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BORIS/CTCFL is an RNA-binding protein that associates with polysomes
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| Zeitschriftentitel: | BMC Cell Biology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | BMC Cell Biology, 14, 2013, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Springer Science and Business Media LLC
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| Schlagwörter: |
| author_facet |
Ogunkolade, Babatunji W Jones, Tania A Aarum, Johan Szary, Jaroslaw Owen, Nicholas Ottaviani, Diego Mumin, Muhammad A Patel, Shyam Pieri, Christopher A Silver, Andrew R Sheer, Denise Ogunkolade, Babatunji W Jones, Tania A Aarum, Johan Szary, Jaroslaw Owen, Nicholas Ottaviani, Diego Mumin, Muhammad A Patel, Shyam Pieri, Christopher A Silver, Andrew R Sheer, Denise |
|---|---|
| author |
Ogunkolade, Babatunji W Jones, Tania A Aarum, Johan Szary, Jaroslaw Owen, Nicholas Ottaviani, Diego Mumin, Muhammad A Patel, Shyam Pieri, Christopher A Silver, Andrew R Sheer, Denise |
| spellingShingle |
Ogunkolade, Babatunji W Jones, Tania A Aarum, Johan Szary, Jaroslaw Owen, Nicholas Ottaviani, Diego Mumin, Muhammad A Patel, Shyam Pieri, Christopher A Silver, Andrew R Sheer, Denise BMC Cell Biology BORIS/CTCFL is an RNA-binding protein that associates with polysomes Cell Biology |
| author_sort |
ogunkolade, babatunji w |
| spelling |
Ogunkolade, Babatunji W Jones, Tania A Aarum, Johan Szary, Jaroslaw Owen, Nicholas Ottaviani, Diego Mumin, Muhammad A Patel, Shyam Pieri, Christopher A Silver, Andrew R Sheer, Denise 1471-2121 Springer Science and Business Media LLC Cell Biology http://dx.doi.org/10.1186/1471-2121-14-52 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>BORIS (CTCFL), a paralogue of the multifunctional and ubiquitously expressed transcription factor CTCF, is best known for its role in transcriptional regulation. In the nucleus, BORIS is particularly enriched in the nucleolus, a crucial compartment for ribosomal RNA and RNA metabolism. However, little is known about cytoplasmic BORIS, which represents the major pool of BORIS protein.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>We show, firstly, that BORIS has a putative nuclear export signal in the C-terminal domain. Furthermore, BORIS associates with mRNA in both neural stem cells and young neurons. The majority of the BORIS-associated transcripts are different in the two cell types. Finally, by using polysome profiling we show that BORIS is associated with actively translating ribosomes.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>We have demonstrated the RNA binding properties of cellular BORIS and its association with actively translating ribosomes. We suggest that BORIS is involved in gene expression at both the transcriptional and post-transcriptional levels.</jats:p> </jats:sec> BORIS/CTCFL is an RNA-binding protein that associates with polysomes BMC Cell Biology |
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10.1186/1471-2121-14-52 |
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Online Free |
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Springer Science and Business Media LLC, 2013 |
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Springer Science and Business Media LLC, 2013 |
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2013 |
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Springer Science and Business Media LLC |
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BMC Cell Biology |
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49 |
| title |
BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| title_unstemmed |
BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| title_full |
BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| title_fullStr |
BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| title_full_unstemmed |
BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| title_short |
BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| title_sort |
boris/ctcfl is an rna-binding protein that associates with polysomes |
| topic |
Cell Biology |
| url |
http://dx.doi.org/10.1186/1471-2121-14-52 |
| publishDate |
2013 |
| physical |
|
| description |
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Background</jats:title>
<jats:p>BORIS (CTCFL), a paralogue of the multifunctional and ubiquitously expressed transcription factor CTCF, is best known for its role in transcriptional regulation. In the nucleus, BORIS is particularly enriched in the nucleolus, a crucial compartment for ribosomal RNA and RNA metabolism. However, little is known about cytoplasmic BORIS, which represents the major pool of BORIS protein.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>We show, firstly, that BORIS has a putative nuclear export signal in the C-terminal domain. Furthermore, BORIS associates with mRNA in both neural stem cells and young neurons. The majority of the BORIS-associated transcripts are different in the two cell types. Finally, by using polysome profiling we show that BORIS is associated with actively translating ribosomes.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>We have demonstrated the RNA binding properties of cellular BORIS and its association with actively translating ribosomes. We suggest that BORIS is involved in gene expression at both the transcriptional and post-transcriptional levels.</jats:p>
</jats:sec> |
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| author | Ogunkolade, Babatunji W, Jones, Tania A, Aarum, Johan, Szary, Jaroslaw, Owen, Nicholas, Ottaviani, Diego, Mumin, Muhammad A, Patel, Shyam, Pieri, Christopher A, Silver, Andrew R, Sheer, Denise |
| author_facet | Ogunkolade, Babatunji W, Jones, Tania A, Aarum, Johan, Szary, Jaroslaw, Owen, Nicholas, Ottaviani, Diego, Mumin, Muhammad A, Patel, Shyam, Pieri, Christopher A, Silver, Andrew R, Sheer, Denise, Ogunkolade, Babatunji W, Jones, Tania A, Aarum, Johan, Szary, Jaroslaw, Owen, Nicholas, Ottaviani, Diego, Mumin, Muhammad A, Patel, Shyam, Pieri, Christopher A, Silver, Andrew R, Sheer, Denise |
| author_sort | ogunkolade, babatunji w |
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| description | <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>BORIS (CTCFL), a paralogue of the multifunctional and ubiquitously expressed transcription factor CTCF, is best known for its role in transcriptional regulation. In the nucleus, BORIS is particularly enriched in the nucleolus, a crucial compartment for ribosomal RNA and RNA metabolism. However, little is known about cytoplasmic BORIS, which represents the major pool of BORIS protein.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>We show, firstly, that BORIS has a putative nuclear export signal in the C-terminal domain. Furthermore, BORIS associates with mRNA in both neural stem cells and young neurons. The majority of the BORIS-associated transcripts are different in the two cell types. Finally, by using polysome profiling we show that BORIS is associated with actively translating ribosomes.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>We have demonstrated the RNA binding properties of cellular BORIS and its association with actively translating ribosomes. We suggest that BORIS is involved in gene expression at both the transcriptional and post-transcriptional levels.</jats:p> </jats:sec> |
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| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 1471-2121 |
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| spelling | Ogunkolade, Babatunji W Jones, Tania A Aarum, Johan Szary, Jaroslaw Owen, Nicholas Ottaviani, Diego Mumin, Muhammad A Patel, Shyam Pieri, Christopher A Silver, Andrew R Sheer, Denise 1471-2121 Springer Science and Business Media LLC Cell Biology http://dx.doi.org/10.1186/1471-2121-14-52 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>BORIS (CTCFL), a paralogue of the multifunctional and ubiquitously expressed transcription factor CTCF, is best known for its role in transcriptional regulation. In the nucleus, BORIS is particularly enriched in the nucleolus, a crucial compartment for ribosomal RNA and RNA metabolism. However, little is known about cytoplasmic BORIS, which represents the major pool of BORIS protein.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>We show, firstly, that BORIS has a putative nuclear export signal in the C-terminal domain. Furthermore, BORIS associates with mRNA in both neural stem cells and young neurons. The majority of the BORIS-associated transcripts are different in the two cell types. Finally, by using polysome profiling we show that BORIS is associated with actively translating ribosomes.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>We have demonstrated the RNA binding properties of cellular BORIS and its association with actively translating ribosomes. We suggest that BORIS is involved in gene expression at both the transcriptional and post-transcriptional levels.</jats:p> </jats:sec> BORIS/CTCFL is an RNA-binding protein that associates with polysomes BMC Cell Biology |
| spellingShingle | Ogunkolade, Babatunji W, Jones, Tania A, Aarum, Johan, Szary, Jaroslaw, Owen, Nicholas, Ottaviani, Diego, Mumin, Muhammad A, Patel, Shyam, Pieri, Christopher A, Silver, Andrew R, Sheer, Denise, BMC Cell Biology, BORIS/CTCFL is an RNA-binding protein that associates with polysomes, Cell Biology |
| title | BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| title_full | BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| title_fullStr | BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| title_full_unstemmed | BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| title_short | BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| title_sort | boris/ctcfl is an rna-binding protein that associates with polysomes |
| title_unstemmed | BORIS/CTCFL is an RNA-binding protein that associates with polysomes |
| topic | Cell Biology |
| url | http://dx.doi.org/10.1186/1471-2121-14-52 |