Eintrag weiter verarbeiten
Epithelial expression of interleukin-37b in inflammatory bowel disease
Gespeichert in:
| Zeitschriftentitel: | Clinical and Experimental Immunology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Clinical and Experimental Immunology, 172, 2013, 3, S. 410-416 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Imaeda, H Takahashi, K Fujimoto, T Kasumi, E Ban, H Bamba, S Sonoda, H Shimizu, T Fujiyama, Y Andoh, A Imaeda, H Takahashi, K Fujimoto, T Kasumi, E Ban, H Bamba, S Sonoda, H Shimizu, T Fujiyama, Y Andoh, A |
|---|---|
| author |
Imaeda, H Takahashi, K Fujimoto, T Kasumi, E Ban, H Bamba, S Sonoda, H Shimizu, T Fujiyama, Y Andoh, A |
| spellingShingle |
Imaeda, H Takahashi, K Fujimoto, T Kasumi, E Ban, H Bamba, S Sonoda, H Shimizu, T Fujiyama, Y Andoh, A Clinical and Experimental Immunology Epithelial expression of interleukin-37b in inflammatory bowel disease Immunology Immunology and Allergy |
| author_sort |
imaeda, h |
| spelling |
Imaeda, H Takahashi, K Fujimoto, T Kasumi, E Ban, H Bamba, S Sonoda, H Shimizu, T Fujiyama, Y Andoh, A 1365-2249 0009-9104 Oxford University Press (OUP) Immunology Immunology and Allergy http://dx.doi.org/10.1111/cei.12061 <jats:title>Summary</jats:title> <jats:p>Interleukin (IL)-37 is a member of the IL-1 cytokine family. We investigated IL-37b expression in the inflamed mucosa of inflammatory bowel disease (IBD) patients. Furthermore, we analysed IL-37b expression in human colonic epithelial cells. The human colonic epithelial cell line T84 and human colonic subepithelial myofibroblasts (SEMFs) were used. IL-37b expression in the IBD mucosa was evaluated by immunohistochemistry. IL-37b mRNA and protein expression were determined by real time-polymerase chain reaction (PCR) and Western blotting, respectively. IL-37b was not detected in the normal colonic mucosa. In the inflamed mucosa of IBD patients, epithelial IL-37b expression was increased markedly. In ulcerative colitis (UC) and Crohn's disease (CD) patients, IL-37b expression was enhanced in the affected mucosa. In the intestinal epithelial cell line T84, the expression of IL-37b mRNA and protein was enhanced by tumour necrosis factor (TNF)-α. This IL-37b induction by TNF-α was mediated by nuclear factor (NF)-κB and activator protein (AP)-1 activation. Furthermore, IL-37b inhibited TNF-α-induced interferon-γ-inducible protein (IP)-10 expression significantly in human colonic SEMFs. Epithelial IL-37b expression was increased in IBD patients, especially UC patients. IL-37b may be involved in the pathophysiology of IBD as an anti-inflammatory cytokine and an inhibitor of both innate and acquired immune responses.</jats:p> Epithelial expression of interleukin-37b in inflammatory bowel disease Clinical and Experimental Immunology |
| doi_str_mv |
10.1111/cei.12061 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9jZWkuMTIwNjE |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9jZWkuMTIwNjE |
| institution |
DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 |
| imprint |
Oxford University Press (OUP), 2013 |
| imprint_str_mv |
Oxford University Press (OUP), 2013 |
| issn |
1365-2249 0009-9104 |
| issn_str_mv |
1365-2249 0009-9104 |
| language |
English |
| mega_collection |
Oxford University Press (OUP) (CrossRef) |
| match_str |
imaeda2013epithelialexpressionofinterleukin37bininflammatoryboweldisease |
| publishDateSort |
2013 |
| publisher |
Oxford University Press (OUP) |
| recordtype |
ai |
| record_format |
ai |
| series |
Clinical and Experimental Immunology |
| source_id |
49 |
| title |
Epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_unstemmed |
Epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_full |
Epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_fullStr |
Epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_full_unstemmed |
Epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_short |
Epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_sort |
epithelial expression of interleukin-37b in inflammatory bowel disease |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1111/cei.12061 |
| publishDate |
2013 |
| physical |
410-416 |
| description |
<jats:title>Summary</jats:title>
<jats:p>Interleukin (IL)-37 is a member of the IL-1 cytokine family. We investigated IL-37b expression in the inflamed mucosa of inflammatory bowel disease (IBD) patients. Furthermore, we analysed IL-37b expression in human colonic epithelial cells. The human colonic epithelial cell line T84 and human colonic subepithelial myofibroblasts (SEMFs) were used. IL-37b expression in the IBD mucosa was evaluated by immunohistochemistry. IL-37b mRNA and protein expression were determined by real time-polymerase chain reaction (PCR) and Western blotting, respectively. IL-37b was not detected in the normal colonic mucosa. In the inflamed mucosa of IBD patients, epithelial IL-37b expression was increased markedly. In ulcerative colitis (UC) and Crohn's disease (CD) patients, IL-37b expression was enhanced in the affected mucosa. In the intestinal epithelial cell line T84, the expression of IL-37b mRNA and protein was enhanced by tumour necrosis factor (TNF)-α. This IL-37b induction by TNF-α was mediated by nuclear factor (NF)-κB and activator protein (AP)-1 activation. Furthermore, IL-37b inhibited TNF-α-induced interferon-γ-inducible protein (IP)-10 expression significantly in human colonic SEMFs. Epithelial IL-37b expression was increased in IBD patients, especially UC patients. IL-37b may be involved in the pathophysiology of IBD as an anti-inflammatory cytokine and an inhibitor of both innate and acquired immune responses.</jats:p> |
| container_issue |
3 |
| container_start_page |
410 |
| container_title |
Clinical and Experimental Immunology |
| container_volume |
172 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792343629962936327 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T16:54:43.457Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Epithelial+expression+of+interleukin-37b+in+inflammatory+bowel+disease&rft.date=2013-04-18&genre=article&issn=0009-9104&volume=172&issue=3&spage=410&epage=416&pages=410-416&jtitle=Clinical+and+Experimental+Immunology&atitle=Epithelial+expression+of+interleukin-37b+in+inflammatory+bowel+disease&aulast=Andoh&aufirst=A&rft_id=info%3Adoi%2F10.1111%2Fcei.12061&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792343629962936327 |
| author | Imaeda, H, Takahashi, K, Fujimoto, T, Kasumi, E, Ban, H, Bamba, S, Sonoda, H, Shimizu, T, Fujiyama, Y, Andoh, A |
| author_facet | Imaeda, H, Takahashi, K, Fujimoto, T, Kasumi, E, Ban, H, Bamba, S, Sonoda, H, Shimizu, T, Fujiyama, Y, Andoh, A, Imaeda, H, Takahashi, K, Fujimoto, T, Kasumi, E, Ban, H, Bamba, S, Sonoda, H, Shimizu, T, Fujiyama, Y, Andoh, A |
| author_sort | imaeda, h |
| container_issue | 3 |
| container_start_page | 410 |
| container_title | Clinical and Experimental Immunology |
| container_volume | 172 |
| description | <jats:title>Summary</jats:title> <jats:p>Interleukin (IL)-37 is a member of the IL-1 cytokine family. We investigated IL-37b expression in the inflamed mucosa of inflammatory bowel disease (IBD) patients. Furthermore, we analysed IL-37b expression in human colonic epithelial cells. The human colonic epithelial cell line T84 and human colonic subepithelial myofibroblasts (SEMFs) were used. IL-37b expression in the IBD mucosa was evaluated by immunohistochemistry. IL-37b mRNA and protein expression were determined by real time-polymerase chain reaction (PCR) and Western blotting, respectively. IL-37b was not detected in the normal colonic mucosa. In the inflamed mucosa of IBD patients, epithelial IL-37b expression was increased markedly. In ulcerative colitis (UC) and Crohn's disease (CD) patients, IL-37b expression was enhanced in the affected mucosa. In the intestinal epithelial cell line T84, the expression of IL-37b mRNA and protein was enhanced by tumour necrosis factor (TNF)-α. This IL-37b induction by TNF-α was mediated by nuclear factor (NF)-κB and activator protein (AP)-1 activation. Furthermore, IL-37b inhibited TNF-α-induced interferon-γ-inducible protein (IP)-10 expression significantly in human colonic SEMFs. Epithelial IL-37b expression was increased in IBD patients, especially UC patients. IL-37b may be involved in the pathophysiology of IBD as an anti-inflammatory cytokine and an inhibitor of both innate and acquired immune responses.</jats:p> |
| doi_str_mv | 10.1111/cei.12061 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9jZWkuMTIwNjE |
| imprint | Oxford University Press (OUP), 2013 |
| imprint_str_mv | Oxford University Press (OUP), 2013 |
| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4 |
| issn | 1365-2249, 0009-9104 |
| issn_str_mv | 1365-2249, 0009-9104 |
| language | English |
| last_indexed | 2024-03-01T16:54:43.457Z |
| match_str | imaeda2013epithelialexpressionofinterleukin37bininflammatoryboweldisease |
| mega_collection | Oxford University Press (OUP) (CrossRef) |
| physical | 410-416 |
| publishDate | 2013 |
| publishDateSort | 2013 |
| publisher | Oxford University Press (OUP) |
| record_format | ai |
| recordtype | ai |
| series | Clinical and Experimental Immunology |
| source_id | 49 |
| spelling | Imaeda, H Takahashi, K Fujimoto, T Kasumi, E Ban, H Bamba, S Sonoda, H Shimizu, T Fujiyama, Y Andoh, A 1365-2249 0009-9104 Oxford University Press (OUP) Immunology Immunology and Allergy http://dx.doi.org/10.1111/cei.12061 <jats:title>Summary</jats:title> <jats:p>Interleukin (IL)-37 is a member of the IL-1 cytokine family. We investigated IL-37b expression in the inflamed mucosa of inflammatory bowel disease (IBD) patients. Furthermore, we analysed IL-37b expression in human colonic epithelial cells. The human colonic epithelial cell line T84 and human colonic subepithelial myofibroblasts (SEMFs) were used. IL-37b expression in the IBD mucosa was evaluated by immunohistochemistry. IL-37b mRNA and protein expression were determined by real time-polymerase chain reaction (PCR) and Western blotting, respectively. IL-37b was not detected in the normal colonic mucosa. In the inflamed mucosa of IBD patients, epithelial IL-37b expression was increased markedly. In ulcerative colitis (UC) and Crohn's disease (CD) patients, IL-37b expression was enhanced in the affected mucosa. In the intestinal epithelial cell line T84, the expression of IL-37b mRNA and protein was enhanced by tumour necrosis factor (TNF)-α. This IL-37b induction by TNF-α was mediated by nuclear factor (NF)-κB and activator protein (AP)-1 activation. Furthermore, IL-37b inhibited TNF-α-induced interferon-γ-inducible protein (IP)-10 expression significantly in human colonic SEMFs. Epithelial IL-37b expression was increased in IBD patients, especially UC patients. IL-37b may be involved in the pathophysiology of IBD as an anti-inflammatory cytokine and an inhibitor of both innate and acquired immune responses.</jats:p> Epithelial expression of interleukin-37b in inflammatory bowel disease Clinical and Experimental Immunology |
| spellingShingle | Imaeda, H, Takahashi, K, Fujimoto, T, Kasumi, E, Ban, H, Bamba, S, Sonoda, H, Shimizu, T, Fujiyama, Y, Andoh, A, Clinical and Experimental Immunology, Epithelial expression of interleukin-37b in inflammatory bowel disease, Immunology, Immunology and Allergy |
| title | Epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_full | Epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_fullStr | Epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_full_unstemmed | Epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_short | Epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_sort | epithelial expression of interleukin-37b in inflammatory bowel disease |
| title_unstemmed | Epithelial expression of interleukin-37b in inflammatory bowel disease |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1111/cei.12061 |