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Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration
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| Zeitschriftentitel: | Learning & Memory |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Learning & Memory, 11, 2004, 5, S. 648-657 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cold Spring Harbor Laboratory
|
| Schlagwörter: |
| author_facet |
Self, David W. Choi, Kwang-Ho Simmons, Diana Walker, John R. Smagula, Cynthia S. Self, David W. Choi, Kwang-Ho Simmons, Diana Walker, John R. Smagula, Cynthia S. |
|---|---|
| author |
Self, David W. Choi, Kwang-Ho Simmons, Diana Walker, John R. Smagula, Cynthia S. |
| spellingShingle |
Self, David W. Choi, Kwang-Ho Simmons, Diana Walker, John R. Smagula, Cynthia S. Learning & Memory Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology |
| author_sort |
self, david w. |
| spelling |
Self, David W. Choi, Kwang-Ho Simmons, Diana Walker, John R. Smagula, Cynthia S. 1072-0502 1549-5485 Cold Spring Harbor Laboratory Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology http://dx.doi.org/10.1101/lm.81404 <jats:p>Cocaine produces multiple neuroadaptations with chronic repeated use. Many of these neuroadaptations can be reversed or normalized by extinction training during withdrawal from chronic cocaine self-administration in rats. This article reviews our past and present studies on extinction-induced modulation of the neuroadaptive response to chronic cocaine in the mesolimbic dopamine system, and the role of this modulation in addictive behavior in rats. Extinction training normalizes tyrosine hydroxylase levels in the nucleus accumbens (NAc) shell, an effect that could help ameliorate dysphoria and depression associated with withdrawal from chronic cocaine use. Extinction training also increases levels of GluR1 and GluR2/3 AMPA receptor subunits, while normalizing deficits in NR1 NMDA receptor subunits, in a manner consistent with long-term potentiation of excitatory synapses in the NAc shell. Our results suggest that extinction-induced increases in AMPA and NMDA receptors may restore deficits in cortico-accumbal neurotransmission in the NAc shell and facilitate inhibitory control over cocaine-seeking behavior. Other changes identified by gene expression profiling, including up-regulation in the AMPA receptor aggregating protein Narp, suggest that extinction training induces extensive synaptic reorganization. These studies highlight potential benefits for extinction training procedures in the treatment of drug addiction.</jats:p> Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration Learning & Memory |
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10.1101/lm.81404 |
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Learning & Memory |
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| title |
Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| title_unstemmed |
Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| title_full |
Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| title_fullStr |
Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| title_full_unstemmed |
Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| title_short |
Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| title_sort |
extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration |
| topic |
Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology |
| url |
http://dx.doi.org/10.1101/lm.81404 |
| publishDate |
2004 |
| physical |
648-657 |
| description |
<jats:p>Cocaine produces multiple neuroadaptations with chronic repeated use. Many
of these neuroadaptations can be reversed or normalized by extinction training
during withdrawal from chronic cocaine self-administration in rats. This
article reviews our past and present studies on extinction-induced modulation
of the neuroadaptive response to chronic cocaine in the mesolimbic dopamine
system, and the role of this modulation in addictive behavior in rats.
Extinction training normalizes tyrosine hydroxylase levels in the nucleus
accumbens (NAc) shell, an effect that could help ameliorate dysphoria and
depression associated with withdrawal from chronic cocaine use. Extinction
training also increases levels of GluR1 and GluR2/3 AMPA receptor subunits,
while normalizing deficits in NR1 NMDA receptor subunits, in a manner
consistent with long-term potentiation of excitatory synapses in the NAc
shell. Our results suggest that extinction-induced increases in AMPA and NMDA
receptors may restore deficits in cortico-accumbal neurotransmission in the
NAc shell and facilitate inhibitory control over cocaine-seeking behavior.
Other changes identified by gene expression profiling, including up-regulation
in the AMPA receptor aggregating protein Narp, suggest that extinction
training induces extensive synaptic reorganization. These studies highlight
potential benefits for extinction training procedures in the treatment of drug
addiction.</jats:p> |
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| author | Self, David W., Choi, Kwang-Ho, Simmons, Diana, Walker, John R., Smagula, Cynthia S. |
| author_facet | Self, David W., Choi, Kwang-Ho, Simmons, Diana, Walker, John R., Smagula, Cynthia S., Self, David W., Choi, Kwang-Ho, Simmons, Diana, Walker, John R., Smagula, Cynthia S. |
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| description | <jats:p>Cocaine produces multiple neuroadaptations with chronic repeated use. Many of these neuroadaptations can be reversed or normalized by extinction training during withdrawal from chronic cocaine self-administration in rats. This article reviews our past and present studies on extinction-induced modulation of the neuroadaptive response to chronic cocaine in the mesolimbic dopamine system, and the role of this modulation in addictive behavior in rats. Extinction training normalizes tyrosine hydroxylase levels in the nucleus accumbens (NAc) shell, an effect that could help ameliorate dysphoria and depression associated with withdrawal from chronic cocaine use. Extinction training also increases levels of GluR1 and GluR2/3 AMPA receptor subunits, while normalizing deficits in NR1 NMDA receptor subunits, in a manner consistent with long-term potentiation of excitatory synapses in the NAc shell. Our results suggest that extinction-induced increases in AMPA and NMDA receptors may restore deficits in cortico-accumbal neurotransmission in the NAc shell and facilitate inhibitory control over cocaine-seeking behavior. Other changes identified by gene expression profiling, including up-regulation in the AMPA receptor aggregating protein Narp, suggest that extinction training induces extensive synaptic reorganization. These studies highlight potential benefits for extinction training procedures in the treatment of drug addiction.</jats:p> |
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| spelling | Self, David W. Choi, Kwang-Ho Simmons, Diana Walker, John R. Smagula, Cynthia S. 1072-0502 1549-5485 Cold Spring Harbor Laboratory Cellular and Molecular Neuroscience Cognitive Neuroscience Neuropsychology and Physiological Psychology http://dx.doi.org/10.1101/lm.81404 <jats:p>Cocaine produces multiple neuroadaptations with chronic repeated use. Many of these neuroadaptations can be reversed or normalized by extinction training during withdrawal from chronic cocaine self-administration in rats. This article reviews our past and present studies on extinction-induced modulation of the neuroadaptive response to chronic cocaine in the mesolimbic dopamine system, and the role of this modulation in addictive behavior in rats. Extinction training normalizes tyrosine hydroxylase levels in the nucleus accumbens (NAc) shell, an effect that could help ameliorate dysphoria and depression associated with withdrawal from chronic cocaine use. Extinction training also increases levels of GluR1 and GluR2/3 AMPA receptor subunits, while normalizing deficits in NR1 NMDA receptor subunits, in a manner consistent with long-term potentiation of excitatory synapses in the NAc shell. Our results suggest that extinction-induced increases in AMPA and NMDA receptors may restore deficits in cortico-accumbal neurotransmission in the NAc shell and facilitate inhibitory control over cocaine-seeking behavior. Other changes identified by gene expression profiling, including up-regulation in the AMPA receptor aggregating protein Narp, suggest that extinction training induces extensive synaptic reorganization. These studies highlight potential benefits for extinction training procedures in the treatment of drug addiction.</jats:p> Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration Learning & Memory |
| spellingShingle | Self, David W., Choi, Kwang-Ho, Simmons, Diana, Walker, John R., Smagula, Cynthia S., Learning & Memory, Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration, Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neuropsychology and Physiological Psychology |
| title | Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| title_full | Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| title_fullStr | Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| title_full_unstemmed | Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| title_short | Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| title_sort | extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration |
| title_unstemmed | Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration |
| topic | Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neuropsychology and Physiological Psychology |
| url | http://dx.doi.org/10.1101/lm.81404 |