Eintrag weiter verarbeiten
Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia
Gespeichert in:
| Zeitschriftentitel: | HIV Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , |
| In: | HIV Medicine, 16, 2015, 7, S. 421-430 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Barakat, LA Juthani‐Mehta, M Allore, H Trentalange, M Tate, J Rimland, D Pisani, M Akgün, KM Goetz, MB Butt, AA Rodriguez‐Barradas, M Duggal, M Crothers, K Justice, AC Quagliarello, VJ Barakat, LA Juthani‐Mehta, M Allore, H Trentalange, M Tate, J Rimland, D Pisani, M Akgün, KM Goetz, MB Butt, AA Rodriguez‐Barradas, M Duggal, M Crothers, K Justice, AC Quagliarello, VJ |
|---|---|
| author |
Barakat, LA Juthani‐Mehta, M Allore, H Trentalange, M Tate, J Rimland, D Pisani, M Akgün, KM Goetz, MB Butt, AA Rodriguez‐Barradas, M Duggal, M Crothers, K Justice, AC Quagliarello, VJ |
| spellingShingle |
Barakat, LA Juthani‐Mehta, M Allore, H Trentalange, M Tate, J Rimland, D Pisani, M Akgün, KM Goetz, MB Butt, AA Rodriguez‐Barradas, M Duggal, M Crothers, K Justice, AC Quagliarello, VJ HIV Medicine Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia Pharmacology (medical) Infectious Diseases Health Policy |
| author_sort |
barakat, la |
| spelling |
Barakat, LA Juthani‐Mehta, M Allore, H Trentalange, M Tate, J Rimland, D Pisani, M Akgün, KM Goetz, MB Butt, AA Rodriguez‐Barradas, M Duggal, M Crothers, K Justice, AC Quagliarello, VJ 1464-2662 1468-1293 Wiley Pharmacology (medical) Infectious Diseases Health Policy http://dx.doi.org/10.1111/hiv.12244 <jats:sec><jats:title>Objectives</jats:title><jats:p>Outcomes of community–acquired pneumonia (<jats:styled-content style="fixed-case">CAP</jats:styled-content>) among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected older adults are unclear.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Associations between <jats:styled-content style="fixed-case">HIV</jats:styled-content> infection and three <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes (30‐day mortality, readmission within 30 days post‐discharge, and hospital length of stay [<jats:styled-content style="fixed-case">LOS</jats:styled-content>]) were examined in the <jats:styled-content style="fixed-case">V</jats:styled-content>eterans <jats:styled-content style="fixed-case">A</jats:styled-content>ging <jats:styled-content style="fixed-case">C</jats:styled-content>ohort <jats:styled-content style="fixed-case">S</jats:styled-content>tudy (<jats:styled-content style="fixed-case">VACS</jats:styled-content>) of male Veterans, age ≥ 50 years, hospitalized for <jats:styled-content style="fixed-case">CAP</jats:styled-content> from 10/1/2002 through 08/31/2010. Associations between the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index and <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes were assessed in multivariable models.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Among 117 557 <jats:styled-content style="fixed-case">V</jats:styled-content>eterans (36 922 <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and 80 635 uninfected), 1203 met our eligibility criteria. The 30‐day mortality rate was 5.3%, the mean <jats:styled-content style="fixed-case">LOS</jats:styled-content> was 7.3 days, and 13.2% were readmitted within 30 days of discharge. In unadjusted analyses, there were no significant differences between <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected participants regarding the three <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes (<jats:italic>P</jats:italic> > 0.2). A higher <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index was associated with increased 30‐day mortality, readmission, and <jats:styled-content style="fixed-case">LOS</jats:styled-content> in both <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected groups. Generic organ system components of the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index were associated with adverse <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes; <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐specific components were not. Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected participants, those not on antiretroviral therapy (<jats:styled-content style="fixed-case">ART</jats:styled-content>) had a higher 30‐day mortality (<jats:styled-content style="fixed-case">HR</jats:styled-content> 2.94 [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 1.51, 5.72]; <jats:italic>P</jats:italic> = 0.002) and a longer <jats:styled-content style="fixed-case">LOS</jats:styled-content> (slope 2.69 days [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 0.65, 4.73]; <jats:italic>P</jats:italic> = 0.008), after accounting for <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index. Readmission was not associated with <jats:styled-content style="fixed-case">ART</jats:styled-content> use (<jats:styled-content style="fixed-case">OR</jats:styled-content> 1.12 [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 0.62, 2.00] <jats:italic>P</jats:italic> = 0.714).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected older adults hospitalized for <jats:styled-content style="fixed-case">CAP</jats:styled-content>, organ system components of the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index were associated with adverse <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes. Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected individuals, <jats:styled-content style="fixed-case">ART</jats:styled-content> was associated with decreased 30‐day mortality and <jats:styled-content style="fixed-case">LOS</jats:styled-content>.</jats:p></jats:sec> Comparing clinical outcomes in <scp>HIV</scp>‐infected and uninfected older men hospitalized with community‐acquired pneumonia HIV Medicine |
| doi_str_mv |
10.1111/hiv.12244 |
| facet_avail |
Online Free |
| finc_class_facet |
Chemie und Pharmazie Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9oaXYuMTIyNDQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9oaXYuMTIyNDQ |
| institution |
DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 |
| imprint |
Wiley, 2015 |
| imprint_str_mv |
Wiley, 2015 |
| issn |
1464-2662 1468-1293 |
| issn_str_mv |
1464-2662 1468-1293 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
barakat2015comparingclinicaloutcomesinhivinfectedanduninfectedoldermenhospitalizedwithcommunityacquiredpneumonia |
| publishDateSort |
2015 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
HIV Medicine |
| source_id |
49 |
| title |
Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_unstemmed |
Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_full |
Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_fullStr |
Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_full_unstemmed |
Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_short |
Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_sort |
comparing clinical outcomes in <scp>hiv</scp>‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| topic |
Pharmacology (medical) Infectious Diseases Health Policy |
| url |
http://dx.doi.org/10.1111/hiv.12244 |
| publishDate |
2015 |
| physical |
421-430 |
| description |
<jats:sec><jats:title>Objectives</jats:title><jats:p>Outcomes of community–acquired pneumonia (<jats:styled-content style="fixed-case">CAP</jats:styled-content>) among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected older adults are unclear.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Associations between <jats:styled-content style="fixed-case">HIV</jats:styled-content> infection and three <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes (30‐day mortality, readmission within 30 days post‐discharge, and hospital length of stay [<jats:styled-content style="fixed-case">LOS</jats:styled-content>]) were examined in the <jats:styled-content style="fixed-case">V</jats:styled-content>eterans <jats:styled-content style="fixed-case">A</jats:styled-content>ging <jats:styled-content style="fixed-case">C</jats:styled-content>ohort <jats:styled-content style="fixed-case">S</jats:styled-content>tudy (<jats:styled-content style="fixed-case">VACS</jats:styled-content>) of male Veterans, age ≥ 50 years, hospitalized for <jats:styled-content style="fixed-case">CAP</jats:styled-content> from 10/1/2002 through 08/31/2010. Associations between the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index and <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes were assessed in multivariable models.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Among 117 557 <jats:styled-content style="fixed-case">V</jats:styled-content>eterans (36 922 <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and 80 635 uninfected), 1203 met our eligibility criteria. The 30‐day mortality rate was 5.3%, the mean <jats:styled-content style="fixed-case">LOS</jats:styled-content> was 7.3 days, and 13.2% were readmitted within 30 days of discharge. In unadjusted analyses, there were no significant differences between <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected participants regarding the three <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes (<jats:italic>P</jats:italic> > 0.2). A higher <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index was associated with increased 30‐day mortality, readmission, and <jats:styled-content style="fixed-case">LOS</jats:styled-content> in both <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected groups. Generic organ system components of the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index were associated with adverse <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes; <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐specific components were not. Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected participants, those not on antiretroviral therapy (<jats:styled-content style="fixed-case">ART</jats:styled-content>) had a higher 30‐day mortality (<jats:styled-content style="fixed-case">HR</jats:styled-content> 2.94 [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 1.51, 5.72]; <jats:italic>P</jats:italic> = 0.002) and a longer <jats:styled-content style="fixed-case">LOS</jats:styled-content> (slope 2.69 days [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 0.65, 4.73]; <jats:italic>P</jats:italic> = 0.008), after accounting for <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index. Readmission was not associated with <jats:styled-content style="fixed-case">ART</jats:styled-content> use (<jats:styled-content style="fixed-case">OR</jats:styled-content> 1.12 [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 0.62, 2.00] <jats:italic>P</jats:italic> = 0.714).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected older adults hospitalized for <jats:styled-content style="fixed-case">CAP</jats:styled-content>, organ system components of the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index were associated with adverse <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes. Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected individuals, <jats:styled-content style="fixed-case">ART</jats:styled-content> was associated with decreased 30‐day mortality and <jats:styled-content style="fixed-case">LOS</jats:styled-content>.</jats:p></jats:sec> |
| container_issue |
7 |
| container_start_page |
421 |
| container_title |
HIV Medicine |
| container_volume |
16 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792334335713476611 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:27:01.774Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Comparing+clinical+outcomes+in+HIV%E2%80%90infected+and+uninfected+older+men+hospitalized+with+community%E2%80%90acquired+pneumonia&rft.date=2015-08-01&genre=article&issn=1468-1293&volume=16&issue=7&spage=421&epage=430&pages=421-430&jtitle=HIV+Medicine&atitle=Comparing+clinical+outcomes+in+%3Cscp%3EHIV%3C%2Fscp%3E%E2%80%90infected+and+uninfected+older+men+hospitalized+with+community%E2%80%90acquired+pneumonia&aulast=Quagliarello&aufirst=VJ&rft_id=info%3Adoi%2F10.1111%2Fhiv.12244&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792334335713476611 |
| author | Barakat, LA, Juthani‐Mehta, M, Allore, H, Trentalange, M, Tate, J, Rimland, D, Pisani, M, Akgün, KM, Goetz, MB, Butt, AA, Rodriguez‐Barradas, M, Duggal, M, Crothers, K, Justice, AC, Quagliarello, VJ |
| author_facet | Barakat, LA, Juthani‐Mehta, M, Allore, H, Trentalange, M, Tate, J, Rimland, D, Pisani, M, Akgün, KM, Goetz, MB, Butt, AA, Rodriguez‐Barradas, M, Duggal, M, Crothers, K, Justice, AC, Quagliarello, VJ, Barakat, LA, Juthani‐Mehta, M, Allore, H, Trentalange, M, Tate, J, Rimland, D, Pisani, M, Akgün, KM, Goetz, MB, Butt, AA, Rodriguez‐Barradas, M, Duggal, M, Crothers, K, Justice, AC, Quagliarello, VJ |
| author_sort | barakat, la |
| container_issue | 7 |
| container_start_page | 421 |
| container_title | HIV Medicine |
| container_volume | 16 |
| description | <jats:sec><jats:title>Objectives</jats:title><jats:p>Outcomes of community–acquired pneumonia (<jats:styled-content style="fixed-case">CAP</jats:styled-content>) among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected older adults are unclear.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Associations between <jats:styled-content style="fixed-case">HIV</jats:styled-content> infection and three <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes (30‐day mortality, readmission within 30 days post‐discharge, and hospital length of stay [<jats:styled-content style="fixed-case">LOS</jats:styled-content>]) were examined in the <jats:styled-content style="fixed-case">V</jats:styled-content>eterans <jats:styled-content style="fixed-case">A</jats:styled-content>ging <jats:styled-content style="fixed-case">C</jats:styled-content>ohort <jats:styled-content style="fixed-case">S</jats:styled-content>tudy (<jats:styled-content style="fixed-case">VACS</jats:styled-content>) of male Veterans, age ≥ 50 years, hospitalized for <jats:styled-content style="fixed-case">CAP</jats:styled-content> from 10/1/2002 through 08/31/2010. Associations between the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index and <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes were assessed in multivariable models.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Among 117 557 <jats:styled-content style="fixed-case">V</jats:styled-content>eterans (36 922 <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and 80 635 uninfected), 1203 met our eligibility criteria. The 30‐day mortality rate was 5.3%, the mean <jats:styled-content style="fixed-case">LOS</jats:styled-content> was 7.3 days, and 13.2% were readmitted within 30 days of discharge. In unadjusted analyses, there were no significant differences between <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected participants regarding the three <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes (<jats:italic>P</jats:italic> > 0.2). A higher <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index was associated with increased 30‐day mortality, readmission, and <jats:styled-content style="fixed-case">LOS</jats:styled-content> in both <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected groups. Generic organ system components of the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index were associated with adverse <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes; <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐specific components were not. Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected participants, those not on antiretroviral therapy (<jats:styled-content style="fixed-case">ART</jats:styled-content>) had a higher 30‐day mortality (<jats:styled-content style="fixed-case">HR</jats:styled-content> 2.94 [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 1.51, 5.72]; <jats:italic>P</jats:italic> = 0.002) and a longer <jats:styled-content style="fixed-case">LOS</jats:styled-content> (slope 2.69 days [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 0.65, 4.73]; <jats:italic>P</jats:italic> = 0.008), after accounting for <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index. Readmission was not associated with <jats:styled-content style="fixed-case">ART</jats:styled-content> use (<jats:styled-content style="fixed-case">OR</jats:styled-content> 1.12 [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 0.62, 2.00] <jats:italic>P</jats:italic> = 0.714).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected older adults hospitalized for <jats:styled-content style="fixed-case">CAP</jats:styled-content>, organ system components of the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index were associated with adverse <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes. Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected individuals, <jats:styled-content style="fixed-case">ART</jats:styled-content> was associated with decreased 30‐day mortality and <jats:styled-content style="fixed-case">LOS</jats:styled-content>.</jats:p></jats:sec> |
| doi_str_mv | 10.1111/hiv.12244 |
| facet_avail | Online, Free |
| finc_class_facet | Chemie und Pharmazie, Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9oaXYuMTIyNDQ |
| imprint | Wiley, 2015 |
| imprint_str_mv | Wiley, 2015 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14 |
| issn | 1464-2662, 1468-1293 |
| issn_str_mv | 1464-2662, 1468-1293 |
| language | English |
| last_indexed | 2024-03-01T14:27:01.774Z |
| match_str | barakat2015comparingclinicaloutcomesinhivinfectedanduninfectedoldermenhospitalizedwithcommunityacquiredpneumonia |
| mega_collection | Wiley (CrossRef) |
| physical | 421-430 |
| publishDate | 2015 |
| publishDateSort | 2015 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | HIV Medicine |
| source_id | 49 |
| spelling | Barakat, LA Juthani‐Mehta, M Allore, H Trentalange, M Tate, J Rimland, D Pisani, M Akgün, KM Goetz, MB Butt, AA Rodriguez‐Barradas, M Duggal, M Crothers, K Justice, AC Quagliarello, VJ 1464-2662 1468-1293 Wiley Pharmacology (medical) Infectious Diseases Health Policy http://dx.doi.org/10.1111/hiv.12244 <jats:sec><jats:title>Objectives</jats:title><jats:p>Outcomes of community–acquired pneumonia (<jats:styled-content style="fixed-case">CAP</jats:styled-content>) among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected older adults are unclear.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Associations between <jats:styled-content style="fixed-case">HIV</jats:styled-content> infection and three <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes (30‐day mortality, readmission within 30 days post‐discharge, and hospital length of stay [<jats:styled-content style="fixed-case">LOS</jats:styled-content>]) were examined in the <jats:styled-content style="fixed-case">V</jats:styled-content>eterans <jats:styled-content style="fixed-case">A</jats:styled-content>ging <jats:styled-content style="fixed-case">C</jats:styled-content>ohort <jats:styled-content style="fixed-case">S</jats:styled-content>tudy (<jats:styled-content style="fixed-case">VACS</jats:styled-content>) of male Veterans, age ≥ 50 years, hospitalized for <jats:styled-content style="fixed-case">CAP</jats:styled-content> from 10/1/2002 through 08/31/2010. Associations between the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index and <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes were assessed in multivariable models.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Among 117 557 <jats:styled-content style="fixed-case">V</jats:styled-content>eterans (36 922 <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and 80 635 uninfected), 1203 met our eligibility criteria. The 30‐day mortality rate was 5.3%, the mean <jats:styled-content style="fixed-case">LOS</jats:styled-content> was 7.3 days, and 13.2% were readmitted within 30 days of discharge. In unadjusted analyses, there were no significant differences between <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected participants regarding the three <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes (<jats:italic>P</jats:italic> > 0.2). A higher <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index was associated with increased 30‐day mortality, readmission, and <jats:styled-content style="fixed-case">LOS</jats:styled-content> in both <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected groups. Generic organ system components of the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index were associated with adverse <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes; <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐specific components were not. Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected participants, those not on antiretroviral therapy (<jats:styled-content style="fixed-case">ART</jats:styled-content>) had a higher 30‐day mortality (<jats:styled-content style="fixed-case">HR</jats:styled-content> 2.94 [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 1.51, 5.72]; <jats:italic>P</jats:italic> = 0.002) and a longer <jats:styled-content style="fixed-case">LOS</jats:styled-content> (slope 2.69 days [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 0.65, 4.73]; <jats:italic>P</jats:italic> = 0.008), after accounting for <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index. Readmission was not associated with <jats:styled-content style="fixed-case">ART</jats:styled-content> use (<jats:styled-content style="fixed-case">OR</jats:styled-content> 1.12 [95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 0.62, 2.00] <jats:italic>P</jats:italic> = 0.714).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected and uninfected older adults hospitalized for <jats:styled-content style="fixed-case">CAP</jats:styled-content>, organ system components of the <jats:styled-content style="fixed-case">VACS</jats:styled-content> Index were associated with adverse <jats:styled-content style="fixed-case">CAP</jats:styled-content> outcomes. Among <jats:styled-content style="fixed-case">HIV</jats:styled-content>‐infected individuals, <jats:styled-content style="fixed-case">ART</jats:styled-content> was associated with decreased 30‐day mortality and <jats:styled-content style="fixed-case">LOS</jats:styled-content>.</jats:p></jats:sec> Comparing clinical outcomes in <scp>HIV</scp>‐infected and uninfected older men hospitalized with community‐acquired pneumonia HIV Medicine |
| spellingShingle | Barakat, LA, Juthani‐Mehta, M, Allore, H, Trentalange, M, Tate, J, Rimland, D, Pisani, M, Akgün, KM, Goetz, MB, Butt, AA, Rodriguez‐Barradas, M, Duggal, M, Crothers, K, Justice, AC, Quagliarello, VJ, HIV Medicine, Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia, Pharmacology (medical), Infectious Diseases, Health Policy |
| title | Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_full | Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_fullStr | Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_full_unstemmed | Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_short | Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_sort | comparing clinical outcomes in <scp>hiv</scp>‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| title_unstemmed | Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia |
| topic | Pharmacology (medical), Infectious Diseases, Health Policy |
| url | http://dx.doi.org/10.1111/hiv.12244 |