Eintrag weiter verarbeiten
Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule.
Gespeichert in:
Zeitschriftentitel: | The Journal of Physiology |
---|---|
Personen und Körperschaften: | , , , |
In: | The Journal of Physiology, 411, 1989, 1, S. 517-528 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Wiley
|
Schlagwörter: |
author_facet |
Jessen, H Jørgensen, K E Røigaard‐Petersen, H Sheikh, M I Jessen, H Jørgensen, K E Røigaard‐Petersen, H Sheikh, M I |
---|---|
author |
Jessen, H Jørgensen, K E Røigaard‐Petersen, H Sheikh, M I |
spellingShingle |
Jessen, H Jørgensen, K E Røigaard‐Petersen, H Sheikh, M I The Journal of Physiology Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. Physiology |
author_sort |
jessen, h |
spelling |
Jessen, H Jørgensen, K E Røigaard‐Petersen, H Sheikh, M I 0022-3751 1469-7793 Wiley Physiology http://dx.doi.org/10.1113/jphysiol.1989.sp017587 <jats:p>1. The characteristics of renal transport of beta‐alanine by luminal membrane vesicles isolated from either the proximal convoluted part (pars convoluta) or the proximal straight part (pars recta) of rabbit proximal tubule were investigated. 2. In vesicles from pars convoluta two transport systems have been characterized: (1) a Na+‐dependent system with intermediate affinity (half‐saturation 2.7 mM), and (2) a Na+‐independent system, which in the presence of a H+ gradient (extravesicular greater than intravesicular) can drive the uphill transport of beta‐alanine into these vesicles. This is the first demonstration of H+‐beta‐alanine co‐transport across luminal membrane of rabbit kidney proximal convoluted tubule. 3. By contrast, in membrane vesicles from pars recta, transport of beta‐alanine was strictly dependent on Na+ and occurred via a dual transport system, namely a high‐affinity (half‐saturation 0.16 mM) and a low‐affinity system (half‐saturation 9.3 mM). 4. The demonstration of competition between the Na+‐gradient‐dependent uptake of beta‐alanine and taurine, without appreciable inhibition by alpha‐amino acids in vesicles from pars convoluta as well as from pars recta, strongly suggests that the luminal membrane of proximal tubule has transport systems for the reabsorption of beta‐amino acids which are distinct from alpha‐amino acid transport systems.</jats:p> Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. The Journal of Physiology |
doi_str_mv |
10.1113/jphysiol.1989.sp017587 |
facet_avail |
Online Free |
finc_class_facet |
Biologie |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMy9qcGh5c2lvbC4xOTg5LnNwMDE3NTg3 |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMy9qcGh5c2lvbC4xOTg5LnNwMDE3NTg3 |
institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-105 DE-Ch1 DE-L229 |
imprint |
Wiley, 1989 |
imprint_str_mv |
Wiley, 1989 |
issn |
0022-3751 1469-7793 |
issn_str_mv |
0022-3751 1469-7793 |
language |
English |
mega_collection |
Wiley (CrossRef) |
match_str |
jessen1989demonstrationofhandnacoupledcotransportofbetaalaninebyluminalmembranevesiclesofrabbitproximaltubule |
publishDateSort |
1989 |
publisher |
Wiley |
recordtype |
ai |
record_format |
ai |
series |
The Journal of Physiology |
source_id |
49 |
title |
Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_unstemmed |
Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_full |
Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_fullStr |
Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_full_unstemmed |
Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_short |
Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_sort |
demonstration of h+‐ and na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
topic |
Physiology |
url |
http://dx.doi.org/10.1113/jphysiol.1989.sp017587 |
publishDate |
1989 |
physical |
517-528 |
description |
<jats:p>1. The characteristics of renal transport of beta‐alanine by luminal membrane vesicles isolated from either the proximal convoluted part (pars convoluta) or the proximal straight part (pars recta) of rabbit proximal tubule were investigated. 2. In vesicles from pars convoluta two transport systems have been characterized: (1) a Na+‐dependent system with intermediate affinity (half‐saturation 2.7 mM), and (2) a Na+‐independent system, which in the presence of a H+ gradient (extravesicular greater than intravesicular) can drive the uphill transport of beta‐alanine into these vesicles. This is the first demonstration of H+‐beta‐alanine co‐transport across luminal membrane of rabbit kidney proximal convoluted tubule. 3. By contrast, in membrane vesicles from pars recta, transport of beta‐alanine was strictly dependent on Na+ and occurred via a dual transport system, namely a high‐affinity (half‐saturation 0.16 mM) and a low‐affinity system (half‐saturation 9.3 mM). 4. The demonstration of competition between the Na+‐gradient‐dependent uptake of beta‐alanine and taurine, without appreciable inhibition by alpha‐amino acids in vesicles from pars convoluta as well as from pars recta, strongly suggests that the luminal membrane of proximal tubule has transport systems for the reabsorption of beta‐amino acids which are distinct from alpha‐amino acid transport systems.</jats:p> |
container_issue |
1 |
container_start_page |
517 |
container_title |
The Journal of Physiology |
container_volume |
411 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792337560650907648 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T15:18:17.819Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Demonstration+of+H%2B%E2%80%90+and+Na%2B%E2%80%90coupled+co%E2%80%90transport+of+beta%E2%80%90alanine+by+luminal+membrane+vesicles+of+rabbit+proximal+tubule.&rft.date=1989-04-01&genre=article&issn=1469-7793&volume=411&issue=1&spage=517&epage=528&pages=517-528&jtitle=The+Journal+of+Physiology&atitle=Demonstration+of+H%2B%E2%80%90+and+Na%2B%E2%80%90coupled+co%E2%80%90transport+of+beta%E2%80%90alanine+by+luminal+membrane+vesicles+of+rabbit+proximal+tubule.&aulast=Sheikh&aufirst=M+I&rft_id=info%3Adoi%2F10.1113%2Fjphysiol.1989.sp017587&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792337560650907648 |
author | Jessen, H, Jørgensen, K E, Røigaard‐Petersen, H, Sheikh, M I |
author_facet | Jessen, H, Jørgensen, K E, Røigaard‐Petersen, H, Sheikh, M I, Jessen, H, Jørgensen, K E, Røigaard‐Petersen, H, Sheikh, M I |
author_sort | jessen, h |
container_issue | 1 |
container_start_page | 517 |
container_title | The Journal of Physiology |
container_volume | 411 |
description | <jats:p>1. The characteristics of renal transport of beta‐alanine by luminal membrane vesicles isolated from either the proximal convoluted part (pars convoluta) or the proximal straight part (pars recta) of rabbit proximal tubule were investigated. 2. In vesicles from pars convoluta two transport systems have been characterized: (1) a Na+‐dependent system with intermediate affinity (half‐saturation 2.7 mM), and (2) a Na+‐independent system, which in the presence of a H+ gradient (extravesicular greater than intravesicular) can drive the uphill transport of beta‐alanine into these vesicles. This is the first demonstration of H+‐beta‐alanine co‐transport across luminal membrane of rabbit kidney proximal convoluted tubule. 3. By contrast, in membrane vesicles from pars recta, transport of beta‐alanine was strictly dependent on Na+ and occurred via a dual transport system, namely a high‐affinity (half‐saturation 0.16 mM) and a low‐affinity system (half‐saturation 9.3 mM). 4. The demonstration of competition between the Na+‐gradient‐dependent uptake of beta‐alanine and taurine, without appreciable inhibition by alpha‐amino acids in vesicles from pars convoluta as well as from pars recta, strongly suggests that the luminal membrane of proximal tubule has transport systems for the reabsorption of beta‐amino acids which are distinct from alpha‐amino acid transport systems.</jats:p> |
doi_str_mv | 10.1113/jphysiol.1989.sp017587 |
facet_avail | Online, Free |
finc_class_facet | Biologie |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMy9qcGh5c2lvbC4xOTg5LnNwMDE3NTg3 |
imprint | Wiley, 1989 |
imprint_str_mv | Wiley, 1989 |
institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229 |
issn | 0022-3751, 1469-7793 |
issn_str_mv | 0022-3751, 1469-7793 |
language | English |
last_indexed | 2024-03-01T15:18:17.819Z |
match_str | jessen1989demonstrationofhandnacoupledcotransportofbetaalaninebyluminalmembranevesiclesofrabbitproximaltubule |
mega_collection | Wiley (CrossRef) |
physical | 517-528 |
publishDate | 1989 |
publishDateSort | 1989 |
publisher | Wiley |
record_format | ai |
recordtype | ai |
series | The Journal of Physiology |
source_id | 49 |
spelling | Jessen, H Jørgensen, K E Røigaard‐Petersen, H Sheikh, M I 0022-3751 1469-7793 Wiley Physiology http://dx.doi.org/10.1113/jphysiol.1989.sp017587 <jats:p>1. The characteristics of renal transport of beta‐alanine by luminal membrane vesicles isolated from either the proximal convoluted part (pars convoluta) or the proximal straight part (pars recta) of rabbit proximal tubule were investigated. 2. In vesicles from pars convoluta two transport systems have been characterized: (1) a Na+‐dependent system with intermediate affinity (half‐saturation 2.7 mM), and (2) a Na+‐independent system, which in the presence of a H+ gradient (extravesicular greater than intravesicular) can drive the uphill transport of beta‐alanine into these vesicles. This is the first demonstration of H+‐beta‐alanine co‐transport across luminal membrane of rabbit kidney proximal convoluted tubule. 3. By contrast, in membrane vesicles from pars recta, transport of beta‐alanine was strictly dependent on Na+ and occurred via a dual transport system, namely a high‐affinity (half‐saturation 0.16 mM) and a low‐affinity system (half‐saturation 9.3 mM). 4. The demonstration of competition between the Na+‐gradient‐dependent uptake of beta‐alanine and taurine, without appreciable inhibition by alpha‐amino acids in vesicles from pars convoluta as well as from pars recta, strongly suggests that the luminal membrane of proximal tubule has transport systems for the reabsorption of beta‐amino acids which are distinct from alpha‐amino acid transport systems.</jats:p> Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. The Journal of Physiology |
spellingShingle | Jessen, H, Jørgensen, K E, Røigaard‐Petersen, H, Sheikh, M I, The Journal of Physiology, Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule., Physiology |
title | Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_full | Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_fullStr | Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_full_unstemmed | Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_short | Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_sort | demonstration of h+‐ and na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
title_unstemmed | Demonstration of H+‐ and Na+‐coupled co‐transport of beta‐alanine by luminal membrane vesicles of rabbit proximal tubule. |
topic | Physiology |
url | http://dx.doi.org/10.1113/jphysiol.1989.sp017587 |