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Incredible journey: how do developmental signals travel through tissue?
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| Zeitschriftentitel: | Genes & Development |
|---|---|
| Personen und Körperschaften: | , |
| In: | Genes & Development, 18, 2004, 24, S. 2985-2997 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cold Spring Harbor Laboratory
|
| Schlagwörter: |
| author_facet |
Zhu, Alan Jian Scott, Matthew P. Zhu, Alan Jian Scott, Matthew P. |
|---|---|
| author |
Zhu, Alan Jian Scott, Matthew P. |
| spellingShingle |
Zhu, Alan Jian Scott, Matthew P. Genes & Development Incredible journey: how do developmental signals travel through tissue? Developmental Biology Genetics |
| author_sort |
zhu, alan jian |
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Zhu, Alan Jian Scott, Matthew P. 0890-9369 1549-5477 Cold Spring Harbor Laboratory Developmental Biology Genetics http://dx.doi.org/10.1101/gad.1233104 <jats:p>How developmental signaling proteins traverse tissue during animal development, through or around tightly packed cells, remains an incompletely resolved mystery. Signaling protein movement is regulated to create gradients, control amounts, impose barriers, or provide direction. Signaling can be controlled by the rate of signal production, modification, active transport, trapping along the path, or by the properties of the receptor apparatus. Signals may move by diffusion outside cells, attached to migrating cells, attached to carrier molecules, through cells by transcytosis, along cell extensions, or in released membrane packets. Recent findings about the movement of Hedgehog, Wingless (Wnt), and TGF-β signaling proteins have helped to clarify the molecular mechanisms used to ensure that developmental signals carry only good news.</jats:p> Incredible journey: how do developmental signals travel through tissue? Genes & Development |
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Cold Spring Harbor Laboratory, 2004 |
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2004 |
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Cold Spring Harbor Laboratory |
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| title |
Incredible journey: how do developmental signals travel through tissue? |
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Incredible journey: how do developmental signals travel through tissue? |
| title_full |
Incredible journey: how do developmental signals travel through tissue? |
| title_fullStr |
Incredible journey: how do developmental signals travel through tissue? |
| title_full_unstemmed |
Incredible journey: how do developmental signals travel through tissue? |
| title_short |
Incredible journey: how do developmental signals travel through tissue? |
| title_sort |
incredible journey: how do developmental signals travel through tissue? |
| topic |
Developmental Biology Genetics |
| url |
http://dx.doi.org/10.1101/gad.1233104 |
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2004 |
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2985-2997 |
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<jats:p>How developmental signaling proteins traverse tissue during animal development, through or around tightly packed cells, remains an incompletely resolved mystery. Signaling protein movement is regulated to create gradients, control amounts, impose barriers, or provide direction. Signaling can be controlled by the rate of signal production, modification, active transport, trapping along the path, or by the properties of the receptor apparatus. Signals may move by diffusion outside cells, attached to migrating cells, attached to carrier molecules, through cells by transcytosis, along cell extensions, or in released membrane packets. Recent findings about the movement of Hedgehog, Wingless (Wnt), and TGF-β signaling proteins have helped to clarify the molecular mechanisms used to ensure that developmental signals carry only good news.</jats:p> |
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| description | <jats:p>How developmental signaling proteins traverse tissue during animal development, through or around tightly packed cells, remains an incompletely resolved mystery. Signaling protein movement is regulated to create gradients, control amounts, impose barriers, or provide direction. Signaling can be controlled by the rate of signal production, modification, active transport, trapping along the path, or by the properties of the receptor apparatus. Signals may move by diffusion outside cells, attached to migrating cells, attached to carrier molecules, through cells by transcytosis, along cell extensions, or in released membrane packets. Recent findings about the movement of Hedgehog, Wingless (Wnt), and TGF-β signaling proteins have helped to clarify the molecular mechanisms used to ensure that developmental signals carry only good news.</jats:p> |
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| series | Genes & Development |
| source_id | 49 |
| spelling | Zhu, Alan Jian Scott, Matthew P. 0890-9369 1549-5477 Cold Spring Harbor Laboratory Developmental Biology Genetics http://dx.doi.org/10.1101/gad.1233104 <jats:p>How developmental signaling proteins traverse tissue during animal development, through or around tightly packed cells, remains an incompletely resolved mystery. Signaling protein movement is regulated to create gradients, control amounts, impose barriers, or provide direction. Signaling can be controlled by the rate of signal production, modification, active transport, trapping along the path, or by the properties of the receptor apparatus. Signals may move by diffusion outside cells, attached to migrating cells, attached to carrier molecules, through cells by transcytosis, along cell extensions, or in released membrane packets. Recent findings about the movement of Hedgehog, Wingless (Wnt), and TGF-β signaling proteins have helped to clarify the molecular mechanisms used to ensure that developmental signals carry only good news.</jats:p> Incredible journey: how do developmental signals travel through tissue? Genes & Development |
| spellingShingle | Zhu, Alan Jian, Scott, Matthew P., Genes & Development, Incredible journey: how do developmental signals travel through tissue?, Developmental Biology, Genetics |
| title | Incredible journey: how do developmental signals travel through tissue? |
| title_full | Incredible journey: how do developmental signals travel through tissue? |
| title_fullStr | Incredible journey: how do developmental signals travel through tissue? |
| title_full_unstemmed | Incredible journey: how do developmental signals travel through tissue? |
| title_short | Incredible journey: how do developmental signals travel through tissue? |
| title_sort | incredible journey: how do developmental signals travel through tissue? |
| title_unstemmed | Incredible journey: how do developmental signals travel through tissue? |
| topic | Developmental Biology, Genetics |
| url | http://dx.doi.org/10.1101/gad.1233104 |