Eintrag weiter verarbeiten
SIRT6 in DNA repair, metabolism and ageing
Gespeichert in:
| Zeitschriftentitel: | Journal of Internal Medicine |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Journal of Internal Medicine, 263, 2008, 2, S. 128-141 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Lombard, D. B. Schwer, B. Alt, F. W. Mostoslavsky, R. Lombard, D. B. Schwer, B. Alt, F. W. Mostoslavsky, R. |
|---|---|
| author |
Lombard, D. B. Schwer, B. Alt, F. W. Mostoslavsky, R. |
| spellingShingle |
Lombard, D. B. Schwer, B. Alt, F. W. Mostoslavsky, R. Journal of Internal Medicine SIRT6 in DNA repair, metabolism and ageing Internal Medicine |
| author_sort |
lombard, d. b. |
| spelling |
Lombard, D. B. Schwer, B. Alt, F. W. Mostoslavsky, R. 0954-6820 1365-2796 Wiley Internal Medicine http://dx.doi.org/10.1111/j.1365-2796.2007.01902.x <jats:title>Abstract.</jats:title><jats:p>Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and Insulin/Igf1‐like signalling. In addition, homologs of yeast Sir2 – the sirtuins – regulate lifespan in diverse organisms. Here, we focus on one particular sirtuin, SIRT6. Mice lacking SIRT6 develop a degenerative disorder that in some respects mimics models of accelerated ageing [<jats:italic>Cell</jats:italic> (2006) <jats:bold>124</jats:bold>:315]. We discuss how sirtuins in general and SIRT6 specifically relate to other evolutionarily conserved pathways affecting ageing, and how SIRT6 might function to ensure organismal homeostasis and normal lifespan.</jats:p> SIRT6 in DNA repair, metabolism and ageing Journal of Internal Medicine |
| doi_str_mv |
10.1111/j.1365-2796.2007.01902.x |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjEzNjUtMjc5Ni4yMDA3LjAxOTAyLng |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjEzNjUtMjc5Ni4yMDA3LjAxOTAyLng |
| institution |
DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 |
| imprint |
Wiley, 2008 |
| imprint_str_mv |
Wiley, 2008 |
| issn |
0954-6820 1365-2796 |
| issn_str_mv |
0954-6820 1365-2796 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
lombard2008sirt6indnarepairmetabolismandageing |
| publishDateSort |
2008 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Internal Medicine |
| source_id |
49 |
| title |
SIRT6 in DNA repair, metabolism and ageing |
| title_unstemmed |
SIRT6 in DNA repair, metabolism and ageing |
| title_full |
SIRT6 in DNA repair, metabolism and ageing |
| title_fullStr |
SIRT6 in DNA repair, metabolism and ageing |
| title_full_unstemmed |
SIRT6 in DNA repair, metabolism and ageing |
| title_short |
SIRT6 in DNA repair, metabolism and ageing |
| title_sort |
sirt6 in dna repair, metabolism and ageing |
| topic |
Internal Medicine |
| url |
http://dx.doi.org/10.1111/j.1365-2796.2007.01902.x |
| publishDate |
2008 |
| physical |
128-141 |
| description |
<jats:title>Abstract.</jats:title><jats:p>Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and Insulin/Igf1‐like signalling. In addition, homologs of yeast Sir2 – the sirtuins – regulate lifespan in diverse organisms. Here, we focus on one particular sirtuin, SIRT6. Mice lacking SIRT6 develop a degenerative disorder that in some respects mimics models of accelerated ageing [<jats:italic>Cell</jats:italic> (2006) <jats:bold>124</jats:bold>:315]. We discuss how sirtuins in general and SIRT6 specifically relate to other evolutionarily conserved pathways affecting ageing, and how SIRT6 might function to ensure organismal homeostasis and normal lifespan.</jats:p> |
| container_issue |
2 |
| container_start_page |
128 |
| container_title |
Journal of Internal Medicine |
| container_volume |
263 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792344848360013824 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:14:06.633Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=SIRT6+in+DNA+repair%2C+metabolism+and+ageing&rft.date=2008-02-01&genre=article&issn=1365-2796&volume=263&issue=2&spage=128&epage=141&pages=128-141&jtitle=Journal+of+Internal+Medicine&atitle=SIRT6+in+DNA+repair%2C+metabolism+and+ageing&aulast=Mostoslavsky&aufirst=R.&rft_id=info%3Adoi%2F10.1111%2Fj.1365-2796.2007.01902.x&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792344848360013824 |
| author | Lombard, D. B., Schwer, B., Alt, F. W., Mostoslavsky, R. |
| author_facet | Lombard, D. B., Schwer, B., Alt, F. W., Mostoslavsky, R., Lombard, D. B., Schwer, B., Alt, F. W., Mostoslavsky, R. |
| author_sort | lombard, d. b. |
| container_issue | 2 |
| container_start_page | 128 |
| container_title | Journal of Internal Medicine |
| container_volume | 263 |
| description | <jats:title>Abstract.</jats:title><jats:p>Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and Insulin/Igf1‐like signalling. In addition, homologs of yeast Sir2 – the sirtuins – regulate lifespan in diverse organisms. Here, we focus on one particular sirtuin, SIRT6. Mice lacking SIRT6 develop a degenerative disorder that in some respects mimics models of accelerated ageing [<jats:italic>Cell</jats:italic> (2006) <jats:bold>124</jats:bold>:315]. We discuss how sirtuins in general and SIRT6 specifically relate to other evolutionarily conserved pathways affecting ageing, and how SIRT6 might function to ensure organismal homeostasis and normal lifespan.</jats:p> |
| doi_str_mv | 10.1111/j.1365-2796.2007.01902.x |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjEzNjUtMjc5Ni4yMDA3LjAxOTAyLng |
| imprint | Wiley, 2008 |
| imprint_str_mv | Wiley, 2008 |
| institution | DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
| issn | 0954-6820, 1365-2796 |
| issn_str_mv | 0954-6820, 1365-2796 |
| language | English |
| last_indexed | 2024-03-01T17:14:06.633Z |
| match_str | lombard2008sirt6indnarepairmetabolismandageing |
| mega_collection | Wiley (CrossRef) |
| physical | 128-141 |
| publishDate | 2008 |
| publishDateSort | 2008 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Journal of Internal Medicine |
| source_id | 49 |
| spelling | Lombard, D. B. Schwer, B. Alt, F. W. Mostoslavsky, R. 0954-6820 1365-2796 Wiley Internal Medicine http://dx.doi.org/10.1111/j.1365-2796.2007.01902.x <jats:title>Abstract.</jats:title><jats:p>Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and Insulin/Igf1‐like signalling. In addition, homologs of yeast Sir2 – the sirtuins – regulate lifespan in diverse organisms. Here, we focus on one particular sirtuin, SIRT6. Mice lacking SIRT6 develop a degenerative disorder that in some respects mimics models of accelerated ageing [<jats:italic>Cell</jats:italic> (2006) <jats:bold>124</jats:bold>:315]. We discuss how sirtuins in general and SIRT6 specifically relate to other evolutionarily conserved pathways affecting ageing, and how SIRT6 might function to ensure organismal homeostasis and normal lifespan.</jats:p> SIRT6 in DNA repair, metabolism and ageing Journal of Internal Medicine |
| spellingShingle | Lombard, D. B., Schwer, B., Alt, F. W., Mostoslavsky, R., Journal of Internal Medicine, SIRT6 in DNA repair, metabolism and ageing, Internal Medicine |
| title | SIRT6 in DNA repair, metabolism and ageing |
| title_full | SIRT6 in DNA repair, metabolism and ageing |
| title_fullStr | SIRT6 in DNA repair, metabolism and ageing |
| title_full_unstemmed | SIRT6 in DNA repair, metabolism and ageing |
| title_short | SIRT6 in DNA repair, metabolism and ageing |
| title_sort | sirt6 in dna repair, metabolism and ageing |
| title_unstemmed | SIRT6 in DNA repair, metabolism and ageing |
| topic | Internal Medicine |
| url | http://dx.doi.org/10.1111/j.1365-2796.2007.01902.x |