Eintrag weiter verarbeiten
Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction
Gespeichert in:
| Zeitschriftentitel: | British Journal of Haematology |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | British Journal of Haematology, 151, 2010, 4, S. 397-401 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Chouliaras, Giorgos L. Kattamis, Antonis Berdoukas, Vasilis Gotsis, Efstathios D. Mavrogeni, Sophie Ladis, Vassilis Chouliaras, Giorgos L. Kattamis, Antonis Berdoukas, Vasilis Gotsis, Efstathios D. Mavrogeni, Sophie Ladis, Vassilis |
|---|---|
| author |
Chouliaras, Giorgos L. Kattamis, Antonis Berdoukas, Vasilis Gotsis, Efstathios D. Mavrogeni, Sophie Ladis, Vassilis |
| spellingShingle |
Chouliaras, Giorgos L. Kattamis, Antonis Berdoukas, Vasilis Gotsis, Efstathios D. Mavrogeni, Sophie Ladis, Vassilis British Journal of Haematology Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction Hematology |
| author_sort |
chouliaras, giorgos l. |
| spelling |
Chouliaras, Giorgos L. Kattamis, Antonis Berdoukas, Vasilis Gotsis, Efstathios D. Mavrogeni, Sophie Ladis, Vassilis 0007-1048 1365-2141 Wiley Hematology http://dx.doi.org/10.1111/j.1365-2141.2010.08365.x <jats:title>Summary</jats:title><jats:p>Cardiac Magnetic Resonance (CMR) has replaced all other surrogate measurements in the determination of transfusional cardiac iron overload in patients with thalassaemia major. We aimed to determine the diagnostic value of CMR T2* with respect to cardiac dysfunction (CD) as determined by CMR‐derived left ventricular ejection fraction (LVEF). Cardiac T2* values and LVEF measured by CMR were recorded in 303 patients with thalassaemia major, at the time of their first CMR. T2* was correlated with LVEF (regression coefficient: 0·57, <jats:italic>P</jats:italic> < 0·001). The prevalence of CD was 32·9% in patients with T2* ≤ 8 ms, 12·5% in patients with T2* > 8 ms and ≤14 ms and reduced to 9·1% in patients with T2* between 14–20 ms. As the probability of CD is progressively, and not suddenly, reduced with increasing values of T2*, CMR has a limited diagnostic value for CD (Receiver operating characteristic analysis, area under the curve = 0·68). Patients with cardiac T2* ≤ 8 ms require careful and intensive management. This risk decreases with increasing values of T2* but even in mildly loaded patients the probability of impaired LVEF is not negligible.</jats:p> Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction British Journal of Haematology |
| doi_str_mv |
10.1111/j.1365-2141.2010.08365.x |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjEzNjUtMjE0MS4yMDEwLjA4MzY1Lng |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjEzNjUtMjE0MS4yMDEwLjA4MzY1Lng |
| institution |
DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 |
| imprint |
Wiley, 2010 |
| imprint_str_mv |
Wiley, 2010 |
| issn |
0007-1048 1365-2141 |
| issn_str_mv |
0007-1048 1365-2141 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
chouliaras2010cardiacmagneticresonanceintransfusiondependentthalassaemiaassessmentofironloadandrelationshiptoleftventricularejectionfraction |
| publishDateSort |
2010 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
British Journal of Haematology |
| source_id |
49 |
| title |
Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_unstemmed |
Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_full |
Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_fullStr |
Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_full_unstemmed |
Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_short |
Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_sort |
cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| topic |
Hematology |
| url |
http://dx.doi.org/10.1111/j.1365-2141.2010.08365.x |
| publishDate |
2010 |
| physical |
397-401 |
| description |
<jats:title>Summary</jats:title><jats:p>Cardiac Magnetic Resonance (CMR) has replaced all other surrogate measurements in the determination of transfusional cardiac iron overload in patients with thalassaemia major. We aimed to determine the diagnostic value of CMR T2* with respect to cardiac dysfunction (CD) as determined by CMR‐derived left ventricular ejection fraction (LVEF). Cardiac T2* values and LVEF measured by CMR were recorded in 303 patients with thalassaemia major, at the time of their first CMR. T2* was correlated with LVEF (regression coefficient: 0·57, <jats:italic>P</jats:italic> < 0·001). The prevalence of CD was 32·9% in patients with T2* ≤ 8 ms, 12·5% in patients with T2* > 8 ms and ≤14 ms and reduced to 9·1% in patients with T2* between 14–20 ms. As the probability of CD is progressively, and not suddenly, reduced with increasing values of T2*, CMR has a limited diagnostic value for CD (Receiver operating characteristic analysis, area under the curve = 0·68). Patients with cardiac T2* ≤ 8 ms require careful and intensive management. This risk decreases with increasing values of T2* but even in mildly loaded patients the probability of impaired LVEF is not negligible.</jats:p> |
| container_issue |
4 |
| container_start_page |
397 |
| container_title |
British Journal of Haematology |
| container_volume |
151 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792336943202172930 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:08:08.933Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Cardiac+magnetic+resonance+in+transfusion+dependent+thalassaemia%3A+assessment+of+iron+load+and+relationship+to+left+ventricular+ejection+fraction&rft.date=2010-11-01&genre=article&issn=1365-2141&volume=151&issue=4&spage=397&epage=401&pages=397-401&jtitle=British+Journal+of+Haematology&atitle=Cardiac+magnetic+resonance+in+transfusion+dependent+thalassaemia%3A+assessment+of+iron+load+and+relationship+to+left+ventricular+ejection+fraction&aulast=Ladis&aufirst=Vassilis&rft_id=info%3Adoi%2F10.1111%2Fj.1365-2141.2010.08365.x&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792336943202172930 |
| author | Chouliaras, Giorgos L., Kattamis, Antonis, Berdoukas, Vasilis, Gotsis, Efstathios D., Mavrogeni, Sophie, Ladis, Vassilis |
| author_facet | Chouliaras, Giorgos L., Kattamis, Antonis, Berdoukas, Vasilis, Gotsis, Efstathios D., Mavrogeni, Sophie, Ladis, Vassilis, Chouliaras, Giorgos L., Kattamis, Antonis, Berdoukas, Vasilis, Gotsis, Efstathios D., Mavrogeni, Sophie, Ladis, Vassilis |
| author_sort | chouliaras, giorgos l. |
| container_issue | 4 |
| container_start_page | 397 |
| container_title | British Journal of Haematology |
| container_volume | 151 |
| description | <jats:title>Summary</jats:title><jats:p>Cardiac Magnetic Resonance (CMR) has replaced all other surrogate measurements in the determination of transfusional cardiac iron overload in patients with thalassaemia major. We aimed to determine the diagnostic value of CMR T2* with respect to cardiac dysfunction (CD) as determined by CMR‐derived left ventricular ejection fraction (LVEF). Cardiac T2* values and LVEF measured by CMR were recorded in 303 patients with thalassaemia major, at the time of their first CMR. T2* was correlated with LVEF (regression coefficient: 0·57, <jats:italic>P</jats:italic> < 0·001). The prevalence of CD was 32·9% in patients with T2* ≤ 8 ms, 12·5% in patients with T2* > 8 ms and ≤14 ms and reduced to 9·1% in patients with T2* between 14–20 ms. As the probability of CD is progressively, and not suddenly, reduced with increasing values of T2*, CMR has a limited diagnostic value for CD (Receiver operating characteristic analysis, area under the curve = 0·68). Patients with cardiac T2* ≤ 8 ms require careful and intensive management. This risk decreases with increasing values of T2* but even in mildly loaded patients the probability of impaired LVEF is not negligible.</jats:p> |
| doi_str_mv | 10.1111/j.1365-2141.2010.08365.x |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjEzNjUtMjE0MS4yMDEwLjA4MzY1Lng |
| imprint | Wiley, 2010 |
| imprint_str_mv | Wiley, 2010 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
| issn | 0007-1048, 1365-2141 |
| issn_str_mv | 0007-1048, 1365-2141 |
| language | English |
| last_indexed | 2024-03-01T15:08:08.933Z |
| match_str | chouliaras2010cardiacmagneticresonanceintransfusiondependentthalassaemiaassessmentofironloadandrelationshiptoleftventricularejectionfraction |
| mega_collection | Wiley (CrossRef) |
| physical | 397-401 |
| publishDate | 2010 |
| publishDateSort | 2010 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | British Journal of Haematology |
| source_id | 49 |
| spelling | Chouliaras, Giorgos L. Kattamis, Antonis Berdoukas, Vasilis Gotsis, Efstathios D. Mavrogeni, Sophie Ladis, Vassilis 0007-1048 1365-2141 Wiley Hematology http://dx.doi.org/10.1111/j.1365-2141.2010.08365.x <jats:title>Summary</jats:title><jats:p>Cardiac Magnetic Resonance (CMR) has replaced all other surrogate measurements in the determination of transfusional cardiac iron overload in patients with thalassaemia major. We aimed to determine the diagnostic value of CMR T2* with respect to cardiac dysfunction (CD) as determined by CMR‐derived left ventricular ejection fraction (LVEF). Cardiac T2* values and LVEF measured by CMR were recorded in 303 patients with thalassaemia major, at the time of their first CMR. T2* was correlated with LVEF (regression coefficient: 0·57, <jats:italic>P</jats:italic> < 0·001). The prevalence of CD was 32·9% in patients with T2* ≤ 8 ms, 12·5% in patients with T2* > 8 ms and ≤14 ms and reduced to 9·1% in patients with T2* between 14–20 ms. As the probability of CD is progressively, and not suddenly, reduced with increasing values of T2*, CMR has a limited diagnostic value for CD (Receiver operating characteristic analysis, area under the curve = 0·68). Patients with cardiac T2* ≤ 8 ms require careful and intensive management. This risk decreases with increasing values of T2* but even in mildly loaded patients the probability of impaired LVEF is not negligible.</jats:p> Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction British Journal of Haematology |
| spellingShingle | Chouliaras, Giorgos L., Kattamis, Antonis, Berdoukas, Vasilis, Gotsis, Efstathios D., Mavrogeni, Sophie, Ladis, Vassilis, British Journal of Haematology, Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction, Hematology |
| title | Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_full | Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_fullStr | Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_full_unstemmed | Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_short | Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_sort | cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| title_unstemmed | Cardiac magnetic resonance in transfusion dependent thalassaemia: assessment of iron load and relationship to left ventricular ejection fraction |
| topic | Hematology |
| url | http://dx.doi.org/10.1111/j.1365-2141.2010.08365.x |