produced by group II Streptococcus mutans. It inhibits the growth of other streptococci as well as many other gram-positive microorganisms by a hitherto unknown mechanism. Mutacin II possess bactericidal activity against susceptible cells. It transiently depolarizes the transmembrane electrical potential (delta psi) and the transmembrane pH gradient (delta pH) and partially inhibits amino acid transport. However, it rapidly depletes the intracellular ATP pool in glucose-energized cells and prevents the generation of ATP. It is concluded that mutacin II does not belong to the group of pore-forming antibiotics (type A) or to the type B antibiotics, which inhibit phospholipases or interfere with peptidoglycan biosynthesis. Mutacin II acts by inhibiting essential enzyme functions at the level of metabolic energy generation, an activity that has not yet been classified for antibiotics.</jats:p> |
| container_issue |
12 |
| container_start_page |
2656 |
| container_title |
Antimicrobial Agents and Chemotherapy |
| container_volume |
39 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792334838195290115 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:35:00.781Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Mutacin+II%2C+a+bactericidal+antibiotic+from+Streptococcus+mutans&rft.date=1995-12-01&genre=article&issn=1098-6596&volume=39&issue=12&spage=2656&epage=2660&pages=2656-2660&jtitle=Antimicrobial+Agents+and+Chemotherapy&atitle=Mutacin+II%2C+a+bactericidal+antibiotic+from+Streptococcus+mutans&aulast=Caufield&aufirst=P+W&rft_id=info%3Adoi%2F10.1128%2Faac.39.12.2656&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792334838195290115 |
| author | Chikindas, M L, Novák, J, Driessen, A J, Konings, W N, Schilling, K M, Caufield, P W |
| author_facet | Chikindas, M L, Novák, J, Driessen, A J, Konings, W N, Schilling, K M, Caufield, P W, Chikindas, M L, Novák, J, Driessen, A J, Konings, W N, Schilling, K M, Caufield, P W |
| author_sort | chikindas, m l |
| container_issue | 12 |
| container_start_page | 2656 |
| container_title | Antimicrobial Agents and Chemotherapy |
| container_volume | 39 |
| description | <jats:p>Mutacin II is an antibiotic that is produced by group II Streptococcus mutans. It inhibits the growth of other streptococci as well as many other gram-positive microorganisms by a hitherto unknown mechanism. Mutacin II possess bactericidal activity against susceptible cells. It transiently depolarizes the transmembrane electrical potential (delta psi) and the transmembrane pH gradient (delta pH) and partially inhibits amino acid transport. However, it rapidly depletes the intracellular ATP pool in glucose-energized cells and prevents the generation of ATP. It is concluded that mutacin II does not belong to the group of pore-forming antibiotics (type A) or to the type B antibiotics, which inhibit phospholipases or interfere with peptidoglycan biosynthesis. Mutacin II acts by inhibiting essential enzyme functions at the level of metabolic energy generation, an activity that has not yet been classified for antibiotics.</jats:p> |
| doi_str_mv | 10.1128/aac.39.12.2656 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin, Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEyOC9hYWMuMzkuMTIuMjY1Ng |
| imprint | American Society for Microbiology, 1995 |
| imprint_str_mv | American Society for Microbiology, 1995 |
| institution | DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
| issn | 0066-4804, 1098-6596 |
| issn_str_mv | 0066-4804, 1098-6596 |
| language | English |
| last_indexed | 2024-03-01T14:35:00.781Z |
| match_str | chikindas1995mutaciniiabactericidalantibioticfromstreptococcusmutans |
| mega_collection | American Society for Microbiology (CrossRef) |
| physical | 2656-2660 |
| publishDate | 1995 |
| publishDateSort | 1995 |
| publisher | American Society for Microbiology |
| record_format | ai |
| recordtype | ai |
| series | Antimicrobial Agents and Chemotherapy |
| source_id | 49 |
| spelling | Chikindas, M L Novák, J Driessen, A J Konings, W N Schilling, K M Caufield, P W 0066-4804 1098-6596 American Society for Microbiology Infectious Diseases Pharmacology (medical) Pharmacology http://dx.doi.org/10.1128/aac.39.12.2656 <jats:p>Mutacin II is an antibiotic that is produced by group II Streptococcus mutans. It inhibits the growth of other streptococci as well as many other gram-positive microorganisms by a hitherto unknown mechanism. Mutacin II possess bactericidal activity against susceptible cells. It transiently depolarizes the transmembrane electrical potential (delta psi) and the transmembrane pH gradient (delta pH) and partially inhibits amino acid transport. However, it rapidly depletes the intracellular ATP pool in glucose-energized cells and prevents the generation of ATP. It is concluded that mutacin II does not belong to the group of pore-forming antibiotics (type A) or to the type B antibiotics, which inhibit phospholipases or interfere with peptidoglycan biosynthesis. Mutacin II acts by inhibiting essential enzyme functions at the level of metabolic energy generation, an activity that has not yet been classified for antibiotics.</jats:p> Mutacin II, a bactericidal antibiotic from Streptococcus mutans Antimicrobial Agents and Chemotherapy |
| spellingShingle | Chikindas, M L, Novák, J, Driessen, A J, Konings, W N, Schilling, K M, Caufield, P W, Antimicrobial Agents and Chemotherapy, Mutacin II, a bactericidal antibiotic from Streptococcus mutans, Infectious Diseases, Pharmacology (medical), Pharmacology |
| title | Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| title_full | Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| title_fullStr | Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| title_full_unstemmed | Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| title_short | Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| title_sort | mutacin ii, a bactericidal antibiotic from streptococcus mutans |
| title_unstemmed | Mutacin II, a bactericidal antibiotic from Streptococcus mutans |
| topic | Infectious Diseases, Pharmacology (medical), Pharmacology |
| url | http://dx.doi.org/10.1128/aac.39.12.2656 |