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The Promoter Targeting Sequence mediates epigenetically heritable transcription memory
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| Zeitschriftentitel: | Genes & Development |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Genes & Development, 18, 2004, 21, S. 2639-2651 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cold Spring Harbor Laboratory
|
| Schlagwörter: |
| author_facet |
Lin, Qing Chen, Qi Lin, Lan Zhou, Jumin Lin, Qing Chen, Qi Lin, Lan Zhou, Jumin |
|---|---|
| author |
Lin, Qing Chen, Qi Lin, Lan Zhou, Jumin |
| spellingShingle |
Lin, Qing Chen, Qi Lin, Lan Zhou, Jumin Genes & Development The Promoter Targeting Sequence mediates epigenetically heritable transcription memory Developmental Biology Genetics |
| author_sort |
lin, qing |
| spelling |
Lin, Qing Chen, Qi Lin, Lan Zhou, Jumin 0890-9369 1549-5477 Cold Spring Harbor Laboratory Developmental Biology Genetics http://dx.doi.org/10.1101/gad.1230004 <jats:p>Large gene complexes frequently use “specialized” DNA elements to ensure proper regulation of gene activities. The Promoter Targeting Sequence (PTS) from the <jats:italic>Abdominal-B</jats:italic> locus of the <jats:italic>Drosophila</jats:italic> Bithorax complex overcomes an insulator, and facilitates, yet restricts, distant enhancers to a single promoter. We found that this promoter-targeting activity is independent of an enhancer's tissue or temporal specificity, and can be remembered in all somatic cells in the absence of promoter activation. It requires an insulator for its establishment, but can be maintained by the PTS in the absence of an insulator. More importantly, the promoter-targeting activity can be remembered after the transgene is translocated to new chromosomal locations. These results suggest that promoter targeting is established independent of enhancer activity, and is maintained epigenetically throughout development and subsequent generations.</jats:p> The Promoter Targeting Sequence mediates epigenetically heritable transcription memory Genes & Development |
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Genes & Development |
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| title |
The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| title_unstemmed |
The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| title_full |
The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| title_fullStr |
The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| title_full_unstemmed |
The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| title_short |
The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| title_sort |
the promoter targeting sequence mediates epigenetically heritable transcription memory |
| topic |
Developmental Biology Genetics |
| url |
http://dx.doi.org/10.1101/gad.1230004 |
| publishDate |
2004 |
| physical |
2639-2651 |
| description |
<jats:p>Large gene complexes frequently use “specialized” DNA elements to ensure proper regulation of gene activities. The Promoter Targeting Sequence (PTS) from the <jats:italic>Abdominal-B</jats:italic> locus of the <jats:italic>Drosophila</jats:italic> Bithorax complex overcomes an insulator, and facilitates, yet restricts, distant enhancers to a single promoter. We found that this promoter-targeting activity is independent of an enhancer's tissue or temporal specificity, and can be remembered in all somatic cells in the absence of promoter activation. It requires an insulator for its establishment, but can be maintained by the PTS in the absence of an insulator. More importantly, the promoter-targeting activity can be remembered after the transgene is translocated to new chromosomal locations. These results suggest that promoter targeting is established independent of enhancer activity, and is maintained epigenetically throughout development and subsequent generations.</jats:p> |
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| author | Lin, Qing, Chen, Qi, Lin, Lan, Zhou, Jumin |
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| author_sort | lin, qing |
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| description | <jats:p>Large gene complexes frequently use “specialized” DNA elements to ensure proper regulation of gene activities. The Promoter Targeting Sequence (PTS) from the <jats:italic>Abdominal-B</jats:italic> locus of the <jats:italic>Drosophila</jats:italic> Bithorax complex overcomes an insulator, and facilitates, yet restricts, distant enhancers to a single promoter. We found that this promoter-targeting activity is independent of an enhancer's tissue or temporal specificity, and can be remembered in all somatic cells in the absence of promoter activation. It requires an insulator for its establishment, but can be maintained by the PTS in the absence of an insulator. More importantly, the promoter-targeting activity can be remembered after the transgene is translocated to new chromosomal locations. These results suggest that promoter targeting is established independent of enhancer activity, and is maintained epigenetically throughout development and subsequent generations.</jats:p> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| publisher | Cold Spring Harbor Laboratory |
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| series | Genes & Development |
| source_id | 49 |
| spelling | Lin, Qing Chen, Qi Lin, Lan Zhou, Jumin 0890-9369 1549-5477 Cold Spring Harbor Laboratory Developmental Biology Genetics http://dx.doi.org/10.1101/gad.1230004 <jats:p>Large gene complexes frequently use “specialized” DNA elements to ensure proper regulation of gene activities. The Promoter Targeting Sequence (PTS) from the <jats:italic>Abdominal-B</jats:italic> locus of the <jats:italic>Drosophila</jats:italic> Bithorax complex overcomes an insulator, and facilitates, yet restricts, distant enhancers to a single promoter. We found that this promoter-targeting activity is independent of an enhancer's tissue or temporal specificity, and can be remembered in all somatic cells in the absence of promoter activation. It requires an insulator for its establishment, but can be maintained by the PTS in the absence of an insulator. More importantly, the promoter-targeting activity can be remembered after the transgene is translocated to new chromosomal locations. These results suggest that promoter targeting is established independent of enhancer activity, and is maintained epigenetically throughout development and subsequent generations.</jats:p> The Promoter Targeting Sequence mediates epigenetically heritable transcription memory Genes & Development |
| spellingShingle | Lin, Qing, Chen, Qi, Lin, Lan, Zhou, Jumin, Genes & Development, The Promoter Targeting Sequence mediates epigenetically heritable transcription memory, Developmental Biology, Genetics |
| title | The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| title_full | The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| title_fullStr | The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| title_full_unstemmed | The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| title_short | The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| title_sort | the promoter targeting sequence mediates epigenetically heritable transcription memory |
| title_unstemmed | The Promoter Targeting Sequence mediates epigenetically heritable transcription memory |
| topic | Developmental Biology, Genetics |
| url | http://dx.doi.org/10.1101/gad.1230004 |