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Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine
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| Zeitschriftentitel: | CNS Neuroscience & Therapeutics |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , |
| In: | CNS Neuroscience & Therapeutics, 25, 2019, 2, S. 261-272 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Liu, Chang‐Bin Yang, De‐Gang Zhang, Xin Zhang, Wen‐Hao Li, Da‐Peng Zhang, Chao Qin, Chuan Du, Liang‐Jie Li, Jun Gao, Feng Zhang, Jie Zuo, Zhen‐Tao Yang, Ming‐Liang Li, Jian‐Jun Liu, Chang‐Bin Yang, De‐Gang Zhang, Xin Zhang, Wen‐Hao Li, Da‐Peng Zhang, Chao Qin, Chuan Du, Liang‐Jie Li, Jun Gao, Feng Zhang, Jie Zuo, Zhen‐Tao Yang, Ming‐Liang Li, Jian‐Jun |
|---|---|
| author |
Liu, Chang‐Bin Yang, De‐Gang Zhang, Xin Zhang, Wen‐Hao Li, Da‐Peng Zhang, Chao Qin, Chuan Du, Liang‐Jie Li, Jun Gao, Feng Zhang, Jie Zuo, Zhen‐Tao Yang, Ming‐Liang Li, Jian‐Jun |
| spellingShingle |
Liu, Chang‐Bin Yang, De‐Gang Zhang, Xin Zhang, Wen‐Hao Li, Da‐Peng Zhang, Chao Qin, Chuan Du, Liang‐Jie Li, Jun Gao, Feng Zhang, Jie Zuo, Zhen‐Tao Yang, Ming‐Liang Li, Jian‐Jun CNS Neuroscience & Therapeutics Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| author_sort |
liu, chang‐bin |
| spelling |
Liu, Chang‐Bin Yang, De‐Gang Zhang, Xin Zhang, Wen‐Hao Li, Da‐Peng Zhang, Chao Qin, Chuan Du, Liang‐Jie Li, Jun Gao, Feng Zhang, Jie Zuo, Zhen‐Tao Yang, Ming‐Liang Li, Jian‐Jun 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.13044 <jats:title>Summary</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>Exploration of the mechanism of spinal cord degeneration may be the key to treatment of spinal cord injury (SCI). This study aimed to investigate the degeneration of white matter and gray matter and pathological mechanism in canine after SCI.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Diffusion tensor imaging (DTI) was performed on canine models with normal (n = 5) and injured (n = 7) spinal cords using a 3.0T MRI scanner at precontusion and 3 hours, 24 hours, 6 weeks, and 12 weeks postcontusion. The tissue sections were stained using H&E and immunohistochemistry.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For white matter, fractional anisotropy (FA) values significantly decreased in lesion epicenter, caudal segment 1 cm away from epicenter, and caudal segment 2 cm away from epicenter (<jats:italic>P</jats:italic> = 0.003, <jats:italic>P</jats:italic> = 0.004, and <jats:italic>P</jats:italic> = 0.013, respectively) after SCI. Apparent diffusion coefficient (ADC) values were initially decreased and then increased in lesion epicenter and caudal segment 1 cm away from epicenter (<jats:italic>P</jats:italic> < 0.001 and <jats:italic>P</jats:italic> = 0.010, respectively). There are no significant changes in FA and ADC values in rostral segments (<jats:italic>P</jats:italic> > 0.05). For gray matter, ADC values decreased initially and then increased in lesion epicenter (<jats:italic>P</jats:italic> < 0.001), and overall trend decreased in caudal segment 1 cm away from epicenter (<jats:italic>P</jats:italic> = 0.039). FA values did not change significantly (<jats:italic>P</jats:italic> > 0.05). Pathological examination confirmed the dynamic changes of DTI parameters.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Diffusion tensor imaging is more sensitive to degeneration of white matter than gray matter, and the white matter degeneration may be not symmetrical which meant the caudal degradation appeared to be more severe than the rostral one.</jats:p></jats:sec> Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine CNS Neuroscience & Therapeutics |
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10.1111/cns.13044 |
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Online Free |
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Chemie und Pharmazie Biologie Medizin Psychologie |
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Wiley, 2019 |
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| title |
Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_unstemmed |
Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_full |
Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_fullStr |
Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_full_unstemmed |
Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_short |
Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_sort |
degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| topic |
Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
| url |
http://dx.doi.org/10.1111/cns.13044 |
| publishDate |
2019 |
| physical |
261-272 |
| description |
<jats:title>Summary</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>Exploration of the mechanism of spinal cord degeneration may be the key to treatment of spinal cord injury (SCI). This study aimed to investigate the degeneration of white matter and gray matter and pathological mechanism in canine after SCI.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Diffusion tensor imaging (DTI) was performed on canine models with normal (n = 5) and injured (n = 7) spinal cords using a 3.0T MRI scanner at precontusion and 3 hours, 24 hours, 6 weeks, and 12 weeks postcontusion. The tissue sections were stained using H&E and immunohistochemistry.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For white matter, fractional anisotropy (FA) values significantly decreased in lesion epicenter, caudal segment 1 cm away from epicenter, and caudal segment 2 cm away from epicenter (<jats:italic>P</jats:italic> = 0.003, <jats:italic>P</jats:italic> = 0.004, and <jats:italic>P</jats:italic> = 0.013, respectively) after SCI. Apparent diffusion coefficient (ADC) values were initially decreased and then increased in lesion epicenter and caudal segment 1 cm away from epicenter (<jats:italic>P</jats:italic> < 0.001 and <jats:italic>P</jats:italic> = 0.010, respectively). There are no significant changes in FA and ADC values in rostral segments (<jats:italic>P</jats:italic> > 0.05). For gray matter, ADC values decreased initially and then increased in lesion epicenter (<jats:italic>P</jats:italic> < 0.001), and overall trend decreased in caudal segment 1 cm away from epicenter (<jats:italic>P</jats:italic> = 0.039). FA values did not change significantly (<jats:italic>P</jats:italic> > 0.05). Pathological examination confirmed the dynamic changes of DTI parameters.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Diffusion tensor imaging is more sensitive to degeneration of white matter than gray matter, and the white matter degeneration may be not symmetrical which meant the caudal degradation appeared to be more severe than the rostral one.</jats:p></jats:sec> |
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| author | Liu, Chang‐Bin, Yang, De‐Gang, Zhang, Xin, Zhang, Wen‐Hao, Li, Da‐Peng, Zhang, Chao, Qin, Chuan, Du, Liang‐Jie, Li, Jun, Gao, Feng, Zhang, Jie, Zuo, Zhen‐Tao, Yang, Ming‐Liang, Li, Jian‐Jun |
| author_facet | Liu, Chang‐Bin, Yang, De‐Gang, Zhang, Xin, Zhang, Wen‐Hao, Li, Da‐Peng, Zhang, Chao, Qin, Chuan, Du, Liang‐Jie, Li, Jun, Gao, Feng, Zhang, Jie, Zuo, Zhen‐Tao, Yang, Ming‐Liang, Li, Jian‐Jun, Liu, Chang‐Bin, Yang, De‐Gang, Zhang, Xin, Zhang, Wen‐Hao, Li, Da‐Peng, Zhang, Chao, Qin, Chuan, Du, Liang‐Jie, Li, Jun, Gao, Feng, Zhang, Jie, Zuo, Zhen‐Tao, Yang, Ming‐Liang, Li, Jian‐Jun |
| author_sort | liu, chang‐bin |
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| description | <jats:title>Summary</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>Exploration of the mechanism of spinal cord degeneration may be the key to treatment of spinal cord injury (SCI). This study aimed to investigate the degeneration of white matter and gray matter and pathological mechanism in canine after SCI.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Diffusion tensor imaging (DTI) was performed on canine models with normal (n = 5) and injured (n = 7) spinal cords using a 3.0T MRI scanner at precontusion and 3 hours, 24 hours, 6 weeks, and 12 weeks postcontusion. The tissue sections were stained using H&E and immunohistochemistry.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For white matter, fractional anisotropy (FA) values significantly decreased in lesion epicenter, caudal segment 1 cm away from epicenter, and caudal segment 2 cm away from epicenter (<jats:italic>P</jats:italic> = 0.003, <jats:italic>P</jats:italic> = 0.004, and <jats:italic>P</jats:italic> = 0.013, respectively) after SCI. Apparent diffusion coefficient (ADC) values were initially decreased and then increased in lesion epicenter and caudal segment 1 cm away from epicenter (<jats:italic>P</jats:italic> < 0.001 and <jats:italic>P</jats:italic> = 0.010, respectively). There are no significant changes in FA and ADC values in rostral segments (<jats:italic>P</jats:italic> > 0.05). For gray matter, ADC values decreased initially and then increased in lesion epicenter (<jats:italic>P</jats:italic> < 0.001), and overall trend decreased in caudal segment 1 cm away from epicenter (<jats:italic>P</jats:italic> = 0.039). FA values did not change significantly (<jats:italic>P</jats:italic> > 0.05). Pathological examination confirmed the dynamic changes of DTI parameters.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Diffusion tensor imaging is more sensitive to degeneration of white matter than gray matter, and the white matter degeneration may be not symmetrical which meant the caudal degradation appeared to be more severe than the rostral one.</jats:p></jats:sec> |
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| imprint | Wiley, 2019 |
| imprint_str_mv | Wiley, 2019 |
| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4 |
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| physical | 261-272 |
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| spelling | Liu, Chang‐Bin Yang, De‐Gang Zhang, Xin Zhang, Wen‐Hao Li, Da‐Peng Zhang, Chao Qin, Chuan Du, Liang‐Jie Li, Jun Gao, Feng Zhang, Jie Zuo, Zhen‐Tao Yang, Ming‐Liang Li, Jian‐Jun 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.13044 <jats:title>Summary</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>Exploration of the mechanism of spinal cord degeneration may be the key to treatment of spinal cord injury (SCI). This study aimed to investigate the degeneration of white matter and gray matter and pathological mechanism in canine after SCI.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Diffusion tensor imaging (DTI) was performed on canine models with normal (n = 5) and injured (n = 7) spinal cords using a 3.0T MRI scanner at precontusion and 3 hours, 24 hours, 6 weeks, and 12 weeks postcontusion. The tissue sections were stained using H&E and immunohistochemistry.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For white matter, fractional anisotropy (FA) values significantly decreased in lesion epicenter, caudal segment 1 cm away from epicenter, and caudal segment 2 cm away from epicenter (<jats:italic>P</jats:italic> = 0.003, <jats:italic>P</jats:italic> = 0.004, and <jats:italic>P</jats:italic> = 0.013, respectively) after SCI. Apparent diffusion coefficient (ADC) values were initially decreased and then increased in lesion epicenter and caudal segment 1 cm away from epicenter (<jats:italic>P</jats:italic> < 0.001 and <jats:italic>P</jats:italic> = 0.010, respectively). There are no significant changes in FA and ADC values in rostral segments (<jats:italic>P</jats:italic> > 0.05). For gray matter, ADC values decreased initially and then increased in lesion epicenter (<jats:italic>P</jats:italic> < 0.001), and overall trend decreased in caudal segment 1 cm away from epicenter (<jats:italic>P</jats:italic> = 0.039). FA values did not change significantly (<jats:italic>P</jats:italic> > 0.05). Pathological examination confirmed the dynamic changes of DTI parameters.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Diffusion tensor imaging is more sensitive to degeneration of white matter than gray matter, and the white matter degeneration may be not symmetrical which meant the caudal degradation appeared to be more severe than the rostral one.</jats:p></jats:sec> Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine CNS Neuroscience & Therapeutics |
| spellingShingle | Liu, Chang‐Bin, Yang, De‐Gang, Zhang, Xin, Zhang, Wen‐Hao, Li, Da‐Peng, Zhang, Chao, Qin, Chuan, Du, Liang‐Jie, Li, Jun, Gao, Feng, Zhang, Jie, Zuo, Zhen‐Tao, Yang, Ming‐Liang, Li, Jian‐Jun, CNS Neuroscience & Therapeutics, Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine, Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| title | Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_full | Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_fullStr | Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_full_unstemmed | Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_short | Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_sort | degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| title_unstemmed | Degeneration of white matter and gray matter revealed by diffusion tensor imaging and pathological mechanism after spinal cord injury in canine |
| topic | Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
| url | http://dx.doi.org/10.1111/cns.13044 |