Eintrag weiter verarbeiten
The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders
Gespeichert in:
| Zeitschriftentitel: | Blood |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Blood, 98, 2001, 6, S. 1836-1841 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society of Hematology
|
| Schlagwörter: |
| author_facet |
Franchini, Massimo Rossetti, Gina Tagliaferri, Annarita Capra, Franco de Maria, Elena Pattacini, Corrado Lippi, Giuseppe Lo Cascio, Giuliana de Gironcoli, Marzia Gandini, Giorgio Franchini, Massimo Rossetti, Gina Tagliaferri, Annarita Capra, Franco de Maria, Elena Pattacini, Corrado Lippi, Giuseppe Lo Cascio, Giuliana de Gironcoli, Marzia Gandini, Giorgio |
|---|---|
| author |
Franchini, Massimo Rossetti, Gina Tagliaferri, Annarita Capra, Franco de Maria, Elena Pattacini, Corrado Lippi, Giuseppe Lo Cascio, Giuliana de Gironcoli, Marzia Gandini, Giorgio |
| spellingShingle |
Franchini, Massimo Rossetti, Gina Tagliaferri, Annarita Capra, Franco de Maria, Elena Pattacini, Corrado Lippi, Giuseppe Lo Cascio, Giuliana de Gironcoli, Marzia Gandini, Giorgio Blood The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders Cell Biology Hematology Immunology Biochemistry |
| author_sort |
franchini, massimo |
| spelling |
Franchini, Massimo Rossetti, Gina Tagliaferri, Annarita Capra, Franco de Maria, Elena Pattacini, Corrado Lippi, Giuseppe Lo Cascio, Giuliana de Gironcoli, Marzia Gandini, Giorgio 1528-0020 0006-4971 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood.v98.6.1836 <jats:title>Abstract</jats:title> <jats:p>This study looked at 102 anti–hepatitis C virus (HCV)–positive, hepatitis B virus (HBV)–negative, and HIV-negative patients (median age, 45.1 years; range, 15-71) affected by hereditary bleeding disorders who have been infected with HCV for 15 to 34 years (median, 25.1). All these patients were infected before the mid 1980s because of non–virally inactivated pooled blood products. Fourteen patients (13.7%) were HCV-RNA negative with no signs of liver disease and were considered to have cleared the virus. Eighty-eight patients (86.3%) were HCV-RNA positive. The HCV genotype distribution was 1a in 20.5%, 1b in 36.4%, 2 in 17.0%, 3 in 15.9%, 4 in 3.4%, and mixed in 6.8% of cases. Twenty-four patients (23.5%) had serum cryoglobulins, symptomatic in 4 cases, and associated with liver disease and with genotype 1. Among the 88 HCV-RNA–positive patients, 15 (17.0%) had normal alanine aminotransferase levels and abdominal ultrasound, 61 (69.3%) had nonprogressive chronic hepatitis, and 12 (13.7%) had severe liver disease (6 [6.9%] liver cirrhosis, 4 [4.5%] hepatic decompensation, and 2 [2.3%] hepatocellular carcinoma) after a follow-up period of 25 years. There were 3 (3.4%) liver-related deaths. HCV genotype 1, patient's age at evaluation, duration of infection, and severity of congenital bleeding disorder were associated with more advanced liver disease. The results confirm the slow progression of HCV infection in HIV-negative hemophiliacs.</jats:p> The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders Blood |
| doi_str_mv |
10.1182/blood.v98.6.1836 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Medizin Chemie und Pharmazie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC52OTguNi4xODM2 |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC52OTguNi4xODM2 |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Rs1 DE-Pl11 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 |
| imprint |
American Society of Hematology, 2001 |
| imprint_str_mv |
American Society of Hematology, 2001 |
| issn |
1528-0020 0006-4971 |
| issn_str_mv |
1528-0020 0006-4971 |
| language |
English |
| mega_collection |
American Society of Hematology (CrossRef) |
| match_str |
franchini2001thenaturalhistoryofchronichepatitiscinacohortofhivnegativeitalianpatientswithhereditarybleedingdisorders |
| publishDateSort |
2001 |
| publisher |
American Society of Hematology |
| recordtype |
ai |
| record_format |
ai |
| series |
Blood |
| source_id |
49 |
| title |
The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| title_unstemmed |
The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| title_full |
The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| title_fullStr |
The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| title_full_unstemmed |
The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| title_short |
The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| title_sort |
the natural history of chronic hepatitis c in a cohort of hiv-negative italian patients with hereditary bleeding disorders |
| topic |
Cell Biology Hematology Immunology Biochemistry |
| url |
http://dx.doi.org/10.1182/blood.v98.6.1836 |
| publishDate |
2001 |
| physical |
1836-1841 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>This study looked at 102 anti–hepatitis C virus (HCV)–positive, hepatitis B virus (HBV)–negative, and HIV-negative patients (median age, 45.1 years; range, 15-71) affected by hereditary bleeding disorders who have been infected with HCV for 15 to 34 years (median, 25.1). All these patients were infected before the mid 1980s because of non–virally inactivated pooled blood products. Fourteen patients (13.7%) were HCV-RNA negative with no signs of liver disease and were considered to have cleared the virus. Eighty-eight patients (86.3%) were HCV-RNA positive. The HCV genotype distribution was 1a in 20.5%, 1b in 36.4%, 2 in 17.0%, 3 in 15.9%, 4 in 3.4%, and mixed in 6.8% of cases. Twenty-four patients (23.5%) had serum cryoglobulins, symptomatic in 4 cases, and associated with liver disease and with genotype 1. Among the 88 HCV-RNA–positive patients, 15 (17.0%) had normal alanine aminotransferase levels and abdominal ultrasound, 61 (69.3%) had nonprogressive chronic hepatitis, and 12 (13.7%) had severe liver disease (6 [6.9%] liver cirrhosis, 4 [4.5%] hepatic decompensation, and 2 [2.3%] hepatocellular carcinoma) after a follow-up period of 25 years. There were 3 (3.4%) liver-related deaths. HCV genotype 1, patient's age at evaluation, duration of infection, and severity of congenital bleeding disorder were associated with more advanced liver disease. The results confirm the slow progression of HCV infection in HIV-negative hemophiliacs.</jats:p> |
| container_issue |
6 |
| container_start_page |
1836 |
| container_title |
Blood |
| container_volume |
98 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792343405408288769 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T16:50:44.668Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=The+natural+history+of+chronic+hepatitis+C+in+a+cohort+of+HIV-negative+Italian+patients+with+hereditary+bleeding+disorders&rft.date=2001-09-15&genre=article&issn=0006-4971&volume=98&issue=6&spage=1836&epage=1841&pages=1836-1841&jtitle=Blood&atitle=The+natural+history+of+chronic+hepatitis+C+in+a+cohort+of+HIV-negative+Italian+patients+with+hereditary+bleeding+disorders&aulast=Gandini&aufirst=Giorgio&rft_id=info%3Adoi%2F10.1182%2Fblood.v98.6.1836&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792343405408288769 |
| author | Franchini, Massimo, Rossetti, Gina, Tagliaferri, Annarita, Capra, Franco, de Maria, Elena, Pattacini, Corrado, Lippi, Giuseppe, Lo Cascio, Giuliana, de Gironcoli, Marzia, Gandini, Giorgio |
| author_facet | Franchini, Massimo, Rossetti, Gina, Tagliaferri, Annarita, Capra, Franco, de Maria, Elena, Pattacini, Corrado, Lippi, Giuseppe, Lo Cascio, Giuliana, de Gironcoli, Marzia, Gandini, Giorgio, Franchini, Massimo, Rossetti, Gina, Tagliaferri, Annarita, Capra, Franco, de Maria, Elena, Pattacini, Corrado, Lippi, Giuseppe, Lo Cascio, Giuliana, de Gironcoli, Marzia, Gandini, Giorgio |
| author_sort | franchini, massimo |
| container_issue | 6 |
| container_start_page | 1836 |
| container_title | Blood |
| container_volume | 98 |
| description | <jats:title>Abstract</jats:title> <jats:p>This study looked at 102 anti–hepatitis C virus (HCV)–positive, hepatitis B virus (HBV)–negative, and HIV-negative patients (median age, 45.1 years; range, 15-71) affected by hereditary bleeding disorders who have been infected with HCV for 15 to 34 years (median, 25.1). All these patients were infected before the mid 1980s because of non–virally inactivated pooled blood products. Fourteen patients (13.7%) were HCV-RNA negative with no signs of liver disease and were considered to have cleared the virus. Eighty-eight patients (86.3%) were HCV-RNA positive. The HCV genotype distribution was 1a in 20.5%, 1b in 36.4%, 2 in 17.0%, 3 in 15.9%, 4 in 3.4%, and mixed in 6.8% of cases. Twenty-four patients (23.5%) had serum cryoglobulins, symptomatic in 4 cases, and associated with liver disease and with genotype 1. Among the 88 HCV-RNA–positive patients, 15 (17.0%) had normal alanine aminotransferase levels and abdominal ultrasound, 61 (69.3%) had nonprogressive chronic hepatitis, and 12 (13.7%) had severe liver disease (6 [6.9%] liver cirrhosis, 4 [4.5%] hepatic decompensation, and 2 [2.3%] hepatocellular carcinoma) after a follow-up period of 25 years. There were 3 (3.4%) liver-related deaths. HCV genotype 1, patient's age at evaluation, duration of infection, and severity of congenital bleeding disorder were associated with more advanced liver disease. The results confirm the slow progression of HCV infection in HIV-negative hemophiliacs.</jats:p> |
| doi_str_mv | 10.1182/blood.v98.6.1836 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Medizin, Chemie und Pharmazie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4Mi9ibG9vZC52OTguNi4xODM2 |
| imprint | American Society of Hematology, 2001 |
| imprint_str_mv | American Society of Hematology, 2001 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 1528-0020, 0006-4971 |
| issn_str_mv | 1528-0020, 0006-4971 |
| language | English |
| last_indexed | 2024-03-01T16:50:44.668Z |
| match_str | franchini2001thenaturalhistoryofchronichepatitiscinacohortofhivnegativeitalianpatientswithhereditarybleedingdisorders |
| mega_collection | American Society of Hematology (CrossRef) |
| physical | 1836-1841 |
| publishDate | 2001 |
| publishDateSort | 2001 |
| publisher | American Society of Hematology |
| record_format | ai |
| recordtype | ai |
| series | Blood |
| source_id | 49 |
| spelling | Franchini, Massimo Rossetti, Gina Tagliaferri, Annarita Capra, Franco de Maria, Elena Pattacini, Corrado Lippi, Giuseppe Lo Cascio, Giuliana de Gironcoli, Marzia Gandini, Giorgio 1528-0020 0006-4971 American Society of Hematology Cell Biology Hematology Immunology Biochemistry http://dx.doi.org/10.1182/blood.v98.6.1836 <jats:title>Abstract</jats:title> <jats:p>This study looked at 102 anti–hepatitis C virus (HCV)–positive, hepatitis B virus (HBV)–negative, and HIV-negative patients (median age, 45.1 years; range, 15-71) affected by hereditary bleeding disorders who have been infected with HCV for 15 to 34 years (median, 25.1). All these patients were infected before the mid 1980s because of non–virally inactivated pooled blood products. Fourteen patients (13.7%) were HCV-RNA negative with no signs of liver disease and were considered to have cleared the virus. Eighty-eight patients (86.3%) were HCV-RNA positive. The HCV genotype distribution was 1a in 20.5%, 1b in 36.4%, 2 in 17.0%, 3 in 15.9%, 4 in 3.4%, and mixed in 6.8% of cases. Twenty-four patients (23.5%) had serum cryoglobulins, symptomatic in 4 cases, and associated with liver disease and with genotype 1. Among the 88 HCV-RNA–positive patients, 15 (17.0%) had normal alanine aminotransferase levels and abdominal ultrasound, 61 (69.3%) had nonprogressive chronic hepatitis, and 12 (13.7%) had severe liver disease (6 [6.9%] liver cirrhosis, 4 [4.5%] hepatic decompensation, and 2 [2.3%] hepatocellular carcinoma) after a follow-up period of 25 years. There were 3 (3.4%) liver-related deaths. HCV genotype 1, patient's age at evaluation, duration of infection, and severity of congenital bleeding disorder were associated with more advanced liver disease. The results confirm the slow progression of HCV infection in HIV-negative hemophiliacs.</jats:p> The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders Blood |
| spellingShingle | Franchini, Massimo, Rossetti, Gina, Tagliaferri, Annarita, Capra, Franco, de Maria, Elena, Pattacini, Corrado, Lippi, Giuseppe, Lo Cascio, Giuliana, de Gironcoli, Marzia, Gandini, Giorgio, Blood, The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders, Cell Biology, Hematology, Immunology, Biochemistry |
| title | The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| title_full | The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| title_fullStr | The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| title_full_unstemmed | The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| title_short | The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| title_sort | the natural history of chronic hepatitis c in a cohort of hiv-negative italian patients with hereditary bleeding disorders |
| title_unstemmed | The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders |
| topic | Cell Biology, Hematology, Immunology, Biochemistry |
| url | http://dx.doi.org/10.1182/blood.v98.6.1836 |