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Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas
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| Zeitschriftentitel: | Brain Pathology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Brain Pathology, 12, 2002, 2, S. 145-153 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Büschges, Rainer Ichimura, Koichi Weber, Ruthild G. Reifenberger, Guido Collins, V. Peter Büschges, Rainer Ichimura, Koichi Weber, Ruthild G. Reifenberger, Guido Collins, V. Peter |
|---|---|
| author |
Büschges, Rainer Ichimura, Koichi Weber, Ruthild G. Reifenberger, Guido Collins, V. Peter |
| spellingShingle |
Büschges, Rainer Ichimura, Koichi Weber, Ruthild G. Reifenberger, Guido Collins, V. Peter Brain Pathology Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas Neurology (clinical) Pathology and Forensic Medicine General Neuroscience |
| author_sort |
büschges, rainer |
| spelling |
Büschges, Rainer Ichimura, Koichi Weber, Ruthild G. Reifenberger, Guido Collins, V. Peter 1015-6305 1750-3639 Wiley Neurology (clinical) Pathology and Forensic Medicine General Neuroscience http://dx.doi.org/10.1111/j.1750-3639.2002.tb00429.x <jats:p>Using comparative genomic hybridization (CGH) we have previously identified amplification at 17q21‐qter as a common aberration in anaplastic meningiomas but not in atypical or benign meningiomas (19). To define the amplified genomic region, we analyzed 44 meningeal tumors, including 7 benign meningiomas of World Health Organization (WHO) grade I, 19 atypical meningiomas (WHO grade II) and 18 anaplastic meningiomas (WHO grade III) at 46 chromosome 17 loci (including 42 17q loci). In line with the CGH data we found evidence of increased numbers of alleles on 17q. The incidence rose with malignancy grade, culminating at 61% (11 of 18 cases) in the anaplastic meningioma group. The majority of cases showing increased allele numbers had, on average, low‐level allelic gains (relative increase in allele dosage of 2‐ to 5‐fold). Amplification of alleles (defined here as an average relative increase in allele dosage of more than 5 times) was detected in 2 anaplastic meningiomas. The amplification patterns in these tumors defined a number of common regions of amplification/increased allele copy number, the best defined include one between <jats:italic>D17S790</jats:italic> and <jats:italic>D17S1607</jats:italic> and one between <jats:italic>D17S1160</jats:italic> and <jats:italic>PS6K.</jats:italic> Real‐time PCR analysis of the <jats:italic>PS6K</jats:italic> candidate gene revealed no high‐level amplification despite this affecting adjacent loci. Our findings are fundamental for the identification of the gene(s) in 17q22‐q23 that is (are) the target(s) for increased copy number in anaplastic meningiomas and possibly other tumor types.</jats:p> Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas Brain Pathology |
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| title |
Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| title_unstemmed |
Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| title_full |
Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| title_fullStr |
Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| title_full_unstemmed |
Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| title_short |
Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| title_sort |
allelic gain and amplification on the long arm of chromosome 17 in anaplastic meningiomas |
| topic |
Neurology (clinical) Pathology and Forensic Medicine General Neuroscience |
| url |
http://dx.doi.org/10.1111/j.1750-3639.2002.tb00429.x |
| publishDate |
2002 |
| physical |
145-153 |
| description |
<jats:p>Using comparative genomic hybridization (CGH) we have previously identified amplification at 17q21‐qter as a common aberration in anaplastic meningiomas but not in atypical or benign meningiomas (19). To define the amplified genomic region, we analyzed 44 meningeal tumors, including 7 benign meningiomas of World Health Organization (WHO) grade I, 19 atypical meningiomas (WHO grade II) and 18 anaplastic meningiomas (WHO grade III) at 46 chromosome 17 loci (including 42 17q loci). In line with the CGH data we found evidence of increased numbers of alleles on 17q. The incidence rose with malignancy grade, culminating at 61% (11 of 18 cases) in the anaplastic meningioma group. The majority of cases showing increased allele numbers had, on average, low‐level allelic gains (relative increase in allele dosage of 2‐ to 5‐fold). Amplification of alleles (defined here as an average relative increase in allele dosage of more than 5 times) was detected in 2 anaplastic meningiomas. The amplification patterns in these tumors defined a number of common regions of amplification/increased allele copy number, the best defined include one between <jats:italic>D17S790</jats:italic> and <jats:italic>D17S1607</jats:italic> and one between <jats:italic>D17S1160</jats:italic> and <jats:italic>PS6K.</jats:italic> Real‐time PCR analysis of the <jats:italic>PS6K</jats:italic> candidate gene revealed no high‐level amplification despite this affecting adjacent loci. Our findings are fundamental for the identification of the gene(s) in 17q22‐q23 that is (are) the target(s) for increased copy number in anaplastic meningiomas and possibly other tumor types.</jats:p> |
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| author | Büschges, Rainer, Ichimura, Koichi, Weber, Ruthild G., Reifenberger, Guido, Collins, V. Peter |
| author_facet | Büschges, Rainer, Ichimura, Koichi, Weber, Ruthild G., Reifenberger, Guido, Collins, V. Peter, Büschges, Rainer, Ichimura, Koichi, Weber, Ruthild G., Reifenberger, Guido, Collins, V. Peter |
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| description | <jats:p>Using comparative genomic hybridization (CGH) we have previously identified amplification at 17q21‐qter as a common aberration in anaplastic meningiomas but not in atypical or benign meningiomas (19). To define the amplified genomic region, we analyzed 44 meningeal tumors, including 7 benign meningiomas of World Health Organization (WHO) grade I, 19 atypical meningiomas (WHO grade II) and 18 anaplastic meningiomas (WHO grade III) at 46 chromosome 17 loci (including 42 17q loci). In line with the CGH data we found evidence of increased numbers of alleles on 17q. The incidence rose with malignancy grade, culminating at 61% (11 of 18 cases) in the anaplastic meningioma group. The majority of cases showing increased allele numbers had, on average, low‐level allelic gains (relative increase in allele dosage of 2‐ to 5‐fold). Amplification of alleles (defined here as an average relative increase in allele dosage of more than 5 times) was detected in 2 anaplastic meningiomas. The amplification patterns in these tumors defined a number of common regions of amplification/increased allele copy number, the best defined include one between <jats:italic>D17S790</jats:italic> and <jats:italic>D17S1607</jats:italic> and one between <jats:italic>D17S1160</jats:italic> and <jats:italic>PS6K.</jats:italic> Real‐time PCR analysis of the <jats:italic>PS6K</jats:italic> candidate gene revealed no high‐level amplification despite this affecting adjacent loci. Our findings are fundamental for the identification of the gene(s) in 17q22‐q23 that is (are) the target(s) for increased copy number in anaplastic meningiomas and possibly other tumor types.</jats:p> |
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| imprint_str_mv | Wiley, 2002 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| spelling | Büschges, Rainer Ichimura, Koichi Weber, Ruthild G. Reifenberger, Guido Collins, V. Peter 1015-6305 1750-3639 Wiley Neurology (clinical) Pathology and Forensic Medicine General Neuroscience http://dx.doi.org/10.1111/j.1750-3639.2002.tb00429.x <jats:p>Using comparative genomic hybridization (CGH) we have previously identified amplification at 17q21‐qter as a common aberration in anaplastic meningiomas but not in atypical or benign meningiomas (19). To define the amplified genomic region, we analyzed 44 meningeal tumors, including 7 benign meningiomas of World Health Organization (WHO) grade I, 19 atypical meningiomas (WHO grade II) and 18 anaplastic meningiomas (WHO grade III) at 46 chromosome 17 loci (including 42 17q loci). In line with the CGH data we found evidence of increased numbers of alleles on 17q. The incidence rose with malignancy grade, culminating at 61% (11 of 18 cases) in the anaplastic meningioma group. The majority of cases showing increased allele numbers had, on average, low‐level allelic gains (relative increase in allele dosage of 2‐ to 5‐fold). Amplification of alleles (defined here as an average relative increase in allele dosage of more than 5 times) was detected in 2 anaplastic meningiomas. The amplification patterns in these tumors defined a number of common regions of amplification/increased allele copy number, the best defined include one between <jats:italic>D17S790</jats:italic> and <jats:italic>D17S1607</jats:italic> and one between <jats:italic>D17S1160</jats:italic> and <jats:italic>PS6K.</jats:italic> Real‐time PCR analysis of the <jats:italic>PS6K</jats:italic> candidate gene revealed no high‐level amplification despite this affecting adjacent loci. Our findings are fundamental for the identification of the gene(s) in 17q22‐q23 that is (are) the target(s) for increased copy number in anaplastic meningiomas and possibly other tumor types.</jats:p> Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas Brain Pathology |
| spellingShingle | Büschges, Rainer, Ichimura, Koichi, Weber, Ruthild G., Reifenberger, Guido, Collins, V. Peter, Brain Pathology, Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas, Neurology (clinical), Pathology and Forensic Medicine, General Neuroscience |
| title | Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| title_full | Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| title_fullStr | Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| title_full_unstemmed | Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| title_short | Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| title_sort | allelic gain and amplification on the long arm of chromosome 17 in anaplastic meningiomas |
| title_unstemmed | Allelic Gain and Amplification on the Long Arm of Chromosome 17 in Anaplastic Meningiomas |
| topic | Neurology (clinical), Pathology and Forensic Medicine, General Neuroscience |
| url | http://dx.doi.org/10.1111/j.1750-3639.2002.tb00429.x |