Eintrag weiter verarbeiten
Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer
Gespeichert in:
| Zeitschriftentitel: | World Journal of Surgical Oncology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | World Journal of Surgical Oncology, 7, 2009, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Springer Science and Business Media LLC
|
| Schlagwörter: |
| author_facet |
Guardiola, Emmanuel Delroeux, Delphine Heyd, Bruno Combe, Marielle Lorgis, Veronique Demarchi, Martin Stein, Ulrich Royer, Bernard Chauffert, Bruno Pivot, Xavier Guardiola, Emmanuel Delroeux, Delphine Heyd, Bruno Combe, Marielle Lorgis, Veronique Demarchi, Martin Stein, Ulrich Royer, Bernard Chauffert, Bruno Pivot, Xavier |
|---|---|
| author |
Guardiola, Emmanuel Delroeux, Delphine Heyd, Bruno Combe, Marielle Lorgis, Veronique Demarchi, Martin Stein, Ulrich Royer, Bernard Chauffert, Bruno Pivot, Xavier |
| spellingShingle |
Guardiola, Emmanuel Delroeux, Delphine Heyd, Bruno Combe, Marielle Lorgis, Veronique Demarchi, Martin Stein, Ulrich Royer, Bernard Chauffert, Bruno Pivot, Xavier World Journal of Surgical Oncology Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer Oncology Surgery |
| author_sort |
guardiola, emmanuel |
| spelling |
Guardiola, Emmanuel Delroeux, Delphine Heyd, Bruno Combe, Marielle Lorgis, Veronique Demarchi, Martin Stein, Ulrich Royer, Bernard Chauffert, Bruno Pivot, Xavier 1477-7819 Springer Science and Business Media LLC Oncology Surgery http://dx.doi.org/10.1186/1477-7819-7-14 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Intra-peritoneal (i.p.) chemotherapy is an encouraging treatment option for ovarian cancer with peritoneum involvement in addition with intravenous (i.v.) chemotherapy. Intra-operative i.p. chemotherapy is an interesting method of administration by enhancing the diffusion of chemotherapy. This study had assessed the feasibility of intra-operative i.p. chemotherapy in patients with peritoneal carcinoma of ovarian cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>From January 2003 to February 2006, 47 patients with stage III ovarian cancer were treated with standard paclitaxel carboplatin intravenous chemotherapy and debulking surgery with intra-operative i.p. chemotherapy. After optimal cytoreductive surgery, defined by no unresectable residual disease > 1 cm, i.p. chemotherapy was performed during surgery. The peritoneal cavity was filled by 3 litres of isotonic saline pre-heated at 37 degrees and 90 mg of cisplatin. The sequence was repeated twice during 2 hours based on previous published studies which optimized the cisplatin dosage and exposure duration. Optimal diffusion was obtained by stirring by hands during the 2 hours.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Median age was 59.6 years. No severe haematological or non-haematological toxicity induced by intra operative i.p. chemotherapy was reported. No patient died due to the complications of surgery or the i.p. chemotherapy. No neurotoxicity occurred, and one patients had renal impairment.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>This study demonstrates the feasibility of intra-operative i.p. chemotherapy with cisplatin after optimal resection of peritoneal tumor nodules. Further randomized trials are planned to investigate the clinical benefit of this therapeutic modality.</jats:p> </jats:sec> Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer World Journal of Surgical Oncology |
| doi_str_mv |
10.1186/1477-7819-7-14 |
| facet_avail |
Online Free |
| finc_class_facet |
Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Ni8xNDc3LTc4MTktNy0xNA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Ni8xNDc3LTc4MTktNy0xNA |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
Springer Science and Business Media LLC, 2009 |
| imprint_str_mv |
Springer Science and Business Media LLC, 2009 |
| issn |
1477-7819 |
| issn_str_mv |
1477-7819 |
| language |
English |
| mega_collection |
Springer Science and Business Media LLC (CrossRef) |
| match_str |
guardiola2009intraoperativeintraperitonealchemotherapywithcisplatininpatientswithperitonealcarcinomatosisofovariancancer |
| publishDateSort |
2009 |
| publisher |
Springer Science and Business Media LLC |
| recordtype |
ai |
| record_format |
ai |
| series |
World Journal of Surgical Oncology |
| source_id |
49 |
| title |
Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_unstemmed |
Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_full |
Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_fullStr |
Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_full_unstemmed |
Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_short |
Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_sort |
intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| topic |
Oncology Surgery |
| url |
http://dx.doi.org/10.1186/1477-7819-7-14 |
| publishDate |
2009 |
| physical |
|
| description |
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Background</jats:title>
<jats:p>Intra-peritoneal (i.p.) chemotherapy is an encouraging treatment option for ovarian cancer with peritoneum involvement in addition with intravenous (i.v.) chemotherapy. Intra-operative i.p. chemotherapy is an interesting method of administration by enhancing the diffusion of chemotherapy. This study had assessed the feasibility of intra-operative i.p. chemotherapy in patients with peritoneal carcinoma of ovarian cancer.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>From January 2003 to February 2006, 47 patients with stage III ovarian cancer were treated with standard paclitaxel carboplatin intravenous chemotherapy and debulking surgery with intra-operative i.p. chemotherapy. After optimal cytoreductive surgery, defined by no unresectable residual disease > 1 cm, i.p. chemotherapy was performed during surgery. The peritoneal cavity was filled by 3 litres of isotonic saline pre-heated at 37 degrees and 90 mg of cisplatin. The sequence was repeated twice during 2 hours based on previous published studies which optimized the cisplatin dosage and exposure duration. Optimal diffusion was obtained by stirring by hands during the 2 hours.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>Median age was 59.6 years. No severe haematological or non-haematological toxicity induced by intra operative i.p. chemotherapy was reported. No patient died due to the complications of surgery or the i.p. chemotherapy. No neurotoxicity occurred, and one patients had renal impairment.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>This study demonstrates the feasibility of intra-operative i.p. chemotherapy with cisplatin after optimal resection of peritoneal tumor nodules. Further randomized trials are planned to investigate the clinical benefit of this therapeutic modality.</jats:p>
</jats:sec> |
| container_issue |
1 |
| container_start_page |
0 |
| container_title |
World Journal of Surgical Oncology |
| container_volume |
7 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792332985711722499 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:05:34.215Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Intra-operative+intra-peritoneal+chemotherapy+with+cisplatin+in+patients+with+peritoneal+carcinomatosis+of+ovarian+cancer&rft.date=2009-12-01&genre=article&issn=1477-7819&volume=7&issue=1&jtitle=World+Journal+of+Surgical+Oncology&atitle=Intra-operative+intra-peritoneal+chemotherapy+with+cisplatin+in+patients+with+peritoneal+carcinomatosis+of+ovarian+cancer&aulast=Pivot&aufirst=Xavier&rft_id=info%3Adoi%2F10.1186%2F1477-7819-7-14&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792332985711722499 |
| author | Guardiola, Emmanuel, Delroeux, Delphine, Heyd, Bruno, Combe, Marielle, Lorgis, Veronique, Demarchi, Martin, Stein, Ulrich, Royer, Bernard, Chauffert, Bruno, Pivot, Xavier |
| author_facet | Guardiola, Emmanuel, Delroeux, Delphine, Heyd, Bruno, Combe, Marielle, Lorgis, Veronique, Demarchi, Martin, Stein, Ulrich, Royer, Bernard, Chauffert, Bruno, Pivot, Xavier, Guardiola, Emmanuel, Delroeux, Delphine, Heyd, Bruno, Combe, Marielle, Lorgis, Veronique, Demarchi, Martin, Stein, Ulrich, Royer, Bernard, Chauffert, Bruno, Pivot, Xavier |
| author_sort | guardiola, emmanuel |
| container_issue | 1 |
| container_start_page | 0 |
| container_title | World Journal of Surgical Oncology |
| container_volume | 7 |
| description | <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Intra-peritoneal (i.p.) chemotherapy is an encouraging treatment option for ovarian cancer with peritoneum involvement in addition with intravenous (i.v.) chemotherapy. Intra-operative i.p. chemotherapy is an interesting method of administration by enhancing the diffusion of chemotherapy. This study had assessed the feasibility of intra-operative i.p. chemotherapy in patients with peritoneal carcinoma of ovarian cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>From January 2003 to February 2006, 47 patients with stage III ovarian cancer were treated with standard paclitaxel carboplatin intravenous chemotherapy and debulking surgery with intra-operative i.p. chemotherapy. After optimal cytoreductive surgery, defined by no unresectable residual disease > 1 cm, i.p. chemotherapy was performed during surgery. The peritoneal cavity was filled by 3 litres of isotonic saline pre-heated at 37 degrees and 90 mg of cisplatin. The sequence was repeated twice during 2 hours based on previous published studies which optimized the cisplatin dosage and exposure duration. Optimal diffusion was obtained by stirring by hands during the 2 hours.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Median age was 59.6 years. No severe haematological or non-haematological toxicity induced by intra operative i.p. chemotherapy was reported. No patient died due to the complications of surgery or the i.p. chemotherapy. No neurotoxicity occurred, and one patients had renal impairment.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>This study demonstrates the feasibility of intra-operative i.p. chemotherapy with cisplatin after optimal resection of peritoneal tumor nodules. Further randomized trials are planned to investigate the clinical benefit of this therapeutic modality.</jats:p> </jats:sec> |
| doi_str_mv | 10.1186/1477-7819-7-14 |
| facet_avail | Online, Free |
| finc_class_facet | Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Ni8xNDc3LTc4MTktNy0xNA |
| imprint | Springer Science and Business Media LLC, 2009 |
| imprint_str_mv | Springer Science and Business Media LLC, 2009 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 1477-7819 |
| issn_str_mv | 1477-7819 |
| language | English |
| last_indexed | 2024-03-01T14:05:34.215Z |
| match_str | guardiola2009intraoperativeintraperitonealchemotherapywithcisplatininpatientswithperitonealcarcinomatosisofovariancancer |
| mega_collection | Springer Science and Business Media LLC (CrossRef) |
| physical | |
| publishDate | 2009 |
| publishDateSort | 2009 |
| publisher | Springer Science and Business Media LLC |
| record_format | ai |
| recordtype | ai |
| series | World Journal of Surgical Oncology |
| source_id | 49 |
| spelling | Guardiola, Emmanuel Delroeux, Delphine Heyd, Bruno Combe, Marielle Lorgis, Veronique Demarchi, Martin Stein, Ulrich Royer, Bernard Chauffert, Bruno Pivot, Xavier 1477-7819 Springer Science and Business Media LLC Oncology Surgery http://dx.doi.org/10.1186/1477-7819-7-14 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Intra-peritoneal (i.p.) chemotherapy is an encouraging treatment option for ovarian cancer with peritoneum involvement in addition with intravenous (i.v.) chemotherapy. Intra-operative i.p. chemotherapy is an interesting method of administration by enhancing the diffusion of chemotherapy. This study had assessed the feasibility of intra-operative i.p. chemotherapy in patients with peritoneal carcinoma of ovarian cancer.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>From January 2003 to February 2006, 47 patients with stage III ovarian cancer were treated with standard paclitaxel carboplatin intravenous chemotherapy and debulking surgery with intra-operative i.p. chemotherapy. After optimal cytoreductive surgery, defined by no unresectable residual disease > 1 cm, i.p. chemotherapy was performed during surgery. The peritoneal cavity was filled by 3 litres of isotonic saline pre-heated at 37 degrees and 90 mg of cisplatin. The sequence was repeated twice during 2 hours based on previous published studies which optimized the cisplatin dosage and exposure duration. Optimal diffusion was obtained by stirring by hands during the 2 hours.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Median age was 59.6 years. No severe haematological or non-haematological toxicity induced by intra operative i.p. chemotherapy was reported. No patient died due to the complications of surgery or the i.p. chemotherapy. No neurotoxicity occurred, and one patients had renal impairment.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>This study demonstrates the feasibility of intra-operative i.p. chemotherapy with cisplatin after optimal resection of peritoneal tumor nodules. Further randomized trials are planned to investigate the clinical benefit of this therapeutic modality.</jats:p> </jats:sec> Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer World Journal of Surgical Oncology |
| spellingShingle | Guardiola, Emmanuel, Delroeux, Delphine, Heyd, Bruno, Combe, Marielle, Lorgis, Veronique, Demarchi, Martin, Stein, Ulrich, Royer, Bernard, Chauffert, Bruno, Pivot, Xavier, World Journal of Surgical Oncology, Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer, Oncology, Surgery |
| title | Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_full | Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_fullStr | Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_full_unstemmed | Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_short | Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_sort | intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| title_unstemmed | Intra-operative intra-peritoneal chemotherapy with cisplatin in patients with peritoneal carcinomatosis of ovarian cancer |
| topic | Oncology, Surgery |
| url | http://dx.doi.org/10.1186/1477-7819-7-14 |