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Neutrophils in host defense: new insights from zebrafish
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| Zeitschriftentitel: | Journal of Leukocyte Biology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Leukocyte Biology, 98, 2015, 4, S. 523-537 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
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Harvie, Elizabeth A Huttenlocher, Anna Harvie, Elizabeth A Huttenlocher, Anna |
|---|---|
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Harvie, Elizabeth A Huttenlocher, Anna |
| spellingShingle |
Harvie, Elizabeth A Huttenlocher, Anna Journal of Leukocyte Biology Neutrophils in host defense: new insights from zebrafish Cell Biology Immunology Immunology and Allergy |
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harvie, elizabeth a |
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Harvie, Elizabeth A Huttenlocher, Anna 0741-5400 1938-3673 Oxford University Press (OUP) Cell Biology Immunology Immunology and Allergy http://dx.doi.org/10.1189/jlb.4mr1114-524r <jats:title>Abstract</jats:title> <jats:p>Neutrophils are highly motile phagocytic cells that play a critical role in the immune response to infection. Zebrafish (Danio rerio) are increasingly used to study neutrophil function and host-pathogen interactions. The generation of transgenic zebrafish lines with fluorescently labeled leukocytes has made it possible to visualize the neutrophil response to infection in real time by use of optically transparent zebrafish larvae. In addition, the genetic tractability of zebrafish has allowed for the generation of models of inherited neutrophil disorders. In this review, we discuss several zebrafish models of infectious disease, both in the context of immunocompetent, as well as neutrophil-deficient hosts and how these models have shed light on neutrophil behavior during infection.</jats:p> Neutrophils in host defense: new insights from zebrafish Journal of Leukocyte Biology |
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Neutrophils in host defense: new insights from zebrafish |
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Neutrophils in host defense: new insights from zebrafish |
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Neutrophils in host defense: new insights from zebrafish |
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Neutrophils in host defense: new insights from zebrafish |
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Neutrophils in host defense: new insights from zebrafish |
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Neutrophils in host defense: new insights from zebrafish |
| title_sort |
neutrophils in host defense: new insights from zebrafish |
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Cell Biology Immunology Immunology and Allergy |
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http://dx.doi.org/10.1189/jlb.4mr1114-524r |
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2015 |
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523-537 |
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<jats:title>Abstract</jats:title>
<jats:p>Neutrophils are highly motile phagocytic cells that play a critical role in the immune response to infection. Zebrafish (Danio rerio) are increasingly used to study neutrophil function and host-pathogen interactions. The generation of transgenic zebrafish lines with fluorescently labeled leukocytes has made it possible to visualize the neutrophil response to infection in real time by use of optically transparent zebrafish larvae. In addition, the genetic tractability of zebrafish has allowed for the generation of models of inherited neutrophil disorders. In this review, we discuss several zebrafish models of infectious disease, both in the context of immunocompetent, as well as neutrophil-deficient hosts and how these models have shed light on neutrophil behavior during infection.</jats:p> |
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| author | Harvie, Elizabeth A, Huttenlocher, Anna |
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| description | <jats:title>Abstract</jats:title> <jats:p>Neutrophils are highly motile phagocytic cells that play a critical role in the immune response to infection. Zebrafish (Danio rerio) are increasingly used to study neutrophil function and host-pathogen interactions. The generation of transgenic zebrafish lines with fluorescently labeled leukocytes has made it possible to visualize the neutrophil response to infection in real time by use of optically transparent zebrafish larvae. In addition, the genetic tractability of zebrafish has allowed for the generation of models of inherited neutrophil disorders. In this review, we discuss several zebrafish models of infectious disease, both in the context of immunocompetent, as well as neutrophil-deficient hosts and how these models have shed light on neutrophil behavior during infection.</jats:p> |
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| imprint | Oxford University Press (OUP), 2015 |
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| spelling | Harvie, Elizabeth A Huttenlocher, Anna 0741-5400 1938-3673 Oxford University Press (OUP) Cell Biology Immunology Immunology and Allergy http://dx.doi.org/10.1189/jlb.4mr1114-524r <jats:title>Abstract</jats:title> <jats:p>Neutrophils are highly motile phagocytic cells that play a critical role in the immune response to infection. Zebrafish (Danio rerio) are increasingly used to study neutrophil function and host-pathogen interactions. The generation of transgenic zebrafish lines with fluorescently labeled leukocytes has made it possible to visualize the neutrophil response to infection in real time by use of optically transparent zebrafish larvae. In addition, the genetic tractability of zebrafish has allowed for the generation of models of inherited neutrophil disorders. In this review, we discuss several zebrafish models of infectious disease, both in the context of immunocompetent, as well as neutrophil-deficient hosts and how these models have shed light on neutrophil behavior during infection.</jats:p> Neutrophils in host defense: new insights from zebrafish Journal of Leukocyte Biology |
| spellingShingle | Harvie, Elizabeth A, Huttenlocher, Anna, Journal of Leukocyte Biology, Neutrophils in host defense: new insights from zebrafish, Cell Biology, Immunology, Immunology and Allergy |
| title | Neutrophils in host defense: new insights from zebrafish |
| title_full | Neutrophils in host defense: new insights from zebrafish |
| title_fullStr | Neutrophils in host defense: new insights from zebrafish |
| title_full_unstemmed | Neutrophils in host defense: new insights from zebrafish |
| title_short | Neutrophils in host defense: new insights from zebrafish |
| title_sort | neutrophils in host defense: new insights from zebrafish |
| title_unstemmed | Neutrophils in host defense: new insights from zebrafish |
| topic | Cell Biology, Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1189/jlb.4mr1114-524r |