Eintrag weiter verarbeiten
The role of ER stress in regulation of retinal angiogenesis and VEGF signaling
Gespeichert in:
| Zeitschriftentitel: | Acta Ophthalmologica |
|---|---|
| Personen und Körperschaften: | |
| In: | Acta Ophthalmologica, 92, 2014, s253, S. 0-0 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
ZHANG, S ZHANG, S |
|---|---|
| author |
ZHANG, S |
| spellingShingle |
ZHANG, S Acta Ophthalmologica The role of ER stress in regulation of retinal angiogenesis and VEGF signaling Ophthalmology General Medicine |
| author_sort |
zhang, s |
| spelling |
ZHANG, S 1755-375X 1755-3768 Wiley Ophthalmology General Medicine http://dx.doi.org/10.1111/j.1755-3768.2014.3212.x <jats:title>Abstract</jats:title><jats:p>The endoplasmic reticulum (ER) is the central hub for lipid and protein biosynthesis, protein folding and intracellular calcium storage in eukaryotic cells. Apart from these important and traditional roles, emerging evidence suggests that the ER functions as a principal stress sensor and signal transducer in the cell and this novel function is fulfilled primarily by the unfolded protein response (UPR). The UPR is an intricate set of adaptive signaling pathways activated upon aberrant accumulation of unfolded and/or misfolded proteins in the ER, or ER stress. Increased ER stress has been implicated in the pathogenesis of many human diseases such as neurodegenerative diseases, cancer and diabetes. The dynamic activation and differential regulation of the UPR signaling pathways plays a central role in coordinating the cellular responses to various metabolic changes and regulates a broad range of physiological and pathophysiological processes such as cell differentiation, proliferation, migration, apoptosis, inflammation, and angiogenesis. This presentation will summarize the role of ER stress in retinal angiogenesis and discuss the novel mechanisms of regulation of VEGF signaling by UPR pathways in relation to diabetic retinopathy.</jats:p> The role of ER stress in regulation of retinal angiogenesis and VEGF signaling Acta Ophthalmologica |
| doi_str_mv |
10.1111/j.1755-3768.2014.3212.x |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE3NTUtMzc2OC4yMDE0LjMyMTIueA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE3NTUtMzc2OC4yMDE0LjMyMTIueA |
| institution |
DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 |
| imprint |
Wiley, 2014 |
| imprint_str_mv |
Wiley, 2014 |
| issn |
1755-375X 1755-3768 |
| issn_str_mv |
1755-375X 1755-3768 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
zhang2014theroleoferstressinregulationofretinalangiogenesisandvegfsignaling |
| publishDateSort |
2014 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Acta Ophthalmologica |
| source_id |
49 |
| title |
The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| title_unstemmed |
The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| title_full |
The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| title_fullStr |
The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| title_full_unstemmed |
The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| title_short |
The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| title_sort |
the role of er stress in regulation of retinal angiogenesis and vegf signaling |
| topic |
Ophthalmology General Medicine |
| url |
http://dx.doi.org/10.1111/j.1755-3768.2014.3212.x |
| publishDate |
2014 |
| physical |
0-0 |
| description |
<jats:title>Abstract</jats:title><jats:p>The endoplasmic reticulum (ER) is the central hub for lipid and protein biosynthesis, protein folding and intracellular calcium storage in eukaryotic cells. Apart from these important and traditional roles, emerging evidence suggests that the ER functions as a principal stress sensor and signal transducer in the cell and this novel function is fulfilled primarily by the unfolded protein response (UPR). The UPR is an intricate set of adaptive signaling pathways activated upon aberrant accumulation of unfolded and/or misfolded proteins in the ER, or ER stress. Increased ER stress has been implicated in the pathogenesis of many human diseases such as neurodegenerative diseases, cancer and diabetes. The dynamic activation and differential regulation of the UPR signaling pathways plays a central role in coordinating the cellular responses to various metabolic changes and regulates a broad range of physiological and pathophysiological processes such as cell differentiation, proliferation, migration, apoptosis, inflammation, and angiogenesis. This presentation will summarize the role of ER stress in retinal angiogenesis and discuss the novel mechanisms of regulation of VEGF signaling by UPR pathways in relation to diabetic retinopathy.</jats:p> |
| container_issue |
s253 |
| container_start_page |
0 |
| container_title |
Acta Ophthalmologica |
| container_volume |
92 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792333852132245512 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:19:17.48Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=The+role+of+ER+stress+in+regulation+of+retinal+angiogenesis+and+VEGF+signaling&rft.date=2014-09-01&genre=article&issn=1755-3768&volume=92&issue=s253&pages=0-0&jtitle=Acta+Ophthalmologica&atitle=The+role+of+ER+stress+in+regulation+of+retinal+angiogenesis+and+VEGF+signaling&aulast=ZHANG&aufirst=S&rft_id=info%3Adoi%2F10.1111%2Fj.1755-3768.2014.3212.x&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792333852132245512 |
| author | ZHANG, S |
| author_facet | ZHANG, S, ZHANG, S |
| author_sort | zhang, s |
| container_issue | s253 |
| container_start_page | 0 |
| container_title | Acta Ophthalmologica |
| container_volume | 92 |
| description | <jats:title>Abstract</jats:title><jats:p>The endoplasmic reticulum (ER) is the central hub for lipid and protein biosynthesis, protein folding and intracellular calcium storage in eukaryotic cells. Apart from these important and traditional roles, emerging evidence suggests that the ER functions as a principal stress sensor and signal transducer in the cell and this novel function is fulfilled primarily by the unfolded protein response (UPR). The UPR is an intricate set of adaptive signaling pathways activated upon aberrant accumulation of unfolded and/or misfolded proteins in the ER, or ER stress. Increased ER stress has been implicated in the pathogenesis of many human diseases such as neurodegenerative diseases, cancer and diabetes. The dynamic activation and differential regulation of the UPR signaling pathways plays a central role in coordinating the cellular responses to various metabolic changes and regulates a broad range of physiological and pathophysiological processes such as cell differentiation, proliferation, migration, apoptosis, inflammation, and angiogenesis. This presentation will summarize the role of ER stress in retinal angiogenesis and discuss the novel mechanisms of regulation of VEGF signaling by UPR pathways in relation to diabetic retinopathy.</jats:p> |
| doi_str_mv | 10.1111/j.1755-3768.2014.3212.x |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE3NTUtMzc2OC4yMDE0LjMyMTIueA |
| imprint | Wiley, 2014 |
| imprint_str_mv | Wiley, 2014 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
| issn | 1755-375X, 1755-3768 |
| issn_str_mv | 1755-375X, 1755-3768 |
| language | English |
| last_indexed | 2024-03-01T14:19:17.48Z |
| match_str | zhang2014theroleoferstressinregulationofretinalangiogenesisandvegfsignaling |
| mega_collection | Wiley (CrossRef) |
| physical | 0-0 |
| publishDate | 2014 |
| publishDateSort | 2014 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Acta Ophthalmologica |
| source_id | 49 |
| spelling | ZHANG, S 1755-375X 1755-3768 Wiley Ophthalmology General Medicine http://dx.doi.org/10.1111/j.1755-3768.2014.3212.x <jats:title>Abstract</jats:title><jats:p>The endoplasmic reticulum (ER) is the central hub for lipid and protein biosynthesis, protein folding and intracellular calcium storage in eukaryotic cells. Apart from these important and traditional roles, emerging evidence suggests that the ER functions as a principal stress sensor and signal transducer in the cell and this novel function is fulfilled primarily by the unfolded protein response (UPR). The UPR is an intricate set of adaptive signaling pathways activated upon aberrant accumulation of unfolded and/or misfolded proteins in the ER, or ER stress. Increased ER stress has been implicated in the pathogenesis of many human diseases such as neurodegenerative diseases, cancer and diabetes. The dynamic activation and differential regulation of the UPR signaling pathways plays a central role in coordinating the cellular responses to various metabolic changes and regulates a broad range of physiological and pathophysiological processes such as cell differentiation, proliferation, migration, apoptosis, inflammation, and angiogenesis. This presentation will summarize the role of ER stress in retinal angiogenesis and discuss the novel mechanisms of regulation of VEGF signaling by UPR pathways in relation to diabetic retinopathy.</jats:p> The role of ER stress in regulation of retinal angiogenesis and VEGF signaling Acta Ophthalmologica |
| spellingShingle | ZHANG, S, Acta Ophthalmologica, The role of ER stress in regulation of retinal angiogenesis and VEGF signaling, Ophthalmology, General Medicine |
| title | The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| title_full | The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| title_fullStr | The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| title_full_unstemmed | The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| title_short | The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| title_sort | the role of er stress in regulation of retinal angiogenesis and vegf signaling |
| title_unstemmed | The role of ER stress in regulation of retinal angiogenesis and VEGF signaling |
| topic | Ophthalmology, General Medicine |
| url | http://dx.doi.org/10.1111/j.1755-3768.2014.3212.x |