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Complex karyotype predicts for inferior outcomes following reduced‐intensity conditioning allogeneic transplant for chronic lymphocytic leukaemia

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Zeitschriftentitel: British Journal of Haematology
Personen und Körperschaften: Jaglowski, Samantha M., Ruppert, Amy S., Heerema, Nyla A., Bingman, Anissa, Flynn, Joseph M., Grever, Michael R., Jones, Jeffrey A., Elder, Patrick, Devine, Steven M., Byrd, John C., Andritsos, Leslie A.
In: British Journal of Haematology, 159, 2012, 1, S. 82-87
Format: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
Hematology
Details
Zusammenfassung: <jats:title>Summary</jats:title><jats:p>Complex karyotype (<jats:styled-content style="fixed-case">CK</jats:styled-content>) on metaphase cytogenetics discriminates poor outcome in chronic lymphocytic leukaemia (<jats:styled-content style="fixed-case">CLL</jats:styled-content>) patients undergoing salvage treatment; we hypothesized that it might provide prognostic information for patients undergoing allogeneic stem cell transplant. Fifty‐one <jats:styled-content style="fixed-case">CLL</jats:styled-content> patients were analysed following transplant; 18‐month overall survival (<jats:styled-content style="fixed-case">OS</jats:styled-content>), event‐free survival (<jats:styled-content style="fixed-case">EFS</jats:styled-content>) and cumulative incidence of progression estimates were 35%, 14% and 63%, respectively, in patients with <jats:styled-content style="fixed-case">CK</jats:styled-content> (<jats:italic>n</jats:italic> = 19) versus 83%, 68% and 29% in patients without (<jats:italic>n</jats:italic> = 32) (<jats:italic>P </jats:italic>≤ 0·0001, <jats:italic>P </jats:italic>≤ 0·0001, and <jats:italic>P</jats:italic> = 0·02). In patients with high‐risk interphase cytogenetics, <jats:styled-content style="fixed-case">CK</jats:styled-content> remained predictive of worse <jats:styled-content style="fixed-case">OS</jats:styled-content> (<jats:italic>P</jats:italic> = 0·02) and <jats:styled-content style="fixed-case">EFS</jats:styled-content> (<jats:italic>P</jats:italic> = 0·009). These findings support further evaluation of metaphase karyotype in transplant risk assessment.</jats:p>
Umfang: 82-87
ISSN: 0007-1048
1365-2141
DOI: 10.1111/j.1365-2141.2012.09239.x