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Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans
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| Zeitschriftentitel: | Clinical and Experimental Immunology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Clinical and Experimental Immunology, 87, 2008, 1, S. 58-64 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
AKUFFO, H O BRITTON, S F F AKUFFO, H O BRITTON, S F F |
|---|---|
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AKUFFO, H O BRITTON, S F F |
| spellingShingle |
AKUFFO, H O BRITTON, S F F Clinical and Experimental Immunology Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans Immunology Immunology and Allergy |
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akuffo, h o |
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AKUFFO, H O BRITTON, S F F 1365-2249 0009-9104 Oxford University Press (OUP) Immunology Immunology and Allergy http://dx.doi.org/10.1111/j.1365-2249.1992.tb06413.x <jats:title>SUMMARY</jats:title><jats:p>Lymphocytes of individuals from a country non-endemic for Leishmania (Sweden), responded with a vigorous interferon-gamma (IFN-γ) and IL-6 response when exposed to live or dead promastigotes of Leishmania aethiopica. This response was sometimes as strong as when the same cells were exposed to the mitogen (phytohaemagglutinin (PHA)). Furthermore, supernatants of cells exposed to Leishmania promastigotes were able to inhibit the amastigote form of the same parasite. In some few instances there was no such reactivity to Leishmania parasites. It is proposed that most individuals have such a first line cytokine response which is enough to prevent further spread and growth of the parasites. In exposed individuals who display disease symptoms, this non-Leishmania-specific response is overcome (by dose) or is weak (for genetic reasons). In the latter instances curbing of parasite growth would depend on acquired immunity.</jats:p> Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans Clinical and Experimental Immunology |
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| title |
Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| title_unstemmed |
Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| title_full |
Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| title_fullStr |
Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| title_full_unstemmed |
Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| title_short |
Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| title_sort |
contribution of non-leishmania-specific immunity to resistance to leishmania infection in humans |
| topic |
Immunology Immunology and Allergy |
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http://dx.doi.org/10.1111/j.1365-2249.1992.tb06413.x |
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2008 |
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58-64 |
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<jats:title>SUMMARY</jats:title><jats:p>Lymphocytes of individuals from a country non-endemic for Leishmania (Sweden), responded with a vigorous interferon-gamma (IFN-γ) and IL-6 response when exposed to live or dead promastigotes of Leishmania aethiopica. This response was sometimes as strong as when the same cells were exposed to the mitogen (phytohaemagglutinin (PHA)). Furthermore, supernatants of cells exposed to Leishmania promastigotes were able to inhibit the amastigote form of the same parasite. In some few instances there was no such reactivity to Leishmania parasites. It is proposed that most individuals have such a first line cytokine response which is enough to prevent further spread and growth of the parasites. In exposed individuals who display disease symptoms, this non-Leishmania-specific response is overcome (by dose) or is weak (for genetic reasons). In the latter instances curbing of parasite growth would depend on acquired immunity.</jats:p> |
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| description | <jats:title>SUMMARY</jats:title><jats:p>Lymphocytes of individuals from a country non-endemic for Leishmania (Sweden), responded with a vigorous interferon-gamma (IFN-γ) and IL-6 response when exposed to live or dead promastigotes of Leishmania aethiopica. This response was sometimes as strong as when the same cells were exposed to the mitogen (phytohaemagglutinin (PHA)). Furthermore, supernatants of cells exposed to Leishmania promastigotes were able to inhibit the amastigote form of the same parasite. In some few instances there was no such reactivity to Leishmania parasites. It is proposed that most individuals have such a first line cytokine response which is enough to prevent further spread and growth of the parasites. In exposed individuals who display disease symptoms, this non-Leishmania-specific response is overcome (by dose) or is weak (for genetic reasons). In the latter instances curbing of parasite growth would depend on acquired immunity.</jats:p> |
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| spelling | AKUFFO, H O BRITTON, S F F 1365-2249 0009-9104 Oxford University Press (OUP) Immunology Immunology and Allergy http://dx.doi.org/10.1111/j.1365-2249.1992.tb06413.x <jats:title>SUMMARY</jats:title><jats:p>Lymphocytes of individuals from a country non-endemic for Leishmania (Sweden), responded with a vigorous interferon-gamma (IFN-γ) and IL-6 response when exposed to live or dead promastigotes of Leishmania aethiopica. This response was sometimes as strong as when the same cells were exposed to the mitogen (phytohaemagglutinin (PHA)). Furthermore, supernatants of cells exposed to Leishmania promastigotes were able to inhibit the amastigote form of the same parasite. In some few instances there was no such reactivity to Leishmania parasites. It is proposed that most individuals have such a first line cytokine response which is enough to prevent further spread and growth of the parasites. In exposed individuals who display disease symptoms, this non-Leishmania-specific response is overcome (by dose) or is weak (for genetic reasons). In the latter instances curbing of parasite growth would depend on acquired immunity.</jats:p> Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans Clinical and Experimental Immunology |
| spellingShingle | AKUFFO, H O, BRITTON, S F F, Clinical and Experimental Immunology, Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans, Immunology, Immunology and Allergy |
| title | Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| title_full | Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| title_fullStr | Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| title_full_unstemmed | Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| title_short | Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| title_sort | contribution of non-leishmania-specific immunity to resistance to leishmania infection in humans |
| title_unstemmed | Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1111/j.1365-2249.1992.tb06413.x |