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An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex.
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| Zeitschriftentitel: | The Journal of Physiology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | The Journal of Physiology, 310, 1981, 1, S. 273-283 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Maxild, J Møller, J V Sheikh, M I Maxild, J Møller, J V Sheikh, M I |
|---|---|
| author |
Maxild, J Møller, J V Sheikh, M I |
| spellingShingle |
Maxild, J Møller, J V Sheikh, M I The Journal of Physiology An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. Physiology |
| author_sort |
maxild, j |
| spelling |
Maxild, J Møller, J V Sheikh, M I 0022-3751 1469-7793 Wiley Physiology http://dx.doi.org/10.1113/jphysiol.1981.sp013548 <jats:p>1. The relation between the coupling of metabolic energy to renalp‐aminohippurate (PAH) accumulation and Na+‐K+ transport was studiedin rabbit cortical slices. 2. Cyanide (CN‐), 2,4‐dinitrophenol (DNP)and fluoride (F‐( at low‐medium concentrations, giving rise to aslight decline of tissue ATP concentration, caused a reduction o PAHaccumulation without significantly affecting intracellular Na+ and K+concentrations. However, higher levels of the metabolic inhibitorsalso resulted in considerable inhibition of active Na+‐K+transport. 3. The rate of carrier‐mediated PAH uptake was slow underanaerobic conditions, relative to that measured under aerobicconditions in Na+‐depleted slices. In the latter case the maximalaccumulation achieved was only 1.55 +/‐ 0.16. 4. The uptake rate ofPAH under anaerobic conditions was not inhibited by the absence of Na+or addition of metabolic inhibitors in the concentrations used underaerobic conditions. 5. It is concluded that although Na+ is requiredfor the attainment of high accumulation ratios of PAH, oxidativemetabolism stimulates PAH flux by a Na+‐independentmechanism.</jats:p> An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. The Journal of Physiology |
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The Journal of Physiology |
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| title |
An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_unstemmed |
An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_full |
An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_fullStr |
An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_full_unstemmed |
An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_short |
An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_sort |
an energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| topic |
Physiology |
| url |
http://dx.doi.org/10.1113/jphysiol.1981.sp013548 |
| publishDate |
1981 |
| physical |
273-283 |
| description |
<jats:p>1. The relation between the coupling of metabolic energy to renalp‐aminohippurate (PAH) accumulation and Na+‐K+ transport was studiedin rabbit cortical slices. 2. Cyanide (CN‐), 2,4‐dinitrophenol (DNP)and fluoride (F‐( at low‐medium concentrations, giving rise to aslight decline of tissue ATP concentration, caused a reduction o PAHaccumulation without significantly affecting intracellular Na+ and K+concentrations. However, higher levels of the metabolic inhibitorsalso resulted in considerable inhibition of active Na+‐K+transport. 3. The rate of carrier‐mediated PAH uptake was slow underanaerobic conditions, relative to that measured under aerobicconditions in Na+‐depleted slices. In the latter case the maximalaccumulation achieved was only 1.55 +/‐ 0.16. 4. The uptake rate ofPAH under anaerobic conditions was not inhibited by the absence of Na+or addition of metabolic inhibitors in the concentrations used underaerobic conditions. 5. It is concluded that although Na+ is requiredfor the attainment of high accumulation ratios of PAH, oxidativemetabolism stimulates PAH flux by a Na+‐independentmechanism.</jats:p> |
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| author | Maxild, J, Møller, J V, Sheikh, M I |
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| description | <jats:p>1. The relation between the coupling of metabolic energy to renalp‐aminohippurate (PAH) accumulation and Na+‐K+ transport was studiedin rabbit cortical slices. 2. Cyanide (CN‐), 2,4‐dinitrophenol (DNP)and fluoride (F‐( at low‐medium concentrations, giving rise to aslight decline of tissue ATP concentration, caused a reduction o PAHaccumulation without significantly affecting intracellular Na+ and K+concentrations. However, higher levels of the metabolic inhibitorsalso resulted in considerable inhibition of active Na+‐K+transport. 3. The rate of carrier‐mediated PAH uptake was slow underanaerobic conditions, relative to that measured under aerobicconditions in Na+‐depleted slices. In the latter case the maximalaccumulation achieved was only 1.55 +/‐ 0.16. 4. The uptake rate ofPAH under anaerobic conditions was not inhibited by the absence of Na+or addition of metabolic inhibitors in the concentrations used underaerobic conditions. 5. It is concluded that although Na+ is requiredfor the attainment of high accumulation ratios of PAH, oxidativemetabolism stimulates PAH flux by a Na+‐independentmechanism.</jats:p> |
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| imprint_str_mv | Wiley, 1981 |
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| spelling | Maxild, J Møller, J V Sheikh, M I 0022-3751 1469-7793 Wiley Physiology http://dx.doi.org/10.1113/jphysiol.1981.sp013548 <jats:p>1. The relation between the coupling of metabolic energy to renalp‐aminohippurate (PAH) accumulation and Na+‐K+ transport was studiedin rabbit cortical slices. 2. Cyanide (CN‐), 2,4‐dinitrophenol (DNP)and fluoride (F‐( at low‐medium concentrations, giving rise to aslight decline of tissue ATP concentration, caused a reduction o PAHaccumulation without significantly affecting intracellular Na+ and K+concentrations. However, higher levels of the metabolic inhibitorsalso resulted in considerable inhibition of active Na+‐K+transport. 3. The rate of carrier‐mediated PAH uptake was slow underanaerobic conditions, relative to that measured under aerobicconditions in Na+‐depleted slices. In the latter case the maximalaccumulation achieved was only 1.55 +/‐ 0.16. 4. The uptake rate ofPAH under anaerobic conditions was not inhibited by the absence of Na+or addition of metabolic inhibitors in the concentrations used underaerobic conditions. 5. It is concluded that although Na+ is requiredfor the attainment of high accumulation ratios of PAH, oxidativemetabolism stimulates PAH flux by a Na+‐independentmechanism.</jats:p> An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. The Journal of Physiology |
| spellingShingle | Maxild, J, Møller, J V, Sheikh, M I, The Journal of Physiology, An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex., Physiology |
| title | An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_full | An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_fullStr | An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_full_unstemmed | An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_short | An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_sort | an energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| title_unstemmed | An energy‐dependent, sodium‐independent component of active p‐aminohippurate transport in rabbit renal cortex. |
| topic | Physiology |
| url | http://dx.doi.org/10.1113/jphysiol.1981.sp013548 |