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Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model
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| Zeitschriftentitel: | Journal of Translational Medicine |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Journal of Translational Medicine, 7, 2009, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Springer Science and Business Media LLC
|
| Schlagwörter: |
| author_facet |
Kvist, Peter H Svensson, Lars Hagberg, Oskar Hoffmann, Vibeke Kemp, Kaare Røpke, Mads A Kvist, Peter H Svensson, Lars Hagberg, Oskar Hoffmann, Vibeke Kemp, Kaare Røpke, Mads A |
|---|---|
| author |
Kvist, Peter H Svensson, Lars Hagberg, Oskar Hoffmann, Vibeke Kemp, Kaare Røpke, Mads A |
| spellingShingle |
Kvist, Peter H Svensson, Lars Hagberg, Oskar Hoffmann, Vibeke Kemp, Kaare Røpke, Mads A Journal of Translational Medicine Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model General Biochemistry, Genetics and Molecular Biology General Medicine |
| author_sort |
kvist, peter h |
| spelling |
Kvist, Peter H Svensson, Lars Hagberg, Oskar Hoffmann, Vibeke Kemp, Kaare Røpke, Mads A 1479-5876 Springer Science and Business Media LLC General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1186/1479-5876-7-107 <jats:title>Abstract</jats:title><jats:p>The aim of the present study was to compare the effects of Daivobet<jats:sup>®</jats:sup>and calcipotriol on clinical score and biomarker responses in a modified version of the Scholtz-Dumas psoriasis plaque assay. Furthermore, it was the aim to compare the effects of calcipotriol and betamethasone in the murine psoriasis xenograft model. Twenty four patients with psoriasis were treated topically once daily for three weeks, whereas the grafted mice were treated for four weeks. Clinical responses were scored twice weekly and biopsies were taken at the end of each study to analyse for skin biomarkers by histology and immunohistochemistry. The results clearly demonstrate effects on both clinical signs and biomarkers. In the patient study the total clinical score was reduced significantly with both Daivobet<jats:sup>®</jats:sup>and calcipotriol. Both treatments reduced epidermal thickness, Ki-67 and cytokeratin 16 expression. T cell infiltration was significantly reduced by Daivobet<jats:sup>®</jats:sup>but only marginally by calcipotriol. Both treatments showed strong effects on the epidermal psoriatic phenotype.</jats:p><jats:p>Results from the xenograft model essentially showed the same results. However differences were observed when investigating subtypes of T cells.</jats:p><jats:p>The study demonstrates the feasibility of obtaining robust biomarker data in the psoriasis plaque test that correlate well with those obtained in other clinical studies. Furthermore, the biomarker data from the plaque test correlate with biopsy data from the grafted mice.</jats:p> Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model Journal of Translational Medicine |
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| title |
Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_unstemmed |
Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_full |
Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_fullStr |
Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_full_unstemmed |
Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_short |
Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_sort |
comparison of the effects of vitamin d products in a psoriasis plaque test and a murine psoriasis xenograft model |
| topic |
General Biochemistry, Genetics and Molecular Biology General Medicine |
| url |
http://dx.doi.org/10.1186/1479-5876-7-107 |
| publishDate |
2009 |
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|
| description |
<jats:title>Abstract</jats:title><jats:p>The aim of the present study was to compare the effects of Daivobet<jats:sup>®</jats:sup>and calcipotriol on clinical score and biomarker responses in a modified version of the Scholtz-Dumas psoriasis plaque assay. Furthermore, it was the aim to compare the effects of calcipotriol and betamethasone in the murine psoriasis xenograft model. Twenty four patients with psoriasis were treated topically once daily for three weeks, whereas the grafted mice were treated for four weeks. Clinical responses were scored twice weekly and biopsies were taken at the end of each study to analyse for skin biomarkers by histology and immunohistochemistry. The results clearly demonstrate effects on both clinical signs and biomarkers. In the patient study the total clinical score was reduced significantly with both Daivobet<jats:sup>®</jats:sup>and calcipotriol. Both treatments reduced epidermal thickness, Ki-67 and cytokeratin 16 expression. T cell infiltration was significantly reduced by Daivobet<jats:sup>®</jats:sup>but only marginally by calcipotriol. Both treatments showed strong effects on the epidermal psoriatic phenotype.</jats:p><jats:p>Results from the xenograft model essentially showed the same results. However differences were observed when investigating subtypes of T cells.</jats:p><jats:p>The study demonstrates the feasibility of obtaining robust biomarker data in the psoriasis plaque test that correlate well with those obtained in other clinical studies. Furthermore, the biomarker data from the plaque test correlate with biopsy data from the grafted mice.</jats:p> |
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| author | Kvist, Peter H, Svensson, Lars, Hagberg, Oskar, Hoffmann, Vibeke, Kemp, Kaare, Røpke, Mads A |
| author_facet | Kvist, Peter H, Svensson, Lars, Hagberg, Oskar, Hoffmann, Vibeke, Kemp, Kaare, Røpke, Mads A, Kvist, Peter H, Svensson, Lars, Hagberg, Oskar, Hoffmann, Vibeke, Kemp, Kaare, Røpke, Mads A |
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| description | <jats:title>Abstract</jats:title><jats:p>The aim of the present study was to compare the effects of Daivobet<jats:sup>®</jats:sup>and calcipotriol on clinical score and biomarker responses in a modified version of the Scholtz-Dumas psoriasis plaque assay. Furthermore, it was the aim to compare the effects of calcipotriol and betamethasone in the murine psoriasis xenograft model. Twenty four patients with psoriasis were treated topically once daily for three weeks, whereas the grafted mice were treated for four weeks. Clinical responses were scored twice weekly and biopsies were taken at the end of each study to analyse for skin biomarkers by histology and immunohistochemistry. The results clearly demonstrate effects on both clinical signs and biomarkers. In the patient study the total clinical score was reduced significantly with both Daivobet<jats:sup>®</jats:sup>and calcipotriol. Both treatments reduced epidermal thickness, Ki-67 and cytokeratin 16 expression. T cell infiltration was significantly reduced by Daivobet<jats:sup>®</jats:sup>but only marginally by calcipotriol. Both treatments showed strong effects on the epidermal psoriatic phenotype.</jats:p><jats:p>Results from the xenograft model essentially showed the same results. However differences were observed when investigating subtypes of T cells.</jats:p><jats:p>The study demonstrates the feasibility of obtaining robust biomarker data in the psoriasis plaque test that correlate well with those obtained in other clinical studies. Furthermore, the biomarker data from the plaque test correlate with biopsy data from the grafted mice.</jats:p> |
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| spelling | Kvist, Peter H Svensson, Lars Hagberg, Oskar Hoffmann, Vibeke Kemp, Kaare Røpke, Mads A 1479-5876 Springer Science and Business Media LLC General Biochemistry, Genetics and Molecular Biology General Medicine http://dx.doi.org/10.1186/1479-5876-7-107 <jats:title>Abstract</jats:title><jats:p>The aim of the present study was to compare the effects of Daivobet<jats:sup>®</jats:sup>and calcipotriol on clinical score and biomarker responses in a modified version of the Scholtz-Dumas psoriasis plaque assay. Furthermore, it was the aim to compare the effects of calcipotriol and betamethasone in the murine psoriasis xenograft model. Twenty four patients with psoriasis were treated topically once daily for three weeks, whereas the grafted mice were treated for four weeks. Clinical responses were scored twice weekly and biopsies were taken at the end of each study to analyse for skin biomarkers by histology and immunohistochemistry. The results clearly demonstrate effects on both clinical signs and biomarkers. In the patient study the total clinical score was reduced significantly with both Daivobet<jats:sup>®</jats:sup>and calcipotriol. Both treatments reduced epidermal thickness, Ki-67 and cytokeratin 16 expression. T cell infiltration was significantly reduced by Daivobet<jats:sup>®</jats:sup>but only marginally by calcipotriol. Both treatments showed strong effects on the epidermal psoriatic phenotype.</jats:p><jats:p>Results from the xenograft model essentially showed the same results. However differences were observed when investigating subtypes of T cells.</jats:p><jats:p>The study demonstrates the feasibility of obtaining robust biomarker data in the psoriasis plaque test that correlate well with those obtained in other clinical studies. Furthermore, the biomarker data from the plaque test correlate with biopsy data from the grafted mice.</jats:p> Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model Journal of Translational Medicine |
| spellingShingle | Kvist, Peter H, Svensson, Lars, Hagberg, Oskar, Hoffmann, Vibeke, Kemp, Kaare, Røpke, Mads A, Journal of Translational Medicine, Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model, General Biochemistry, Genetics and Molecular Biology, General Medicine |
| title | Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_full | Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_fullStr | Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_full_unstemmed | Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_short | Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_sort | comparison of the effects of vitamin d products in a psoriasis plaque test and a murine psoriasis xenograft model |
| title_unstemmed | Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model |
| topic | General Biochemistry, Genetics and Molecular Biology, General Medicine |
| url | http://dx.doi.org/10.1186/1479-5876-7-107 |