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Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report
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| Zeitschriftentitel: | Cardiovascular Ultrasound |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Cardiovascular Ultrasound, 3, 2005, 1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Springer Science and Business Media LLC
|
| Schlagwörter: |
| author_facet |
Jochmann, Nicoline Kiecker, Felix Borges, Adrian C Hofmann, Maja A Eddicks, Stephan Sterry, Wolfram Baumann, Gert Trefzer, Uwe Jochmann, Nicoline Kiecker, Felix Borges, Adrian C Hofmann, Maja A Eddicks, Stephan Sterry, Wolfram Baumann, Gert Trefzer, Uwe |
|---|---|
| author |
Jochmann, Nicoline Kiecker, Felix Borges, Adrian C Hofmann, Maja A Eddicks, Stephan Sterry, Wolfram Baumann, Gert Trefzer, Uwe |
| spellingShingle |
Jochmann, Nicoline Kiecker, Felix Borges, Adrian C Hofmann, Maja A Eddicks, Stephan Sterry, Wolfram Baumann, Gert Trefzer, Uwe Cardiovascular Ultrasound Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report Cardiology and Cardiovascular Medicine Radiology, Nuclear Medicine and imaging General Medicine |
| author_sort |
jochmann, nicoline |
| spelling |
Jochmann, Nicoline Kiecker, Felix Borges, Adrian C Hofmann, Maja A Eddicks, Stephan Sterry, Wolfram Baumann, Gert Trefzer, Uwe 1476-7120 Springer Science and Business Media LLC Cardiology and Cardiovascular Medicine Radiology, Nuclear Medicine and imaging General Medicine http://dx.doi.org/10.1186/1476-7120-3-26 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>background</jats:title> <jats:p>Interferon alpha2 is widely used in hepatitis and high-risk melanoma. Interferon-induced pulmonary arterial hypertension as a side effect is rare.</jats:p> </jats:sec> <jats:sec> <jats:title>Case presentation</jats:title> <jats:p>We describe a melanoma patient who developed severe pulmonary arterial hypertension 30 months after initiation of adjuvant interferon alpha2b therapy. Discontinuation of interferon did not improve pulmonary arterial hypertension. This patient could be treated successfully with phosphodiesterase-5 inhibitor therapy.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>This is only the 5th case of interferon-induced pulmonary arterial hypertension and the first documented case where pulmonary arterial hypertension was not reversible after termination of interferon alpha2 therapy. If interferon alpha2 treated patients develop respiratory symptoms, pulmonary arterial hypertension should be considered in the differential diagnosis. For these patients phosphodiesterase-5 inhibitors, e.g. sildenafil or vardenafil, could be an effective therapeutic approach.</jats:p> </jats:sec> Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report Cardiovascular Ultrasound |
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Springer Science and Business Media LLC, 2005 |
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2005 |
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| title |
Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| title_unstemmed |
Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| title_full |
Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| title_fullStr |
Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| title_full_unstemmed |
Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| title_short |
Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| title_sort |
long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different pde-5 inhibitors: a case report |
| topic |
Cardiology and Cardiovascular Medicine Radiology, Nuclear Medicine and imaging General Medicine |
| url |
http://dx.doi.org/10.1186/1476-7120-3-26 |
| publishDate |
2005 |
| physical |
|
| description |
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>background</jats:title>
<jats:p>Interferon alpha2 is widely used in hepatitis and high-risk melanoma. Interferon-induced pulmonary arterial hypertension as a side effect is rare.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Case presentation</jats:title>
<jats:p>We describe a melanoma patient who developed severe pulmonary arterial hypertension 30 months after initiation of adjuvant interferon alpha2b therapy. Discontinuation of interferon did not improve pulmonary arterial hypertension. This patient could be treated successfully with phosphodiesterase-5 inhibitor therapy.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>This is only the 5th case of interferon-induced pulmonary arterial hypertension and the first documented case where pulmonary arterial hypertension was not reversible after termination of interferon alpha2 therapy. If interferon alpha2 treated patients develop respiratory symptoms, pulmonary arterial hypertension should be considered in the differential diagnosis. For these patients phosphodiesterase-5 inhibitors, e.g. sildenafil or vardenafil, could be an effective therapeutic approach.</jats:p>
</jats:sec> |
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| author | Jochmann, Nicoline, Kiecker, Felix, Borges, Adrian C, Hofmann, Maja A, Eddicks, Stephan, Sterry, Wolfram, Baumann, Gert, Trefzer, Uwe |
| author_facet | Jochmann, Nicoline, Kiecker, Felix, Borges, Adrian C, Hofmann, Maja A, Eddicks, Stephan, Sterry, Wolfram, Baumann, Gert, Trefzer, Uwe, Jochmann, Nicoline, Kiecker, Felix, Borges, Adrian C, Hofmann, Maja A, Eddicks, Stephan, Sterry, Wolfram, Baumann, Gert, Trefzer, Uwe |
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| description | <jats:title>Abstract</jats:title> <jats:sec> <jats:title>background</jats:title> <jats:p>Interferon alpha2 is widely used in hepatitis and high-risk melanoma. Interferon-induced pulmonary arterial hypertension as a side effect is rare.</jats:p> </jats:sec> <jats:sec> <jats:title>Case presentation</jats:title> <jats:p>We describe a melanoma patient who developed severe pulmonary arterial hypertension 30 months after initiation of adjuvant interferon alpha2b therapy. Discontinuation of interferon did not improve pulmonary arterial hypertension. This patient could be treated successfully with phosphodiesterase-5 inhibitor therapy.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>This is only the 5th case of interferon-induced pulmonary arterial hypertension and the first documented case where pulmonary arterial hypertension was not reversible after termination of interferon alpha2 therapy. If interferon alpha2 treated patients develop respiratory symptoms, pulmonary arterial hypertension should be considered in the differential diagnosis. For these patients phosphodiesterase-5 inhibitors, e.g. sildenafil or vardenafil, could be an effective therapeutic approach.</jats:p> </jats:sec> |
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| institution | DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1 |
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| spelling | Jochmann, Nicoline Kiecker, Felix Borges, Adrian C Hofmann, Maja A Eddicks, Stephan Sterry, Wolfram Baumann, Gert Trefzer, Uwe 1476-7120 Springer Science and Business Media LLC Cardiology and Cardiovascular Medicine Radiology, Nuclear Medicine and imaging General Medicine http://dx.doi.org/10.1186/1476-7120-3-26 <jats:title>Abstract</jats:title> <jats:sec> <jats:title>background</jats:title> <jats:p>Interferon alpha2 is widely used in hepatitis and high-risk melanoma. Interferon-induced pulmonary arterial hypertension as a side effect is rare.</jats:p> </jats:sec> <jats:sec> <jats:title>Case presentation</jats:title> <jats:p>We describe a melanoma patient who developed severe pulmonary arterial hypertension 30 months after initiation of adjuvant interferon alpha2b therapy. Discontinuation of interferon did not improve pulmonary arterial hypertension. This patient could be treated successfully with phosphodiesterase-5 inhibitor therapy.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>This is only the 5th case of interferon-induced pulmonary arterial hypertension and the first documented case where pulmonary arterial hypertension was not reversible after termination of interferon alpha2 therapy. If interferon alpha2 treated patients develop respiratory symptoms, pulmonary arterial hypertension should be considered in the differential diagnosis. For these patients phosphodiesterase-5 inhibitors, e.g. sildenafil or vardenafil, could be an effective therapeutic approach.</jats:p> </jats:sec> Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report Cardiovascular Ultrasound |
| spellingShingle | Jochmann, Nicoline, Kiecker, Felix, Borges, Adrian C, Hofmann, Maja A, Eddicks, Stephan, Sterry, Wolfram, Baumann, Gert, Trefzer, Uwe, Cardiovascular Ultrasound, Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report, Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and imaging, General Medicine |
| title | Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| title_full | Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| title_fullStr | Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| title_full_unstemmed | Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| title_short | Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| title_sort | long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different pde-5 inhibitors: a case report |
| title_unstemmed | Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report |
| topic | Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and imaging, General Medicine |
| url | http://dx.doi.org/10.1186/1476-7120-3-26 |