author_facet Eugen‐Olsen, J.
Andersen, O.
Linneberg, A.
Ladelund, S.
Hansen, T. W.
Langkilde, A.
Petersen, J.
Pielak, T.
Møller, L. N.
Jeppesen, J.
Lyngbæk, S.
Fenger, M.
Olsen, M. H.
Hildebrandt, P. R.
Borch‐Johnsen, K.
Jørgensen, T.
Haugaard, S. B.
Eugen‐Olsen, J.
Andersen, O.
Linneberg, A.
Ladelund, S.
Hansen, T. W.
Langkilde, A.
Petersen, J.
Pielak, T.
Møller, L. N.
Jeppesen, J.
Lyngbæk, S.
Fenger, M.
Olsen, M. H.
Hildebrandt, P. R.
Borch‐Johnsen, K.
Jørgensen, T.
Haugaard, S. B.
author Eugen‐Olsen, J.
Andersen, O.
Linneberg, A.
Ladelund, S.
Hansen, T. W.
Langkilde, A.
Petersen, J.
Pielak, T.
Møller, L. N.
Jeppesen, J.
Lyngbæk, S.
Fenger, M.
Olsen, M. H.
Hildebrandt, P. R.
Borch‐Johnsen, K.
Jørgensen, T.
Haugaard, S. B.
spellingShingle Eugen‐Olsen, J.
Andersen, O.
Linneberg, A.
Ladelund, S.
Hansen, T. W.
Langkilde, A.
Petersen, J.
Pielak, T.
Møller, L. N.
Jeppesen, J.
Lyngbæk, S.
Fenger, M.
Olsen, M. H.
Hildebrandt, P. R.
Borch‐Johnsen, K.
Jørgensen, T.
Haugaard, S. B.
Journal of Internal Medicine
Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
Internal Medicine
author_sort eugen‐olsen, j.
spelling Eugen‐Olsen, J. Andersen, O. Linneberg, A. Ladelund, S. Hansen, T. W. Langkilde, A. Petersen, J. Pielak, T. Møller, L. N. Jeppesen, J. Lyngbæk, S. Fenger, M. Olsen, M. H. Hildebrandt, P. R. Borch‐Johnsen, K. Jørgensen, T. Haugaard, S. B. 0954-6820 1365-2796 Wiley Internal Medicine http://dx.doi.org/10.1111/j.1365-2796.2010.02252.x <jats:p><jats:bold>Abstract. </jats:bold> Eugen‐Olsen J, Andersen O, Linneberg A, Ladelund S, Hansen TW, Langkilde A, Petersen J, Pielak T, Møller LN, Jeppesen J, Lyngbæk S, Fenger M, Olsen MH, Hildebrandt PR, Borch‐Johnsen K, Jørgensen T, Haugaard SB (Copenhagen University, Hvidovre Hospital, Hvidovre; Copenhagen University Hospital, Glostrup; Copenhagen University Hospital, Copenhagen; Copenhagen University Hospital, Glostrup; Copenhagen University, Hvidovre Hospital, Hvidovre; Steno Diabetes Center, Gentofte; University of Aarhus, Aarhus; University of Copenhagen, Copenhagen; Copenhagen University, Hvidovre Hospital, Hvidovre, Denmark). Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population. <jats:italic>J Intern Med</jats:italic> 2010; <jats:bold>268</jats:bold>: 296–308.</jats:p><jats:p><jats:bold>Background. </jats:bold> Low‐grade inflammation is thought to contribute to the development of cardiovascular disease (CVD), type‐2 diabetes mellitus (T2D), cancer and mortality. Biomarkers of inflammation may aid in risk prediction and enable early intervention and prevention of disease.</jats:p><jats:p><jats:bold>Objective. </jats:bold> The aim of this study was to investigate whether plasma levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) are predictive of disease and mortality in the general population.</jats:p><jats:p><jats:bold>Design. </jats:bold> This was an observational prospective cohort study. Cohort participants were included from June 1993 to December 1994 and followed until the end of 2006.</jats:p><jats:p><jats:bold>Setting. </jats:bold> General adult Caucasian population.</jats:p><jats:p><jats:bold>Participants. </jats:bold> The MONICA10 study, a population‐based cohort recruited from Copenhagen, Denmark, included 2602 individuals aged 41, 51, 61 or 71 years.</jats:p><jats:p><jats:bold>Measurements. </jats:bold> Blood samples were analysed for suPAR levels using a commercially available enzyme‐linked immunosorbent assay. Risk of cancer (<jats:italic>n</jats:italic> = 308), CVD (<jats:italic>n</jats:italic> = 301), T2D (<jats:italic>n</jats:italic> = 59) and mortality (<jats:italic>n</jats:italic> = 411) was assessed with a multivariate proportional hazards model using Cox regression.</jats:p><jats:p><jats:bold>Results. </jats:bold> Elevated baseline suPAR level was associated with an increased risk of cancer, CVD, T2D and mortality during follow‐up. suPAR was more strongly associated with cancer, CVD and mortality in men than in women, and in younger compared with older individuals. suPAR remained significantly associated with the risk of negative outcome after adjustment for a number of relevant risk factors including C‐reactive protein levels.</jats:p><jats:p><jats:bold>Limitation. </jats:bold> Further validation in ethnic populations other than Caucasians is needed.</jats:p><jats:p><jats:bold>Conclusion. </jats:bold> The stable plasma protein suPAR may be a promising biomarker because of its independent association with incident cancer, CVD, T2D and mortality in the general population.</jats:p> Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population Journal of Internal Medicine
doi_str_mv 10.1111/j.1365-2796.2010.02252.x
facet_avail Online
Free
finc_class_facet Medizin
format ElectronicArticle
fullrecord blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjEzNjUtMjc5Ni4yMDEwLjAyMjUyLng
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjEzNjUtMjc5Ni4yMDEwLjAyMjUyLng
institution DE-Zwi2
DE-D161
DE-Gla1
DE-Zi4
DE-15
DE-Pl11
DE-Rs1
DE-105
DE-14
DE-Ch1
DE-L229
DE-D275
DE-Bn3
DE-Brt1
imprint Wiley, 2010
imprint_str_mv Wiley, 2010
issn 0954-6820
1365-2796
issn_str_mv 0954-6820
1365-2796
language English
mega_collection Wiley (CrossRef)
match_str eugenolsen2010circulatingsolubleurokinaseplasminogenactivatorreceptorpredictscancercardiovasculardiseasediabetesandmortalityinthegeneralpopulation
publishDateSort 2010
publisher Wiley
recordtype ai
record_format ai
series Journal of Internal Medicine
source_id 49
title Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_unstemmed Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_full Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_fullStr Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_full_unstemmed Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_short Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_sort circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
topic Internal Medicine
url http://dx.doi.org/10.1111/j.1365-2796.2010.02252.x
publishDate 2010
physical 296-308
description <jats:p><jats:bold>Abstract. </jats:bold> Eugen‐Olsen J, Andersen O, Linneberg A, Ladelund S, Hansen TW, Langkilde A, Petersen J, Pielak T, Møller LN, Jeppesen J, Lyngbæk S, Fenger M, Olsen MH, Hildebrandt PR, Borch‐Johnsen K, Jørgensen T, Haugaard SB (Copenhagen University, Hvidovre Hospital, Hvidovre; Copenhagen University Hospital, Glostrup; Copenhagen University Hospital, Copenhagen; Copenhagen University Hospital, Glostrup; Copenhagen University, Hvidovre Hospital, Hvidovre; Steno Diabetes Center, Gentofte; University of Aarhus, Aarhus; University of Copenhagen, Copenhagen; Copenhagen University, Hvidovre Hospital, Hvidovre, Denmark). Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population. <jats:italic>J Intern Med</jats:italic> 2010; <jats:bold>268</jats:bold>: 296–308.</jats:p><jats:p><jats:bold>Background. </jats:bold> Low‐grade inflammation is thought to contribute to the development of cardiovascular disease (CVD), type‐2 diabetes mellitus (T2D), cancer and mortality. Biomarkers of inflammation may aid in risk prediction and enable early intervention and prevention of disease.</jats:p><jats:p><jats:bold>Objective. </jats:bold> The aim of this study was to investigate whether plasma levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) are predictive of disease and mortality in the general population.</jats:p><jats:p><jats:bold>Design. </jats:bold> This was an observational prospective cohort study. Cohort participants were included from June 1993 to December 1994 and followed until the end of 2006.</jats:p><jats:p><jats:bold>Setting. </jats:bold> General adult Caucasian population.</jats:p><jats:p><jats:bold>Participants. </jats:bold> The MONICA10 study, a population‐based cohort recruited from Copenhagen, Denmark, included 2602 individuals aged 41, 51, 61 or 71 years.</jats:p><jats:p><jats:bold>Measurements. </jats:bold> Blood samples were analysed for suPAR levels using a commercially available enzyme‐linked immunosorbent assay. Risk of cancer (<jats:italic>n</jats:italic> = 308), CVD (<jats:italic>n</jats:italic> = 301), T2D (<jats:italic>n</jats:italic> = 59) and mortality (<jats:italic>n</jats:italic> = 411) was assessed with a multivariate proportional hazards model using Cox regression.</jats:p><jats:p><jats:bold>Results. </jats:bold> Elevated baseline suPAR level was associated with an increased risk of cancer, CVD, T2D and mortality during follow‐up. suPAR was more strongly associated with cancer, CVD and mortality in men than in women, and in younger compared with older individuals. suPAR remained significantly associated with the risk of negative outcome after adjustment for a number of relevant risk factors including C‐reactive protein levels.</jats:p><jats:p><jats:bold>Limitation. </jats:bold> Further validation in ethnic populations other than Caucasians is needed.</jats:p><jats:p><jats:bold>Conclusion. </jats:bold> The stable plasma protein suPAR may be a promising biomarker because of its independent association with incident cancer, CVD, T2D and mortality in the general population.</jats:p>
container_issue 3
container_start_page 296
container_title Journal of Internal Medicine
container_volume 268
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
_version_ 1792345633068154886
geogr_code not assigned
last_indexed 2024-03-01T17:26:32.678Z
geogr_code_person not assigned
openURL url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Circulating+soluble+urokinase+plasminogen+activator+receptor+predicts+cancer%2C+cardiovascular+disease%2C+diabetes+and+mortality+in+the+general+population&rft.date=2010-09-01&genre=article&issn=1365-2796&volume=268&issue=3&spage=296&epage=308&pages=296-308&jtitle=Journal+of+Internal+Medicine&atitle=Circulating+soluble+urokinase+plasminogen+activator+receptor+predicts+cancer%2C+cardiovascular+disease%2C+diabetes+and+mortality+in+the+general+population&aulast=Haugaard&aufirst=S.+B.&rft_id=info%3Adoi%2F10.1111%2Fj.1365-2796.2010.02252.x&rft.language%5B0%5D=eng
SOLR
_version_ 1792345633068154886
author Eugen‐Olsen, J., Andersen, O., Linneberg, A., Ladelund, S., Hansen, T. W., Langkilde, A., Petersen, J., Pielak, T., Møller, L. N., Jeppesen, J., Lyngbæk, S., Fenger, M., Olsen, M. H., Hildebrandt, P. R., Borch‐Johnsen, K., Jørgensen, T., Haugaard, S. B.
author_facet Eugen‐Olsen, J., Andersen, O., Linneberg, A., Ladelund, S., Hansen, T. W., Langkilde, A., Petersen, J., Pielak, T., Møller, L. N., Jeppesen, J., Lyngbæk, S., Fenger, M., Olsen, M. H., Hildebrandt, P. R., Borch‐Johnsen, K., Jørgensen, T., Haugaard, S. B., Eugen‐Olsen, J., Andersen, O., Linneberg, A., Ladelund, S., Hansen, T. W., Langkilde, A., Petersen, J., Pielak, T., Møller, L. N., Jeppesen, J., Lyngbæk, S., Fenger, M., Olsen, M. H., Hildebrandt, P. R., Borch‐Johnsen, K., Jørgensen, T., Haugaard, S. B.
author_sort eugen‐olsen, j.
container_issue 3
container_start_page 296
container_title Journal of Internal Medicine
container_volume 268
description <jats:p><jats:bold>Abstract. </jats:bold> Eugen‐Olsen J, Andersen O, Linneberg A, Ladelund S, Hansen TW, Langkilde A, Petersen J, Pielak T, Møller LN, Jeppesen J, Lyngbæk S, Fenger M, Olsen MH, Hildebrandt PR, Borch‐Johnsen K, Jørgensen T, Haugaard SB (Copenhagen University, Hvidovre Hospital, Hvidovre; Copenhagen University Hospital, Glostrup; Copenhagen University Hospital, Copenhagen; Copenhagen University Hospital, Glostrup; Copenhagen University, Hvidovre Hospital, Hvidovre; Steno Diabetes Center, Gentofte; University of Aarhus, Aarhus; University of Copenhagen, Copenhagen; Copenhagen University, Hvidovre Hospital, Hvidovre, Denmark). Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population. <jats:italic>J Intern Med</jats:italic> 2010; <jats:bold>268</jats:bold>: 296–308.</jats:p><jats:p><jats:bold>Background. </jats:bold> Low‐grade inflammation is thought to contribute to the development of cardiovascular disease (CVD), type‐2 diabetes mellitus (T2D), cancer and mortality. Biomarkers of inflammation may aid in risk prediction and enable early intervention and prevention of disease.</jats:p><jats:p><jats:bold>Objective. </jats:bold> The aim of this study was to investigate whether plasma levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) are predictive of disease and mortality in the general population.</jats:p><jats:p><jats:bold>Design. </jats:bold> This was an observational prospective cohort study. Cohort participants were included from June 1993 to December 1994 and followed until the end of 2006.</jats:p><jats:p><jats:bold>Setting. </jats:bold> General adult Caucasian population.</jats:p><jats:p><jats:bold>Participants. </jats:bold> The MONICA10 study, a population‐based cohort recruited from Copenhagen, Denmark, included 2602 individuals aged 41, 51, 61 or 71 years.</jats:p><jats:p><jats:bold>Measurements. </jats:bold> Blood samples were analysed for suPAR levels using a commercially available enzyme‐linked immunosorbent assay. Risk of cancer (<jats:italic>n</jats:italic> = 308), CVD (<jats:italic>n</jats:italic> = 301), T2D (<jats:italic>n</jats:italic> = 59) and mortality (<jats:italic>n</jats:italic> = 411) was assessed with a multivariate proportional hazards model using Cox regression.</jats:p><jats:p><jats:bold>Results. </jats:bold> Elevated baseline suPAR level was associated with an increased risk of cancer, CVD, T2D and mortality during follow‐up. suPAR was more strongly associated with cancer, CVD and mortality in men than in women, and in younger compared with older individuals. suPAR remained significantly associated with the risk of negative outcome after adjustment for a number of relevant risk factors including C‐reactive protein levels.</jats:p><jats:p><jats:bold>Limitation. </jats:bold> Further validation in ethnic populations other than Caucasians is needed.</jats:p><jats:p><jats:bold>Conclusion. </jats:bold> The stable plasma protein suPAR may be a promising biomarker because of its independent association with incident cancer, CVD, T2D and mortality in the general population.</jats:p>
doi_str_mv 10.1111/j.1365-2796.2010.02252.x
facet_avail Online, Free
finc_class_facet Medizin
format ElectronicArticle
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
geogr_code not assigned
geogr_code_person not assigned
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjEzNjUtMjc5Ni4yMDEwLjAyMjUyLng
imprint Wiley, 2010
imprint_str_mv Wiley, 2010
institution DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1
issn 0954-6820, 1365-2796
issn_str_mv 0954-6820, 1365-2796
language English
last_indexed 2024-03-01T17:26:32.678Z
match_str eugenolsen2010circulatingsolubleurokinaseplasminogenactivatorreceptorpredictscancercardiovasculardiseasediabetesandmortalityinthegeneralpopulation
mega_collection Wiley (CrossRef)
physical 296-308
publishDate 2010
publishDateSort 2010
publisher Wiley
record_format ai
recordtype ai
series Journal of Internal Medicine
source_id 49
spelling Eugen‐Olsen, J. Andersen, O. Linneberg, A. Ladelund, S. Hansen, T. W. Langkilde, A. Petersen, J. Pielak, T. Møller, L. N. Jeppesen, J. Lyngbæk, S. Fenger, M. Olsen, M. H. Hildebrandt, P. R. Borch‐Johnsen, K. Jørgensen, T. Haugaard, S. B. 0954-6820 1365-2796 Wiley Internal Medicine http://dx.doi.org/10.1111/j.1365-2796.2010.02252.x <jats:p><jats:bold>Abstract. </jats:bold> Eugen‐Olsen J, Andersen O, Linneberg A, Ladelund S, Hansen TW, Langkilde A, Petersen J, Pielak T, Møller LN, Jeppesen J, Lyngbæk S, Fenger M, Olsen MH, Hildebrandt PR, Borch‐Johnsen K, Jørgensen T, Haugaard SB (Copenhagen University, Hvidovre Hospital, Hvidovre; Copenhagen University Hospital, Glostrup; Copenhagen University Hospital, Copenhagen; Copenhagen University Hospital, Glostrup; Copenhagen University, Hvidovre Hospital, Hvidovre; Steno Diabetes Center, Gentofte; University of Aarhus, Aarhus; University of Copenhagen, Copenhagen; Copenhagen University, Hvidovre Hospital, Hvidovre, Denmark). Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population. <jats:italic>J Intern Med</jats:italic> 2010; <jats:bold>268</jats:bold>: 296–308.</jats:p><jats:p><jats:bold>Background. </jats:bold> Low‐grade inflammation is thought to contribute to the development of cardiovascular disease (CVD), type‐2 diabetes mellitus (T2D), cancer and mortality. Biomarkers of inflammation may aid in risk prediction and enable early intervention and prevention of disease.</jats:p><jats:p><jats:bold>Objective. </jats:bold> The aim of this study was to investigate whether plasma levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) are predictive of disease and mortality in the general population.</jats:p><jats:p><jats:bold>Design. </jats:bold> This was an observational prospective cohort study. Cohort participants were included from June 1993 to December 1994 and followed until the end of 2006.</jats:p><jats:p><jats:bold>Setting. </jats:bold> General adult Caucasian population.</jats:p><jats:p><jats:bold>Participants. </jats:bold> The MONICA10 study, a population‐based cohort recruited from Copenhagen, Denmark, included 2602 individuals aged 41, 51, 61 or 71 years.</jats:p><jats:p><jats:bold>Measurements. </jats:bold> Blood samples were analysed for suPAR levels using a commercially available enzyme‐linked immunosorbent assay. Risk of cancer (<jats:italic>n</jats:italic> = 308), CVD (<jats:italic>n</jats:italic> = 301), T2D (<jats:italic>n</jats:italic> = 59) and mortality (<jats:italic>n</jats:italic> = 411) was assessed with a multivariate proportional hazards model using Cox regression.</jats:p><jats:p><jats:bold>Results. </jats:bold> Elevated baseline suPAR level was associated with an increased risk of cancer, CVD, T2D and mortality during follow‐up. suPAR was more strongly associated with cancer, CVD and mortality in men than in women, and in younger compared with older individuals. suPAR remained significantly associated with the risk of negative outcome after adjustment for a number of relevant risk factors including C‐reactive protein levels.</jats:p><jats:p><jats:bold>Limitation. </jats:bold> Further validation in ethnic populations other than Caucasians is needed.</jats:p><jats:p><jats:bold>Conclusion. </jats:bold> The stable plasma protein suPAR may be a promising biomarker because of its independent association with incident cancer, CVD, T2D and mortality in the general population.</jats:p> Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population Journal of Internal Medicine
spellingShingle Eugen‐Olsen, J., Andersen, O., Linneberg, A., Ladelund, S., Hansen, T. W., Langkilde, A., Petersen, J., Pielak, T., Møller, L. N., Jeppesen, J., Lyngbæk, S., Fenger, M., Olsen, M. H., Hildebrandt, P. R., Borch‐Johnsen, K., Jørgensen, T., Haugaard, S. B., Journal of Internal Medicine, Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population, Internal Medicine
title Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_full Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_fullStr Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_full_unstemmed Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_short Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_sort circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
title_unstemmed Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population
topic Internal Medicine
url http://dx.doi.org/10.1111/j.1365-2796.2010.02252.x