author_facet Wolday, D.
Meles, H.
Hailu, E.
Messele, T.
Mengistu, Y.
Fekadu, M.
Parekh, B. S.
Wuhib, T.
Wolday, D.
Meles, H.
Hailu, E.
Messele, T.
Mengistu, Y.
Fekadu, M.
Parekh, B. S.
Wuhib, T.
author Wolday, D.
Meles, H.
Hailu, E.
Messele, T.
Mengistu, Y.
Fekadu, M.
Parekh, B. S.
Wuhib, T.
spellingShingle Wolday, D.
Meles, H.
Hailu, E.
Messele, T.
Mengistu, Y.
Fekadu, M.
Parekh, B. S.
Wuhib, T.
Journal of Internal Medicine
Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
Internal Medicine
author_sort wolday, d.
spelling Wolday, D. Meles, H. Hailu, E. Messele, T. Mengistu, Y. Fekadu, M. Parekh, B. S. Wuhib, T. 0954-6820 1365-2796 Wiley Internal Medicine http://dx.doi.org/10.1111/j.1365-2796.2006.01740.x <jats:title>Abstract</jats:title><jats:p><jats:bold>Background. </jats:bold> The HIV incidence data are relevant in depicting the current dynamics and trend of the epidemic. Using a new laboratory method for HIV‐1 incidence, we aimed at estimating a 10‐year trend in HIV‐1 incidence in Addis Ababa, Ethiopia.</jats:p><jats:p><jats:bold>Methods. </jats:bold> We determined the temporal trends in HIV incidence based on a total of 7744 serum specimens from pregnant women who attended antenatal clinics in Addis Ababa between 1995 and 2003. HIV incidence was determined by IgG‐capture HIV‐1 BED incidence enzyme immunoassay following a validation using a well‐characterized panel of serial serum specimens from subtype C‐infected seroconverters.</jats:p><jats:p><jats:bold>Findings. </jats:bold> Of the 1350 HIV+ specimens tested as part of the annual sentinel survey between 1995 and 2003, a total of 1332 (98.7%) were tested by BED HIV‐1 incidence assay. The incidence rate of HIV‐1 infection declined significantly from 7.7% (95% CI, 3.9–11.5%) in 1995 to 2.0% (95% CI, 0.7–3.3%) in 2003. Although there was a trend, amongst the age group of 15–29 years, in age‐specific decline in incidence, it was not statistically significant. No change in HIV incidence rate was observed for the group aged above 30 years.</jats:p><jats:p><jats:bold>Interpretation. </jats:bold> A corresponding decline in the incidence of HIV infection was observed with the decline in the prevalence of HIV infection between 1995 and 2003 in Addis Ababa City. Whether the declines were because of changes in sexual behaviours or other reasons needs to be explored. The BED HIV‐1 incidence assay provides a valuable tool in obtaining information on recent HIV‐1 infection.</jats:p> Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003 Journal of Internal Medicine
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title Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
title_unstemmed Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
title_full Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
title_fullStr Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
title_full_unstemmed Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
title_short Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
title_sort temporal trends in the incidence of hiv infection in antenatal clinic attendees in addis ababa, ethiopia, 1995–2003
topic Internal Medicine
url http://dx.doi.org/10.1111/j.1365-2796.2006.01740.x
publishDate 2007
physical 132-137
description <jats:title>Abstract</jats:title><jats:p><jats:bold>Background. </jats:bold> The HIV incidence data are relevant in depicting the current dynamics and trend of the epidemic. Using a new laboratory method for HIV‐1 incidence, we aimed at estimating a 10‐year trend in HIV‐1 incidence in Addis Ababa, Ethiopia.</jats:p><jats:p><jats:bold>Methods. </jats:bold> We determined the temporal trends in HIV incidence based on a total of 7744 serum specimens from pregnant women who attended antenatal clinics in Addis Ababa between 1995 and 2003. HIV incidence was determined by IgG‐capture HIV‐1 BED incidence enzyme immunoassay following a validation using a well‐characterized panel of serial serum specimens from subtype C‐infected seroconverters.</jats:p><jats:p><jats:bold>Findings. </jats:bold> Of the 1350 HIV+ specimens tested as part of the annual sentinel survey between 1995 and 2003, a total of 1332 (98.7%) were tested by BED HIV‐1 incidence assay. The incidence rate of HIV‐1 infection declined significantly from 7.7% (95% CI, 3.9–11.5%) in 1995 to 2.0% (95% CI, 0.7–3.3%) in 2003. Although there was a trend, amongst the age group of 15–29 years, in age‐specific decline in incidence, it was not statistically significant. No change in HIV incidence rate was observed for the group aged above 30 years.</jats:p><jats:p><jats:bold>Interpretation. </jats:bold> A corresponding decline in the incidence of HIV infection was observed with the decline in the prevalence of HIV infection between 1995 and 2003 in Addis Ababa City. Whether the declines were because of changes in sexual behaviours or other reasons needs to be explored. The BED HIV‐1 incidence assay provides a valuable tool in obtaining information on recent HIV‐1 infection.</jats:p>
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author Wolday, D., Meles, H., Hailu, E., Messele, T., Mengistu, Y., Fekadu, M., Parekh, B. S., Wuhib, T.
author_facet Wolday, D., Meles, H., Hailu, E., Messele, T., Mengistu, Y., Fekadu, M., Parekh, B. S., Wuhib, T., Wolday, D., Meles, H., Hailu, E., Messele, T., Mengistu, Y., Fekadu, M., Parekh, B. S., Wuhib, T.
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description <jats:title>Abstract</jats:title><jats:p><jats:bold>Background. </jats:bold> The HIV incidence data are relevant in depicting the current dynamics and trend of the epidemic. Using a new laboratory method for HIV‐1 incidence, we aimed at estimating a 10‐year trend in HIV‐1 incidence in Addis Ababa, Ethiopia.</jats:p><jats:p><jats:bold>Methods. </jats:bold> We determined the temporal trends in HIV incidence based on a total of 7744 serum specimens from pregnant women who attended antenatal clinics in Addis Ababa between 1995 and 2003. HIV incidence was determined by IgG‐capture HIV‐1 BED incidence enzyme immunoassay following a validation using a well‐characterized panel of serial serum specimens from subtype C‐infected seroconverters.</jats:p><jats:p><jats:bold>Findings. </jats:bold> Of the 1350 HIV+ specimens tested as part of the annual sentinel survey between 1995 and 2003, a total of 1332 (98.7%) were tested by BED HIV‐1 incidence assay. The incidence rate of HIV‐1 infection declined significantly from 7.7% (95% CI, 3.9–11.5%) in 1995 to 2.0% (95% CI, 0.7–3.3%) in 2003. Although there was a trend, amongst the age group of 15–29 years, in age‐specific decline in incidence, it was not statistically significant. No change in HIV incidence rate was observed for the group aged above 30 years.</jats:p><jats:p><jats:bold>Interpretation. </jats:bold> A corresponding decline in the incidence of HIV infection was observed with the decline in the prevalence of HIV infection between 1995 and 2003 in Addis Ababa City. Whether the declines were because of changes in sexual behaviours or other reasons needs to be explored. The BED HIV‐1 incidence assay provides a valuable tool in obtaining information on recent HIV‐1 infection.</jats:p>
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spelling Wolday, D. Meles, H. Hailu, E. Messele, T. Mengistu, Y. Fekadu, M. Parekh, B. S. Wuhib, T. 0954-6820 1365-2796 Wiley Internal Medicine http://dx.doi.org/10.1111/j.1365-2796.2006.01740.x <jats:title>Abstract</jats:title><jats:p><jats:bold>Background. </jats:bold> The HIV incidence data are relevant in depicting the current dynamics and trend of the epidemic. Using a new laboratory method for HIV‐1 incidence, we aimed at estimating a 10‐year trend in HIV‐1 incidence in Addis Ababa, Ethiopia.</jats:p><jats:p><jats:bold>Methods. </jats:bold> We determined the temporal trends in HIV incidence based on a total of 7744 serum specimens from pregnant women who attended antenatal clinics in Addis Ababa between 1995 and 2003. HIV incidence was determined by IgG‐capture HIV‐1 BED incidence enzyme immunoassay following a validation using a well‐characterized panel of serial serum specimens from subtype C‐infected seroconverters.</jats:p><jats:p><jats:bold>Findings. </jats:bold> Of the 1350 HIV+ specimens tested as part of the annual sentinel survey between 1995 and 2003, a total of 1332 (98.7%) were tested by BED HIV‐1 incidence assay. The incidence rate of HIV‐1 infection declined significantly from 7.7% (95% CI, 3.9–11.5%) in 1995 to 2.0% (95% CI, 0.7–3.3%) in 2003. Although there was a trend, amongst the age group of 15–29 years, in age‐specific decline in incidence, it was not statistically significant. No change in HIV incidence rate was observed for the group aged above 30 years.</jats:p><jats:p><jats:bold>Interpretation. </jats:bold> A corresponding decline in the incidence of HIV infection was observed with the decline in the prevalence of HIV infection between 1995 and 2003 in Addis Ababa City. Whether the declines were because of changes in sexual behaviours or other reasons needs to be explored. The BED HIV‐1 incidence assay provides a valuable tool in obtaining information on recent HIV‐1 infection.</jats:p> Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003 Journal of Internal Medicine
spellingShingle Wolday, D., Meles, H., Hailu, E., Messele, T., Mengistu, Y., Fekadu, M., Parekh, B. S., Wuhib, T., Journal of Internal Medicine, Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003, Internal Medicine
title Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
title_full Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
title_fullStr Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
title_full_unstemmed Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
title_short Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
title_sort temporal trends in the incidence of hiv infection in antenatal clinic attendees in addis ababa, ethiopia, 1995–2003
title_unstemmed Temporal trends in the incidence of HIV infection in antenatal clinic attendees in Addis Ababa, Ethiopia, 1995–2003
topic Internal Medicine
url http://dx.doi.org/10.1111/j.1365-2796.2006.01740.x