Eintrag weiter verarbeiten
Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach
Gespeichert in:
| Zeitschriftentitel: | Journal of Cellular and Molecular Medicine |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Cellular and Molecular Medicine, 14, 2010, 7, S. 1877-1889 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Bader, Augustinus Macchiarini, Paolo Bader, Augustinus Macchiarini, Paolo |
|---|---|
| author |
Bader, Augustinus Macchiarini, Paolo |
| spellingShingle |
Bader, Augustinus Macchiarini, Paolo Journal of Cellular and Molecular Medicine Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach Cell Biology Molecular Medicine |
| author_sort |
bader, augustinus |
| spelling |
Bader, Augustinus Macchiarini, Paolo 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/j.1582-4934.2010.01073.x <jats:title>Abstract</jats:title><jats:p> <jats:list list-type="explicit-label"> <jats:list-item><jats:p>Introduction</jats:p></jats:list-item> <jats:list-item><jats:p>Rationales for tracheal transplantation</jats:p></jats:list-item> <jats:list-item><jats:p>Historical background</jats:p></jats:list-item> <jats:list-item><jats:p>Regenerative approach to tracheal replacement</jats:p></jats:list-item> <jats:list-item><jats:p>Human tissue engineering tracheal replacement</jats:p></jats:list-item> <jats:list-item><jats:p> ‐ Mesenchymal stem cell derived chondrocytes</jats:p></jats:list-item> <jats:list-item><jats:p> ‐ Epithelial respiratory cells</jats:p></jats:list-item> <jats:list-item><jats:p>Ongoing progress</jats:p></jats:list-item> <jats:list-item><jats:p>Conclusions</jats:p></jats:list-item> </jats:list> </jats:p><jats:p>In June 2008, the world’s first whole tissue‐engineered organ – the windpipe – was successfully transplanted into a 31‐year‐old lady, and about 18 months following surgery she is leading a near normal life without immunosuppression. This outcome has been achieved by employing three groundbreaking technologies of regenerative medicine: (<jats:italic>i</jats:italic>) a donor trachea first decellularized using a detergent (without denaturing the collagenous matrix), (<jats:italic>ii</jats:italic>) the two main autologous tracheal cells, namely mesenchymal stem cell derived cartilage‐like cells and epithelial respiratory cells and (<jats:italic>iii</jats:italic>) a specifically designed bioreactor that reseed, before implantation, the <jats:italic>in vitro</jats:italic> pre‐expanded and pre‐differentiated autologous cells on the desired surfaces of the decellularized matrix. Given the long‐term safety, efficacy and efforts using such a conventional approach and the potential advantages of regenerative implants to make them available for anyone, we have investigated a novel alternative concept how to fully avoid <jats:italic>in vitro</jats:italic> cell replication, expansion and differentiation, use the human native site as micro‐niche, potentiate the human body’s site‐specific response by adding boosting, permissive and recruitment impulses in full respect of sociological and regulatory prerequisites. This tissue‐engineered approach and ongoing research in airway transplantation is reviewed and presented here.</jats:p> Moving towards <i>in situ</i> tracheal regeneration: the bionic tissue engineered transplantation approach Journal of Cellular and Molecular Medicine |
| doi_str_mv |
10.1111/j.1582-4934.2010.01073.x |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE1ODItNDkzNC4yMDEwLjAxMDczLng |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE1ODItNDkzNC4yMDEwLjAxMDczLng |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-105 DE-Ch1 DE-L229 |
| imprint |
Wiley, 2010 |
| imprint_str_mv |
Wiley, 2010 |
| issn |
1582-1838 1582-4934 |
| issn_str_mv |
1582-1838 1582-4934 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
bader2010movingtowardsinsitutrachealregenerationthebionictissueengineeredtransplantationapproach |
| publishDateSort |
2010 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Cellular and Molecular Medicine |
| source_id |
49 |
| title |
Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_unstemmed |
Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_full |
Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_fullStr |
Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_full_unstemmed |
Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_short |
Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_sort |
moving towards <i>in situ</i> tracheal regeneration: the bionic tissue engineered transplantation approach |
| topic |
Cell Biology Molecular Medicine |
| url |
http://dx.doi.org/10.1111/j.1582-4934.2010.01073.x |
| publishDate |
2010 |
| physical |
1877-1889 |
| description |
<jats:title>Abstract</jats:title><jats:p>
<jats:list list-type="explicit-label">
<jats:list-item><jats:p>Introduction</jats:p></jats:list-item>
<jats:list-item><jats:p>Rationales for tracheal transplantation</jats:p></jats:list-item>
<jats:list-item><jats:p>Historical background</jats:p></jats:list-item>
<jats:list-item><jats:p>Regenerative approach to tracheal replacement</jats:p></jats:list-item>
<jats:list-item><jats:p>Human tissue engineering tracheal replacement</jats:p></jats:list-item>
<jats:list-item><jats:p> ‐ Mesenchymal stem cell derived chondrocytes</jats:p></jats:list-item>
<jats:list-item><jats:p> ‐ Epithelial respiratory cells</jats:p></jats:list-item>
<jats:list-item><jats:p>Ongoing progress</jats:p></jats:list-item>
<jats:list-item><jats:p>Conclusions</jats:p></jats:list-item>
</jats:list>
</jats:p><jats:p>In June 2008, the world’s first whole tissue‐engineered organ – the windpipe – was successfully transplanted into a 31‐year‐old lady, and about 18 months following surgery she is leading a near normal life without immunosuppression. This outcome has been achieved by employing three groundbreaking technologies of regenerative medicine: (<jats:italic>i</jats:italic>) a donor trachea first decellularized using a detergent (without denaturing the collagenous matrix), (<jats:italic>ii</jats:italic>) the two main autologous tracheal cells, namely mesenchymal stem cell derived cartilage‐like cells and epithelial respiratory cells and (<jats:italic>iii</jats:italic>) a specifically designed bioreactor that reseed, before implantation, the <jats:italic>in vitro</jats:italic> pre‐expanded and pre‐differentiated autologous cells on the desired surfaces of the decellularized matrix. Given the long‐term safety, efficacy and efforts using such a conventional approach and the potential advantages of regenerative implants to make them available for anyone, we have investigated a novel alternative concept how to fully avoid <jats:italic>in vitro</jats:italic> cell replication, expansion and differentiation, use the human native site as micro‐niche, potentiate the human body’s site‐specific response by adding boosting, permissive and recruitment impulses in full respect of sociological and regulatory prerequisites. This tissue‐engineered approach and ongoing research in airway transplantation is reviewed and presented here.</jats:p> |
| container_issue |
7 |
| container_start_page |
1877 |
| container_title |
Journal of Cellular and Molecular Medicine |
| container_volume |
14 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792344413024813064 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:07:12.639Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Moving+towards+in+situ+tracheal+regeneration%3A+the+bionic+tissue+engineered+transplantation+approach&rft.date=2010-07-01&genre=article&issn=1582-4934&volume=14&issue=7&spage=1877&epage=1889&pages=1877-1889&jtitle=Journal+of+Cellular+and+Molecular+Medicine&atitle=Moving+towards+%3Ci%3Ein+situ%3C%2Fi%3E+tracheal+regeneration%3A+the+bionic+tissue+engineered+transplantation+approach&aulast=Macchiarini&aufirst=Paolo&rft_id=info%3Adoi%2F10.1111%2Fj.1582-4934.2010.01073.x&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792344413024813064 |
| author | Bader, Augustinus, Macchiarini, Paolo |
| author_facet | Bader, Augustinus, Macchiarini, Paolo, Bader, Augustinus, Macchiarini, Paolo |
| author_sort | bader, augustinus |
| container_issue | 7 |
| container_start_page | 1877 |
| container_title | Journal of Cellular and Molecular Medicine |
| container_volume | 14 |
| description | <jats:title>Abstract</jats:title><jats:p> <jats:list list-type="explicit-label"> <jats:list-item><jats:p>Introduction</jats:p></jats:list-item> <jats:list-item><jats:p>Rationales for tracheal transplantation</jats:p></jats:list-item> <jats:list-item><jats:p>Historical background</jats:p></jats:list-item> <jats:list-item><jats:p>Regenerative approach to tracheal replacement</jats:p></jats:list-item> <jats:list-item><jats:p>Human tissue engineering tracheal replacement</jats:p></jats:list-item> <jats:list-item><jats:p> ‐ Mesenchymal stem cell derived chondrocytes</jats:p></jats:list-item> <jats:list-item><jats:p> ‐ Epithelial respiratory cells</jats:p></jats:list-item> <jats:list-item><jats:p>Ongoing progress</jats:p></jats:list-item> <jats:list-item><jats:p>Conclusions</jats:p></jats:list-item> </jats:list> </jats:p><jats:p>In June 2008, the world’s first whole tissue‐engineered organ – the windpipe – was successfully transplanted into a 31‐year‐old lady, and about 18 months following surgery she is leading a near normal life without immunosuppression. This outcome has been achieved by employing three groundbreaking technologies of regenerative medicine: (<jats:italic>i</jats:italic>) a donor trachea first decellularized using a detergent (without denaturing the collagenous matrix), (<jats:italic>ii</jats:italic>) the two main autologous tracheal cells, namely mesenchymal stem cell derived cartilage‐like cells and epithelial respiratory cells and (<jats:italic>iii</jats:italic>) a specifically designed bioreactor that reseed, before implantation, the <jats:italic>in vitro</jats:italic> pre‐expanded and pre‐differentiated autologous cells on the desired surfaces of the decellularized matrix. Given the long‐term safety, efficacy and efforts using such a conventional approach and the potential advantages of regenerative implants to make them available for anyone, we have investigated a novel alternative concept how to fully avoid <jats:italic>in vitro</jats:italic> cell replication, expansion and differentiation, use the human native site as micro‐niche, potentiate the human body’s site‐specific response by adding boosting, permissive and recruitment impulses in full respect of sociological and regulatory prerequisites. This tissue‐engineered approach and ongoing research in airway transplantation is reviewed and presented here.</jats:p> |
| doi_str_mv | 10.1111/j.1582-4934.2010.01073.x |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9qLjE1ODItNDkzNC4yMDEwLjAxMDczLng |
| imprint | Wiley, 2010 |
| imprint_str_mv | Wiley, 2010 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229 |
| issn | 1582-1838, 1582-4934 |
| issn_str_mv | 1582-1838, 1582-4934 |
| language | English |
| last_indexed | 2024-03-01T17:07:12.639Z |
| match_str | bader2010movingtowardsinsitutrachealregenerationthebionictissueengineeredtransplantationapproach |
| mega_collection | Wiley (CrossRef) |
| physical | 1877-1889 |
| publishDate | 2010 |
| publishDateSort | 2010 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Journal of Cellular and Molecular Medicine |
| source_id | 49 |
| spelling | Bader, Augustinus Macchiarini, Paolo 1582-1838 1582-4934 Wiley Cell Biology Molecular Medicine http://dx.doi.org/10.1111/j.1582-4934.2010.01073.x <jats:title>Abstract</jats:title><jats:p> <jats:list list-type="explicit-label"> <jats:list-item><jats:p>Introduction</jats:p></jats:list-item> <jats:list-item><jats:p>Rationales for tracheal transplantation</jats:p></jats:list-item> <jats:list-item><jats:p>Historical background</jats:p></jats:list-item> <jats:list-item><jats:p>Regenerative approach to tracheal replacement</jats:p></jats:list-item> <jats:list-item><jats:p>Human tissue engineering tracheal replacement</jats:p></jats:list-item> <jats:list-item><jats:p> ‐ Mesenchymal stem cell derived chondrocytes</jats:p></jats:list-item> <jats:list-item><jats:p> ‐ Epithelial respiratory cells</jats:p></jats:list-item> <jats:list-item><jats:p>Ongoing progress</jats:p></jats:list-item> <jats:list-item><jats:p>Conclusions</jats:p></jats:list-item> </jats:list> </jats:p><jats:p>In June 2008, the world’s first whole tissue‐engineered organ – the windpipe – was successfully transplanted into a 31‐year‐old lady, and about 18 months following surgery she is leading a near normal life without immunosuppression. This outcome has been achieved by employing three groundbreaking technologies of regenerative medicine: (<jats:italic>i</jats:italic>) a donor trachea first decellularized using a detergent (without denaturing the collagenous matrix), (<jats:italic>ii</jats:italic>) the two main autologous tracheal cells, namely mesenchymal stem cell derived cartilage‐like cells and epithelial respiratory cells and (<jats:italic>iii</jats:italic>) a specifically designed bioreactor that reseed, before implantation, the <jats:italic>in vitro</jats:italic> pre‐expanded and pre‐differentiated autologous cells on the desired surfaces of the decellularized matrix. Given the long‐term safety, efficacy and efforts using such a conventional approach and the potential advantages of regenerative implants to make them available for anyone, we have investigated a novel alternative concept how to fully avoid <jats:italic>in vitro</jats:italic> cell replication, expansion and differentiation, use the human native site as micro‐niche, potentiate the human body’s site‐specific response by adding boosting, permissive and recruitment impulses in full respect of sociological and regulatory prerequisites. This tissue‐engineered approach and ongoing research in airway transplantation is reviewed and presented here.</jats:p> Moving towards <i>in situ</i> tracheal regeneration: the bionic tissue engineered transplantation approach Journal of Cellular and Molecular Medicine |
| spellingShingle | Bader, Augustinus, Macchiarini, Paolo, Journal of Cellular and Molecular Medicine, Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach, Cell Biology, Molecular Medicine |
| title | Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_full | Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_fullStr | Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_full_unstemmed | Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_short | Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_sort | moving towards <i>in situ</i> tracheal regeneration: the bionic tissue engineered transplantation approach |
| title_unstemmed | Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach |
| topic | Cell Biology, Molecular Medicine |
| url | http://dx.doi.org/10.1111/j.1582-4934.2010.01073.x |